DAVID GRANOVSKY

Posts Tagged ‘TREAT’

Anecdotal – The Dirty Word in Gordie Howe’s Stem Cell Treatment

In ALL ARTICLES on February 10, 2015 at 7:35 pm

What does it tell you when expert after expert tries to discredit the results of Gordie Howe’s stem cell treatment while his son Dr. Murray Howe, chairman of Toledo Hospital’s department of radiology, credits the stem cells for his recovery?

Dr. Murray Howe is the chairman of Toledo Hospital's department of radiology.

Dr. Murray Howe is the chairman of Toledo Hospital’s department of radiology.

What does it tell you when expert after expert claim his recovery and improvements are insignificant…while simultaneously attributing his recovery and improvements to everything except the stem cells he received?

What does it tell you when expert after expert discredits the anecdotal evidence of Gordie Howe’s recovery as “merely anecdotal” while it is actually one mere drop in an ocean of tens of thousands per year who have improved from cancer with cellular therapies over the last 59 years and tens of thousands who have improved over the past 12-14 years from non-cancer conditions?

And what is the value of this huge array of empirical and anecdotal evidence?

Gordie Howe Recovers From Stroke with Stem Cells

Gordie Howe Recovers From Stroke with Stem Cells

There are many types of evidence, not just trials or anecdotal.  Too often we reduce the evidential options to either clinical trials or anecdote.  Wrong.  That’s 5 blind men describing an elephant all over again.  We must take into account ALL of the different types of evidence and only THEN we can make a judgment based on the cumulative evidential data.

Anecdotal Evidence – Peyton Manning, Kobe Bryant, Rafael Nadar, Bartolo Colon…athletes from major sports organizations all over the world are embracing and anecdotally illustrating the safety and efficacy of cellular therapies

Statistical Evidence – 50,000 patients per year… are statistically illustrating the safety and efficacy of cellular therapies

Testimonial Evidence – Youtube is chock full of testimonies of athletes and patients who are benefiting from cellular therapies and via testimonial, illustrating the safety and efficacy of cellular therapies

Analogical Evidence – 59 years and thousands of trials and studies are analogously illustrating the safety and efficacy of cellular therapies

Clinical Trial evidence – Even though it may be the wrong process to evaluate cellular therapies, the vast majority of over 2,400 clinical trials are scientifically and empirically illustrating the safety and efficacy of cellular therapies

Miracle results? No.  This is par for the course results from real expectations based on the multitude of evidence types collected over the past six decades for cellular therapies.  The combined patchwork of all of the data from all of these evidences paints a very compelling conclusion.

Are cellular therapies safe and effective?  All of the evidences seem to say so.  Not just the anecdotal evidence;
anecdotal,
statistical,
testimonial,
analogical
and clinical trial evidences.

by David Granovsky, Stem Cell Writer and Author

Read one of the many myopically evidential articles here: http://www.theglobeandmail.com/globe-debate/the-stem-cell-miracle-is-anecdotal/article22880977/

LORI MILLS WINS BATTLE WITH BLUE CROSS IN WAR ON CIDP

In ALL ARTICLES, BUSINESS OF STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 9, 2015 at 8:08 pm

“A journey of a thousand miles begins with a single step.”Lao-tzu,

Lori Mills’ story is now mainstream and may affect millions of people in years to come.  You may have seen her in the dictionary under “persistence” or next to the quote: “be the change you want to see in the world.”  Certainly she is a very lucky woman.  Or maybe it’s simpler than that.  Maybe she is simply a mother and a wife who wants to live her life as best as she can without simultaneously carrying the burden of a debilitating illness.

Lori has chronic inflammatory demyelinating polyneuropathy or CIDP and she was denied insurance coverage by Blue Cross Blue Shield in the Summer of 2014.  One week ago, believe it or not, they reversed their decision. This is a huge victory for Lori in the battle with Blue Cross Blue Shield.  This is also the first of many skirmishes in her war on CIDP and a minor victory for those that follow her.  Here’s how it breaks down:

  • Be excited for Lori as she now has a chance at a better life.  She has defeated the one thing standing in her way of getting treated.
  • Don’t expect insurance companies to start caving tomorrow as BCBS has already stated with conviction that this is not to be seen as a precedent.
  • The treatment she is approved for is a clinical trial with exclusionary criteria, not from a treatment center so this is not available to the general public.

