DAVID GRANOVSKY

Posts Tagged ‘stroke’

SCIENTISTS “STUNNED” AS STROKE PATIENT WALKS AGAIN

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS FROM THE PAST, STEM CELLS IN THE NEWS on January 14, 2017 at 12:34 pm

“Stunned?”
C’mon guys…

stroke

STROKE CLINICAL TRIALS

  • The University of Texas, Health Science Center at Houston July 1, 2009       Several months after becoming the first patient in the United States to undergo a revolutionary new stroke treatment, Roland “Bud” Henrich continues to improve. Doctors intravenously injected Henrich, 61, with stem cells taken from his own bone marrow…”The stem cells, we believe, may help repair the damage to his brain caused by the stroke,” said Sean Savitz, M.D., assistant professor of neurology at The University of Texas Medical School at Houston and the study’s lead investigator. “Animal studies have shown that when you administer stem cells after stroke, the cells enhance the healing. We know that stem cells have some kind of guidance system and migrate to the area of injury. They’re not making new brain cells but they may be enhancing the repair processes and reducing inflammatory damage.” http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

Other STROKE articles:

  1. https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
  2. https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
  3. http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
  4. http://www.sciencedaily.com/releases/2011/08/110831160216.htm
  5. https://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/
  6. http://www.philly.com/philly/health/HealthDay686541_20140407_Stem_Cells_Show_Pro

—————-

New Stem Cell Treatment Leaves Scientists “Stunned” As Wheelchair-Bound Stroke Patient Walks Again

MORE THAN 70 PERCENT OF STROKE PATIENTS END UP WITH LONG-TERM DISABILITIES.

Researchers are said to be “stunned” by the success of a recent clinical trial of a new stem cell treatment for stroke patients. By injecting the cells into participants’ brains, scientists were able to produce some remarkable improvements, with several patients regaining motor function in their limbs.

A full report of the study has been published in the journal Stroke, with lead author Gary Steinberg telling the Washington Post that patients’ improvements were “not just minimal recovery like someone who couldn’t move a thumb now being able to wiggle it. It was much more meaningful. One 71-year-old wheelchair-bound patient was walking again.”

The trial involved the use of modified bone marrow–derived mesenchymal stem cells, which were injected into the specific region of each patient’s brain that had become damaged following their stroke. Amazingly, the researchers were not actually expecting to see any clinically relevant results at this stage, as they were just testing out a low dose of the treatment in order to assess its safety.

However, of the 18 patients involved in the study, seven experienced dramatic improvements in their cognitive and motor capabilities. In terms of safety, the study authors report that all participants experienced at least one temporary adverse effect, ranging from headaches and nausea to muscle spasticity. Importantly, though, all of these are thought to have been caused by the surgical procedure itself rather than the stem cells.

 

To evaluate the success of the treatment, the researchers used a number of standardized scales that are commonly used to assess the severity of symptoms in stroke patients. For instance, the Fugl-Meyer motor function total score is often used to measure recovery, with an improvement of 10 points representing a “clinically meaningful” change.

The patients involved in the study experienced an average improvement of 11.4 points on this scale, which translated into a “clinical improvement in the power of upper and lower limbs, ranging from an improvement in the ability to stand to the disappearance of tremor.”

Furthermore, the study authors make a point of noting that their patients had been suffering from their various symptoms for an average of 22 months prior to treatment. This is well beyond the six-month cut-off period that is typically considered to represent the point at which stroke-related brain damage becomes permanent and untreatable.

Exactly how the treatment works is not entirely understood, although Steinberg suspects that the stem cells somehow kick-start the brain’s own ability to repair itself, rather than developing into new neurons themselves.

Given that at present, more than 70 percent of people who suffer strokes end up with some sort of enduring disability, this new treatment could potentially be a game-changer – although more trials will be needed before it becomes readily available.

 

http://www.iflscience.com/brain/new-stem-cell-treatment-leaves-scientists-stunned-as-wheelchairbound-stroke-patient-walks-again/

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Anecdotal – The Dirty Word in Gordie Howe’s Stem Cell Treatment

In ALL ARTICLES on February 10, 2015 at 7:35 pm

What does it tell you when expert after expert tries to discredit the results of Gordie Howe’s stem cell treatment while his son Dr. Murray Howe, chairman of Toledo Hospital’s department of radiology, credits the stem cells for his recovery?

