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Posts Tagged ‘virus’

Two More Patients HIV-Free After Bone Marrow Transplants – ABC News

In VICTORIES & SUCCESS STORIES on September 12, 2012 at 5:08 pm

Read the story on the first man to recover from HIV Positive with a stem cell transplant who is now symptom free for 5 years! https://repairstemcell.wordpress.com/2010/12/10/man-appears-free-of-hiv-after-stem-cell-transplant-for-3-years/

And with these 2 more men now HIV free, perhaps the dream of an HIV Free Generation is one step closer to reality!

Two More Patients HIV-Free After Bone Marrow Transplants

Researchers at Brigham and Women’s Hospital in Boston have discovered that, following bone marrow transplants, two men no longer have detectable HIV in their blood cells.

The finding is significant because it suggests that by giving these patients transplants while they were on anti-retroviral therapy, they may have been cured of the AIDS-causing virus.

“We expected HIV to vanish from the patients’ plasma, but it is surprising that we can’t find any traces of HIV in their cells,” said Dr. Timothy Henrich, one of the researchers studying the two men. “It suggests that under the cover of anti-retroviral therapy, the cells that repopulated the patient’s immune system appear to be protected from becoming re-infected with HIV.”…


Two More Patients HIV-Free After Bone Marrow Transplants – ABC News
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Man appears free of HIV after stem cell transplant – FOR 3 YEARS!

In STEM CELLS FROM THE PAST, VICTORIES & SUCCESS STORIES on December 10, 2010 at 7:43 am
Man appears free of HIV after stem cell transplant – FOR 5 YEARS! …and now there are TWO MORE HIV FREE PATIENTS!!!
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UPDATE TO STORY!!  Jul 26, 2012 3:06pm
Two More Patients HIV-Free After Bone Marrow Transplants

https://repairstemcell.wordpress.com/2012/09/12/two-more-patients-hiv-free-after-bone-marrow-transplants-abc-news/

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THE SIMPLE STORY

  1. 42 year old man has leukemia.
  2. 42 year old man also has HIV.
  3. Man needs bone marrow transplant for leukemia.
  4. Creative doctor uses bone marrow from “retrovirus resistant” donor (the donor can NOT get HIV due to a genetic mutation).
  5. Procedure costs about $150,000 (“retrovirus resistant” donors are very rare and very hard to find).
  6. 42 year old man’s body “TAKES ON” the retrovirus resistance from the donor’s bone marrow.
  7. 42 year old man’s symptoms go away and stay away for one year, two years, 3 years, 4 years  next month.
  8. 42 year old man is now a 46 year old man with no leukemia and no HIV to be found in his body.

SOME DETAILS

  • Doctors have not been able to detect the virus in his blood since about Jan of 2007.
  • In this case, there were 80 compatible blood donors living in Germany and on the 61st sample tested, they found one with the “retrovirus resistant” mutation from both parents.
  • There were no embryonic stem cells involved in this.  The stem cells in bone marrow are adult stem cells only.  Any time you see the words “treated” or “improved” or “recovered” associated with the words “stem cells”, assume it was from adult or repair stem cells until proven otherwise. https://repairstemcell.wordpress.com/stem-cells-for-newbies/

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STEM CELLS AND HIV – SOME PRE-HISTORY

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HISTORY OF THIS STORY (scroll down for full articles below)

  1. The original article that got almost no coverage is from Wall Street Journal – Nov 2008
  2. This article was then posted here in Feb 2009https://repairstemcell.wordpress.com/2009/02/20/stem-cells-hiv-part-2-a-doctor-a-mutation-and-a-potential-cure-for-aids-wsjcom/
  3. The abstract of the case was posted in the New England Journal of Medicine in Feb 2009 – See abstract below
  4. One of the most recent articles was in foxnews.com Dec 2010

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THE NOVEMBER 7, 2008 STORY

A Doctor, a Mutation and a Potential Cure for AIDS – A Bone Marrow Transplant to Treat a Leukemia Patient Also Gives Him Virus-Resistant Cells; Many Thanks, Sample 61

“A 42-year-old HIV patient with leukemia appears to have no detectable HIV in his blood and no symptoms after a stem cell transplant from a donor carrying a gene mutation that confers natural resistance to the virus that causes AIDS, according to a report published Wednesday in the New England Journal of Medicine.”

