DAVID GRANOVSKY

Posts Tagged ‘therap’

Gene therapy shows promise for Parkinson’s | Reuters

In VICTORIES & SUCCESS STORIES on March 17, 2011 at 11:02 am

I’m glad to see other therapies are producing benefits to Parkinson’s patients.

There now seems to be 3 options for Parkinson’s patients:
Gene therapy = 23.1 % improvement
Placebo effect = 12.7 % improvement

Adult Stem Cells = 60 % improvement*

* 60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS! https://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

-dg

Gene therapy article below pic


“The treated group showed a 23.1 percent improvement on a scale of Parkinson’s symptoms six months after treatment, compared to a 12.7 percent improvement for patients who received sham surgery, according to the published research.”

Gene therapy shows promise for Parkinson’s | Reuters.

Advertisements

Cerebral spinal fluid guides stem cell development in the brain | Science Codex

In STEM CELLS IN THE NEWS on March 9, 2011 at 1:50 pm

Cerebral spinal fluid guides stem cell development in the brain

Posted On: March 9, 2011 – 5:30pm

Cerebrospinal fluid—the clear and watery substance that bathes the brain and spinal cord—is much more important to brain development than previously realized.

Howard Hughes Medical Institute investigator Christopher Walsh, his postdoctoral fellow Maria Lehtinen, former student Mauro Zappaterra, and their colleagues have discovered that cerebrospinal fluid (CSF) contains a complex mix of proteins that changes dramatically with age. In the lab, CSF by itself is enough to support the growth of neural stem cells, and this effect is particularly robust in young brains.

What’s more, the protein make-up of CSF in people with malignant brain cancer is different from that of healthy people, the researchers found. “This suggests that the CSF can make a more supportive or less supportive environment for tumor growth,” notes Walsh, Chief of Genetics at Children’s Hospital Boston. The work is published in the March 10, 2011, issue of the journal Neuron.

Centuries ago, philosophers thought spinal fluid held particular importance for health. The French philosopher and mathematician René Descartes, for example, described the brain as a simple hydraulic machine, pumping fluid—pneuma anima, or ‘animal spirits’—through the body’s nerves like a Parisian water fountain.

“Recent history has not been so kind to CSF,” Walsh notes. Today, most researchers think of it as a relatively simple salt solution that gives the brain buoyancy and helps protect it from knocking against the skull.

Several years ago, Walsh’s work on brain development led him to suspect that there is much more to the unassuming fluid. He noticed that neural stem cells tend to line up around the brain’s inner chambers, where CSF is stored, and stick cellular fingers, called cilia, into the pool of CSF. “That made us think, there’s got to be something in CSF that’s binding to cilia and controlling how the cell divides,” Walsh says.

In 2007, Zappaterra and Walsh performed the first comprehensive analysis of embryonic human CSF. They found it holds hundreds of different proteins that are involved in a variety of tasks, including cell growth, transport, support, and signaling. “We were amazed at the diversity of substances that we identified in there, many of which people had no clue would be there,” Walsh says.

In the new study, the researchers took small pieces of embryonic rat brain tissue and, using a thin platinum wire, deftly moved them onto culture plates made up of CSF from rats of different ages. They found that when brain stem cells bathe in CSF from young rats, they furiously divide. In contrast, when grown on CSF from older rats, there is less cell division, but CSF from all ages contains all that is needed to maintain brain stem cells in a dish. Subsequent analysis of the fluid showed that the amount of a protein called Insulin-like growth factor 2 (Igf2) strongly correlates with the level of cell division.

The researchers then teamed up with a group of scientists from Beth Israel Deaconess Medical Center that has a unique collection of CSF samples isolated from people with various stages of glioblastoma, a type of brain cancer in which tumors infiltrate the whole brain. The Beth Israel Deaconess group, led by Eric Wong, found that people with more advanced cancer have higher levels of Igf2 in CSF than do those with less severe forms of the disease.

The scientists don’t know whether the increase in Igf2 levels is partly causing the cancer, or is instead a consequence of living with the disease. “We certainly don’t think Igf2 is the only contributor to the pathology, because glioblastomas are very complex. But it may be an interesting biomarker to consider,” says Maria Lehtinen, who is a joint first author of the study, along with Zappaterra.

Taking a closer look at CSF could be helpful in other brain diseases as well. Some researchers are investigating whether the levels of certain proteins, like Tau and Beta amyloid, might be used as predictors of Alzheimer’s disease, for example.

Because CSF is made in the choroid plexus—the tiny knob in the brain’s chambers that forms the interface between the bloodstream and the brain—it could explain part of the mystery of how changes in the body link up to the brain. For example, if you exercise a lot, you form more brain cells, but no one knows exactly how this works.

