DAVID GRANOVSKY

Posts Tagged ‘RESEARCH’

RESURRECTING THE DEAD WITH STEM CELLS

In ALL ARTICLES, BUSINESS OF STEM CELLS, Doctors Practicing Excellence, HOPE AND INSPIRATION, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 6, 2017 at 2:08 pm

Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death. It is also called rebirth or transmigration, and is a part of the Saṃsāra doctrine of cyclic existence.”
reincarnation-symbol-25893_960_720
“In Greek mythology, a phoenix is a long-lived bird that is cyclically regenerated or reborn. Associated with the Sun, a phoenix obtains new life by arising from the ashes of its predecessor.”
phoenix_rising_by_something44
“The resurrection of Jesus is the Christian religious belief that, after being put to death, Jesus rose again from the dead. It is the central tenet of Christian theology and part of the Nicene Creed: “On the third day he rose again in accordance with the Scriptures”.
christ-rresurrection

“Frankenstein; or, The Modern Prometheus is a novel written by English author Mary Shelley that tells the story of Victor Frankenstein, a young scientist who creates a grotesque but sapient creature in an unorthodox scientific experiment.”Frankenstein's_monster_(Boris_Karloff).jpg

Humanity has always been fascinated by resurrection – bringing the dead back to life.  The references are plentiful and many will cry out that science should not mess with the great barrier of death for it is absolute and divine and we should not mess with nature.  But, are life and death truly black and white?

Perhaps not.  The “Lazarus syndrome, also known as autoresuscitation after failed cardiopulmonary resuscitation, is the spontaneous return of circulation after failed attempts at resuscitation. Its occurrence has been noted in medical literature at least 38 times since 1982.”

Are there shades of gray between the absolute states of life and death?
Miracle Max: It just so happens that your friend here is only MOSTLY dead. There’s a big difference between mostly dead and all dead. Mostly dead is slightly alive. With all dead, well, with all dead there’s usually only one thing you can do.
Inigo Montoya: What’s that?
Miracle Max: Go through his clothes and look for loose change.
billy-crystal
Perhaps Benjamin Franklin was only half right: “…in this world nothing can be said to be certain, except death and taxes

Death, it seems is not as final as we once thought.  But, can it be done?  Scientists have been given the green light to try:
“By implanting stem cells in the patient’s brain…they hope to reboot the brain and jump-start neural activity. The result could be people coming back to life.”

On a serious note 

The above pics and quips aside…
this work is monumental and can have huge ramifications to the treatments of chronic and terminal disease, brain disorders and more.  Many people would like to classify AGING as a disease which we need to study, treat and conquer and scientists around the world are making great strides in their efforts.  Maybe one day soon we will also classify DEATH as a disease which we need to study, treat and conquer.  Let’s keep an open mind and support the discovery of new methods for treating disease. 

Article

ULTRASOUND GOES INSIDE LIVE CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS on February 17, 2017 at 9:06 am

Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells…like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants

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Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells, with potential application in stem-cell transplants and cancer diagnosis.

The new nanoscale ultrasound technique uses shorter-than-optical wavelengths of sound and could even rival the optical super-resolution techniques which won the 2014 Nobel Prize for Chemistry.

This new kind of sub-optical phonon (sound) imaging provides invaluable information about the structure, mechanical properties and behaviour of individual living cells at a scale not achieved before.

Researchers from the Optics and Photonics group in the Faculty of Engineering, University of Nottingham, are behind the discovery, which is published in the paper ‘High resolution 3D imaging of living cells with sub-optical wavelength phonons’ in the journal, Scientific Reports.

“People are most familiar with ultrasound as a way of looking inside the body — in the simplest terms we’ve engineered it to the point where it can look inside an individual cell. Nottingham is currently the only place in the world with this capability,” said Professor Matt Clark, who contributed to the study.

In conventional optical microscopy, which uses light (photons), the size of the smallest object you can see (or the resolution) is limited by the wavelength.