Dr. Murray Howe is the chairman of Toledo Hospital's department of radiology.

Dr. Murray Howe is the chairman of Toledo Hospital’s department of radiology.

What does it tell you when expert after expert claim his recovery and improvements are insignificant…while simultaneously attributing his recovery and improvements to everything except the stem cells he received?

What does it tell you when expert after expert discredits the anecdotal evidence of Gordie Howe’s recovery as “merely anecdotal” while it is actually one mere drop in an ocean of tens of thousands per year who have improved from cancer with cellular therapies over the last 59 years and tens of thousands who have improved over the past 12-14 years from non-cancer conditions?

And what is the value of this huge array of empirical and anecdotal evidence?

Gordie Howe Recovers From Stroke with Stem Cells

Gordie Howe Recovers From Stroke with Stem Cells

There are many types of evidence, not just trials or anecdotal.  Too often we reduce the evidential options to either clinical trials or anecdote.  Wrong.  That’s 5 blind men describing an elephant all over again.  We must take into account ALL of the different types of evidence and only THEN we can make a judgment based on the cumulative evidential data.

Anecdotal Evidence – Peyton Manning, Kobe Bryant, Rafael Nadar, Bartolo Colon…athletes from major sports organizations all over the world are embracing and anecdotally illustrating the safety and efficacy of cellular therapies

Statistical Evidence – 50,000 patients per year… are statistically illustrating the safety and efficacy of cellular therapies

Testimonial Evidence – Youtube is chock full of testimonies of athletes and patients who are benefiting from cellular therapies and via testimonial, illustrating the safety and efficacy of cellular therapies

Analogical Evidence – 59 years and thousands of trials and studies are analogously illustrating the safety and efficacy of cellular therapies

Clinical Trial evidence – Even though it may be the wrong process to evaluate cellular therapies, the vast majority of over 2,400 clinical trials are scientifically and empirically illustrating the safety and efficacy of cellular therapies

Miracle results? No.  This is par for the course results from real expectations based on the multitude of evidence types collected over the past six decades for cellular therapies.  The combined patchwork of all of the data from all of these evidences paints a very compelling conclusion.

Are cellular therapies safe and effective?  All of the evidences seem to say so.  Not just the anecdotal evidence;
anecdotal,
statistical,
testimonial,
analogical
and clinical trial evidences.

by David Granovsky, Stem Cell Writer and Author

Read one of the many myopically evidential articles here: http://www.theglobeandmail.com/globe-debate/the-stem-cell-miracle-is-anecdotal/article22880977/

STEM CELLS ARE OUT OF THIS WORLD

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on July 21, 2014 at 4:38 pm

The potential of stem cells to regrow and/or prevent the deterioration of muscle and bone cells over time when subjected to zero gravity has garnered an enormous amount of interest from NASA and the entire space travel industry.   This has lead NASA to send stem cells into space to be researched in low or zero gravity on the space station.   The findings are extraordinary.  “The team discovered that 64 percent of the proteins found in the stem cells grown in simulated microgravity were not in control samples. In particular, the bioreactor cells contained several proteins involved in the breakdown of bone and in the regulation of calcium, neither type of which were found in stem cells grown in regular, Earth gravity.” 

We’ve know for some time that stem cells are smart and capable of:

  • differentiating into whatever cell types are needed without direction
  • growing every cell in a heart and organizing those cells perfectly into where they need to be
  • retro-differentiate into other cell types after finishing work on a particular organ or tissue type
  • traveling back through the umbilical cord from fetus in womb to mother with heart disease to aid the mother in the healing process
  • and many more incredible capabilities

But those actions took place in the patient’s body where the stem cells are able to read the needs of the body with the help of  numerous cues, messenger cells and the entire physiological road map of the patient to guide them.   Essentially, they have an awesome GPS system and just have to follow the directions they are given on roads the GPS “knows” very well.  Conversely, the astro-stem cells (stem cell-nauts?) are able to grow better in space than on earth and to grow with “space relevant capabilities.”  This is incredible.  Imagine going to space for the first time and knowing intrinsically what to do and further, knowing what to do to help your host body better survive and thrive in the conditions of space.  The astro-stem cells are taking cues from their external environment from factors they have never even been exposed to (unless you adhere to the ancient aliens theories) and modifying their proteins and genetic make up to accommodate for the difference in gravity.