“We sometimes get very spiritual about this,” Walsh says, laughing. “It presents mechanisms about how different parts of the body are talking to each other in ways that I hadn’t really conceived of before.”

 

via Cerebral spinal fluid guides stem cell development in the brain | Science Codex.

The Future of Stem Cell Research: BCVS Advances in 2010 – AHA Science Network

In STEM CELLS IN THE NEWS on March 9, 2011 at 1:14 pm

Basic Cardiovascular Science Advances for 2010: The Future of Stem Cell Research

By Dr. Mark Sussman

The mission of our council is to improve understanding of mechanisms of basic cardiovascular regulation to support the development of new therapies and insights into clinical cardiovascular disease. Special emphasis is placed on integrating molecular/cellular and physiological approaches to address problems relating to functional genomics, cell signaling, myocardial biology, circulatory physiology, pathophysiology and peripheral vascular disease. The council plays a major role in linking basic science to clinical science and is concerned with advancing and applying knowledge derived from basic science to the patient.

Annually AHA asks all of its Councils and science groups what in their estimation have been the most important advances in their respective fields within the past year. We have pulled out of all of those suggestions the ones that came from or are relevant to our community. Several studies this year brought the future of medicine closer to the present with new insight into emerging technologies. These studies evaluate the role of stem cells in cardiac repair and their ability to differentiate into cardiac myocytes and the ability of the heart to replace and regenerate myocytes on its own. The findings from stem cell therapy have been shown to improve quality of life and survival in patients with chronic heart failure and support the development of future cell based therapeutics.

Dr. Mark Sussman is the Chair of the BCVS Council. He is the Distinguished Professor of Biology at the SD

CLICK CHART FOR AN ENLARGED VIEW (YOU CAN CLICK TWICE)

Posted by Melissa AHA Science on Mar 9, 2011 9:13 AM CST

“Stem Cell Awareness Seminar”

In STEM CELLS IN THE NEWS on July 27, 2010 at 5:36 pm

“Stem Cell Awareness Seminar”

  • Tampa, Florida
  • August 28,2010 1:00pm – 5:00pm
  • Free Admission – open to the public
SEMINAR FOCUS:

Learn the Truth regarding the differences between embryonic and adult stem cell treatments. Doctors, patients and others will share their knowledge and experiences with you and answer any questions you may have on stem cells.

Regenerative stem cell therapies for diseases, disorders and injuries will be discussed: ALS, Alzheimer’s disease, Ataxia, Autism, Cerebral Palsy, Diabetes, Heart disease, Lupus, Multiple Sclerosis, Muscular Dystrophy, ONH & optic disorders, Parkinson’s disease, Spinal Cord Injury and Stroke patients have shown significant improvements after treatment.

Several doctors will speak about the progress they have noted in their patients. They will share information with you both pre and post stem cell therapies. You will also hear from several stem cell patients who will share their personal experiences and views of this regenerative therapy. You can also read documented case studies of adult stem cell patients.

David Granovsky, author of “The Stem Cell Blog” and the 1st children’s book on stem cells  “Super Stemmys Doris and the Super Cells” will begin the discussions.

We look forward to meeting you!

LOCATION:

Marriott Tampa Airport Hotel
Tampa International Airport
4200 George J. Bean Pkwy.
Tampa, Florida 33607

Hotel Reservations 800-564-3440, ask for Stem Cell awareness room block or Http://www.marriott.com/hotels/travel/tpaap? group Code= STCSTCA

SIGN UP:

Please RSVP by filling out the following survey:

STEM CELL AWARENESS SEMINAR SIGN UP SHEET/SURVEY

ORGANIZER’S CONTACT INFO:

Carol Petersen
Stem Cell Advocate
Ph: 1-941-235-0088

carolptrsn@msn.com

Spinal Cord Injury Patient Wins…and Loses

In VICTORIES & SUCCESS STORIES on February 8, 2010 at 1:39 pm

Spinal Cord Injury Patient Wins With Stem Cell Therapy, But Loses In Court

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form

Stem Cells Helps Spinal Cord Injury Patient, but Michigan Court Does Not

A spinal cord injury (SCI) patient who improved after stem cell treatment in Portugal has lost a court decision in Michigan declaring that insurance did not have to pay for the therapy despite the success of it. Kevin Krohn, who regained feelings in his lower body after the adult stem cells from his nose were implanted into his spinal cord, lost in the Michigan Court of Appeals when the judges reversed a jury decision earlier which had awarded Kevin $51,000 for the treatment and stem cell research which improved his quality of life.

