DAVID GRANOVSKY

Posts Tagged ‘tumor’

Stem cells VS chemo resistant metastatic esophageal cancer?

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 28, 2013 at 9:00 am

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“…chemo resistant metastatic esophageal cancer…”

I was recently contacted by a patient with chemo resistant metastatic esophageal cancer.  This is the 2nd patient in a row with this condition.  The prior one presented with stage 4 esophageal cancer. We had to determine if the cancer is/is not in the bone marrow to assess how much it has metastasized or whether it is localized to the esophagus. In any case, the first patient was treated with the protocol I posted previously and it reduced the cancer cell markers by 40% within 3 weeks. The mesenchymal stem cells recruited NTK (Natural Killer Cells) which reduce the tumors and cancer cell markers. The patient is now 3 months post op (as of 1/26/13) and is doing extremely well. He is at Stage 1 down from Stage 4. He has decided to receive a second treatment and we are hopeful he will retain full remission.
- DG

Stem cells for cancer? Yes.

This works because:
“…tumor-oriented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. The dual-targeted strategy is based on MSCs’ capacity of tumor-directed migration and incorporation and in situ expression of tumor-specific anticancer genes.”
From http://www.wjgnet.com/1948-0210/pdf/v3/i11/96.pdf

Look for this article and others on my blog: repairstemcell.wordpress.com

STEM CELL VACCINE IN DEVELOPMENT TO FIGHT CANCER

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 10, 2013 at 9:00 am

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Cancer Stem Cell Vaccine in Development Shows Anti-tumor Effect

Philadelphia – Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.”

“This is a major breakthrough in immunotherapy research because we were able to use purified cancer stem cells to generate a vaccine, which strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells.  We found that these enriched cancer stem cells were immunogenic and far more effective as an antigen source compared with the unselected tumor cells normally used in previous immunotherapy trials. The mechanistic investigations found that when antibodies were primed with cancer stem cells, they were capable of targeting cancer stem cells and conferring anti-tumor immunity.”

-          Qiao Li, Ph.D., a research assistant professor, department of surgery, University of Michigan.

imgname--threeparent_embryo---50226711--images--IVF_egg

The researchers also found that cytotoxic T lymphocytes harvested from cancer stem cell-vaccinated hosts were capable of killing cancer stem cells in vitro.”

http://www.aacr.org/home/public–media/aacr-press-releases.aspx?d=2744

Journal Reference:  Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity. Cancer Research, 2012; 72 (7): 1853 DOI: 10.1158/0008-5472.CAN-11-1400

STEM CELL THERAPIES TARGET OVARIAN CANCER

In STEM CELLS IN THE NEWS on January 9, 2013 at 10:46 pm

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“Each year, about 20,000 women in the United States get ovarian cancer. Among women in the United States, ovarian cancer is the eighth most common cancer and the fifth leading cause of cancer death, after lung and bronchus, breast, colorectal, and pancreatic cancers. Ovarian cancer causes more deaths than any other cancer of the female reproductive system, but it accounts for only about 3% of all cancers in women. When ovarian cancer is found in its early stages, treatment is most effective.†”

Ovarian cancer stem cell study puts targeted therapies within reach

“Researchers at Yale School of Medicine have identified a key link between stem cell factors that fuel ovarian cancer’s growth and patient prognosis.  Yingqun Huang, M.D. and her colleagues have demonstrated a connection between two concepts that are revolutionizing the way cancer is treated.

First, the “cancer stem cell” idea suggests that at the heart of every tumor there is a small subset of difficult-to-identify tumor cells that fuel the growth of the bulk of the tumor. This concept predicts that ordinary therapies typically kill the bulk of tumor cells while leaving a rich environment for continued growth of the stem cell tumor population.  The second concept defines a critical role for the tumor cells’ “microenvironment,” which is the special environment required for cancer cell growth and spread.  “Both concepts have particular relevance for the treatment of adult solid tumors such as ovarian cancer, which has been notoriously difficult to diagnose and treat. Ovarian cancer patients are plagued by recurrences of tumor cells that are resistant to chemotherapy, ultimately leading to uncontrolled cancer growth and death.”