What else can they do? If we assume the stem cells will react to the external cues as well as the internal cues, what other factors will they respond to?  We know they grow better in space and in a hyperbaric chamber; what type of response would they have to being underground, on the ocean or under it (long submarine voyages or sub-oceanic colonization), in the dark (increased optic nerve proliferation?), in radioactive areas (radiation resistance)?  Time will tell.  I would say the sky is the limit but apparently, it’s not.

Are we witnessing evolution?
evo·lu·tion  noun \ˌe-və-ˈlü-shən, ˌē-və-\ biology : a theory that the differences between modern plants and animals are because of changes that happened by a natural process over a very long time.  the process by which changes in plants and animals happen over time, a process of slow change and development

No.  Not evolution.  This is faster than the classic definition of evolution.  This is accelerated and positive mutation as a response to external and internal environmental factors.   This is…adaption, rapid adaption…”  Lending support to my analogy that stem cells are born Marines because “Marines are taught to adapt, improvise, overcome…” via

…and the line between science fiction and science reality grows ever thinner.
– David

Growing-stem-cells-in-space

Growing stem cells in space: Medicine’s next big thing

“When challenged by microgravity, living organisms’ genes can ‘turn on,’ transforming growth. Scientists at Zero Gravity Solutions work to direct cells toward healthier, hardier strains. It’s not genetic engineering, but accelerated hybridization.” via http://www.space.com/21885-stem-cells-in-space-can-solve-plant-and-animal-problems-video.html

Date:
March 31, 2014
Source:
Ivanhoe / Powered by NewsLook.com
Summary:
Currently, treatments for hemorrhagic stroke aim to control swelling but not regeneration of the damaged tissue. Now, researchers are using an out of this world idea to help stroke survivors. Video provided by Ivanhoe

http://www.sciencedaily.com/videos/58f619e8b7a37890f1857c84110e7e91.htm

RELATED/SOURCES:

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

– See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

Welcome to the CASIS Request for Proposals

The Impact of Microgravity on Fundamental Stem Cell Properties:

A Call for Spaceflight and Ground-Based Experiments

– See more at: http://www.iss-casis.org/Opportunities/Solicitations/RFPStemCellsResearch.aspx#sthash.Y6sDtvQa.dpuf

 

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:20 pm
https://repairstemcell.files.wordpress.com/2013/11/8c5a1-strokebrainimage.jpg
Stem Cells Improve Cognition After Brain Injury

Research led by Charles Cox at the University of Texas Health Science Center has shown that stem cell therapy given during the critical time window after traumatic brain injury promotes lasting cognitive improvement. These experiments, which were published in the latest issue of the journal Stem Cells Translational Medicine, provide a pre-clinical model for experiments with larger animals.

After the brain has suffered a traumatic injury, there are few treatment options. Damage to the brain can be severe, and can also cause ongoing neurological impairment. Approximately half of all patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

In this work from Cox’s lab, stem cells from bone marrow known as multipotent adult progenitor cells (MAPCs) were used. MAPCs seem to be a subpopulation of mesenchymal stem cells, and they have a documented ability to reduce inflammation in mice immediately after traumatic brain injury. Unfortunately, no one has measured the ability of MAPCs to improve the condition of the brain over time.

Cox, Distinguished Professor of Pediatric Surgery at the UTHealth Medical School and in collaboration with the Children’s Fund, Inc., injected two groups of brain-injured mice with MAPCs two hours after injury and then once again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times greater.

After four months, those mice that had received the stronger dose not only continued to have less inflammation, but they also showed significant gains in cognitive function. Laboratory examination of the brains of these rodents confirmed that those that had received the higher dose of MAPCs had better brain function than those that had received the lower dose.

According to Cox, “Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs.” Cox also indicated that this study indicates that intravenous injection of MAPCs might very well become a viable treatment for people with traumatic brain injury in the future.

 

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish.

