DAVID GRANOVSKY

Posts Tagged ‘spinal cord’

AUSTRALIAN OF THE YEAR, ‘NOSE’ STEM CELLS

In Doctors Practicing Excellence, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 27, 2017 at 1:50 pm

Biomedical scientist Alan Mackay-Sim is one of the pioneers in stem cell research, digging into (pun intended) the enormously productive (flowing?) area of “olfactoric mucosal stem cells” or neurological stem cells from inside your nose responsible for your sense of smell.

  1. Lu, J.; Feron, F.; Ho, S. H.; Mackay-Sim, A.; Waite, P. M. E. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 2001, 889, 344-357.
  2. Lu, J.; Feron, F.; Mackay-Sim, A.; Waite, P. M. E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002, 125, 14-21.

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Alan Mackay-Sim, the scientist whose miracle made a paraplegic walk again, named Australian of the Year

JANUARY 25 2017 – Biomedical scientist Alan Mackay-Sim, whose research helped achieve a feat described as “more impressive than man walking on the moon”, has been named the 2017 Australian of the Year for his pioneering stem cell research.

Professor Mackay-Sim’s work was central to the 2014 surgery that allowed Darek Fidyka, a Polish firefighter, to walk again and even ride a custom-built bicycle. This made him the first (well, not the first but no less significant) paraplegic in the world to recover mobility after the complete severing of the spinal nerves. The success was hailed by fellow researcher Geoff Raisman as more impressive than the moon landing.

Professor Mackay-Sim is a leading global authority on the human sense of smell and the biology of nasal cells. The successful surgery that allowed Mr Fidyka to walk again involved taking cells from his nose, growing them in a lab and injecting them into his spinal cord.

Prime Minister Malcolm Turnbull gives Alan Mackay-Sim his honour.

Professor Mackay-Sim, 65, himself relied on a stem cell transplant two years ago when he was diagnosed with myeloma, a rare form of blood cancer that develops in the bone marrow.

He was presented with his Australian of the Year award by Prime Minister Malcolm Turnbull on Wednesday night…

 

A history of stem cell treatments for spinal cord injury

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(NOT) FIRST PARALYZED HUMAN TREATED WITH STEM CELLS FOR SCI

In ALL ARTICLES, DISEASE INFO, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, THIS IS SPINAL... on January 27, 2017 at 12:05 pm

First paralyzed human treated with stem cells has now regained his upper body movement http://theheartysoul.com/stem-cells-cure-paralysis/

stem-cell-patient

CONGRATS! But…
NOT the FIRST!

This is the sort of article which makes me crazy because on the one hand, it is a triumph!  A mainstream coverage of a stem cell success, increasing awareness and helping to erode our entrenched concepts of what can be done with medicine and what is and isn’t really “incurable.”

On the other….it grossly misrepresents the long history of stem cell successes versus spinal cord injury. It devalues the patients who have recovered, the loved ones who supported them during their treatments and the doctors who worked their butts off developing the protocols and pushing the envelops, often in the face of massive popular skepticism.

 
These people, these patients and loved ones and doctors who risked everything; life, limb, money, time and more…they are the mavericks, the trail blazers, the ones who sacrificed everything for the one pure goal of advancing medicine, of advancing healing. They deserve to be honored and credited with their barrier breaking work, not dismissed in some ill conceived misinformation campaign, weakly relying upon the un-sturdy columns of anti-Piaget-ian Object Permanence.

hear_speak_see_no_evil_toshogu_cropped_enhanced

And no mention of Spinal Cord Injury and Stem Cell Treatment should be made without a HUGE nod to the God-Fathers, Prof Mackay-Sim and Dr Carlos Lima.

Dr Mackay-Sim was researching olfactoric mucosal stem cell applications for spinal cord injury in murine models as far back as 2001:

  1. Lu, J.; Feron, F.; Ho, S. H.; Mackay-Sim, A.; Waite, P. M. E. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 2001, 889, 344-357.
  2. Lu, J.; Feron, F.; Mackay-Sim, A.; Waite, P. M. E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002, 125, 14-21.

Dr Lima was “improving” and “recovering” Spinal Cord Injury patients with stem cells derived from their own noses as far back as…wait for it…2003.

“Olfactory stem cells have been shown to be most versatile. Indeed, Adult stem cells from the nose have now helped paraplegic patients walk. From the primary source, Carlos Lima et al., Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury, Neurorehabil Neural Repair 24(1):10–22 | doi: 10.1177/1545968309347685.”