For biological specimens, the wavelength cannot go smaller than that of blue light because the energy carried on photons of light in the ultraviolet (and shorter wavelengths) is so high it can destroy the bonds that hold biological molecules together damaging the cells.

Optical super-resolution imaging also has distinct limitations in biological studies. This is because the fluorescent dyes it uses are often toxic and it requires huge amounts of light and time to observe and reconstruct an image which is damaging to cells.

Unlike light, sound does not have a high-energy payload. This has enabled the Nottingham researchers to use smaller wavelengths and see smaller things and get to higher resolutions without damaging the cell biology.

“A great thing is that, like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants,” adds Professor Clark.

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More information is available from Professor Matt Clark in the Faculty of Engineering, University of Nottingham on +44 (0)115 951 5536, matt.clark@nottingham.ac.uk; or Emma Lowry, Media Relations Manager, on +44 (0)115 846 7156, emma.lowry@nottingham.ac.uk

Our academics can now be interviewed for broadcast via our Media Hub, which offers a Globelynx fixed camera and ISDN line facilities at University Park campus. For further information please contact a member of the Communications team on +44 (0)115 951 5798, email mediahub@nottingham.ac.uk or see the Globelynx website for how to register for this service.

About The University of Nottingham: The University of Nottingham has 43,000 students and is ‘the nearest Britain has to a truly global university, with a “distinct” approach to internationalisation, which rests on those full-scale campuses in China and Malaysia, as well as a large presence in its home city.’ (Times Good University Guide 2016). It is also one of the most popular universities in the UK among graduate employers and winner of both ‘University of the Year for Graduate Employment’, according to the 2017 The Times and The Sunday Times Good University Guide and ‘Outstanding Support for Early Career Researchers’ at the Times Higher Education Awards 2015. It is ranked in the world’s top 75 by the QS World University Rankings 2015/16. More than 97 per cent of research at The University of Nottingham is recognised internationally and it is 8th in the UK by research power according to the Research Excellence Framework 2014. It has been voted the world’s greenest campus for four years running, according to Greenmetrics Ranking of World Universities.

LONG TERM REMISSION OF MULTIPLE SCLEROSIS WITH STEM CELLS

In Daily Dose of Stem Cells, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 16, 2017 at 12:36 pm

While high-dose immunosuppressive therapy is not without complications, we must remember that research is rarely linear and every step closer is a step closer – we learn a bit more and refine the process with each step as our understanding of all of the elements which make up our health, recover and illness are slowly puzzled together like a patch-work quilt…

ms-recovery

Stem cell transplants may induce long-term remission of multiple sclerosis

Encouraging results help set stage for larger studies.

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person’s own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

Five years after receiving the treatment, called high-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT), 69 percent of trial participants had survived without experiencing progression of disability, relapse of MS symptoms or new brain lesions. Notably, participants did not take any MS medications after receiving HDIT/HCT. Other studies have indicated that currently available MS drugs have lower success rates.

The trial, called HALT-MS, was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and conducted by the NIAID-funded Immune Tolerance Network (ITN). The researchers published three-year results from the study in December 2014, and the final five-year results appear online Feb. 1 in Neurology, the medical journal of the American Academy of Neurology.

Related:

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

NOT FDA APPROVED, NOT INSURANCE COVERED SO IT MUST BE BAD!

In BUSINESS OF STEM CELLS, HOPE AND INSPIRATION, OFF THE BEATEN PATH, STEM CELLS IN THE NEWS on February 9, 2017 at 5:37 pm
failure-missed-opps

NOT FDA APPROVED, NOT INSURANCE COVERED SO IT MUST BE BAD!

Someone reminded me that most stem cell treatments and immunotherapies aren’t FDA approved or covered by insurance in the USA.
 