STEM CELLS REDUCE BRAIN DAMAGE AFTER STROKE

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 7, 2013 at 9:00 am

stroke

Stroke – Stem Cells Can Reduce Brain Damage

Rescuing a patient from a stroke and restoring cognitive functions are two significant medical challenges today. Blockage of a brain artery, usually by a clot or atherosclerotic plaque, results in reduction in oxygen supply to brain cells. If the supply of oxygen is interrupted for a long time, brain cells die resulting in severe loss of motor and cognitive functions. Therapeutic approaches to prevent the formation of plaques or blood clots are not a hundred percent successful in preventing a stroke. Recent research has focused on aiding regeneration of brain cells after an ischemic stroke and stem cells have been used with reasonable success.

Experiments conducted on rats show that intravenous injection of stem cells derived from adipose tissues as well as mesenchymal stem cells derived from bone marrow supported the recovery of brain cells after a stroke. In these experiments, rats were subjected to a stroke by blocking their middle cerebral artery permanently. Stem cells from bone marrow as well as fat cells were injected 30 minutes after induction and the health of the animals was assessed at 24 hours and 14 days after stroke. In the recovery period, animals injected with stem cells showed increased levels of vascular endothelial growth factor and synaptophysin. The injected stem cells did not migrate to the site of the lesion but presumably acted as a source of neurotrophic growth factors.

In another study, stem cells from the dental pulp of human deciduous teeth (milk teeth) were grafted in the brains of mice one day after induction of a stroke. In some animals, the culture medium in which these cells were grown was used instead of the cells. Mice treated with human dental pulp stem cells and conditioned medium from these cells showed better recovery and neurological outcome than untreated mice. Grafted stem cells as well as the conditioned medium inhibited death of neurons in the recovery period and prevented cell destruction resulting from inflammation. In these experiments, the actual integration of human dental pulp stem cells into the brain tissue occurred at very low frequency.

Both studies present important insights in the process of regeneration of brain cells followed hypoxic and ischemic stroke. Stem cells secrete a number of growth factors which help to promote generation of new neurons post a stroke. The results presented by Yamagata and colleagues where just the culture medium from dental pulp stem cells was effective in restoring brain tissue and neurological functions indicate that a suitable “growth factor cocktail” can be derived from cultures of stem cells to treat stroke. Since intravenous injection of stem cells also helps recovery from stroke, it is easy to deliver such a therapeutic intervention. A xenograft of human dental pulp stem cells was successful in helping mice recover from a stroke. It would be interesting to know whether stem cells from other animal systems have a similar beneficial effect on human neurons as well.

References

Gutierrez-Fernandez M, Rodriguez-Frutos B, Ramos-Cejudo J, Vallejo-Cremades MT, Fuentes B, Cerdan S, & Diez-Tejedor E (2013). Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem cell research & therapy, 4 (1) PMID: 23356495

Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, Sawamoto K, & Ueda M (2013). Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke; a journal of cerebral circulation, 44 (2), 551-4 PMID: 23238858

Brain Blogger

STROKE RECOVERY IMPROVED THROUGH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 30, 2013 at 9:00 am

_65521433_stems

Stem Cells Aid Recovery from Stroke, Study Suggests

Jan. 28, 2013 — Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central’s open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain and nerve repair and the ability of the animals to complete behavioural tasks.

Stem cell therapy holds promise for patients but there are many questions which need to be answered, regarding treatment protocols and which cell types to use. This research attempts to address some of these questions.

Rats were treated intravenously with stem cells or saline 30 minutes after a stroke. At 24 hours after stroke the stem cell treated rats showed a better functional recovery. By two weeks these animals had near normal scores in the tests. This improvement was seen even though the stem cells did not appear to migrate to the damaged area of brain. The treated rats also had higher levels of biomarkers implicated in brain repair including, the growth factor VEGF.

A positive result was seen for both fat (adipose) and bone-marrow derived stem cells. Dr Exuperio Díez-Tejedor from La Paz University Hospital, explained, “Improved recovery was seen regardless of origin of the stem cells, which may increase the usefulness of this treatment in human trials. Adipose-derived cells in particular are abundant and easy to collect without invasive surgery.”  (sciencedaily.com)

 

“The ease of collection, and the ability to use “allogenic” cells from other rats rather than having to harvest the animal’s own cells and culture them, meant a treatment was available not weeks after a stroke, when the damage was done, but in this case minutes.