“Of the 13 patients assessed by functional studies, 1 paraplegic patient (patient 9) can ambulate with 2 crutches and knee braces with no physical assistance and 10 other patients can ambulate with walkers with or without braces with physical assistance.

One tetraplegic [paralyzed in both arms and legs] patient (patient 13) ambulates with a walker, without knee braces or physical assistance.”

Why haven’t you heard of this?  I don’t know.  Perhaps you missed the “Testimony of Ms. Laura Dominguez, delivered at a hearing held by the United States Senate Subcommittee on Science, Technology, and Space on July 14, 2004. Accessed at: http://commerce.senate.gov/hearings/testimony.cfm?id=1268andwit_id=3673

If that doesn’t work, go here and skip ahead to 1 hour, 16 minutes to 2hrs 21min: https://www.c-span.org/video/?182693-1/stem-cell-research-treatment

Laura Dominguez, also featured in the article  here, was treated in 2004.  By then,

Dr “Lima’s procedure had proven successful in 26 patients, states Dr. Jean D. Peduzzi-Nelson, a co-researcher at the University of Alabama in Birmingham. [9] Dominguez was the tenth person in the world and the second American to undergo the surgery.

Completion of the surgery permitted a return to the United States, which ushered in the continuation of the therapeutic process and the resumption of home life in San Antonio. After an MRI was conducted, physicians informed her that her spinal cord had begun healing and that 70 percent of the lesion had recovered into normal spinal tissue. Within six months she had acquired sensation down to the abdominal region. By 2004, she had gained upper body agility and the ability to stand for extended periods of time with the aid of a walker. In addition, she reported improved motor skills, including the ability to stand on her toes and contract her quadriceps and hamstring muscles. She also announced that she had walked more than 1400 feet with the use of braces and outside help. Laura is inspired by the results and hopes to walk unassisted by the time she turns 21. [10]

Not first.  Missed it by just a baker’s dozen of years.

Here are just a small selection of more stem cell heroes from the past:

SPINAL CORD SUCCESSES

 https://repairstemcell.wordpress.com/2009/03/25/spinal-cord-injury-success/

 

MORE SPINAL CORD SUCCESSES

https://repairstemcell.wordpress.com/2009/03/25/more-spinal-cord-injury-success-from-adult-stem-cells/

 

STEM CELLS FOR SPINAL CORD

https://repairstemcell.wordpress.com/2009/03/20/stem-cell-surgery-spinal-cord-injury/

 

16 YEAR OLD PARALYZED KARTING CHAMP

https://repairstemcell.wordpress.com/2009/09/07/16-year-old-paralyzed-karting-champ-undergoing-stem-cell-treatment/

 

PARALYZED WOMAN WALKS ON 21ST BIRTHDAY
https://repairstemcell.wordpress.com/2009/04/23/strength-and-determination-help-paralyzed-woman-walk-on-21st-birthday/

 

QUEST TO CURE HIS DAUGHTER

https://repairstemcell.wordpress.com/2009/04/14/a-father%e2%80%99s-quest-to-cure-his-daughter-well-blog-nytimescom/

 

PARALYSIS IN RATS REVERSED

https://repairstemcell.wordpress.com/2009/04/02/adult-spinal-stem-cells-reverse-paralysis-in-rats/

 

ADULT STEM CELL PROGRAMS

https://repairstemcell.wordpress.com/2009/03/30/il-sussidiarionet-raisman-the-best-results-are-coming-from-the-adult-stem-cell-research-programmes/

 

IMPROVED QUALITY OF LIFE FOR THE PARALYZED

https://repairstemcell.wordpress.com/2009/03/26/adult-stem-cell-study-demonstrates-improved-quality-of-life-for-patients-suffering-from-spinal-cord-injury/

 

A PERSONAL NOTE

http://reflectionsofaparalytic.com/?p=2052

 

FUNDRAISING FOR SPINAL CORD/STEM CELL THERAPY

https://repairstemcell.wordpress.com/2009/03/20/fundraiser-for-spinal-cord-injury-patient-for-stem-cell-treatment/

 

STEM CELLS HELP 52 SPINAL CORD INJURY PATIENTS

https://repairstemcell.wordpress.com/2009/03/19/stem-cell-research-helps-52-spinal-cord-injury-patients-stem-cell-research-adult-stem-cell-research-spinal-cord-injury/