This is true, but…
we’ve known about the rampant capacity for stem cells regenerating/regrowing finger tips since the work of Dr Illingsworth in the early 70’s. Children under 8 regrew their fingertips unassisted. That was their natural stem cells in their own bodies regenerating the distal phalanx, blood vessels, skin, nail, etc. but our natural healing system is not FDA approved.
 
We’ve known about bone marrow derived stem cell treatments in the form of bone marrow transplants for Leukemia/blood cancers. They regrow the patients immune system and are approved and have been used successfully in the USA for 60 years.
 
We know of stem cell treatments recovering patients from many chronic and terminal diseases successfully around the world for over 2-3 decades but that is only outside of our country and medical system for what I think are probably obvious reasons.
 
We know immunotherapy, like the 2 bubble babies cured and out of bubbles in 2001 and the Cuban originated lung cancer vaccine has been working for decades and treated thousands successfully but that is years from getting approvals here.
 
Sadly, as you said, many of these treatments – which merely expand on and accentuate the natural regenerative capacity and natural immune response capacity of the human body – are not covered by insurance or FDA approved.
 
I guess the only question I have is:
If these treatments have worked years to decades everywhere else they are used…
Is this a failing of the treatments or of the FDA and insurance…

Only you can decide.

 
“Many of life’s failures are people who did not realize how close they were to success when they gave up.” – Edison

“All that was great in the past was ridiculed, condemned, combated, suppressed — only to emerge all the more powerfully, all the more triumphantly from the struggle.” – Tesla

“Success is not final, failure is not fatal: it is the courage to continue that counts.” – Winston Churchill

“The scientific man does not aim at an immediate result. He does not expect that his advanced ideas will be readily taken up. His work is like that of the planter—for the future. His duty is to lay the foundation for those who are to come, and point the way.” – Tesla

INTER-SPECIES PANCREAS TRANSPLANT REVERSES DIABETES

In HEALTH AND WELLNESS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 8, 2017 at 12:33 pm

Color Rat Laboratory Cage Mammal Rat Rodent Pet

Let’s take a page out of what was not too long ago science fiction; which is now science-fact.

  • A pancreas was grown in a rat,
  • the organ was transplanted into a mouse,
  • the mouse was given immunosuppressive therapy to prevent rejection,
  • the diabetic mice were able to normalize their blood glucose levels for over a year.

This illustrates the long proven regenerative capacity of stem cells and the recent advancements scientists have made with anti-rejection protocols…And of course, the cool inter-species transplant of rat to mouse.

Rat-grown mouse pancreases help reverse diabetes in mice

Growing organs from one species in the body of another may one day relieve transplant shortages. Now researchers show that islets from rat-grown mouse pancreases can reverse disease when transplanted into diabetic mice.

White rat with black patches

A rat in which researchers were able to grow a mouse pancreas. Islets from the pancreases were transplanted into mice with diabetes. The transplants helped control the mice’s blood sugar levels.
Courtesy of the Nakauchi lab

 Mouse pancreases grown in rats generate functional, insulin-producing cells that can reverse diabetes when transplanted into mice with the disease, according to researchers at the Stanford University School of Medicine and the Institute of Medical Science at the University of Tokyo.

The recipient animals required only days of immunosuppressive therapy to prevent rejection of the genetically matched organ rather than lifelong treatment.

The success of the interspecies transplantation suggests that a similar technique could one day be used to generate matched, transplantable human organs in large animals like pigs and sheep.

To conduct the work, the researchers implanted mouse pluripotent stem cells, which can become any cell in the body, into early rat embryos. The rats had been genetically engineered to be unable to develop their own pancreas and were thus forced to rely on the mouse cells for the development of the organ.

Once the rats were born and grown, the researchers transplanted the insulin-producing cells, which cluster together in groups called islets, from the rat-grown pancreases into mice genetically matched to the stem cells that formed the pancreas. These mice had been given a drug to cause them to develop diabetes.