The panel reversed the jury verdict ordering Home-Owners Insurance Co. to pay a $51,400 claim by Krohn for an experimental stem cell procedure.

The case went to court after the insurance company denied the claim, arguing the procedure was not reasonable nor necessary. (Not necessary? What if they were in Kevin’s unfortunate condition? -DM)

Krohn suffered a severe spinal injury in a 2001 traffic crash, leaving him with no feeling below his chest. A stem cell treatment in 2005 restored some nerve connections, giving Krohn control of his bowels and bladder and allowing some movement of his hips.

The fact the treatment was successful in improving Krohn’s condition is irrelevant, the panel ruled. The majority opinion stated the case should have been dismissed by the trial court for lack of evidence of the “scientific reliability” of the the surgery.

Before allowing the jury to decide the case, the opinion said, Lenawee County Circuit Judge Timothy Pickard should have required evidence the procedure had “gained general acceptance in the medical community.”

The procedure was done at a government hospital in Portugal’s capital of Lisbon.

A dissenting opinion by Judge Karen Fort Hood said the panel was overstepping its authority in ruling on the scientific reliability of the procedure when no hearing on that issue was held.

The insurance company did not challenge admission of the surgeon’s testimony, said Hood, so there was no opportunity at the trial level for Krohn to present evidence of scientific reliability. The Appeals Court panel erroneously made its own analysis based on a limited record, said Hood.

Michigan’s no-fault auto insurance statute does not require medical procedures to be approved by the federal Food & Drug Administration and performed in the United States, as the majority opinion indicates, she said.

Hood also rejected the insurance company’s argument that the Lenawee County jury’s decision would cause a flood of claims for experimental procedures.

The Fact The Treatment Was Successful Is Irrelevant?

“The fact the treatment was successful in improving Krohn’s condition is irrelevant.”   What a terrible statment that is.  I see a man in distress and doing what was best for him under the circumstances– going to Dr. Carlos Lima for stem cells which improved his quality of life.  If he had left it up to the insurance company, he would NOT have anything now- no feeling in his bowels, no feelings in his legs, no movement at all in his hips.

This is the problem with Obama’s proposed healthcare reform and socialized medicine in general.  It takes the individual’s personal choice or preference for medical treatment out of the equation.  If Kevin had left his fate up to a insurance commission or a “medical commission” appointed by the state,  he would not have any of the improvements in his quality of life that he has today thanks to the adult stem cell research.

TREATMENT INFO NOW

Stem cell infusion shows promise for treating heart disease

In VICTORIES & SUCCESS STORIES on February 7, 2010 at 6:37 pm

Stem cell infusion shows promise for treating heart disease

DAVID WAHLBERG | dwahlberg@madison.com | 608-252-6125 | Posted: Sunday, February 7, 2010 2:00 pm | 1 Comment

After Bernie Treichel had a heart attack in December, she received the standard treatment: angioplasty, in which doctors propped open her clogged arteries with stents.

Then she tried something unusual. She signed up for a study in which stem cells are infused into the arm to potentially do what the body can’t do on its own: grow new heart muscle…

 

DO STEM CELL TREATMENTS WORK?!?!
https://repairstemcell.wordpress.com/do-stem-cell-treatments-work/

via Stem cell infusion shows promise for treating heart disease.

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!

In VICTORIES & SUCCESS STORIES on February 6, 2010 at 10:16 am

https://repairstemcell.files.wordpress.com/2009/02/muhammed_ali_michael_j_fox.jpg

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!


Majority of Parkinson’s Patients Improved After Stem Cell Treatment

February 04, 2010

A follow-up study of 50 Parkinson’s disease patients treated with autologous bone marrow stem cells. Overall, almost 60% improved following treatment.
—————————-
MICHAEL J FOX, FREDDIE ROACH & MUHAMMED ALI TAKE NOTE!!!
THESE RESULTS ARE FROM ADULT/REPAIR STEM CELLS,
NOT EMBRYONIC!!
—————————-
These results support the premise that patients with Parkinson’s disease can be treated safely and effectively with autologous stem cell therapy.  The most common improvements reported by patients were decreased rigidity (74%) and better walking/gait (over 80%).

“Two months after the stem cell therapy, I had a checkup for a hole in my eardrum that had been there for several years and it was healed up completely! As for the Parkinson’s symptoms, I am much stronger. I still fall occasionally but nothing compared to before therapy. People tell me that I am talking much better. I am blinking and smiling and I have more facial expression My ability to use utensils at mealtime is almost back to normal,” said Mr. Herman Engman, who was treated in January 2009.