WHAT REALLY HAPPENED?

The startling case of an AIDS patient who underwent a bone marrow transplant to treat leukemia is stirring new hope that gene-therapy strategies on the far edges of AIDS research might someday cure the disease.

The patient, a 42-year-old American living in Berlin, is still recovering from his leukemia therapy, but he appears to have won his battle with AIDS. Doctors have not been able to detect the virus in his blood for more than 600 days, despite his having ceased all conventional AIDS medication. Normally when a patient stops taking AIDS drugs, the virus stampedes through the body within weeks, or days.

[Dr. Gero Hutter]
Sixten Koerper
Dr. Gero Hütter isn’t an AIDS specialist, but he ‘functionally cured’ a patient, who shows no sign of the disease.

“I was very surprised,” said the doctor, Gero Hütter.

The breakthrough appears to be that Dr. Hütter, a soft-spoken hematologist who isn’t an AIDS specialist, deliberately replaced the patient’s bone marrow cells with those from a donor who has a naturally occurring genetic mutation that renders his cells immune to almost all strains of HIV, the virus that causes AIDS.

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THE December 14, 2010 STORY

Doctors Claim HIV-Positive Man Cured by Stem Cell Transplant

Published December 14, 2010 – | FoxNews.com

There’s an estimated 33 million people worldwide living with HIV/AIDS, and now doctors believe one of them may have been cured of the virus after receiving a stem cell transplant in 2007, the medical journal Blood reported.

Timothy Ray Brown, an HIV-positive American living in Germany, had leukemia and was undergoing chemotherapy, when he received a transplant of stem cells from a donor carrying a rare, inherited gene mutation that seems to make carriers virtually immune to HIV infection.

The transplant appeared to wipe out both diseases, giving hope to doctors, but Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases, who has been studying HIV/AIDS for almost 30 years, said while this is an interesting proof of concept, it’s absurdly impractical.

“It’s hard enough to get a good compatible match for a transplant like this,” Fauci told FoxNews.com, “But you also have to find compatible donor that has this genetic defect, and this defect is only found in 1 percent of the Caucasian population and zero percent of the black population. This is very rare.”

Fauci said while this patient is “functionally cured” this is not something you can do with every HIV-infected individual.

“This is not prime time to me at all,” he said. “This is a very unusual situation that has little practical application for a simple reason. This donor not only had to be a good compatible match, but the donor had to have a genetic defect of cells that do not express the receptor that the HIV virus needs to enter the cell.”

Fauci also pointed to the fact that this transplant process is not only expensive, it’s incredibly painful and complicated, and requires the patient to start a whole new regimen of drugs.

“This patient is trading one poison for another. He may not have to be on antiretroviral drugs anymore, but he has to take immunosuppressant drugs now to prevent the rejection of his transplant cells. Again, what this is, is an interesting proof of concept, but it’s absolutely impractical.”

Dr. Thomas Quinn, director of Johns Hopkins Center for Global Health told FoxNews.com that he is very familiar with the “Berlin patient” case.

“This was a new report that looked much deeper into whether HIV could still be present or lurking in the body in some way, not cured, and since the transplant he remains viral free and his cells appear to be resistant to infection,” he said.

Quinn said he agrees with the researchers on this case that it would be qualified as the first HIV cure, opening the door to alternative means of curing HIV.

“He [Brown] has been without therapy for three years and appears to be free of the virus,” he said. “It gives hope to the millions of people infected with HIV that cure is a feasible option in the future.”

Even though Brown’s procedure proved to be successful, Quinn also warns that this was a rare case and a bone marrow transplant is not a cure-all for other HIV patients.

“It is a near fatal procedure that he had to have done because of the leukemia, but this procedure is very expensive and you have to be transplanted with a donor who is shown to be already resistant to HIV,” Quinn said. “You’re asking for a tall order to replicate this in the future.”