Cell Cycle Vol. 12, Issue 1

Source: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2009 Incidence and Mortality Web-based Report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; 2013. Available at: http://www.cdc.gov/uscs.

Need information on a specific disease, click HERE for more information.

EMBRYONICS’ BLEAK FUTURE AND BOTCHED PAST

In ALL ARTICLES on November 15, 2011 at 6:42 pm

Request more treatment info.

EMBRYONICS’ BLEAK FUTURE AND BOTCHED PAST

BLEAK FUTURE

I just received a comment from MB and despite Geron and the rest of the world abandoning embryonic stem cells for adult, he is still optimistic about the future of embryonic stem cells (with a little plug snuck in for a company he probably owns stock in).

My original comment:

embryonic research has been 100% fruitless (in regard to generating
treatments) for well-funded and government supported scientists around the world for the last 13 years.  Embryonic stem cells are the only significant obstacles to embryonic stem cell treatments.  Adult stem cells on the other hand have successfully treated 10s of thousands over the past decade.

MB’s response:

hESCs (human embryonic stem cells) have only been around for 13 years compared to adult stem cells 30+ years…. give it some time… human embryonic stem cells (especially ACT’s embryo SAFE blastomere-derived) will be THE GOLD standard :)  watch and SEEE the difference…soon..

My response:

MB – Not even close.   Embryonic stem cells have been around for way longer than since James Thompson and friends derived the first human embryonic stem cell line at the University of Wisconsin-Madison in 1998.

To clarify:

“Research in the human stem cell field grew out of findings by Canadian scientists Ernest A. McCulloch and James E. Till in the 1960s.”

1963: Becker AJ, McCulloch EA, Till JE (1963). “Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells”. Nature 197: 452-4. PMID 13970094.

1963: Siminovitch L, McCulloch EA, Till JE (1963). “The distribution of colony-forming cells among spleen colonies”. Journal of Cellular and Comparative Physiology 62: 327-36. PMID 14086156.

1978: Stem cells were discovered in human cord blood

1981: First in vitro stem cell line developed from mice

1981 – Mouse embryonic stem cells are derived from the inner cell mass

That’s 30 years ago!

Evans, M.J. & Kaufman, M. Establishment in culture of pluripotential stem cells from mouse embryos. Nature 292, 151–156 (1981).

1981 – Martin, G.R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci USA 78, 7634–7638 (1981).

1984 – Andrews, P.W. et al. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Lab. Invest. 50, 147–162 (1984).

Blastomeres isolated from the ICM of mammalian embryos and grown in culture are known as embryonic stem (ES) cells. These pluripotent cells, when grown in a carefully coordinated media, can give rise to all three germ layers (ectoderm, endoderm, and mesoderm) of the adult body.

1986: Robertson, Elizabeth , et al. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323, 445 – 448 (02 October 1986)

1988: Embryonic stem cell lines created from a hamster

1995: First embryonic stem cell line derived from a primate

1995: Thomson, J.A. et al. Isolation of a primate embryonic stem cell line. Proc. Natl. Acad. Sci. USA 92, 7844–7844 (1995).

And then we get to what MB considers the “discovery of embryonic stem cells”:

1998 – James Thomson and coworkers derive the first human embryonic stem cell line at the University of Wisconsin-Madison.

Not to worry, though MB.  Adult stem cells HAVE been used in bone marrow transplants for over 40 years so they still have the upper hand in “time we’ve worked with them.”  Then again, it was only in 1998 that adult stem cells were considered for treating other illnesses.

Just out of curiosity, besides

“embryonic stem cells have proven 100% fruitless (in regard to generating treatments) for well-funded and government supported scientists around the world for the last 13 years,”

how do you plan on addressing these other embryonic stem cell issues to name a few?

