DAVID GRANOVSKY

Posts Tagged ‘safe’

Stem Cells Safe for Young Traumatic Brain Injury

In SCIENCE & STEM CELLS on March 6, 2012 at 4:02 am
Image showing potential uses of stem cell research with traumatic brain injuries checked.
A Phase 1 clinical trial studying the safety of using bone marrow stem cells to treat traumatic brain injuries in children is reported. The procedures look to be safe even after 6 months of being applied. The image is adapted from a public domain image

Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients

Saturday March 3rd 2012

A procedure involving stem cells taken from patients’ own bone marrow to treat traumatic brain injury in children is safe, according to the results of a Phase 1 clinical trial.

The trial included 10 children aged 5-14 with severe traumatic brain injuries. Within 48 hours of their injuries, the children received stem cells processed from their own bone marrow.

Six months following the procedures, the children are showing no signs of further damage caused by the use of the stem cells. Though this study only points out that the procedure is safe so far, all of the children from the study had significant improvements.

Stem cell research studies such as this one are producing more and more evidence that stem cell treatments can be safe and effective.

With very few effective treatments for brain injury patients, these studies provide great promise for the future of medicine.

The University of Texas Health Science Center at Houston press release below offers more details about this and other stem cell studies.

UTHealth study: Stem cells may provide treatment for brain injuries

Preliminary results show safety of bone marrow stem cells in traumatic brain injury

Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month’s issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

“Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe,” said Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children’s Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth’s Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient’s own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a “good outcome,” meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Read more: Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients | Neuroscience News.

BENNY HILL IS ALIVE AND WELL AS BRITAIN GOES BLIND

In ALL ARTICLES on September 23, 2011 at 7:00 am

Remember in the final scene of every episode of Benny Hill where he does something really scandalous and then gets chased by the entire cast around and around in circles?  Turns out, Benny Hill is ALIVE AND WELL and advising Britain on their medical protocols!  https://i2.wp.com/www.webtvwire.com/wp-content/uploads/2010/06/the-benny-hill-show-logo.jpg

You see, Britain, like the USA, is chasing this fleet footed “embryonic stem cell treatment comedy of errors” around and around in circles just like in the Benny Hill episodes.  Every week, the same scene is played out with Benny running, the entire cast chasing and he never gets caught.  So in Art, so in life.  Britain is chasing embryonic stem cells used for treatment of optic diseases.  And remember…

  • Embryonic stem cells STILL have ZERO successful clinical trials
  • Embryonic stem cells STILL cause cysts and tumors that can become cancerous (wait 20 years and ask again though)
  • Embryonic stem cells STILL have rejection issues that require immunosuppressive drugs
  • Embryonic stem cells STILL carry the genetic anomalies of the donor
ON THE OTHER HAND…

So on top of wasting time chasing a cure with no prior history of success and huge negative side effects, thy are running right past a treatment with a huge history of success and safety and trials.

So cue up the cameras, get everyone in costume and let’s start that famous music going as everyone chases embryonic stem cell treatments around and around.  Wait! STOP! Hold it! CUT!

How on earth can we explain the entire medical community and government running right past what already works?  Got it! Give them all blindfolds!  That way they can be assured to miss the forest but they will hit every damn tree in it and so will the patients, patiently waiting for treatments which will never come!

…annndddd   ACTION!!!

Iris of a human eye

First trial of embryonic stem cell treatment in Europe gets green light

Patients in Britain with an eye disease that leads to blindness will take part in Europe’s first human embryonic stem cell trial

British surgeons are to take part in the first trial in patients of a human embryonic stem cell therapy to gain approval from regulators in Europe.

Surgeons at Moorfields Eye Hospital in London will inject cells into the eyes of 12 patients with an incurable eye disease called Stargardt’s macular dystrophy, one of the main causes of blindness in young people…

Read more

STEM CELLS FOR MS

In STEM CELLS IN THE NEWS on September 17, 2011 at 9:42 am

MORE CONFIRMATION IT WORKS!

Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2 Suppl 2):72-6.

[Transplantation of mesenchymal

stem cells in multiple sclerosis].

Abstract

To assess safety and tolerability of treatment with autologic multipotent mesenchymal stem cells (MSC) in multiple sclerosis (MS), we have obtained autologic red bone marrow-derived MSC from 8 patients. Proliferation, immunophenotype and caryotype of MSC, their sterility, the absence of hemopoetic cells, chromosomal aberrations and signs of aging were controlled during the cell growth. The inverse injection of MSC in patient’s blood was conducted in accordance to the elaborated protocol in a short intravenous infusion in dose 2.0 x 10(6)/kg of body mass once in 30 days.

  • The duration of treatment was from 4 to 8 months.
  • The efficacy of treatment was assessed after 4, 8 and 12 months.
  • All patients tolerated repeated intravenous infusions of autologic MSC well with no significant side-effects as in the early as well in the remote periods of treatment.
  • The distinct positive effect was seen in some cases 2 months after the beginning of treatment.
  • The improvement of 0.5 point on EDSS was seen in 5/8 patients after 4 months.
  • After 12 months, the improvement of 0.5-1 point on EDSS was seen in 6/8, stabilization in 1/8, progression in 1/8.
  • These results revealed the safety of the elaborated protocol of treatment and the moderate clinical efficacy of treatment in non-curable patients or those with poor response to treatment that suggested continuing the study and enrollment of new patients.

Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients – Safe + Improve

In VICTORIES & SUCCESS STORIES on March 11, 2010 at 11:48 am
Don’t miss any important stem cell news! Follow me on twitter! http://twitter.com/stemcellblogger
Autologous Bone Marrow Stem Cells Transplant into Parkinson’s Disease Patients is Safe and May Improve Their Quality of Life

michael_j_fox_011

Clinical study showing a minimally invasive approach was presented in The XVIII World Congress on Parkinson’s Disease and Related Disorders of the World Federation of Neurology.

(PRWEB) March 11, 2010 — Eight Parkinson’s Disease (PD) patients were treated with their own bone marrow stem cells (BMSC) injected via minimally invasive routes and discharged the next morning without complications.

Evaluations with UPDRS, Hoehn & Yahr scale and Schwab & England score showed encouraging improvements and the total L- dopamine dose could be decreased suggesting that stem cells may enhance endogenous dopamine synthesis. As a matter of sample, the writing test pre versus post procedure showed significant changes.

Eight Parkinson’s Disease (PD) patients were treated with their own bone marrow stem cells (BMSC) injected via minimally invasive routes and discharged the next morning without complications.

“It is high time we focused our efforts in what is possible and reachable and what suffering patients demand. Not all what is researched and developed in Petri dishes or rats can automatically be used in patients, so we should stop to augment their confusion. We expect this study in PD real patients, not in animals, draws the attention of those interested in getting clinical data since, funnily enough, there are billions of dollars spent in endless animal studies but very little in clinical ones” leader investigator Dr. Luis Geffner said.

  • this is a tool that may complement standard treatments and delay the progress of both the illness and the complications of the medication currently used to treat it. PD patients should be cared comprehensively; therefore, their treatment may include physical therapies as well as optimal medication and stem cells transplant, trying to improve their independence and self-care he added.

  • The treating doctor’s team has already transplanted 147 patients suffering from different illnesses or trauma states and many of them have been followed up 5 years showing that autologous adult BMSC neither provoke tumors, immunologic rejection, pain, infections nor arise ethical or religious controversies. That is why they stand to push these investigations forward.

  • This clinical study Transplant of Autologous Bone Marrow Stem Cells into Parkinson’s Disease Patients Is Safe And May Improve Their Quality Of Life was shown in Miami on December 15th, 2009 in the XVIII World Congress on Parkinson’s Disease and Related Disorders organized by the World Federation of Neurology and published in December 2009 issue of Parkinson’s Disease and Related Disorders journal.

For more info on stem cells and Parkinson’s:

Muhammad Ali seeks ADULT STEM CELL treatment in Israel

60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS!

michael-j-fox-foundation-commits-up-to-5-75-million-in-funding-for-2010-critical-challenges-new-york-march-2-prnewswire-usnewswire/

Do Stem Cells Repair Damaged Brain Cells

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