Brown’s case was published in a February 2009 issue of the New England Journal of Medicine

Read more: http://www.foxnews.com/health/2010/12/14/doctors-claim-hiv-positive-man-cured-stem-cell-transplant/#ixzz18Cug4Euz

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THE ABSTRACT FROM NEW ENGLAND JOURNAL OF MEDICINE

Volume 360:692-698  February 12, 2009  Number 7
NextNext

Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell

Transplantation

Gero Hütter, M.D., Daniel Nowak, M.D., Maximilian Mossner, B.S., Susanne Ganepola, M.D., Arne Müßig, M.D., Kristina Allers, Ph.D., Thomas Schneider, M.D., Ph.D., Jörg Hofmann, Ph.D., Claudia Kücherer, M.D., Olga Blau, M.D., Igor W. Blau, M.D., Wolf K. Hofmann, M.D., and Eckhard Thiel, M.D.

SUMMARY

Infection with the human immunodeficiency virus type 1 (HIV-1)requires the presence of a CD4 receptor and a chemokine receptor,principally chemokine receptor 5 (CCR5). Homozygosity for a32-bp deletion in the CCR5 allele provides resistance againstHIV-1 acquisition. We transplanted stem cells from a donor whowas homozygous for CCR5 delta32 in a patient with acute myeloidleukemia and HIV-1 infection. The patient remained without viralrebound 20 months after transplantation and discontinuationof antiretroviral therapy. This outcome demonstrates the criticalrole CCR5 plays in maintaining HIV-1 infection.
Source Information

From the Department of Hematology, Oncology, and Transfusion Medicine (G.H., D.N., M.M., S.G., A.M., O.B., I.W.B., W.K.H., E.T.) and the Department of Gastroenterology, Infectious Diseases, and Rheumatology (K.A., T.S.), Campus Benjamin Franklin; and the Institute of Medical Virology, Campus Mitte (J.H.) — all at Charité Universitätsmedizin Berlin; and the Robert Koch Institute (C.K.) — all in Berlin.

Drs. Hofmann and Thiel contributed equally to this article.

Address reprint requests to Dr. Hütter at Medical Department III Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin, Hindenburgdamm 30 D-12203 Berlin, Germany, or at gero.huetter@charite.de// <!–[CDATA[–>
var u = “gero.huetter”, d = “charite.de”; document.getElementById(“em0”).innerHTML = ‘‘ + u + ‘@’ + d + ”
// ]]>.

Full Text of this Article

This article has been cited by other articles:

  • Arababadi, M. K., Hassanshahi, G., Azin, H., Salehabad, V. A., Araste, M., Pourali, R., Nekhei, Z. (2010). No Association Between CCR5-{Delta}32 Mutation and Multiple Sclerosis in Patients of Southeastern Iran. Lab Med 41: 31-33 [Abstract] [Full Text]
  • Fauci, A. S., Folkers, G. K. (2009). Investing To Meet The Scientific Challenges Of HIV/AIDS. Health Aff (Millwood) 28: 1629-1641 [Abstract] [Full Text]
  • Bonsignori, M., Moody, M. A., Parks, R. J., Holl, T. M., Kelsoe, G., Hicks, C. B., Vandergrift, N., Tomaras, G. D., Haynes, B. F. (2009). HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection. J. Immunol. 183: 2708-2717 [Abstract] [Full Text]
  • Levy, J. A. (2009). The Unexpected Pleiotropic Activities of RANTES. J. Immunol. 182: 3945-3946 [Full Text]
  • (2009). All you need to read in the other general journals. BMJ 338: b627-b627 [Full Text]
  • (2009). Stem-Cell Transplantation Enables Long-Term HIV Control. AIDS Clin Care 2009: 1-1 [Full Text]
  • Levy, J. A. (2009). Not an HIV Cure, but Encouraging New Directions. NEJM 360: 724-725 [Full Text]

From http://content.nejm.org/cgi/content/short/360/7/692

New Disease Identified By Australian Researchers

In VICTORIES & SUCCESS STORIES on May 27, 2010 at 9:40 am

And now, stem cells are treating disease that we don’t even know about yet! – dg

New Disease Identified By Australian Researchers

Researchers at the Queensland Institute of Medical Research (QIMR) and the Royal Brisbane Women’s Hospital have identified a previously undiagnosed condition and successfully treated it by performing an experimental stem cell transplant.