“We found that the diabetic mice were able to normalize their blood glucose levels for over a year after the transplantation of as few as 100 of these islets,” said Hiromitsu Nakauchi, MD, PhD, a professor of genetics at Stanford. “Furthermore, the recipient animals only needed treatment with immunosuppressive drugs for five days after transplantation, rather than the ongoing immunosuppression that would be needed for unmatched organs.”

Nakauchi, who is a member of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, is the senior author of a paper describing the findings, which was published online Jan. 25 in Nature. Tomoyuki Yamaguchi, PhD, an associate professor of stem cell therapy, and researcher Hideyuki Sato, both from the University of Tokyo, share lead authorship of the paper.

Hiro Nakauchi

Although much research remains to be done, scientist Hiromitsu Nakauchi and his colleagues believe their work with rodents shows that a similar technique could one day be used to generate matched, transplantable human organs in large animals like pigs and sheep.
Wing Hon Films

Organs in short supply

About 76,000 people in the United States are currently waiting for an organ transplant, but organs are in short supply. Generating genetically matched human organs in large animals could relieve the shortage and release transplant recipients from the need for lifelong immunosuppression, the researchers say.

People suffering from diabetes could also benefit from this approach. Diabetes is a life-threating metabolic disease in which a person or animal is unable to either make or respond appropriately to insulin, which is a hormone that allows the body to regulate its blood sugar levels in response to meals or fasting. The disease affects hundreds of millions of people worldwide and is increasing in prevalence. The transplantation of functional islets from healthy pancreases has been shown to be a potentially viable option to treat diabetes in humans, as long as rejection can be avoided.

The researchers’ current findings come on the heels of a previous study in which they grew rat pancreases in mice. Although the organs appeared functional, they were the size of a normal mouse pancreas rather than a larger rat pancreas. As a result, there were not enough functional islets in the smaller organs to successfully reverse diabetes in rats.

Mouse pancreases grown in rats

In the current study, the researchers swapped the animals’ roles, growing mouse pancreases in rats engineered to lack the organ. The pancreases were able to successfully regulate the rats’ blood sugar levels, indicating they were functioning normally. Rejection of the mouse pancreases by the rats’ immune systems was uncommon because the mouse cells were injected into the rat embryo prior to the development of immune tolerance, which is a period during development when the immune system is trained to recognize its own tissues as “self.” Most of these mouse-derived organs grew to the size expected for a rat pancreas, rendering enough individual islets for transplantation

Next, the researchers transplanted 100 islets from the rat-grown pancreases back into mice with diabetes. Subsequently, these mice were able to successfully control their blood sugar levels for over 370 days, the researchers found.

Because the transplanted islets contained some contaminating rat cells, the researchers treated each recipient mouse with immunosuppressive drugs for five days after transplant. After this time, however, the immunosuppression was stopped.

After about 10 months, the researchers removed the islets from a subset of the mice for inspection.

“We examined them closely for the presence of any rat cells, but we found that the mouse’s immune system had eliminated them,” said Nakauchi. “This is very promising for our hope to transplant human organs grown in animals because it suggests that any contaminating animal cells could be eliminated by the patient’s immune system after transplant.”

Importantly, the researchers also did not see any signs of tumor formation or other abnormalities caused by the pluripotent mouse stem cells that formed the islets. Tumor formation is often a concern when pluripotent stem cells are used in an animal due to the cells’ remarkable developmental plasticity. The researchers believe the lack of any signs of cancer is likely due to the fact that the mouse pluripotent stem cells were guided to generate a pancreas within the developing rat embryo, rather than coaxed to develop into islet cells in the laboratory. The researchers are working on similar animal-to-animal experiments to generate kidneys, livers and lungs.

Although the findings provide proof-of-principle for future work, much research remains to be done. Ethical considerations are also important when human stem cells are transplanted into animal embryos, the researchers acknowledge.