“From the viewpoint of clinical translation allogenic stem cells are attractive because they can be easily obtained from young healthy donors, amplified, and stored for immediate use when needed after a stroke.”  They suggested that it might be possible to overcome the risk of immune rejection of the donor cells in humans.”  (bbc.co.uk/news/health)

TRAUMATIC BRAIN INJURY and STROKE

In DISEASE INFO on March 26, 2012 at 1:17 am

TO SEE IF YOU ARE A CANDIDATE FOR STEM CELL TREATMENT, PLEASE FILL OUT THE FOLLOWING FORM:  STEM CELL PATIENT QUESTIONNAIRE

I was told this was a con…here is my response:

My Stem Cells vs. Stroke page:
https://repairstemcell.wordpress.com/stroke-stem-cells/

Additional articles sorted by date (YEAR/MONTH/DAY):
https://repairstemcell.wordpress.com/2012/03/06/stem-cells-safe-for-young-traumatic-brain-injury/
https://repairstemcell.wordpress.com/2012/01/22/cellnews-scientists-learn-how-stem-cell-implants-help-heal-traumatic-brain-injury/

http://www.sciencedaily.com/releases/2011/08/110831160216.htm
https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
https://repairstemcell.wordpress.com/2010/08/28/cord-blood-wakes-up-drowning-victim%e2%80%99s-brain/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
https://repairstemcell.wordpress.com/2010/07/12/stem-cell-gel-helps-repair-traumatic-brain-injuries-smartplanet/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
https://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/

https://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

A con? Ok my skeptical friends, I understand. You’ve been researching stroke treatments for so long and been so disheartened you don’t believe your condition can ever improve. You’ve read all the outdated literature saying the central nervous system can not regrow (except for the most recent studies which prove it can be.) You’ve skimmed my articles and realize they are uncorroborated by “hard science.”

Fair enough. Ignore the 14 articles above which show the positive benefits of adult stem cells on stroke. You’re right, they are unsubstantiated. They are not peer reviewed medical journal articles. I appreciate your skepticism but know this:

*there are over 2,600 peer reviewed medical journal clinical trials that utilized adult stem cells with a record of safety and efficacy,
*there are many trials that cover the use of adult stem cells for stroke, ataxia, TBI, etc
*there are 60 trials that have the key words “adult stem cell” and “stroke.”
*there are 14 “Completed” trials that have the key words “adult stem cell” and “stroke.”

Research it yourself if you like. http://clinicaltrials.gov/ct2/results?term=adult+stem+cell+stroke&pg=1&show_flds=Y

Here are only the 14 “completed” trials:

Completed Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients

Conditions: Stroke;   Middle Cerebral Artery Infarction
Interventions: Procedure: Intercerebral implantation of Autulogous Stem Cells;   Drug: convention therapy
Completed Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke

Condition: Acute Stroke
Intervention: Biological: Autologous bone marrow stem cell
Completed Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.

Conditions: Stroke, Acute;   Infarction, Middle Cerebral Artery
Intervention: Procedure: Infusion on autologous CD34+ stem cells into middle cerebral artery
Completed Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke

Condition: Infarction, Middle Cerebral Artery
Intervention: Other: Autologous cell transplantation
21 Completed Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke

Condition: Ischemic Stroke
Intervention: Drug: Filgrastim
31 Completed Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)

Condition: Sickle Cell Anemia
Intervention: Procedure: Angiography
34 Completed Investigating Endothelial Precursor Cells (EPCs)

Condition: Central Nervous System
Intervention:
38 Completed Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention: Procedure: Stem Cell Transplanataion
40 Completed Gene Therapy for Gaucher’s and Fabry Disease Using Viruses and Blood-Forming Cells

Condition: Gaucher’s Disease
Intervention: Genetic: human glucocerebrosidase cDNA
51 Completed Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189

Condition: Depression
Intervention: Drug: NSI-189 Phosphate
52 Completed Beta-hCG + Erythropoietin in Acute Stroke

Condition: Acute Stroke
Intervention: Drug: Beta-hCG + Erythropoietin
54 Completed Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study

Conditions: Autism;   Oxidative Stress;   Inflammation
Intervention: Drug: Hyperbaric Oxygen Therapy
59 Completed Effects of Enzyme Replacement in Gaucher’s Disease