 

PARALYZED LAWMAKER MAKES STEM CELL DECISION

https://repairstemcell.wordpress.com/2009/03/11/paralyzed-ri-lawmaker-hails-stem-cell-decision-international-herald-tribune/

 

JAPAN AHEAD OF USA IN STEM CELLS FOR SCI

https://repairstemcell.wordpress.com/2009/02/10/spinal-cord-injury-sci-stem-cell-trials-japan-plays-catch-up/

 

CHINA AHEAD OF USA FOR STEM CELL TREATMENTS/SCI

https://repairstemcell.wordpress.com/2009/02/27/stem-cell-research-yields-benefits-for-american-man-traveling-to-china/

 

WHY DO WE PRETEND STEM CELLS DON’T WORK?

https://repairstemcell.wordpress.com/2009/02/18/adult-stem-cells-get-the-shaft-none-are-so-blind-as-those-who-will-not-see/

 

IRAN AHEAD OF USA IN STEM CELLS

https://repairstemcell.wordpress.com/2009/02/12/stem-cells-in-iran-catch-up/

 

 

TODDLER, CANCER, STEM CELLS, SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/02/08/toddler-helps-bring-about-a-medical-miracle-cancer-spimal-cord-injury/

 

REGENERATING THE CENTRAL NERVOUS SYSTEM https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

 

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6…-C7 injury

https://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

 

Paraplegic – Adult Stem Cell Success Stories – Laura Dominguez

https://repairstemcell.wordpress.com/2010/05/05/paraplegic-adult-stem-cell-success-stories-laura-dominguez/

 

PARALYZED COUSINS PLEASED WITH STEM CELL TREATMENT

https://repairstemcell.wordpress.com/2010/02/15/paralyzed-cousins-pleased-with-stem-cell-treatment/

 

Successful Stem Cell Treatment of Spinal Cord Injury in Dogs

https://repairstemcell.wordpress.com/2010/02/08/successful-stem-cell-treatment-of-spinal-cord-injury-in-dogs/

 

Spinal Cord Injury Patient Wins…and Loses

https://repairstemcell.wordpress.com/2010/02/08/spinal-cord-injury-patient-wins-and-loses/

 

STEM CELLS FOR SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/12/31/stem-cells-for-spinal-cord-injury/

 

Adult Stem Cell Grafts Help Paralyzed Heal

https://repairstemcell.wordpress.com/2009/10/21/adult-stem-cell-grafts-help-paralyzed-heal/

 

Medical hope as paralysed dog cured by stem cell therapy

https://repairstemcell.wordpress.com/2009/10/08/medical-hope-as-paralysed-dog-cured-by-stem-cell-therapy-mirror-co-uk/

 

and even, Major the Roseville police dog gets stem cell treatment

http://blogs.citypages.com/blotter/2011/01/major_police_dog_stem_cell.php

 

Time to set the record straight.  Too many have waited too long to get news which blacks out a dozen years of research and progress.

SPINAL CORD REPAIRED THROUGH STEM CELLS

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 23, 2013 at 9:00 am

spinal-cord

Stem cells breathe new life into paralyzed gymnast

At the Dasara Games in September of 2010, a meticulous gymnast with the ambition to achieve the same stardom as his hero Ashish Kumar, met an untimely misfortune when mistiming a somersault during a practice routine.

“Ananth Rao’s head crashed on to the mat and he heard a cracking sound. His spine was shattered at the cervical region (C-6, C-7), paralyzing him for life. “I’ve always been told that one must learn from mistakes,” Ananth said. “One small mistake I made has cost me so much. I lost hope completely, I thought my life was over,” said the youngster, who was operated upon after his accident at the JSS Hospital in his hometown.  Although the doctors stabilized his neck, Ananth became a bedridden quadriplegic (all four limbs paralyzed) with no control over his bowel movements and was susceptible to a number of ailments.” He was forced to drop out of Mysore Maharaja College to focus on receiving vigorous physiotherapy and standard forms of treatment. But there was little improvement in his condition.  Just over a year after his accident, doctors heard about Ananth’s condition and decided to take up his case in a bid to improve his quality of life.  With the backing of the HCG Foundation, Ananth was exposed to advanced treatment in the form of mesenchymal stem cells – connective tissue cells that can differentiate into a variety of cell types – in a bid to try to regenerate nerve cells in his spinal cord.

After two stem cell injections and 11 months of focused rehabilitation, Ananth has shown remarkable signs of improvement.

“Today, I can dream new dreams of a future where I am not dependant on anyone and I can see myself living with dignity,” said Ananth, who showed no signs of difficulty lifting his arms, holding a pen or a cup of coffee. “He had been undergoing regular treatment for a year,” said HCG chairman and CEO Dr Ajaikumar, who along with orthopaedician Dr Pramod S Chinder, took a personal interest in Ananth’s case. “He was someone who led an active life as a gymnast and I felt we should take up this challenging case to show how regeneration can happen through stem cell treatment. We are glad our efforts have finally paid off,” he said, without ruling out further improvement.” “Ananth’s case was studied in detail. Stem cells of the patient were cultured and two injections were given to him,” said Dr Chinder, who was quick to add recovery chances were case specific. “Post treatment, the patient progressed significantly, with the movements of hands and there is sensation in his legs. There is increasing evidence in the benefits of stem cell therapies and spinal cord injuries are one of the most researched. In patients, who do not have any other option of recovering from spinal cord injuries, stem cell treatment is the way to go forward,” Dr. Chinder added.

http://timesofindia.indiatimes.com

A TREATMENT FOR ALS? Neural stem cell transplants slow progression of disease

In SCIENCE & STEM CELLS, VICTORIES & SUCCESS STORIES on January 3, 2013 at 2:33 pm
A treatment for ALS?
Neural stem cell transplants slow progression of disease

Stem-Cells-360_605

“The transplanted neural stem cells help by producing factors that preserve the health and function of the host’s remaining nerve cells. They also reduce inflammation and suppress the number of disease-causing cells in the host’s spinal cord. The neural stem cells did not replace deteriorating nerve cells in the mice with ALS.  Researchers observed improved motor performance and respiratory function in the treated mice. The neural stem cell transplant also slowed the disease’s progression.

Twenty-five percent of the treated ALS mice in the study survived for one year or more — roughly three to four times longer than the untreated mice.”

Results from a meta-analysis of 11 independent amyotrophic lateral sclerosis (ALS) research studies are giving hope to the ALS community by showing, for the first time, that the fatal disease may be treatable.

Researchers say progress in treating ALS, also known as Lou Gehrig’s disease, may be made by targeting new mechanisms revealed by neural stem cell-based studies.

“This significant research will help us better understand the mechanisms underlying motor neuron diseases,” said Yang (Ted) Teng, Harvard Medical School associate professor of surgery at the Harvard-affiliated Brigham and Women’s Hospital and one of the study’s co-lead authors. Teng is also director of the Spinal Cord Injury and Stem Cell Biology Research Laboratory in the Department of Neurosurgery at Brigham and Women’s.

The research studies were conducted at Brigham and Women’s; the Harvard affiliates Children’s Hospital Boston and Veterans Affairs Boston Healthcare System; Sanford-Burnham Medical Research Institute; University of Massachusetts Medical School; Johns Hopkins University; State University of New York Upstate Medical University; and Columbia University.

“This is not a cure for ALS. But it shows the potential that mechanisms used by neural stem cells in our study have for improving an ALS patient’s quality of life and length of life,” said Yang (Ted) Teng, one of the principal investigators of Project ALS’ consortium project. File photo by Justin Ide/Harvard Staff Photographer

ALS causes nerve cells in the spinal cord to die, eventually taking away a person’s ability to move or even breathe. A decade of research conducted at multiple institutions showed, however, that when neural stem cells were transplanted into multilevels of the spinal cord of a mouse model with familial ALS, disease onset and progression slowed, motor and breathing function improved, and treated mice survived three to four times longer than untreated mice.

A summary of the findings from all 11 studies was published online in December in Science Translational Medicine.

“This work sheds new light on detrimental roles played by non-neuronal cells in triggering motor neuron death, and these events should be targeted for developing more effective therapeutics to treat ALS,” Teng said.

The transplanted neural stem cells help by producing factors that preserve the health and function of the host’s remaining nerve cells. They also reduce inflammation and suppress the number of disease-causing cells in the host’s spinal cord. The neural stem cells did not replace deteriorating nerve cells in the mice with ALS.

Researchers observed improved motor performance and respiratory function in the treated mice. The neural stem cell transplant also slowed the disease’s progression. Twenty-five percent of the treated ALS mice in the study survived for one year or more — roughly three to four times longer than the untreated mice.

“This is not a cure for ALS,” said Teng, who is one of the principal investigators of Project ALS’ consortium project. “But it shows the potential that mechanisms used by neural stem cells in our study have for improving an ALS patient’s quality of life and length of life.”

To read the full story, visit the Harvard Medical School website.

Adult Stem Cells Saved My Life Campaign

In VICTORIES & SUCCESS STORIES on November 15, 2009 at 10:16 pm

Adult Stem Cells Saved My Life

Kansas City, Kan., Nov 12, 2009 / 08:03 pm (CNA).- …campaign to spread awareness about how successful adult stem cells are in treating a variety of diseases. The most recent count places the number of conditions successfully treated at close to 80.

On Saturday, November 14, 2009, the FRC will kick off the “Adult Stem Cells Saved My Life Education & Awareness Campaign” at the Town Hall in Shawnee, Kansas. At the premier, they will publicly launch http://www.stemcellresearchfacts.com and present the stories of people who have been successfully treated with adult stem cells via short videos.

Laura Dominguez knows firsthand about the impact a stem cell treatment can make. In the summer of 2001, when Dominguez was just 16 years-old, she was involved in a car accident that broke her neck, paralyzing her from the neck down.

After a Portuguese surgeon took stem cells from her nose, cultured them, and used them to replace the scar tissue in her neck, she is now able to feel her body below her chest. She can grasp and move the mouse of a computer and is able to walk with leg braces. Though her range of motion is limited compared to her abilities before the accident, due to the treatment which used her own stem cells, she is no longer a paraplegic.

via Adult Stem Cells Saved My Life campaign set to launch.

Medical hope as paralysed dog cured by stem cell therapy – mirror.co.uk

In VICTORIES & SUCCESS STORIES on October 8, 2009 at 2:03 pm

“”We hope if the results are positive in a few years’ time the treatment could perhaps be used to help people.””

This procedure is already being used successfully on people: https://repairstemcell.wordpress.com/2009/09/24/spinal-cord-injury-stem-cells-%E2%80%93-a-brief-history-of-treatment/

Medical hope as paralysed dog cured by stem cell therapy

By Emily Nash 8/10/2009

Just months ago he was paralysed by a damaged spine, but here’s Henry the dog walking again thanks to pioneering stem cell treatment.

Vets took the cells from the six-year-old’s nose and implanted them in his back to successfully repair ruptured discs.

via Medical hope as paralysed dog cured by stem cell therapy – mirror.co.uk.

Only (NOT ON YOUR LIFE) in America

In ALL ARTICLES, STEM CELLS IN THE NEWS on May 12, 2009 at 10:26 am

A recent article I read about the embryonic stem cell debate concluded with this silly comment: “What if stem cell research does create a major breakthrough? If stem cells provided a cure for juvenile diabetes, this issue would be a whisper in the wind”

ostrich

Here is my response:

I am sorry to say, you are dead wrong. It will NEVER happen in the US…even though it already has.

1. First of all, in the US, you can never say “cure.” A treatment can make you symptom free for 40 years and the AMA and FDA will not let you say the patient is cured, only that they have been symptom free for 40 years.

2. In the US, when a major breakthrough occurs, you WILL NOT hear about it…in the US anyway. One brilliant doctor has enabled paraplegics to walk after adult stem cell treatment. Do you remember where you were when you heard this incredible news? No? You never heard anything about it? Right. Not in the US. Here is one of those patients. https://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

Here are more (scroll down past the swine flu article): https://repairstemcell.wordpress.com/?s=spinal+cord+injury

3. In the US, we like to talk about Embryos. And we are the only ones. Did you know that the top embryonic stem cell scientists in the world have walked away from using embryos to develop treatments? *** Embryonic research has been 100% fruitless (in regard to generating treatments) for well-funded and government supported scientists around the world for the last 11 years. *** Dr James Thomson, father of embryonic research said about embryonic research: “…embryonic stem cells are not being used in any clinical applications yet, while alternatives such as adult stem cells figure in scores of therapies.” *** Dr Oz said on national TV “the stem cell debate is dead,” recognizing the lack of potential in embryonic stem cells to produce cures. https://repairstemcell.wordpress.com/2009/03/31/oprah-michael-j-fox-dr-mehmet-oz-the-stem-cell-debate-is-over/ *** Ian Wilmut, who led the team that cloned Dolly the sheep, abandoned his license to attempt human cloning, saying that the researchers “may have achieved what no politician could: an end to the embryonic stem cell debate.” *** Dr. Bernadine Healy, director of the National Institutes of Health under the first President Bush, wrote in U.S. News & World Report that these recent developments “in the first six weeks of Obama’s term, several events reinforced the notion that embryonic stem cells, once thought to hold the cure for Alzheimer’s, Parkinson’s, and diabetes, are obsolete….. In fact, adult stem cells, which occur in small quantities in organs throughout the body for natural growth and repair, have become stars despite great skepticism early on.”

4. I can refer you to many studies showing the huge therapeutic benefits of stem cells for treating over 130 diseases, including Type 1 diabetes. Here’s one about your example, juvenile diabetes. One patient has gone 4 years symptom free (ZERO INSULIN). Many others had only slightly less spectacular results. https://repairstemcell.wordpress.com/2009/04/15/stem-cells-%e2%80%98can-treat-diabetes%e2%80%99-is-obscured-by-wet-blanket/

The problem is, these results and studies used Adult stem cells (the one’s that actually work) and not Embryonic stem cells (which is all that anyone in the US knows about or wants to talk about). Even if you do hear about it, the word “controversial” will be plastered all over the article although there are virtually NO SIDE EFFECTS to adult stem cell treatments that standard lab practices can’t avoid or an Advil can’t cure.

5. Thousands of people all over the world are being treated successfully for ALS, ALzheimer’s, Parkinson’s, Heart Disease, Autism and ~130 others. This issue IS a whisper in the wind, everywhere in the world except in the US. In the US, the trumpets are sounding so loud “for” and “against” Embryonic stem cell research, that Americans can NOT hear that they are wasting their time, embryonic stem cells will not produce treatments for 20-50 years, adult stem cells work now, diseases are being treated all over the world, embryonic scientists are abandoning their work, etc. etc.

Strength and determination help paralyzed woman walk on 21st birthday

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on April 23, 2009 at 11:24 pm
I, for one, fully applaud her strength and determination.  No doubt, without them this amazing accomplishment wouldn’t have been possible.
And yet, out of respect to the thousands of other SCI patients who have illustrated the same amount of strength and determination, I feel it is my duty to add:  maybe, just maybe…the adult stem cell therapy that she received 7 times in 3 years might have had something to do with her recovery?!?! -dg
spinal-cord woman
Posted By: Chris Zoladz Posted By: Jessica Puchala

GRAND RAPIDS (WZZM)- The strength and determination of a West Michigan woman have helped her overcome paralysis. Kadi DeHaan was injured from the chest down in a bad car accident four years ago. But Wednesday night she got out of her wheel chair and walked into her 21st birthday party.

“I always knew that I was going to walk again. That was my attitude from the get go,” said DeHaan.

Doctors told Kadi she would never walk after a car accident four years ago.

“It was a rainy night and I was driving and I hydro-planed into oncoming traffic and then a car hit me and then I flew out of the windshield,” she said.

Kadi’s parents found a therapy for her in Russia. They’ve been there seven times in three years. Doctors take her adult stem cells and put them in her spine to regrow neuro pathways in her spine.

“We also knew of a couple other people who have been to Russia and were getting results back, but Kadi is getting remarkable results,” said Bonnie DeHaan.

The idea to walk into a bar at 21 started as a fun motivator one year ago, but Kadi took it as a serious challenge.

“She works at night time, she works on the weekends and then she’ll come and work with us. She’s definitely a hard worker,” said Kadi’s physical therapist Sandy Burns.

“Maybe I could have done it with just therapy but I wouldn’t have gotten this far but the stem cells definitely pushed me further and I probably wouldn’t have been where I am today without them,” said DeHaan.

Where she is today is far beyond the odds that were stacked against her.

“This is the best thing that’s ever happened to us. This is it today,” said Bonnie DeHaan.

Since she already made this year’s wish come true, Kadi’s on to next year when she hopes to ditch that wheelchair for good.

via http://www.wzzm13.com/news/local/story.aspx?storyid=108384&catid=48

Stem Cell Research Helps 52 Spinal Cord Injury Patients: Stem cell research, adult stem cell research, spinal cord injury

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on March 19, 2009 at 12:06 pm

stem cells treat spinal cord injury

New Stem Cell Research for Spinal Cord Injuries

Posted By: Don Margolis, Mar. 18, 2009 at 8:41 AM

A published stem cell research study shows that Adult Stem Cells implanted into Spinal Cord Injury patients is not only safe, but also improves their quality of life.

Published in the new issue of Cell Transplantation (Vol. 17 No.12), doctors in Ecuador did 8 individual case studies of Adult Stem Cell treatment for Spinal Cord Injury patients.

Different Ways to Deliver the Adult Stem Cells

The stem cells were implanted 3 different ways:

* Into the spinal column

* Into the spinal cavity

* Administered intravenously

The 8 patients (4 acute and 4 chronic) were followed for 2 years using MRI scans to assess any changes in the spinal cord.  From the stem cell article abstract:

Comprehensive evaluations demonstrate improvements in ASIA, Barthel (quality of life), Frankel, and Ashworth scoring. Moreover, in order to assess bladder function, we designed a simple numerical clinical scoring system that demonstrates significant changes in bladder function following BMSCs administration.

Patient Quality of Life Improved- No Adverse Events

Dr. Silva, one of the authors of the study says “To date, we have administered BMCs into 52 patients with SCI and have had no tumor formations, no cases of infection or increased pain, and few instances of minor adverse events. We also found that patient quality of life improved.

For patients with spinal cord injuries- these improvements, especially in bladder function makes a big difference in their quality of life.

Stem Cell Treatment in Ecuador, Not the USA

The stem cell treatment is being carried out by  Dr. Luis Geffner at the Luis Vernaza hospital in Guayaquil, Ecuador.  We first heard about Dr. Geffner after he treated Michael Flounders who was extremely pleased with his stem cell therapy in Ecuador as he traveled all the way from the United Kingdom:

“It has broadened the horizons of my recovery; it has given me a sense of hope. Everyday things are changing; the feelings in my legs are becoming a lot more powerful.”

Effects of Adult Stem Cell Research Explained

“Autologous stem cell transplantation of BMCs (Bone Marrow Cells) can promote the growth of blood vessels and, therefore, represent an alternative therapy,” said Dr. Silva.

“BMCs are well known for their ability to grow blood vessels,” explained Dr. Silva. “This angiogenesis is necessary for wound healing and establishing a growth permissive environment. We hypothesized that improved blood flow and oxygen supply could contribute to functional improvements for SCI transplanted with autologous BMCs.

More Stem Cell Research for Spinal Cord Injury Information

Please see our archives for more patients who have been helped with stem cells for SCI

Dr. Carlos Lima, the pioneer of stem cell research for Spinal Cord Injury, implanting Adult Stem Cells taken from the patients’ noses.

via Stem Cell Research Helps 52 Spinal Cord Injury Patients: Stem cell research, adult stem cell research, spinal cord injury.

Geron’s Stem-Cell Research Hype Soaks Investors

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 13, 2009 at 10:01 pm

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Geron’s Stem-Cell Research Hype Soaks Investors

02/13/09 – 09:46 AM EST – GERN , STEM , OSI – Adam Feuerstein

A surefire way to ensure some measure of public enmity is make a public recommendation to short a stem-cell stock. That’s what I did on Jan. 26, when I added Geron(GERN Quote – Cramer on GERN – Stock Picks) as a short to the model portfolio I manage as part of TheStreet.com’s Biotech Select investment newsletter.

As I told my subscribers at that time, I’m not against stem-cell medicine, and I certainly hope one day that the field provides medical breakthroughs. I simply don’t believe Geron is going to be the company to deliver on the promise of stem cells, based on its ignominious track record of drug development so far.

In fact, the only thing Geron has done exceedingly well in its 13 years as a public company is surf the waves of stem-cell hype and use that momentum to raise lots of money.

Geron reverted to this well-worn tactic again Thursday night, when it quickly sold 7.25 million shares at a price of $6.60, a 14% discount to the stock’s Thursday closing price of $7.77. The spot-financing deal grossed Geron about $43 million.

I was the first to report Geron’s stock sale Thursday night on RealMoney.com. Geron confirmed the financing in a press release Friday morning but did not disclose the sale price. Geron said the financing will close on Feb. 19.

Geron shares were falling 14% to $6.68 in early Friday trading.

via Geron’s Stem-Cell Research Hype Soaks Investors | Biotech | Financial Articles & Investing News | TheStreet.com.

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