I reached out to Lori today and both she and her friends responded with grace and respect:

Hi Lori,
I’m following your story with great interest. I am a 10 year stem cell educator and while Blue Cross is clear in stating that this shouldn’t be considered precedent setting I just wanted to personally thank you for your hard work to get the doors open just a little bit more for those people who are suffering needlessly with conventional drug and treatment protocols which do not work for them. Kudos to you and yours! Wishing you the best,
David

We wish her great success and hope to do a follow up on her progress at the end of her trial.

————————-

I’d like to share something with you.  Look at the image below.  It jumped out at me.
A simple statement.  “I’m a CIDP Fighter.”
We can all understand what it means to fight a single adversary.
With awareness and education we can learn what it means to fight an invisible neurological illness like CIDP.
And that should be enough.  For anyone.  But it isn’t.

Today’s patients seek answers, seek cures, seek stem cell therapies…
but they are not just fighting their conditions…
they often are simultaneously fighting the medical establishment, fighting insurance companies, fighting ignorance and fighting resistance.
It should not be this hard.  We should do more to make it easier for patients to get the treatments they need.  We must do more.

https://i2.wp.com/api.ning.com/files/g3sZFdca7acig06FeFWUZqdRPlquxI2mTDs9uAFPDyLXkzcpRZ7I43vUcRg17SeZXVckqdfYklRANSSUHPFwBNvR9VB6NnHt/603671_10102191952132385_769765818_n1.jpg

Blue Cross overturns decision, approves stem cell transplant coverage

GREENVILLE, Mich. — Lori Mills has been approved to receive a stem cell transplant under her Blue Cross Blue Shield coverage.

The insurance company has overturned its previous denial from the summer of 2014.

In a letter Mills received January 2, 2015, Blue Cross states the company will now pay for the potentially life-changing procedure.

“I know it’s going to be a shot at a whole new life for me,” Mills said today.

She added, “I know that because of our previous interview, it really helped get this approval letter because whenever I call they talk about it.”

FOX 17 also interviewed Mills in October, questioned Blue Cross, and aired her story.

She suffers from chronic inflammatory demyelinating polyneuropathy or CIDP. Her immune system attacks her nervous system. She shakes, has numbness, and it impairs her movement.

Doctors told her a stem cell transplant could be the cure.

via

RELATED ARTICLES:

NONMYELOABLATIVE AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR REFRACTORY CIDP

http://www.neurology.org/content/69/18/1802.short

Haemopoietic stem cell transplantation—an evolving treatment for severe autoimmune and inflammatory diseases in rheumatology, neurology and gastroenterology

http://www.maneyonline.com/doi/abs/10.1080/10245330701255106

Autologous haemopoietic stem cell transplantation for autoimmune diseases
http://informahealthcare.com/doi/abs/10.1517/14712598.2011.580272

PROOF THE ENVIRONMENT CONTRIBUTES TO DISEASE

In ALL ARTICLES, DISEASE INFO, HEALTH AND WELLNESS on November 26, 2014 at 4:33 pm

Science has poo-pooed the effect of environmental toxins for years citing that the miniscule concentrations of toxins couldn’t possibly cause harm to the human body. Everything from GMOs to toxins in vaccines were ignored based on this premise. New science reveals though that the environment can not only effect the human body but it can change DNA and contribute to diseases. Now that there’s proof, it’s time to get the crap out of our lives. -David Granovsky toxin-problem HOW ENVIRONMENT CONTRIBUTES TO SEVERAL HUMAN DISEASES National Institute of Environmental Health Sciences (NIEHS) Using a new imaging technique, researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures. These damaged molecules trigger cell death that produces some human diseases, according to the researchers. The work provides a possible explanation for how one type of DNA damage may lead to cancer, diabetes, hypertension, cardiovascular and lung disease, and Alzheimer’s disease… Samuel Wilson, M.D., senior NIEHS researcher on the team, explained that the damage is caused by oxidative stress, or the generation of free oxygen molecules, in response to environmental factors, such as ultraviolet exposure, diet, and chemical compounds in paints, plastics, and other consumer products… “When one of these oxidized nucleotides is placed into the DNA strand, it can’t pair with the opposing nucleotide as usual, which leaves a gap in the DNA,” Wilson said. “Until this paper, no one had actually seen how the polymerase did it or understood the downstream implications.” http://www.niehs.nih.gov/news/newsroom/releases/2014/november25/index.cfm http://www.sciencedaily.com/releases/2014/11/141125101703.htm

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

WHAT DOES THE FOXO1 SAY? HERE’S MORE INSULIN!

In ALL ARTICLES, BUSINESS OF STEM CELLS on July 5, 2014 at 10:20 am
It May Take Guts to Cure Diabetes -Human GI Cells Retrained to Produce Insulin

Imagine taking cells from your gastrointestinal tract and then switching off one gene, the FOXO1 gene, and then ending up with insulin producing cells.  From gut cell to diabetes fighter in one easy gene switch-off.  Scientists did this successfully in 2012 in mice and recently in humans.  What does the FOXO1 say? ‘Here’s more insulin!’  Awesome.

The next step is where it gets…awkward.  I’d like this information to generate a gene therapy protocol or to improve success rates in stem cell/Diabetes treatment protocols,  etc.  But that’s not the way our system works.  The next step is to find a drug that inhibits the FOXO1 gene so it “…could retrain cells inside a person’s GI tract to produce insulin…”  Unfortunately, this drug will also have side effects as all drugs do which will create other symptoms requiring other drugs to mitigate.  And so it goes.

When will US Diabetes patients be able to benefit from a medical protocol based on this discovery?  An educated guess puts it at:
7-10 years for clinical trials and drug development for a name brand Pharma product and then 10-15 years for the drug patent to open up to an affordable generic.
Sorry Diabetes patients.

New York, NY (June 30, 2014) “By switching off a single gene, scientists at Columbia University’s Naomi Berrie Diabetes Center have converted human gastrointestinal cells into insulin-producing cells, demonstrating in principle that a drug could retrain cells inside a person’s GI tract to produce insulin…The Columbia researchers were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells’ FOXO1 gene.”

DO ADULT STEM CELLS CAUSE CANCER?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 1, 2014 at 4:31 pm

NO!

cancer-free-zone

What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?

~10,000 ADULT STEM CELL TREATMENT PATIENTS showing NO CANCER!

 

“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments

but NOT FROM ADULT STEM CELL TREATMENTS.

Sources:

PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, VICTORIES & SUCCESS STORIES on June 25, 2014 at 11:42 am

fight pancreatic cancer FPC_shirt


PANCREATIC CANCER TUMORS DEFEATED WITH CORD BLOOD STEM CELLS

What happens when you “genetically engineer MSCs isolated from human umbilical cord blood so that they expressed IL-15” (which fights cancer tumors) and inject them into mice with pancreatic  tumors?

  • The IL-15 migrate to the tumor
  • Other cancer and tumor fighting immune cells migrate to the tumor
  • The IL-15 attack the tumor
  • Other cancer and tumor fighting immune cells attack the tumor
  • Tumors show cell death
  • Tumor growth is significantly inhibited
  • Survival is prolonged
  • The mice immune systems are effectively vaccinated against future tumor growth

Scientists “used these souped-up cells to treat In mice afflicted with pancreatic tumors. Pancreatic cancer is an indiscriminate killer, since by the time it causes any symptoms, it is usually so advanced, that there is little to be done in order to treat it. Thus new strategies to treat this type of cancer are eagerly being sought. Systemic administration of IL-15-expressing MSCs significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. The tumors of these mice showed extensive cell death, and other types of immune cells known to fight tumor cells (NK and T cells) had also accumulated around the tumor. Other experiments confirmed that the injected MSCs did indeed migrate toward the tumors and secrete IL-15 at the site of the tumors…Interestingly, those mice that were cured from the pancreatic tumors, appeared to have a kind of resistance of these tumors. Namely, when Fan and his colleagues tried to reintroduce the same tumor cells back into the cured mice, the tumor cells would not grow. Thus the engineered MSCs not only tuned the immune system against the tumor, but they effectively vaccinated the mice against it as well.”

via http://beyondthedish.wordpress.com/2014/06/23/engineered-stem-cels-from-human-umbilical-cord-blood-eradicates-pancreatic-tumor/

 

 

Thanks Squeeky!

mouse-grown-from-stem-cells

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING

In ALL ARTICLES, BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS on June 23, 2014 at 2:55 pm

broken-bone-cast

REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING
“Stem cells are smart and will only stay in one place to repair damaged cells and tissues until called away for more dire situations requiring attention.  Like little ADHD multi-tasking mechanics/repairmen, they run all over the body where the body has decided (through a very complex set of devices) they are most needed.  This results in stem cells dedicated to mending bones, suddenly running off to fix the heart, pancreas, etc before finishing the job on the broken bone.  While this is a great holistic and triage approach (paying attention and dedicating resources to that which needs it most), it makes it difficult to access how powerful and successful stem cells are at resolving a single issue/condition in the body.

A lot can be said for repairing many areas in the entire body simultaneously, in fact, this is one of stem cells’ greatest strengths…but it doesn’t sit well with the concept of “completing one job before moving on to another.”  Scientists have devised a new way to make stem cells stay put and finish the job they were directed to do.  No more stem cell ADHD.

keep-calm-and-oh-look-a-squirrel-1

In the case of serious and terminal diseases, this is an excellent innovation.  If you can fix that which is going to fail first, you can then move on to what’s next.  It also makes commercialization of stem cells easier.  Nobody picks up their car with the damaged exhaust from the mechanic and he says: ‘I got the exhaust half done but realized your distributor, struts and alternator were shot so I fixed them instead.’  But your body is not a car.

This may be a wonderful innovation or it may be another instance of scientists trying to aggressively control a natural healing system in the body.  I think it’s both and the result is we now have one more extraordinary tool for fighting disease…and like any tool, it will be used well and for the right reasons and results and also used poorly for the wrong reasons and results.  Ultimately, our understanding of the modus operandi of stem cells has increased, our ability to manipulate stem cells has increased and the everyday miracles of stem cell treatment results are getting better and better understood and more common place all the time.” – David Granovsky

 ——————-

Delivering Capsules of Stem Cells Helps Repair Injured Bones

“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.

Researchers, and a couple of renegade doctors in Colorado, have shown that stem cells do help bones heal. While bones, even the intricately shaped jawbone, have been grown in the lab, researchers have been somewhat stymied in their efforts at the seemingly more banal task of using stem cells and grafts to help heal major fractures, bones removed in surgery and other hard-to-fix injuries inside the body.

That’s where materials science comes in.

University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone…”

via
​http://singularityhub.com/2014/06/23/delivering-capsules-of-stem-cells-helps-repair-injured-bones/

SHE WASN’T DEAD ENOUGH FOR STEM CELLS IN THE US

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 19, 2014 at 9:22 am

Finding no promising treatment programs in the United States, and nothing that would be covered by her health insurance, Cristy traveled to Istanbul, Turkey, in 2011 for a life-saving stem-cell transplant

WHY!

CRISTY SCT
University of Hawaii Professor, Stem Cell Transplant Surgery Survivor and author of “5 Steps To Being Your Own Patient Advocate” is taking her “5 Steps Movement” on the road in July….

Cristy Kessler, Ed.D., NBCT

With over 19 years of teaching experience, Dr. Cristy Kessler has been motivating audiences of all ages with her message of determination, survival, faith, and hope. Cristy has a natural ability for speaking to large groups of people of all ages and a style of speaking that helps them feel like they’re sitting in her living room.

Cristy Kessler has been a role model for countless students from 5th grade through university whose lives she has touched as a social studies teacher, coach, and associate professor in education at the University of Hawaii. This, in spite of a lifetime of pain and a constant battle with health issues throughout her life.

A three-sport standout in high school, Cristy coached both soccer and basketball, including a five-year stint as coach for TourneySport USA in Hawaii. She earned her doctorate in educational leadership and innovation in 2003, and as part of her commitment to being the best teacher and role model she could be, she achieved certification through the National Board for Professional Teaching Standards (NBPTS), even though this certification is generally recognized as a program for K-12 teachers. Rarely has a university professor sought (or achieved) this recognition, but Cristy did exactly that in 2005, even as she was recovering from cancer surgery. In her role as an associate professor at the university, she has guided scores of teachers through successful achievement of NBPTS certification.

Plagued by constant pain and fatigue, Cristy was finally diagnosed in 2006 with a constellation of auto-immune diseases: scleroderma, ankylosing spondylitis, and vasculitis, any one of which is ultimately fatal. Following years of treatment for the symptoms of these disorders, it became clear that the only way to save her life was to somehow tackle the diseases themselves, not just the symptoms. Finding no promising treatment programs in the United States, and nothing that would be covered by her health insurance, Cristy traveled to Istanbul, Turkey, in 2011 for a life-saving stem-cell transplant at Anadolu Hospital, an affiliate of Johns Hopkins University. Extensive fund-raising efforts by friends and family helped make this incredible journey a reality.

The transplant succeeded such that Cristy has a brand-new immune system and has resumed her work with university students and teachers. She continues to look for opportunities to inspire and encourage others through the story of her determination to live, even in the face of chronic pain and imminent death.

Dr. Kessler recently released a new book, “5 Steps To Being Your Own Patient Advocate” and is touring in July in support of the book.

Check out the current tour schedule at:
http://www.5stepstobeingyourownpatientadvocate.com

“My Health. My Body. My Voice….Learning To Live Tour” campaign:
https://www.indiegogo.com/projects/my-health-my-body-my-voice-learning-to-live-tour/x/3387656

You can read Cristy’s compelling story at:
http://www.cristykessler.com

Youtube Channel:
https://www.youtube.com/channel/UCoL–mQB2KXhcVkJXxMZwFg

YOUR BRAIN, THE EMPTY CUP

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 4, 2014 at 8:40 am

empty-cup  819px-Complete_neuron_cell_diagram_en.svg

15 years ago, modern science was confronted with the premise that HEART type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results (The first clinical trial of a novel therapy was conducted unintentionally by the Renaissance surgeon Ambroise Parè in 1537).  Ask your doctor if heart cells can regenerate.  There is still ENORMOUS resistance.

10 years ago, modern science was confronted with the premise that BRAIN type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results.  Ask your doctor if brain cells can regenerate.  There is still ENORMOUS resistance.

3 days ago Duke researchers published a study in the peer reviewed journal Nature about how they “found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons.”

While this is incredible news, science is still moving too slowly for those suffering from chronic and terminal diseases, dementia, TBI and other neurological disorders.  Is it time to revamp the system?  Is it time to approach healing and science with the premise that the human body has regenerative capabilities and we should tap into those systems to heal disorders instead of treating symptoms far removed from the original disorders?  What other premises are in place which are blocking medical advancements?

A story from Zen Buddhism:
Nan-in served tea. He poured his visitor’s cup full, and then kept on pouring.  The professor watched the overflow until he no longer could restrain himself. “It is overfull. No more will go in!”  “Like this cup,” Nan-in said, “you are full of your own opinions and speculations. How can I show you Zen unless you first empty your cup?”

Regenerative medicine is a new frontier.  Already around for decades, most have yet to recognize it as the huge paradigm shift which necessitates our emptier our cups and approaching medicine from a completely new perspective.  A new perspective which includes an empty cup.

Is your thinking, holding you back?

via
http://www.sciencedaily.com/releases/2014/06/140602102006.htm
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3734.html

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