Condition: Gaucher’s Disease
Intervention:
60 Completed Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)

Condition: Sturge – Weber Syndrome (SWS)
Intervention:

 

 

If you still feel this is a con, tell me what you would need to see to prove otherwise. Respectfully, David

THE COST OF NOT PURSUING ADULT STEM CELL TREATMENTS IN THE USA

In VICTORIES & SUCCESS STORIES on February 9, 2011 at 9:40 am
COST BY DISEASE # OF PATIENTS COST PER YEAR
TYPE 1 DIABETES 5.8 MILLION PATIENTS $125.1 BILLION
STROKE 5.7 MILLION PATIENTS $62.7 BILLION
HEART FAILURE 5.2 MILLION PATIENTS $50.7 BILLION
SPINAL CORD INJURY 250,000 PATIENTS $37.2 BILLION
PARKINSON’S DISEASE 650,000 PATIENTS $23 BILLION

TOTAL COST THAT ADULT STEM CELLS COULD SAVE THE UNITED STATES

$250 BILLION PER YEAR


SCOTLAND JUMPS INTO STEM CELL CLINICAL TRIALS

In ALL ARTICLES on July 29, 2010 at 12:11 pm

This video shows the Health Minister of Scotland discussing current stem clinical trials in Scotland for stroke and for eye repair.  It’s significant that they are in the stem cell game.  One more country recognizing the power of stem cells.

p.s.  It’s a short video and armed with my explanation above, you probably know everything you need to know without even watching it – http://video.forbes.com/fvn/tech/scotland-stem-cell-edge

 

And now for your viewing pleasure…a pic of Cuillin Mountains in Scotland

https://i2.wp.com/www.1adventure.com/archives/images/cuillin-mountains-scotland-backside.jpg

Other STROKE articles:

  1. https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
  2. https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
  3. http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
  4. http://www.sciencedaily.com/releases/2011/08/110831160216.htm

ReNeuron – PRESENTS NEW DATA – STEM CELLS REPAIR BRAIN DAMAGE

In BUSINESS OF STEM CELLS on July 19, 2010 at 2:44 pm

ReNeuron presents new data showing how its stem cells work to repair brain damage. 12/07/10

Guildford, UK, 12 July 2010: ReNeuron Group plc (LSE: RENE.L) today announces important new data regarding the mechanisms of action of its lead CTX stem cell line in pre-clinical models of brain damage. The results of these studies will be presented in two posters1 at the UK National Stem Cell Network Annual Scientific Conference, taking place on 12 – 14 July, 2010 at the University of Nottingham, East Midlands Conference Centre, Nottingham, UK.

Image of stroke in the brain

In one series of studies, the angiogenic potential of the CTX stem cell line was tested, both in vitro and in rodent models of stroke damage. Angiogenesis is a multiple-step process whereby new blood vessels develop from pre-existing vasculature, potentially contributing to the functional recovery of the brain from damage such as that caused by ischaemic stroke. The results of these studies showed that the CTX cells express several trophic and pro-angiogenic factors in culture and also induce endothelial cell markers associated with blood vessel formation in the host at both 72 hours and 7 days post-implantation of the cells into the brain. Taken together, these results suggest that the CTX cells may play a role in promoting the functional recovery of stroke patients through up-regulation of angiogenesis in the region of ischaemic brain damage.

In a series of further studies, the CTX cells were seen to inhibit T cell activation. This immunosuppressive activity was in part attributed to the up-regulation of the ligand CD274, a regulator of T cell function. T cells are a type of white blood cell associated with the mediation of immune responses in the body. These results suggest that the CTX cells may act to suppress the inflammatory response associated with brain damage, thereby aiding the natural healing processes in the brain. This anti-inflammatory characteristic opens up a number of exciting new potential applications for the CTX cell line as a cell-based therapy for certain inflammatory diseases both within and beyond the brain.

ReNeuron recently announced the commencement of a UK Phase I clinical trial of its lead ReN001 stem cell therapy for disabled stroke patients. The ReN001 therapy represents the initial therapeutic application of the Company’s CTX stem cell line. Due in part to the anti-inflammatory properties of the CTX cells, patients in this clinical trial will not require immunosuppressive drug treatments alongside their cell therapy.

via ReNeuron –.

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