Having spent her late teenage years in and out of hospital Katie Pulling had almost given up hope. “It was very confusing and very daunting. I kept hearing the doctors say, ‘We don’t know what is wrong’, ‘We don’t know why you are so sick’,” said Katie, who lives in north-eastern NSW.

With no options left Katie agreed to an experimental stem cell transplant – a transplant which ultimately saved her life.

“Katie presented with a range of symptoms when she was eleven. No one could identify her condition and no treatment had been successful. She did not respond to regular treatments and she continued to get sick, often complicated by life-threatening infections,” said Dr Maher Gandhi head of QIMR’s Clinical Immunohaemotology Laboratory.

The key to unlocking the reason for Katie’s reoccurring symptoms came when she contracted the common teenage virus that causes glandular fever. Usually most people come down with only a mild infection. However, Katie developed a full-blown version known as fulminant infectious mononucleosis (FIM)…

via New Disease Identified By Australian Researchers.

First Ever Multicellular Animals Found In Oxygen-Free Environment | Popular Science

In OFF THE BEATEN PATH on April 7, 2010 at 3:48 pm

First Ever Multicellular Animals Found In Oxygen-Free Environment

Unnamed Loriciferan:   via Nature

By Stuart Fox Posted 04.06.2010 at 5:30 pm

In the 236 years since oxygen was identified as a life-giving necessity, no scientist anywhere has discovered a multicellular animal capable of living without the stuff. Until now. Researchers from the Polytechnic University of Marche in Ancona, Italy, have discovered three new species that live their entire life in an anoxic pit beneath the Mediterranean Sea. This discovery drastically revises science’s understand of where animals can thrive.Prior to this discovery, the only organisms capable of life in oxygen-free environments were viruses and bacteria.

via First Ever Multicellular Animals Found In Oxygen-Free Environment | Popular Science.

Baxter Admits Contaminating 72 Kilos Of Vaccine

In ALL ARTICLES on November 22, 2009 at 1:45 pm

Vodpod videos no longer available.

On TVN24 in Poland Baxter has admitted they contaminated 72 KG of vaccine material with the live bird flu virus.

As a result of handling this contaminated material in February, 36 people working for the labs Avir and BioTest had to be treated preventatively for the bird flu in hospitals in Austria and the Czech Republic, underlining that their health was threatened by the material in the opinion of medical experts.
Both Avir and BioTest have stated that the final purpose of the contaminated Baxter material was for use in regular seasonal flu vaccines, strongly suggesting the notion it would have been injected into people if it had not been detected by staff at BioTest.

The Times of India reported on March 6th that a global bird flu pandemic had nearly been triggerd by the Baxter material.

thevirus

Because Baxter is obliged under EU rules to handle the bird flu virus using biosafety level 3 or 4 precautions in its ultra modern biomedical facilities in Austria, an accidental contamination can be virtually ruled out.  No evidence has been presented by Baxter to prove otherwise.

Biosafety level 3 regulations apply to any virus that can cause a serious disease in human beings. The bird flu, a lab engineered virus, has a mortality rate of over 60%. The gigantic amount of 72 kilos of vaccine material was contaminated in Orth an der Donau.

It is not clear why Baxter had the bird flu virus in its vaccine production facilities in Orth an der Donau in the first place.

WHO supplied the bird flu virus to Baxter. For what purpose?

Vodpod videos no longer available.

 

SWINE FLU EXPOSE 1977 & SWINE FLU PANIC 2009

In ALL ARTICLES on April 28, 2009 at 10:41 pm

SWINE FLU EXPOSE (1977)

SWINE FLU EXPOSE (1977) is a book by Eleanora McBean Ph.D., N.D.

You can read SWINE FLU EXPOSE (1977) here: https://repairstemcell.wordpress.com/swine-flu-expose-1977-long/

Quotes by Eleanora McBean:

“TYPHOID MARY” WAS NEVER A CARRIER by Eleanora I. McBean, Ph.D., N.D.

Other Eleanora McBean Books:
[1977] Vaccination, The Silent Killer—-Honorof, Ida, and McBean.