More than 50% of the patients who improved reported decreased tremors while more than 60% experienced better speech. Approximately 60% of the patients surveyed had their improvement confirmed by their own physician.

“Now, I am walking like I was before I had Parkinson’s and my shaking is more under control I am sleeping longer at night and have also gained 10 pounds This is the first time in four years that I have been able to gain any weight,” stated Mr. John Andresen. Mr. Andresen was treated in July 2009.

SURVEY RESULTS

Parkinson’s – Autologous Stem Cell Therapy Results (N=50)

Introduction

Parkinson’s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer’s motor skills, speech, and other functions.[1]

Parkinson’s disease belongs to a group of conditions called movement disorders. It is characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and a loss of physical movement (akinesia) in extreme cases. The primary symptoms are the results of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problems. PD is both chronic and progressive.

Method

50 patients with Parkinson’s disease were treated with Autologous stem cells. Injection of the Stem Cells was performed by Lumbar Puncture. 200 ml of Bone Marrow was extracted out of the Iliaca crest and was concentrated for transplantation using gradient centrifugation. After treatment, the patients were evaluated using a post treatment survey. The results are presented below.

Results

Nearly 60% of patients treated reported an improvement in their condition after treatment.

Parkinson Overall Results

The average patient age was 65 years old.  Patients as young as 38 years old and as old as 85 years old were treated.  80% were female.  The average follow-up time was 7 months after treatment.  Most patients experienced improvements after a couple of months.

Parkinson Age Distribution

Approximately 60% of improved patients reported better speech, handwriting and ability to use utensils.  About 1/3 experienced improved ability to swallow and control saliva (drooling).

Parkinson Daily Living Improvements 1

3 out of 4 patients who improved experienced decreased rigidity and a little more than half reported decreased tremors.  Over 85% reported improved walking ability.  While greater than 80% experienced improved gait.

Parkinson Motor Function Improvements

60% of patients who reported improvements had them confirmed by their personal physician.

Parkinson Doctor Confirmations

Approximately 40% of all improved patients reduced or eliminated their use of Parkinson’s medications.

Parkinson Medication Change B

In a Patient’s Own Words

Johannes W. – 72 years old
“…I no longer have any pain and I am completely drug free…”

Aubra P. – 59 years old
“…After the stem cell treatment I would no longer freeze…”

Ted E. – 66 years old
“…My neurologist saw me during this time and confirmed that I looked like I was doing very well…”

Jon A. – 71 years old
“…Now, I am walking like I was before I had Parkinson’s…”

PARKINSON’S FLASHBACK!

Almost exactly a year ago, a study was published in The Open Stem Cell Journal, 2009, 1, 20-29 called Therapeutic Microinjection of Autologous Adult Human Neural Stem Cells and Differentiated Neurons for Parkinson’s Disease: Five-Year Post- Operative Outcome

The paper describes how a team consisting of members from

  • 1UCLA School of Medicine and Brain Research Institute, UCLA, Los Angeles, California, USA;
  • 2Movement Disorders Program, Los Angeles Neurosurgical Institute, Los Angeles, California, USA;
  • 3Neural Transplantation and Molecular Biology Laboratories, NeuroGeneration, Inc, Los Angeles, California, USA and
  • 4Feinberg School of Medicine, NorthwesternUniversity, Chicago, Illinois, USA

 

was able to isolate patient-derived (ADULT/REPAIR) neural stem cells, multiply them in vitro and ultimately differentiate them to produce mature neurons before they were reintroduced into the brain.  The team was able to inject the adult stem cells without the need for immunosuppressants. Unlike embryonic stem cells, adult stem cell injections don’t cause a patient’s immune system to reject the cells.

The adult stem cells were highly beneficial for the patient involved in the study.  “Of particular note are the striking results this study yielded — for the five years following the procedure the patient’s motor scales improved by over 80% for at least 36 months,” Levesque wrote.

Via https://repairstemcell.wordpress.com/2009/02/23/adult-stem-cell-use-proves-successful-once-again/

IF YOU HAVE PARKINSON’S AND WANT TO KNOW IF YOU ARE A CANDIDATE FOR STEM CELL TREATMENT, http://bit.ly/PATIENTQUESTIONNAIRE

Adult Stem Cells Reverse Heart Attack Damage

In VICTORIES & SUCCESS STORIES on February 6, 2010 at 9:41 am

Proven safe and effective Repair Stem Cell Treatments for heart disease have been performed around the world for over half a decade. https://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/

Can Repair Stem Cell Treatments help your heart disease?

Adult stem-cell therapy continues to prove useful for treating heart disease patients, according to researchers at the Interdisciplinary Stem Cell Institute at the University of Miami’s Miller School of Medicine.

