DAVID GRANOVSKY

Posts Tagged ‘symptom’

LEAKY GUT + BLOOD BRAIN BARRIER =AUTISM?

In DISEASE INFO, HEALTH AND WELLNESS, SCIENCE & STEM CELLS on January 24, 2017 at 10:55 am

leaking

Does leaking cause autism and schizophrenia?

Remember those hysterical soccer Moms who said Autism has to do with the gut, the immune system and the brain.  Guess what, they were pretty spot on…it looks like in ASD and schizophrenia patients, there is a significant incidence of leaking in both the intestines and the blood-brain barrier

  1. “Blood-brain-barrier integrity and function and with inflammation was detected in ASD tissue samples, supporting the hypothesis that an impaired blood-brain barrier associated with neuroinflammation contributes to ASD”
  2. Gut: “75 percent of the individuals affected by ASD had reduced expression of barrier-forming cellular components, compared with controls, and 66 percent showed a higher expression of molecules that increase intestinal permeability”

autism-awareness

Wednesday, January 18, 2017

Study finds alterations in both blood-brain barrier and intestinal permeability in individuals with autism

Autism spectrum disorder (ASD) has the dubious distinction of being the fastest-growing developmental disability in the U.S., according to the Centers for Disease Control and Prevention. With 1 in every 68 children born in this country diagnosed with ASD, parents are looking everywhere for answers about best treatments. Along with selective medication to treat certain symptoms, traditional treatments include intensive behavioral approaches. But with no “one-size-fits-all” treatment approach, parents often turn to diverse complementary and alternative therapies.

Just as parents are looking for answers, scientists are trying to tease out the causes of this multifactorial and complex condition. “Although we are fairly certain that there is a genetic component, there are many pathways for an individual to arrive at autism’s final destination,” says Alessio Fasano, MD, director of the Center for Celiac Research and Treatment at Massachusetts General Hospital (MGH) and co-senior author of a study published in the journal Molecular Autism. “What might dispose one person to develop ASD – either pre- or post-natally – might have no such effect on another person,” he adds.

Looking at the interconnectivity of the gut-brain axis – the biochemical signaling between the gastrointestinal and central nervous systems – researchers led by Maria Rosaria Fiorentino, PhD, of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC), have opened up a new avenue of research into the pathophysiology of ASD and other neurodevelopmental disorders. “As far as we know, this is the first study to look at the molecular signature of blood-brain barrier dysfunction in ASD and schizophrenia in samples from human patients,” says Fiorentino. In collaboration with researchers from the University of Maryland School of Medicine and others, Fiorentino’s group found an altered blood-brain barrier in tissue samples from people with ASD when compared with healthy controls.

The group analyzed postmortem cerebral cortex and cerebellum tissues from 33 individuals – 8 with ASD, 10 with schizophrenia and 15 healthy controls. Altered expression of genes associated with blood-brain-barrier integrity and function and with inflammation was detected in ASD tissue samples, supporting the hypothesis that an impaired blood-brain barrier associated with neuroinflammation contributes to ASD.

In keeping with the hypothesis that the interplay within the gut-brain axis is a crucial component in the development of neurodevelopmental disorders, the group also analyzed intestinal epithelial tissue from 12 individuals with ASD and 9 without such disorders. That analysis revealed that 75 percent of the individuals affected by ASD had reduced expression of barrier-forming cellular components, compared with controls, and 66 percent showed a higher expression of molecules that increase intestinal permeability.

The study was driven in part by the high number of gastrointestinal problems that occur in people with ASD. Although considered controversial by some health care practitioners, a gluten- and casein-free diet has been shown to produce some improvement in behavioral and gastrointestinal symptoms in a subgroup of children with ASD. “This is the first time anyone has shown that an altered blood-brain barrier and impaired intestinal barrier might both play a role in neuroinflammation in people with ASD,” says Fiorentino.

Fasano adds, “As well as information on the blood-brain barrier, we were looking for more information on how increased intestinal permeability, otherwise known as a ‘leaky gut,’ might affect the development of ASD in the context of a dysfunctional gut-brain axis.”

Fiorentino’s next project involves looking more mechanistically at how microbiota – the collection of microorganisms in the gut – are linked with intestinal permeability and behavior. “There is definitely something going on between the gut and the brain with ASD and other neurodevelopmental disorders, and of course the microbiome has a big role to play,” she says. “It has already been shown that ASD kids have an altered composition of gut microbial communities. If we can figure out what is required or missing, then maybe we can come up with a treatment that might be able to improve some of the behavioral issues and/or the gastrointestinal symptoms.”