[1977] Swine Flu Expose by Eleanora I. McBean, Ph.D., N.D.

[1957 CLASSIC] THE POISONED NEEDLE by Eleanor McBean

[1957] The Hidden Dangers In Polio Vaccine (Chapter 10 of Poisoned Needle) by Eleanor McBean

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Swine flu panic 2009

Read it here: Swine flu panic 2009

“Virus Mania is a social disease of our highly developed society. To cure it will require conquering fear, fear being the most deadly contagious virus, most efficiently transmitted by the media. Errare humanum est sed diabolicum preservare… (to err is human, but to preserve an error is diabolic).”—-Etienne de Harven

Doctors sound alarm on pig flu

In ALL ARTICLES on April 26, 2009 at 10:03 pm
swine flu?

swine flu?

Doctors sound alarm on pig flu

  • Julia Medew
  • April 27, 2009

AUSTRALIANS have been urged to look out for symptoms of a deadly swine flu that appears to have spread from Mexico to New Zealand, France and the US, sparking fears of a major pandemic.

Australia’s chief medical officer Jim Bishop briefed hospital emergency departments and GPs on the flu’s symptoms at the weekend after the World Health Organisation warned it was a “public health emergency of international concern”…

via http://www.theage.com.au/national/doctors-sound-alarm-on-pig-flu-20090426-ajeg.html

pig-science_history

SWINE FLU WATCH – 04/26/09 9:50 PM EST

In ALL ARTICLES on April 26, 2009 at 9:51 pm

  swine flu virus  The swine flu virus seen through a microscope.  Image: Reuters-TV

swine flu virus The swine flu virus seen through a microscope. Image: Reuters-TV

Hong Kong, Minding SARS, Announces Tough Measures in Response to

New York Times – ‎3 hours ago‎ Hong Kong should “prepare for the worst” if the swine flu virus develops a clear ability to pass from person to person, Dr. Chow said, adding that the risk Video: Containing Swine Flu In Mexico CBS

Swine Flu Confirmed in New York Students

Washington Post Swine flu ‘debacle’ of 1976 is recalled Los Angeles Times ABC News – San Jose Mercury News all 15,354 news articles » Canoe.ca

Mexico Seeks to Contain Swine Flu, Economic Impact

Bloomberg – ‎3 hours ago‎ In the US, 20 people have confirmed cases of swine flu linked to the Mexican virus, and the acting head of the Centers for Disease Control and Prevention World Bank gives aid to Mexico for swine flu The Associated Press Mexico granted $205m swine flu loan from World Bank guardian.co.uk World Bank to support Mexico’s Strategy to fight Swine Flu with World Bank Group Monsters and Critics.com – NASDAQ all 254 news articles »

Yen Rises on Concern US Slump Deepening, Swine Flu Spreading

Bloomberg – ‎30 minutes ago‎ The dollar weakened along with high-yielding currencies including those of Australia and New Zealand as the number of cases of swine flu in the US and Dollar falls to lowest in month vs yen on swine flu Reuters Japanese Banks Lead Stocks Higher Wall Street Journal NZ Dollar Drops on Rate-Cut Concerns, Australia’s Declines Bloomberg all 14 news articles »

NYC prep school cancels classes over suspected flu

The Associated Press – ‎10 hours ago‎ NEW YORK (AP) – Classes and student activities have been canceled at a New York City private school where eight students may have come down with swine flu.

Epidemiologist says no cases of swine flu in Iowa

Chicago Tribune – ‎7 hours ago‎ AP DES MOINES, Iowa – As international health officials watch for the spread of swine flu, the Iowa public health officials are recommending that anyone who State epidemiologist says no cases of swine flu reported in Iowa WQAD all 19 news articles »

Mexico Peso Falls on Concern Swine Flu to Deepen Economic Slump

Bloomberg – ‎1 hour ago‎ By Valerie Rota April 27 (Bloomberg) — Mexico’s peso sank to its lowest in almost three weeks on concern an outbreak of the deadly swine flu will deepen an FOREX-Yen, dollar gain, peso falls on flu jitters Reuters Mexico’s peso falls 3 percent in Asian trading Reuters all 9 news articles »

No swine flu in Ind; 2 specimens go to CDC

Chicago Tribune – ‎5 hours ago‎ By KEN KUSMER | AP Writer INDIANAPOLIS – State health officials urged public vigilance Sunday to guard against an outbreak of swine flu in Indiana, No swine flu in Ind; 2 specimens go to CDC Fox 28 all 9 news articles »

Santa Clara County plans for swineflu outbreak

San Jose Mercury News – ‎32 minutes ago‎ By Joe Rodriguez No one in Santa Clara County has turned up with the swine flu, but local health officials met Sunday after the federal government declared Think Progress

Texas Gov. Perry seeks anti-viral treatment for swine flu for Texas

Dallas Morning News – ‎18 hours ago‎ Rick Perry has asked for 37430 courses of anti-viral medicine from the Centers for Disease Control and Prevention because of the swine flu outbreak. Texas prepares for possible swine flu outbreak CBS 42 Secessionist Gov. Rick Perry asks for federal help to deal with Think Progress all 17 news articles »

World govts race to contain swine flu outbreak

Kansas City Star – ‎4 hours ago‎ COURTESY: WABC-TV White House press secretary Robert Gibbs says there’s no reason for Americans to panic over reported cases of swine flu.

SWINE FLU WATCH & PICS

In ALL ARTICLES on April 26, 2009 at 9:29 pm
  • This is a map Tracking all of the Confirmed H1N1 Swine Flu Cases

http://maps.google.com/maps/ms?hl=en&ie=UTF8&msa=0&msid=106484775090296685271.0004681a37b713f6b5950&ll=47.100045,9.316406&spn=34.792294,79.101563&t=h&z=4

This does not factor in the avian (bird) flu cases.  Swine flu is a new strain of bird flu that is transmitted respiratorially from pig to people, people to pig and people to people.

LEGEND:

Pink markers are suspected cases.
Purple markers are confirmed cases.
Deaths lack a dot in marker.

CORRECTION Mexico Swine Flu

Mexico Swine Flu - military personnel hands out masks

CORRECTION Mexico Flu

Mexico - workers line up with masks on

swine-flu-alg_pig_testing

Vet tests pigs for swine flu

swine-flu-painting

swine-flu-painting?

  • March 24, 1976: Ford Orders Swine-Flu Shots for All

By Tony Long Email 03.24.08 October 12, 1976: Nurse Jacqueline Spaky administers a swine-flu injection with an injector gun on the first day of the immunization program in New York City.
Photo courtesy Bettman/Corbis

1976: President Gerald Ford orders a nationwide vaccination program to prevent a swine-flu epidemic.

Ford was acting on the advice of medical experts, who believed they were dealing with a virus potentially as deadly as the one that caused the 1918 Spanish influenza pandemic.

The virus surfaced in February at Fort Dix, New Jersey, where 19-year-old Pvt. David Lewis told his drill instructor that he felt tired and weak, although not sick enough to skip a training hike. Lewis was dead with 24 hours.

The autopsy revealed that Lewis had been killed by “swine flu,” an influenza virus originating in pigs. By then several other soldiers had been hospitalized with symptoms. Government doctors became alarmed when they discovered that at least 500 soldiers on the base were infected without becoming ill…

http://www.wired.com/science/discoveries/news/2008/03/dayintech_0324

Virus-free Embryonic-like Stem Cells Made From Skin Of Parkinson’s Disease Patients

In ALL ARTICLES, SCIENCE & STEM CELLS on March 10, 2009 at 10:13 pm

The researchers stained the cells green for a neuron-specific protein (class III beta-tubulin) and red for a dopamine-producing neuron-specific enzyme (tyrosine hydroxylase).

ScienceDaily: Your source for the latest research news and science breakthroughs — updated daily

As I’ve mentioned over and over…very soon, adult stem cells will do anything that embryonic stem cells can do…minus the tumor causing property of course. – dg

This marks the first time researchers have generated human iPS cells that have maintained their embryonic stem-cell-like properties after the removal of reprogramming genes. The findings are published in the March 6 edition of the journal Cell.

via Virus-free Embryonic-like Stem Cells Made From Skin Of Parkinson’s Disease Patients.

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