DAVID GRANOVSKY

Posts Tagged ‘teeth’

Experts grow whole tooth units using mouse stem cells

In VICTORIES & SUCCESS STORIES on July 12, 2011 at 6:57 pm

 

 

 

 

 

 

 

 

Old news, I covered this story and other similar stories as far back as August of 2009 (see below)…but they are just picking it up now so I thought I would post it.  CATCH UP!!!!  –  DSG

 

Experts grow whole tooth units using mouse stem cells – Reuters
Credit: Reuters/Dr. Takashi Tsuji/Tokyo University of Science/Handout By Tan Ee Lyn HONG KONG (Reuters) – Scientists in Japan said on Wednesday they have created teeth — complete with connective fibers and bones — by using mouse stem cells and 

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New Teeth From Stem Cells in Mice

In VICTORIES & SUCCESS STORIES on August 25, 2009 at 10:11 pm

Teeth have been grown from stem cell “seeds” and planted in the mouths of mice, scientists from Tokyo University reported in Proceedings of the National Academy of Sciences. They hope it could lead to replacing teeth in humans, or even to rebuilding whole organs.

The Japanese scientists developed a bioengineered “tooth germ” — a seed-like package containing all the cells and instructions necessary to form a tooth…


Scientists grow fully functional tooth from stem cells

In VICTORIES & SUCCESS STORIES on September 8, 2009 at 1:18 pm

Scientists grow fully functional tooth from stem cells

August 22, 4:12 PMNY Holistic Body & Spirit ExaminerTima Vlasto

Though teeth have been grown in mice before, scientists revealed in the Proceedings of the National Academy of Sciences their success at growing a “fully functional” tooth from stem cells in mice…

 

 

A denture-free world with adult stem cells

In VICTORIES & SUCCESS STORIES on September 13, 2009 at 1:35 pm

bush stole my denturesNova Southeastern University’s dental researchers at the College of Dental Medicine are growing and harvesting human dental stem cells in the laboratory.A 2009 NSU survey of dentists around the nation revealed that more than half thought that they would be using stem cell and tissue engineering therapies on their patients within the next decade.

An overwhelming 96 percent of dentists believe the ability to regenerate and replace teeth and dental tissues is the future of dentistry, according to the survey…

 

Jaw bone created from (patient’s own) stem cells

In VICTORIES & SUCCESS STORIES on April 21, 2010 at 5:13 pm

Jaw bone created from (patient’s own) stem cells – BBC NEWS | Health | – New bone created in the lab

The new bone was created from bone marrow stem cells

Scientists have created part of the jaw joint in the lab using human adult stem cells.

Two points from me:

1. Cloning, shmoning! The facts is, they have already created hearts, windpipes and jawbones from adult stem cells. No clones needed, no rejection issues, no transplants, no immunosuppressive drugs,….we can just make the bone, organ, teeth, etc that fit perfectly into your body because they are made from your body (and from your own stem cells)…

 

Body’s Own Stem Cells Can Lead to Tooth Regeneration

In VICTORIES & SUCCESS STORIES on May 24, 2010 at 7:37 pm

I met with Dr. Mao last summer and I found his presentation fascinating and informative.  Imagine taking stem cells from your own body and regrowing your won teeth. No dentures, crowns, implants, foreign materials, etc. etc.  Imagine; tooth regeneration from your own body, for your own body.  -dg

Monday, May 24, 2010

Body’s Own Stem Cells Can Lead to Tooth Regeneration

A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a 3-D scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted…

Body’s Own Stem Cells Can Lead to Tooth Regeneration

In VICTORIES & SUCCESS STORIES on May 24, 2010 at 7:37 pm

I met with Dr. Mao last summer and I found his presentation fascinating and informative.  Imagine taking stem cells from your own body and regrowing your won teeth. No dentures, crowns, implants, foreign materials, etc. etc.  Imagine; tooth regeneration from your own body, for your own body.  -dg