Fasano is a professor of Pediatrics, and Fiorentino is an assistant professor of Pediatrics at Harvard Medical School. Additional co-authors of the Molecular Autism paper are Anna Sapone, PhD, Stefania Senger, PhD, and Stephanie Camhi, MGHfC Mucosal Immunology and Biology Research Center; Sarah Kadzielski, MD, and Timothy Buie, MGHfC Gastoenterology and Lurie Center for Autism; Deanna L. Kelly, PharmD, BCPP, University of Maryland School of Medicine, and Nicola Cascella, MD, Sheppard Pratt Health System, Baltimore.

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $800 million and major research centers in HIV/AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, photomedicine and transplantation biology. The MGH topped the 2015 Nature Index list of health care organizations publishing in leading scientific journals and earned the prestigious 2015 Foster G. McGaw Prize for Excellence in Community Service. In August 2016 the MGH was once again named to the Honor Roll in the U.S. News & World Report list of “America’s Best Hospitals.”

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PARKINSON’S – FREDDIE ROACH

In ALL ARTICLES on February 9, 2012 at 1:22 pm

https://i1.wp.com/fightnetwork.com/wp-content/uploads/2011/11/FreddieRoach1.jpg

For those that don’t know him, Freddie Roach is the greatest boxing coach of all time.  He has accomplished this incredible feat with slurred speech and tremors.  Freddie Roach has Parkinson’s.  On the HBO special about him, in a conversation with another Parkinson’s patient Roach says:

“That’s why Muhammad Ali shakes so much.  He doesn’t take the medication.”

The side effects of the medication are worse than the symptoms of the disease.

https://i1.wp.com/www.maniacworld.com/muhammad-ali-2.jpg

In a special on Muhammad Ali’s daughter, a brilliant fighter in her own right, she says:

Ali is perfectly coherent and easy to talk to in the morning before he takes his meds.  After he takes his meds you can’t talk to him.

https://i2.wp.com/www.sportsclb.com/wp-content/uploads/laila-ali-picture-1.jpg

What have we learned here?

https://repairstemcell.wordpress.com/2011/03/17/gene-therapy-shows-promise-for-parkinsons-reuters/

https://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients – Safe + Improve
https://repairstemcell.wordpress.com/2010/03/11/autologous-bone-marrow-stem-cells-transplant-into-parkinson%e2%80%99s-disease-patients-safe-improve/

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!
https://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

Do Stem Cells Repair Damaged Brain Cells
https://repairstemcell.wordpress.com/2009/08/25/mesenchymal-stem-cells-may-repair-damaged-brain-cells-%c2%ab-adult-stem-cell-awareness/

* OPRAH, MICHAEL J FOX, DR OZ – STEM CELL DEBATE IS DEAD! –http://tinyurl.com/DEBATEisDEAD

“Give them nothing! But take from them everything!”

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on May 12, 2009 at 9:12 am
In the movie 300, King Leonidas rallies his troops for the clash with the insurmountable odds of the Persian forces.  Just before the armies slam into each other, Leonidas shouts: “Give them nothing! But take from them everything!”
leonidas
Imagine an army of brilliant doctors who oppose the seemingly insurmountable forces of both Multiple Sclerosis AND the regulatory boards that refuse to allow patients to receive adult stem cell treatments in the US.

Their battle is a difficult one and not all patients will benefit from the treatment (~74% do) so the doctors must “promise them nothing.”

But the doctors WILL give the patients the beneficial treatments, WILL give them their own stem cells, NONE shall stand in the way of treating their patients and MOST patients will be SYMPTOM FREE and get their lives back…in short, they will be given EVERYTHING!

“Promise them NOTHING,

but give them EVERYTHING!”

Multiple Sclerosis Patients Promised Nothing But Are Symptom Free After Stem Cell Treatment | Culture11

May 11, 2009

Multiple Sclerosis Patients Improve After Stem Cell Research and Therapy Preston Walker and Richard Humphries are shining examples of how stem cell research using Adult Stem Cells are improving lives right now. Preston and Richard were the first two Multiple Sclerosis patients to receive stem cell treatment with their own cells derived from their fat. Stem […]…read more

via Multiple Sclerosis Patients Promised Nothing But Are Symptom Free After Stem Cell Treatment | Culture11.

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