  1. they create cysts and tumors that can develop into cancer at the site of the injection and injury
  2. rejection issues require immunosuppressive drugs for the ill patient
  3. embryonic stem cells (and induced pluripotent stem cells) carry the genetic anomalies of the donor
  4. they have to date treated zero diseases successfully
  5. scientists probably need to cure cancer first to use them
MIRROR THE RESULTS

MIRROR THE RESULTS

But if MB can mirror the results of  the success rate of adult stem cell treatments (~65% of patients have significant improvement in their incurable, chronic or terminal illnesses) and do so without the side effects alluded to above (adult stem cells have virtually zero side effects except for sometimes additionally fixing more than the intended organ/illness) then I would love to hear about it!

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO

In BUSINESS OF STEM CELLS on November 15, 2011 at 1:27 am

http://geekcentricity.com/wp-content/uploads/2010/09/Fiasco.jpg

Embryonic stem cell treatment are now an unrealized potential.

Adult stem cell treatments are a realized potential.

To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

GERON GIVES UP on EMBRYONIC STEM CELLS!

In STEM CELLS IN THE NEWS on November 14, 2011 at 11:13 pm

THE

WAR

IS

OVER!!

GERON THROWS IN THE TOWEL!If stem cell treatments were a boxing match, Embryonic stem cell treatments would be the 500 lb Gorilla and Adult stem cell treatments would be the small, unknown underdog.   Today, that Gorilla threw in the towel!

Despite the huge disparity in their media coverage, with positive Embryonic stem cell potential articles outnumbering all Adult stem cell articles by 1,000 to one, only Adult stem cells have a proven history of safety and efficacy, only Adult stem cell treatments are available today.  Click here to see if your condition can be treated with Adult stem cells:

While Geron and the US media, big Pharma, the AMA and the FDA have all given Embryonic stem cell their full throated support, the number of patients helped with adult stem cells is in the 10s of thousands while the number of patients helped by Embryonic stem cells in zero.

HORSE FALLING DOWN DURING RACEIf Embryonic treatments were a horse race, Geron would be the strongest horse in the field.  Geron would be the horse who was 9/10 of the way around the track with all other competitors still milling about in the starting blocks.  So what would make that horse stop dead in his tracks, fall flat on his face and walk away from the race?

What does it mean for the other Embryonic focused companies when the front runner pulls out of the race?

What would cause the leading Embryonic stem cell Pharmaceutical company with multiple Embryonic stem cell products in development to end all of their Embryonic stem cell programs? 

Product Product Description Application Development Stage
GRNOPC1 Oligodendrocyte Progenitor Cells Spinal Cord Injury Phase I Clinical Trial
GRNCM1 Cardiomyocytes Heart Disease Preclinical
GRNIC1 Islets Type 1 Diabetes Research
GRNCHND1 Chondrocytes Osteoarthritis Research
Hepatocytes ADME Drug Screening Research
GRNVAC2 Mature Dendritic Cells Cancer Immunotherapy Product Research
Immature Dendritic Cells Immune Rejection Research
Osteoblasts Osteoporosis Research

via Geron.com

Perhaps their clinical trial patients developed cysts and tumors as do all Embryonic stem cell patients.  Perhaps Geron decided to end their trials before these tumors and cysts turned into cancer so they could still say their product “has been well tolerated with no serious adverse events.”

Perhaps Geron couldn’t figure out how to address the need for immunosuppressive drugs required to implant a human with ALL Embryonic stem cells when there are many Adult stem cells that have no rejection issues.

Perhaps Geron couldn’t determine how to deal with Embryonic stem cells carrying the genetic abnormalities and maladies of the donor.

Or perhaps they read some of the quotes from my articles going back to March of 2009:

  • To date, ESC research has been 100% fruitless (in regard to generating treatments) for well-funded + government supported scientists around the world for the last 11 years.
  • Dr James Thomson, father of ESC research said: “…[ESC] are not being used in any clinical applications yet, while alternatives such as adult stem cells figure in scores of therapies.”
  • Ian Wilmut, who led the team that cloned Dolly the sheep, abandoned his license to attempt human cloning, saying that the researchers “may have achieved what no politician could: an end to the [ESC] debate.”
  • Dr. Bernadine Healy, former director of the NIH in U.S. News & World Report: “…[ESC], once thought to hold the cure for Alzheimer’s, Parkinson’s, and diabetes, are obsolete….. In fact, adult stem cells, which occur in small quantities in organs throughout the body for natural growth and repair, have become stars despite great skepticism early on.
Or maybe they reviewed the timeline for Embryonic stem cell success and realized they couldn’t afford 50 YEARS OF RESEARCH!
Dr. Colin McGuckin, a noted UK embryonic research leader at Newcastle U. before departing for more useful RSC research in France announced:

  • “For me, the unnecessary row over stem cells has obscured the very real issue that patients are waiting to be treated…The best estimates of the embryonic scientists in our own university in Newcastle is that embryonic stem cells may not be able to help people this side of 50 years. That’s my lifetime. And that’s worrying. We can’t wait that long.”
I do have to applaud their spin department.  It is a brilliant move to take the news story
“GERON GIVES UP ON EMBRYONIC STEM CELLS”
and spin it into
“GERON PUTS 100% FOCUS INTO CURING CANCER.” 
Even so, we are not fooled.  The red headed step child in the family always knows when they are neglected. 
They also published their press release at 4:05 Eastern so the regular stock market was closed and couldn’t react to the news. Unfortunately for them, their stock dropped over 20% in after hours trading.
Whatever the reason for Geron abandoning Embryonic stem cells, we can now finally exalt that THE WAR IS OVER and get on with Adult Stem Cell Treatments, the only stem cells to cure a human patient.

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal neurological, breast milk, menstruation, dental pulp, and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)
  • To see if your condition can be treated with Adult stem cells, please fill out this form: http://bit.ly/PATIENTQUESTIONNAIRE

via STEM CELLS 101

  • 100+ DISEASES treated around the world with adult stem cells!
  • 60-70% SUCCESS RATE typical therapeutic benefit on INCURABLE DISEASES!!
  • POTENTIAL CURES of Autism, Parkinson’s, AIDs, Diabetes, Heart Disease and more!
  • HUGE REWARDS of life extension!
  • SIGNIFICANTLY IMPROVED quality of life!

http://www.maniacworld.com/muhammad-ali-2.jpg

Geron to Focus on Its Novel Cancer Programs
Company Plans to Partner All Stem Cell Programs

MENLO PARK, Calif.–(BUSINESS WIRE)–Geron Corporation (Nasdaq: GERN) today announced that, effective immediately, the Company will focus on its first-in-class oncology programs. As a consequence, the Company will discontinue further development of its stem cell programs and is seeking partners for these novel assets.

“Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic”

“In the current environment of capital scarcity and uncertain economic conditions, we intend to focus our resources on advancing our Phase 2 clinical trials of imetelstat and GRN1005. These two novel and promising oncology drug candidates target major unmet medical needs and have important clinical development milestones occurring over the next 20 months,” said Geron’s Chief Executive Officer, John A. Scarlett, M.D. “By narrowing our focus to the oncology therapeutic area, we anticipate having sufficient financial resources to reach these important near-term value inflection points for shareholders without the necessity of raising additional capital. This would not be possible if we continue to fund the stem cell programs at the current levels.

…The decision to narrow Geron’s technology and therapeutic focus was made after a strategic review of the costs, value inflection timelines and clinical, manufacturing and regulatory complexities associated with the Company’s research and clinical-stage assets. With this decision, Geron is eliminating 66 full-time positions, representing 38% of its workforce. As a result, the Company expects one-time cash expenditures of approximately $5 million in the fourth quarter of 2011 and approximately $3 million in the first half of 2012. Geron expects to end 2011 with cash and investments in excess of $150 million.

Geron is seeking partners with the technical and financial resources to enable further development of its stem cell programs. “Our employees, collaborators and shareholders can be proud of the pioneering role they have played to advance our stem cell technology into the clinic,” said Dr. Scarlett. “Stem cells continue to hold great medical promise. We believe that our leadership role in the field and the quality of our stem cell assets — which are widely recognized as being among the most innovative, comprehensive and advanced cell therapy programs in the world — will be an important point of differentiation in our discussions to partner these assets.” In order to facilitate transfer of these programs to partners, Geron will retain a core group of employees from its stem cell operations through the end of the second quarter of 2012.

Geron plans to close the GRNOPC1 trial for spinal cord injury to further enrollment, although it will continue to follow all enrolled patients, accruing data and updating FDA and the medical community on their progress. In this trial, GRNOPC1 has been well tolerated with no serious adverse events

Read more

Related articles:

A HISTORY OF THE GERON EMBRYONIC STEM CELL FIASCO November 15, 2011

EMBRYONICS’ BLEAK FUTURE AND BOTCHED PAST November 15, 2011

To see if your condition can be treated with Adult stem cells, please fill out this form:

GERON’S EMBRYONIC “WASTE OF TIME” CONTINUES…

In ALL ARTICLES on September 21, 2011 at 9:51 pm

Here’s an 867 word article I’d like to not waste your time with.

http://www.epiphanymarketing.com/blog/wp-content/uploads/2010/03/waste-of-time-283x300.jpg

The premise is:  “The study is not meant to determine whether the stem cells can cure or even improve the patients’ condition, but to find out if the treatment itself is safe. Researchers will be monitoring patients over the following months and years to look for side effects, including possible benign tumor growth if the stem cells start to replicate, or adverse immune reactions.”

So let’s not waste your time, I’ll give you the results right now:

EMBRYONIC STEM CELL = ESC

  • SOURCE/DERIVED FROM•comes from embryos
  • PURPOSE IN BODY•split for 7 weeks until you have a fetus the size of a thumbnail
  • OBSTACLES+SIDE EFFECTS•they create cysts and tumors, rejection requires immunosuppressive drugs for the ill patient, they carry the genetic anomalies of the donor, etc
  • TREATMENT HISTORY•can currently treat zero diseases, probably need to cure cancer first to use them

Read it if you want but that’s really “all she wrote.”  Then again, this will allow billions to be pumped into embryonic research for treatments over “the following months and years” despite this fact…

SCREW THE EMBRYOS, THEY’RE IRRELEVANT!

———————————————

———————————————

Paralyzed patient in major Geron stem cell study

Erin Allday, Chronicle Staff Writer, Wednesday, September 21, 2011

A Bay Area patient who recently suffered a serious spinal cord injury and is now paralyzed from the waist down joined the world’s first-ever embryonic stem cell study in humans last week, when Stanford doctors injected 2 million cells designed to replace damaged neurons in the patient’s spine.

The patient, who is not being identified, is the fourth person to be enrolled in the clinical trial being run by Menlo Park’s Geron Corp. and the first person in California. The patient, whose participation in the trial was revealed Tuesday, received the stem cell injection Saturday at Santa Clara Valley Medical Center and is now at the rehabilitation center there.

The study is not meant to determine whether the stem cells can cure or even improve the patients’ condition, but to find out if the treatment itself is safe. Researchers will be monitoring patients over the following months and years to look for side effects, including possible benign tumor growth if the stem cells start to replicate, or adverse immune reactions…

Read more

ADULT CELLS, STEM CELLS & CANCER

In ALL ARTICLES on September 21, 2011 at 2:19 pm

Wow, this one was devious!! Some of these articles must be read very carefully as they are misleading and confusing, perhaps even intentionally so.

http://elrodsgodisney.files.wordpress.com/2011/07/confused_mickey_mouse_poster-p228990749419197094vhwx0_328-e1309635341795.jpg?w=197&h=281They start by telling you ‘adult stem cells‘ may fight cancer….

but later in the article refer to them as ‘adult cells…’

and even later as ‘induced pluripotent stem cells.’

But don’t be fooled by this semantic sleight of hand.

Induced pluripotent stem cells are semantically ‘adult cells’ only in the sense that all cells in an adult can be referred to as adult cells.  Perhaps this is the author’s attempt to make them distinct from embryonic cells. In any case, if your friend asks you for an APPLE from the MARKET, it is not acceptable to bring him back a BAG OF FLOUR just because they both can be “found at a MARKET.”

ANd let’s be clear.  Only ADULT STEM CELLS have thousands of studies and trials and thousands of patients treated safely and effectively.  Induced pluripotent stem cells have NONE.  And while Induced pluripotent stem cells ARE a manipulated type of ‘stem cell,’ they have a lot of problems too, as the article owns up to (one of the problems) in the end:

potential side effects need to be considered. iPS cells may develop into other harmful cells in the body.”

              “other harmful cells in the body”  =  tumors, cysts, cancer

THEY HAVE TO SOLVE THE ISSUES OF REJECTION & CANCER BEFORE THEY CAN

  1. USE THESE CELLS TO COMBAT CANCER!!
  2. USE THESE CELLS IN STEM CELL TREATMENTS!!

(dichotomy? I think so, makes me think of vaccines where you get injected with the disease to build anti-bodies to the disease.)

But the good news is, there are cancer treatments out there with high results and low or virtually no side effects that make chemo and radiation look ineffective and barbaric by comparison!

———————————————————-

Stem cells, potential source of cancer-fighting T cells

ScienceDaily (Sep. 20, 2011) — Adult stem cells from mice converted to antigen-specific T cells — the immune cells that fight cancer tumor cells — show promise in cancer immunotherapy and may lead to a simpler, more efficient way to use the body’s immune system to fight cancer, according to Penn State College of Medicine researchers.

“Cancer immunotherapy is a promising method to treat cancer patients,” said Jianxsun Song, Ph.D., assistant professor, microbiology and immunology. “Tumors grow because patients lack the kind of antigen-specific T cells needed to kill the cancer. An approach called adoptive T cell immunotherapy generates the T cells outside the body, which are then used inside the body to target cancer cells.”

It is complex and expensive to expand T cell lines in the lab, so researchers have been searching for ways to simplify the process. Song and his team found a way to use induced pluripotent stem (iPS) cells, which are adult cells that are genetically changed to be stem cells.

“Any cell can become a stem cell,” Song explained. “It’s a very good approach to generating the antigen-specific T cells and creates an unlimited source of cells for adoptive immunotherapy.”

By inserting DNA, researchers change the mouse iPS cells into immune cells and inject them into mice with tumors. After 50 days, 100 percent of the mice in the study were still alive, compared to 55 percent of control mice, which received tumor-reactive immune cells isolated from donors.

Researchers reported their results and were featured as the cover story in a recent issue of the journal Cancer Research.

A limitation of this potential therapy is that it currently takes at least six weeks for the iPS cells to develop into T cells in the body. In addition, potential side effects need to be considered. iPS cells may develop into other harmful cells in the body.

Researchers are now studying how to use the process in human cells.

Other researchers on this paper are Fengyang Lei, and Rizwanul Haque, Department of Microbiology and Immunology; Lynn Budgeon and Neil D. Christensen, Ph.D., Department of Pathology, Penn State College of Medicine.

This study was funded through the Pennsylvania Department of Health using Tobacco Settlement Funds, the W.W. Smith Charitable Trust and the Melanoma Research Foundation.

CELEBRATE 420!!! POT, WEED, MARIJUANA REDUCES CANCER, TUMORS

In ALL ARTICLES on April 20, 2011 at 11:02 am
Today is April 20th but besides that it is also 420. What is 420?

What does 420 mean? There are varying theories on the origin of 420. Some say that 420 originated from a police code that announces marijuana use is taking place. Yet another story is that a group of guys (Waldo’s) in the 1970′s made 4:20 their official meeting time to smoke marijuana after school. Whether or not 4:20 p.m. is the best time of day for your first hit depends on your own body, your own needs. Some folks feel that waiting until 4:20 enhances ones appreciation of the herb. Of course, your mileage may vary.

    • In the 21st Century, 420 is firmly established as a code amongst tokers, a time of day and even sort of a toker’s New Year’s Day. It’s in our culture now and only time will tell where it ends up.

      April 20th (4/20) is another usage, meaning that it is time for to plant before the summer.

      Whatever the real story is, 420 has been an important part of the marijuana culture since the 1970′s. The significance of 420 has been kept underground and is mostly known only among marijuana smokers. Many non-smokers aren’t aware of the symbolism when they see someone wearing a T-shirt or baseball cap that says 420 across the front.

      When the 420 icon is somehow discreetly worked into a mainstream product like a film, marijuana users take notice. The film Pulp Fiction is rumored to have had all clocks throughout the movie set to 4:20. Marijuana smokers familiar with the symbol picked up on it—most people, however, did not.

      While some marijuana smokers are using 420 as a code that enables them to openly speak about marijuana in front of parents or teachers. 420 has been to some, a sacred symbol for nearly 30 years.

      Simply put, 420 is a symbol of cannabis and its culture. Today, April 20th events are international, and 4:20 pm has become sort of a world wide “burn time”.

    • U.S. Government Repressed Marijuana-Tumor ResearchAlternet, May 31, 2000
      Title: Pot Shrinks Tumors; Government Knew in ‘74
      Author: Raymond Cushing
      http://www.alternet.org/print.html?StoryID=9257

      Faculty Evaluator: Mary King M.D.
      Student researchers: Jennifer Swift, Licia Marshall,

      Corporate media coverage: AP and UPI news wires 2/29/00

      A Spanish medical team’s study released in Madrid in February 2000 has shown that tetrahydrocannabinol (THC), the active chemical in marijuana, destroys tumors in lab rats. These findings, however, are not news to the U.S. government. A study in Virginia in 1974 yielded similar results but was suppressed by the DEA, and in 1983 the Reagan/Bush administration tried to persuade U.S. universities and researchers to destroy all cannabis research work done between 1966 and 1976, including compendiums in libraries…http://www.projectcensored.org/top-stories/articles/22-us-government-repressed-marijuana-tumor-research/

    • ‎”Antineoplastic activity of cannabinoids,” an article in a 1975 Journal of the National Cancer Institute –The summary of the Virginia study begins, “Lewis lung adenocarcinoma growth was retarded by the oral administration of tetrahydrocannabinol (THC) and cannabinol (CBN)” — two types of cannabinoids, a family of active components in marijuana. “Mice treated for 20 consecutive days with THC and CBN had reduced primary tumor size.”

      The 1975 journal article doesn’t mention breast cancer tumors, which featured in the only newspaper story ever to appear about the 1974 study — in the Local section of the Washington Post on August 18, 1974. Under the headline, “Cancer Curb Is Studied,” it read in part:

      “The active chemical agent in marijuana curbs the growth of three kinds of cancer in mice and may also suppress the immunity reaction that causes rejection of organ transplants, a Medical College of Virginia team has discovered.” The researchers “found that THC slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.” – http://www.alternet.org/story/9257/comments/?page=2

Girl cured of brain cancer using umbilical cord stem cells

In VICTORIES & SUCCESS STORIES on March 11, 2011 at 2:07 pm

In the first transplant of umbilical cord stem cells in Spanish history, a four year old girl has been cured of a brain tumor…

Alba Martinez was born in the province of Cádiz in 2007 and despite her good health, her parents say they decided to provide her with “life insurance” by means of preserving her umbilical cord in cold storage, an option taken by only a handful of parents in Spain.

At 22 months, Martinez began to suffer from a brain tumor and needed several intensive rounds of chemotherapy, which destroyed her blood cells, requiring her to receive infusions of stem cells from her umbilical cord.  The availability of such a treatment in infants suffering from cancer is rare, due to the fact that in most cases the child suffers from leukemia, which originates in a genetic defect also found in the child’s stem cells.

Today, 16 months after her stem cells restored her blood system, Martinez remains cancer free. Doctors will be able to certify her as “cured” after living a total of five years without a relapse. Her parents say that the procedure is their “best investment” ever.  “Conserving the umbilical cord is betting on the future, a life insurance that you don’t know if you will need sometime, but that can save a life,” said Theresa Molina, the child’s mother…

Girl cured of brain cancer using umbilical cord stem cells | LifeSiteNews.com.

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