Monday, May 24, 2010

Body’s Own Stem Cells Can Lead to Tooth Regeneration

A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a 3-D scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.
People who have lost some or all of their adult teeth typically look to dentures, or, more recently, dental implants to improve a toothless appearance that can have a host of unsettling psycho-social ramifications. Despite being the preferred (but generally painful and potentially protracted) treatment for missing teeth nowadays, dental implants can fail and are unable to “remodel” with surrounding jaw bone that undergoes necessary changes throughout a person’s life.
An animal-model study has shown that by homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown “orthotopically,” or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials.
Human molar scaffolding from the lab of Dr. Jeremy Mao
Human Molar Scaffold
“These findings represent the first report of regeneration of anatomically shaped tooth-like structures in vivo, and by cell homing without cell delivery,” Dr. Mao and his colleagues say in the paper. “The potency of cell homing is substantiated not only by cell recruitment into scaffold microchannels, but also by the regeneration of periodontal ligaments and newly formed alveolar bone.”
This study is published in the most recent Journal of Dental Research, the top-rated, peer-reviewed scientific journal dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry, the oral cavity and associated structures in health and disease.
Dental implants usually consist of a cone-shaped titanium screw with a roughened or smooth surface and are placed in the jaw bone. While implant surgery may be performed as an outpatient procedure, healing times vary widely and successful implantation is a result of multiple visits to different clinicians, including general dentists, oral surgeons, prosthodontists and periodontists. Implant patients must allow two to six months for healing and if the implant is installed too soon, it is possible that the implant may fail. The subsequent time to heal, graft and eventually put into place a new implant may take up to 18 months.
The work of Dr. Mao and his laboratory, however, holds manifold promise: a more natural process, faster recovery times and a harnessing of the body’s own potential to re-grow tissue that will not give out and could ultimately last the patient’s lifetime.
“A key consideration in tooth regeneration is finding a cost-effective approach that can translate into therapies for patients who cannot afford or who aren’t good candidates for dental implants,” Dr. Mao says. “Cell-homing-based tooth regeneration may provide a tangible pathway toward clinical translation.”

Dr. Ira B. Lamster, dean of the College of Dental Medicine, stated: “This research provides an example of what is achievable when today’s biology is applied to common clinical problems. Dr. Mao’s research is a look into the future of dental medicine.”

via Nano Patents and Innovations: Body’s Own Stem Cells Can Lead to Tooth Regeneration.

A denture-free world with adult stem cells

In VICTORIES & SUCCESS STORIES on September 13, 2009 at 1:35 pm

bush stole my denturesNova Southeastern University’s dental researchers at the College of Dental Medicine are growing and harvesting human dental stem cells in the laboratory.A 2009 NSU survey of dentists around the nation revealed that more than half thought that they would be using stem cell and tissue engineering therapies on their patients within the next decade.

An overwhelming 96 percent of dentists believe the ability to regenerate and replace teeth and dental tissues is the future of dentistry, according to the survey.

The practical application of NSU’s research is for replacement teeth and dental tissues to be grown in the lab and implanted into patients. Having “real” replacement teeth will allow patients to better experience normal dental sensations, such as taste. Their teeth will have the ability to function, grow and develop as normal healthy teeth.

The goal of NSU’s research is to ultimately put an end to the fear of millions of Americans, who will no longer have to worry about a lack of teeth, dental pain, dental disease and using dentures.

teeth

Scientists grow fully functional tooth from stem cells

In VICTORIES & SUCCESS STORIES on September 8, 2009 at 1:18 pm

Scientists grow fully functional tooth from stem cells

August 22, 4:12 PMNY Holistic Body & Spirit ExaminerTima Vlasto

Though teeth have been grown in mice before, scientists revealed in the Proceedings of the National Academy of Sciences their success at growing a “fully functional” tooth from stem cells in mice.

The article states:

“Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.”