The study found that injecting stem cells into patients within 10 days of a heart attack could repair heart damage.

Researchers said it could be several years before there are federally approved cardiac stem-cell therapies [IN THE US].

Wesley J. Smith, senior fellow in human rights and bioethics at the Discovery Institute, said it demonstrates the effectiveness of stem cells that do not require the destruction of human embryos.

“It is a tremendous potential victory for medical science,” he said.

Jeff Karp, assistant professor at the Harvard Medical School, explained that the process may eliminate the need for drugs.

“You can take mesenchymal stem cells from one person,” he said, “implant them or inject them into another person and not require any matching or immune-suppressive drugs.”

via Illinois Federation for Right to Life: NEWS SHORTS FOR FRIDAY.

Investors.com – California’s Proposition 71 Failure

In BUSINESS OF STEM CELLS on February 2, 2010 at 3:43 am

California’s Proposition 71 Failure

Posted 01/12/2010 06:36 PM ET

Bioethics: Five years after a budget-busting $3 billion was allocated to embryonic stem cell research, there have been no cures, no therapies and little progress. So supporters are embracing research they once opposed.

California’s Proposition 71 was intended to create a $3 billion West Coast counterpart to the National Institutes of Health, empowered to go where the NIH could not — either because of federal policy or funding restraints on biomedical research centered on human embryonic stem cells.

Supporters of the California Stem Cell Research and Cures Initiative, passed in 2004, held out hopes of imminent medical miracles that were being held up only by President Bush’s policy of not allowing federal funding of embryonic stem cell research (ESCR) beyond existing stem cell lines and which involved the destruction of embryos created for that purpose.

Five years later, ESCR has failed to deliver and backers of Prop 71 are admitting failure. The California Institute for Regenerative Medicine, the state agency created to, as some have put it, restore science to its rightful place, is diverting funds from ESCR to research that has produced actual therapies and treatments: adult stem cell research. It not only has treated real people with real results; it also does not come with the moral baggage ESCR does.

To us, this is a classic bait-and-switch, an attempt to snatch success from the jaws of failure and take credit for discoveries and advances achieved by research Prop. 71 supporters once cavalierly dismissed. We have noted how over the years that when funding was needed, the phrase “embryonic stem cells” was used. When actual progress was discussed, the word “embryonic” was dropped because ESCR never got out of the lab.

Prop 71 had a 10-year mandate and by 2008, as miracle cures looked increasingly unlikely, a director was hired for the agency with a track record of bringing discoveries from the lab to the clinic. “If we went 10 years and had no clinical treatments, it would be a failure,” says the institute’s director, Alan Trounson, a stem cell pioneer from Australia. “We need to demonstrate that we are starting a whole new medical revolution.”

The institute is attempting to do that by funding adult stem cell research. Nearly $230 million was handed out this past October to 14 research teams. Notably, only four of those projects involve embryonic stem cells.

Among the recipients, the Los Angeles Times reports, is a group from UCLA and Children’s Hospital in Los Angeles that hopes to cure patients with sickle cell disease by genetically modifying their own blood-forming stem cells to produce healthy red blood cells. Researchers at Cedars-Sinai Medical Center will use their grant to research injecting heart-attack patients with concentrated amounts of their own cardiac stem cells that naturally repair heart tissue.

Dr. Bernadine Healy, director of the National Institutes of Health under Bush 41, wrote in her U.S. News & World Report column recently that “embryonic stem cells, once thought to hold the cure for Alzheimer’s, Parkinson’s and diabetes, are obsolete.”

Even worse, they can be dangerous.

They are difficult to control, to coax into the specific type of tissue desired. Unlike adult stem cells taken from a patient’s own body, ES cells require the heavy use of immunosuppressive drugs. Their use can lead to a form of tumor called a teratoma.

.

…It is ESCR researchers who have politicized science and stood in the way of real progress. We are pleased to see California researchers beginning to put science in its rightful place.

via Investors.com – California’s Proposition 71 Failure.

BrainStorm Reschedule Webcast Audio Conference

In BUSINESS OF STEM CELLS on October 15, 2009 at 12:27 pm

NEW YORK & PETACH TIKVAH, Israel–(Business Wire)– BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI – News) , announced today that it will reschedule the webcast audio conference to update shareholders on its strategy and report on the way forward towards clinical trials. This event will be rescheduled for a later date to be announced soon. We apologize for any inconvenience.

via BrainStorm Announces That It Will Reschedule Its Webcast Audio Conference | Reuters.

http://www.clipartheaven.com/clipart/business_&_office/cartoons_(a_-_c)/brainstorm.gif

%d bloggers like this: