Posts Tagged ‘sickle’

Chicago Woman Cured of Sickle Cell Disease

In VICTORIES & SUCCESS STORIES on June 20, 2012 at 11:14 pm
Chicago Woman Cured of Sickle Cell Disease

Posted: June  18, 2012 by Sherri McGinnis Gonzalez

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure using medication to suppress her immune system and one small dose of total body radiation right before the transplant.The transplant technique is relatively uncommon and is a much more tolerable treatment for patients with aggressive sickle cell disease who often have underlying organ disease and other complications, says Dr. Damiano Rondelli, professor of medicine at UIC, who performed Thomas’s transplant.

The procedure initially allows a patient’s own bone marrow to coexist with that of the donor. Since the patient’s bone marrow is not completely destroyed by chemotherapy or radiation prior to transplant, part of the immune defense survives, lessening the risk of infection. The goal is for the transplanted stem cells to gradually take over the bone marrow’s role to produce red blood cells — normal, healthy ones…

About sickle cell disease and cure

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 12, 2009 at 1:08 pm


About sickle cell disease and cure -Thursday, March 12, 2009 -Ann Arbor News

# Sickle cell disease is an inherited blood disorder that affects about one in 625 African Americans. Sickle cells are defective red blood cells that are supposed to carry oxygen, but instead clump and block blood vessels, causing excruciating pain, strokes, and damage to the brain, heart, kidneys, lungs, bones and muscle.

# The only cure has been a bone marrow transplant from a related donor, usually a sibling. African-American donors are the best genetic match for African-American sickle cell and cancer patients. Patients have only a 14 percent chance of a family match because family members also tend to have the disease. People who have the sickle cell trait, but not the disease, may donate blood and bone marrow.

# Bone marrow donation no longer requires drilling holes in the donor’s pelvic bones to harvest marrow. Donors receive injections of a medication that draws stem cells out of bone marrow into the bloodstream. Blood is taken through an intravenous line in the donor’s arm, stem cells are filtered out, then the blood is returned to the donor.

via About sickle cell disease and cure – MLive.com.

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