The process is described in a paper titled “The development of a bioengineered organ germ method” in the journal Nature Methods by researchers with the Department of Biological Science and Technology at the Tokyo University of Science.

via Scientists grow fully functional tooth from stem cells.

New Teeth From Stem Cells in Mice

In VICTORIES & SUCCESS STORIES on August 25, 2009 at 10:11 pm

Teeth have been grown from stem cell “seeds” and planted in the mouths of mice, scientists from Tokyo University reported in Proceedings of the National Academy of Sciences. They hope it could lead to replacing teeth in humans, or even to rebuilding whole organs.

The Japanese scientists developed a bioengineered “tooth germ” — a seed-like package containing all the cells and instructions necessary to form a tooth.

A number of these were implanted into the jaw bones of mice which had earlier had molar back teeth removed. The “tooth germs” sprouted fully formed teeth in the gaps left by the extractions.

To make them easier to see, they incorporated a green fluorescent protein which glowed under ultraviolet light. The engineered teeth were as hard as their natural counterparts and threaded with nerve fibres which responded to pain.

Dr Takashi Tsuji, from the Tokyo University of Science and colleagues wrote: “The bioengineered tooth. . . had the correct tooth structure, hardness of mineralised tissues for mastication, and response to noxious stimulations such as mechanical stress and pain.”

“This study represents a substantial advance and emphasises the potential for bioengineered organ replacement in future regenerative therapies.”

via Scientists Grow New Teeth From Stem Cell Seeds Planted in Mice – Science News | Science & Technology | Technology News – FOXNews.com.

Saving Stem Cells – Banking Stem Cells – From your teeth

In ALL ARTICLES, STEM CELLS IN THE NEWS on April 7, 2009 at 3:43 pm

baby_teeth_stem_cell_bank_wisdom_stemsave

Saving Stem Cells – Banking Stem Cells – From your teeth

Kristin Lowman

Megan Brown is no stranger to surgery. At 10 years old, Megan had a brain tumor

Megan says, “two surgeries to get the turmor out, now, I’m fine.”

So today’s wisdom teeth removal is nearly a walk in the park for Megan and her family.

But this procedure is special, because one day, it could save her life.

Megan says, “its been a recent discovery that your wisdom teeth contain stem cells. So I’m going to bank them.”

Dr. Robert Carpenter says, “in teeth, particularly dediuous baby teeth and wisdom teeth there is a tremendous quality of stem cells.”

There are two sources of stem cells, embryonic and adult. Obtaining embryonic stem cells is quite controversial while adult stem cells can be found in many organs and tissues in the body, including your teeth.

Living stem cells in extracted teeth are usually thrown out, but now, research shows saving those cells, could help with medical treatments down the road.

Dr. Carpenter uses a service called Stem Save, to harvest the stem cells.

Stem Save also tests the viability of those cells and cryogenically freezes them until they are needed.

Dr. Carpenter says, “you’re getting your own stem cells so there is no chance for rejection, no disease, and you can personalize them for any use you need throughout your life.”

Right now, dental stem cells are being used to treat MS, Parkinson’s, even liver and heart disease. Several hundred clinical trials are also underway around the world.

In just over a year, around 200 dentists across the country are using this service alone.

For Megan and her parents, its a safety net they are glad to have.

They start up cost for the service is around $600. Thats for testing the cells and for the first year of storage.

Right now, Dr. Carpenter says the service is not covered by insurance

via Saving Stem Cells – FOX23 News – The 10 O’Clock News.

www.Stemsave.com

FIGHT OR FLIGHT, we are programmed for survival

In ALL ARTICLES, OFF THE BEATEN PATH on March 30, 2009 at 6:48 pm

fight-or-flight-dog-humor1

Fight or Flight, We are programmed for survival

We are born with a fight or flight instinct. It is the strongest instinct in our arsenal (except in the spring when perpetuation of the species can over ride). Wanting to cure disease and live longer is a natural extension of that instinct and it is hard wired into us and is not only completely natural, but unavoidable.

With pluripotent stem cells being induced from skin and testes and adult stem cells treating over 100+ diseases around the world successfully and adult stem cells being found in places all over the body – breast milk, fat, menstruation, bone marrow, blood, noses and of course, teeth; the history of medicine and the advancements for healing have taken an undeniable  quantum leap forward.

https://repairstemcell.wordpress.com

Oral Surgeon Harvests Stem Cells For Patients – Denver News Story – KMGH Denver

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 1, 2009 at 2:56 pm

girl-smile-missing-tooeth

Oral Surgeon Harvests Stem Cells For Patients

UPDATED: 8:50 am MST March 1, 2009

STEAMBOAT SPRINGS, Colo. — Some Steamboat Springs residents are forgoing the Tooth Fairy, hoping their teeth wind up being worth much more than a quarter.

Steamboat Springs oral surgeon Dr. John Lupori offers patients the chance to store the stem cells in the teeth he extracts. Lupori partners with StemSave, a New York-based company that freezes and stores stem cells found in the pulp at the base of teeth. Science is moving fast, those involved said, and the cells might someday save the patient’s life.

stemsave

“Potentially, they’re incredibly miraculous,” said Dr. Bob Pensack, who had his daughter, Miriam, save her cells. “They’ve already been miraculous in the lab.”

Stem cells exist throughout the body and differentiate into organs and tissue. Stem cells that could be used to grow new organs, for example, are the type that haven’t differentiated. Dental stem cells fall into this category, StemSave CEO Art Greco said.

via Oral Surgeon Harvests Stem Cells For Patients – Denver News Story – KMGH Denver.

Your Child’s Teeth Can Save their Life using StemSave service

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 22, 2009 at 11:19 pm

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Your Child’s Teeth Can Save their Life using StemSave service
February 22, 2009 – By Lauri Harrison – 1 Tot & 1 Teen

Wait! Before you plan for the tooth fairy to come and take away your child’s tooth, consider preserving it for future use. Believe it or not, the human tooth contains healthy pulp tissue which contains stem cells that can be utilized to regenerate your child’s health if needed. Sounds like a Sci-Fi movie, but it’s not. It works along the same principles as preserving the cord blood when your baby is born. Stem cells extracted from the healthy tissue within your child’s tooth can help fix medical ailments, grow new organs, repair bone, and much more…

http://www.workingmother.com/web?service=direct/1/ViewBlogPage/dlinkBlog&sp=S1406

Steamboat Springs oral surgeon Dr. John Lupori offers patients the chance to store the stem cells in the teeth he extracts. Lupori partners with StemSave, a New York-based company that freezes and stores stem cells found in the pulp at the base of teeth.

via https://repairstemcell.wordpress.com/2009/02/08/local-oral-surgeon-harvests-stem-cells-for-patients/

Did you know your child’s tooth can save their life down the road?

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 22, 2009 at 11:18 pm

Sunday, February 22, 2009

MomToBeDepot focuses on educating and informing parents about important issues. Whether it’s a new product for mom or baby, a great book to read, or some service you just shouldn’t live without. After almost 2 years of writing this blog and the bigger site MomToBeDepot, I can honestly say this particular posting is the most important information I can pass along to parents. It’s about a company called StemSave.

What they are doing is absolutely incredible and a godsend to parents who take advantage of their service.

Let me back up a little bit. When you’re pregnant, you have the opportunity to store cord blood, so stem cells could be utilized down the road if your child becomes ill. But what if you didn’t take advantage of that at the time or if you’ve adopted a child and don’t have access to family medical history? StemSave is your second chance to save your child’s life. We spoke with CEO and treasurer of StemSave, Art Greco to learn about the company and the future direction of stem cell research.

Believe it or not, the healthy tissue within a tooth contains stem cells…

http://momtobedepot.blogspot.com/2009/02/did-you-know-your-childs-tooth-can-save.html

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