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Caught on tape: Muscle stem cells captured on video

In STEM CELLS - 101 on May 6, 2010 at 1:21 pm

Caught on tape: Muscle stem cells captured on video

May 6, 2010

When muscle tissue experiences trauma or disease, such as muscular dystrophy, stem cells in the muscle known as “satellite cells” respond to repair and regenerate the muscle. These cells are particularly important in neuromuscular diseases, such as muscular dystrophy, which affect muscle stability and repair. Now, University of Missouri researchers have used time-lapse photography to document satellite cell movements and behaviors when they interact with their ‘host’ myofiber. Scientists hope that if they can understand more about what satellite cells do in healthy muscle, obstacles to cell or gene therapies for muscular dystrophy might be overcome.

“We have been trying to understand what’s happening in these cells using the technology we have, which basically lets us take one snap shot per cell,” said Dawn Cornelison, assistant professor of biological sciences in the College of Arts and Science and investigator in the Bond Life Sciences Center. “That’s like taking one picture per game of a series of different football games and trying to use them to figure out the rules of football. This new technology is like watching the football game on TV. Now, we can see what’s going on with groups of cells over time, how they move, how they’re related and what kinds of different things they do. We were really surprised by a lot of things we saw because we never expected them to act that way.”

TOO VIEW THE VIDEO, CLICK HERE

University of Missouri researchers have used time-lapse photography to document satellite cell movements and behaviors when they interact with their “host” myofiber. Credit: Video courtesy of Dawn Cornelison

are small and rare, and only become active in specific conditions associated with damage or disease. Once activated, they multiply, establishing a large population of replacement cells in the , then differentiate to replace or repair damaged muscle. Patients with Duchenne’s Muscular Dystrophy have so fragile that simply moving or breathing causes them to tear. While the satellite cells do a good job repairing this damage in early childhood, the cells eventually fall behind. Because this is a genetic disease, the new muscle made from the satellite cells has the same defect, so even the repaired doesn’t last long. Without repair, the muscles in these patients eventually stop working. In the severest form, this disease is fatal by early adulthood.

Since 1989, scientists and physicians have tried to use transplanted satellite cells from healthy donors as a therapy for , but have had very little success. One major problem with therapies being tried now is that the transplanted cells never move away from the site where they are injected, so patients require a large number of injections over a very small area, up to 4,000 injections in a single individual.

“Previous studies had little data about how satellite cells moved, and many scientists thought that satellite cells didn’t move,” Cornelison said. “The time-lapse videomicroscopy showed that they can and do move. Some cells travel a few centimeters in a day. Now, we can ask things like ‘is it important for them to be able to move?’, ‘where are they going?’, ‘what factors do they need to tell them where and how to move?’ and ‘what are the cells saying to each other?’ Hopefully, the answers to these questions will help us think of ways to improve satellite cell therapies. For example, it would be wonderful if we could just tell all the cells in a transplant to move away from where they were injected, so they wouldn’t be overcrowded and die.”

More information: The study, “3D Time-lapse Analysis of Muscle Satellite Cell Motility,” was published in Stem Cells.

Provided by University of Missouri-Columbia

via Caught on tape: Muscle stem cells captured on video.

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Adult stem cells fix hearts – part 4 – LINKS OF PROOF

In ALL ARTICLES on September 11, 2009 at 4:59 pm

Adult stem cells fix hearts – part 4

LINKS OF PROOF

BY JAMES EILERT heart_attack1
Vice President
Save A Life Heal A Heart Foundation
JUNE 24, 2009

Below are links showing how adult stem cell therapy has regrown much of my heart. I am now living a much fuller life and wish others to enjoy these benefits as well. Please take the time to watch these videos and tell others what you have seen. Heart failure does not have to be a death sentence anymore. Spread the word, you may just save a life just from talking about it!

Best Wishes,

James Eilert

http://www.repairstemcells.org/N…

http://repairstemcell.wordpress….

http://www.facebook.com/profile….

http://www.facebook.com/profile….

http://www.facebook.com/home.php…

http://www.facebook.com/home.php…

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Wanna video chat live today with a stem cell therapy recipient in China? | The Pluripotent

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 18, 2009 at 10:22 am

Wanna video chat live today with a stem cell therapy recipient in China?

TODAY AT 3:15 p.m.  MST (Colorado time) HERE:

http://www.coloradoan.com/article/20090218/UPDATES01/302180001

Posted by James Oh On February – 18 – 2009

CB013130Patients with disorders that can be treated by stem cell therapy may find that they can’t find treatments in the US. Some of them end up traveling overseas to try experimental stem cell therapy procedures that aren’t legally offered in the United States. These treatments can be dangerous because these unproven treatments may lack appropriate oversight or patient monitoring. And clinics targeting medical tourists may use poorly characterized cells.

You can to live chat today with Macie Morse, who’s in China for receiving stem cell therapy to improve her vision. She’ll be on this website at 3:15 p.m. MST (Colorado time). Viewers can log on to Coloradoan.com and watch a live interview with Morse, as well as chat and ask her questions. You can also submit questions in advance to halliewoods@coloradoan.com.

via Wanna video chat live today with a stem cell therapy recipient in China? | The Pluripotent.

STEM CELLS & Autism Cure?

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 12:37 pm

Video of an autistic girl improving after receiving stem cell injections

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Treatment center uses adult stem cells to treat Autism.

Stem Cells Used In Woman’s Windpipe Transplant : NPR

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 12:10 pm

Stem Cells Used In Woman’s Windpipe Transplant

by Joe Neel and Joanne Silberner


Windpipe transplant patient Claudia Castillo. CREDIT: Courtesy of The Lancet

All Things Considered, November 19, 2008 · Doctors in Spain have implanted a new windpipe into a woman whose airway was badly damaged by tuberculosis.

The pioneering operation used a section of windpipe engineered in a laboratory with adult human stem cells, according to Dr. Paolo Macchiarini, of the Hospital Clinic in Barcelona, Spain.

Engineering new tissues and organs from stem cells has long been a goal of researchers, because it would help overcome a chronic shortage of donor organs.

via Stem Cells Used In Woman’s Windpipe Transplant : NPR.

SKorean Firm: Dogs Cloned Using Stem Cells

In ALL ARTICLES, STEM CELLS IN THE NEWS, VIDEOS on February 12, 2009 at 12:01 pm

REX IS BESIDES HIMSELF

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STEM CELLS & MS – Multiple Sclerosis Cured by Adult Stem Cells- Video – Stem Cell Research and Stem Cell Therapy

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES, VIDEOS on February 12, 2009 at 11:40 am

Multiple Sclerosis Cured by Adult Stem Cells- Video

Today, Edwin's symptoms of MS have completely disappeared.

Written by Stemcells on Feb-11-09 2:13am

From: donmargolis.com

Posted 11 February, 2009 in Multiple Sclerosis |

In yet another triumph for Adult Stem Cell research- two weeks ago, Dr. Richard Burt came out with sensational results of his study at Northwestern University treating Multiple Sclerosis (MS) with the patient’s own Adult Stem Cells. This study showed that of the 21 patients with Multiple Sclerosis treated with their own stem cells taken from their bone marrow, 16 have had their MS “disappear” . Excellent!

Edwin McClure was one of those treated and cured of his MS by the stem cell treatment . He is interviewed by CBS on their “Early Show” here. This is a great video. Edwin talks about how he was shocked when he was diagnosed with Multiple Sclerosis in high school and how at first he didn’t want the stem cell treatment. I think it is safe to say he has changed his way of thinking- watch the whole video- FANTASTIC!

via Multiple Sclerosis Cured by Adult Stem Cells- Video – Stem Cell Research and Stem Cell Therapy – Zimbio.

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