The research was funded by the Japan Science and Technology Agency, the Japan Agency for Medical Research and Development, the Japan Society for the Promotion of Science, a KAKENHI grant, the Japan Insulin Dependent Diabetes Mellitus Network and the California Institute for Regenerative Medicine.

Stanford’s Department of Genetics also supported the work.

CAN STEM CELLS CURE DOWN SYNDROME?

In HEALTH AND WELLNESS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 3, 2017 at 5:00 pm

There’s a lot going on in this article.  14 patients with Down Syndrome were treated with stem cells.  Down Syndrome is a common chromosomal disorder caused by trisomy of chromosome 21 (HSA21q). I’m not going to introduce a critical analysis of this.  This article does that with great skepticism.  Let’s take a different tact.  Let’s approach this with the idea that it could happen but we don’t yet know how.  How about I raise some questions of my own with the intention to not tear down but rather to perhaps, inspire someone else to discover a new path to some answers.  Let’s throw away conventional thought and limitations and try to grasp a kernel of truth from a bag of confusion.  I’m going to blue sky here…
Blue Sky: adjective – using the imagination to think of ideas that do not yet have practical uses or make money.

can-stem-cells-cure-down-syndrome

How can stem cells possibly modify a genetic disorder?   Maybe they can’t, but maybe they can.  Epigenetics tells us that our gene expressions are constantly changing and our concept of what can and can’t change in the human body is constantly evolving.  Are the stem cells modifying the chromosome?  Conventional science would indicate that this is impossible.  But maybe we are seeing the results from a change in phenotype without a change in genotype.  15 years ago, conventional science was positive that heart cells couldn’t regenerate either.  We still have an enormous amount to learn.  Perhaps our genetics are even less stable than we thought?

Non-scientist gene therapy? Gene therapy is a technique that uses genes to treat or prevent disease.  Three techniques of gene therapy are:

  • Replacing a mutated gene that causes disease with a healthy copy of the gene.
  • Inactivating, or “knocking out,” a mutated gene that is functioning improperly.
  • Introducing a new gene into the body to help fight a disease.

Is it so far fetched to imagine that the stem cells can do already what scientists do?  We know stem cells can heal and regenerate.  Why not also perform gene therapy?  We’ve seen modified allogeneic stem cells recover fetuses (in the womb) from the genetic disorder of severe osteogenesis imperfecta before 2005.  1, 2  We know stem cells can regrow finger tips in kids under 8, become skin cells and then if not needed, reverting back to a nascent state and becoming nail cells and then reverting back, etc.  So maybe they can modify at the genetic level too, but how?

clint_eastwood_-_1960s

What’s mine is…yours?  (The Good, The Bad and the Ugly)  What needs to happen to modify genetics?  Not the science, but the logic.  The stem cells would need to recognize that the chromosomal disorder is atypical – an aberrant construct needing modification – and then change it towards a different paradigm.  Maybe they can do that because the cells used are from someone else (allogenic) – so perhaps the stem cells carry the blue prints and adhere to the donor’s physiology?  
The donor’s physiology then, becomes the road map, the standard which the stem cells are healing the patient towards.  The “normal standard,” so to speak.  It makes some sense as, often, in allogenic stem cell treatment scenarios (Embryonic and induced Pluripotent for example), the genetic anomalies of the donor influence the recipient.  So if the negative elements within the donor can influence the patient, why not the positive?  Why wouldn’t the relative genetic normalcies of the donor influence the physiology of the recipient?
 

An improvement by any other name would smell just as sweet?  ‘“He started babbling and crawling, and his facial features underwent a change.” The boy, who lives in Singapore, is now 3 years old. “He continues to develop age-appropriate skills,” says Titus.’  

If the indicators and symptoms of  Down Syndrome reduced or went away  and they ARE tied to the genetics, how did that happen? If the indicators and symptoms of  Down Syndrome reduced or went away and they are NOT tied to the genetics, maybe the connections between the cause and the result is not as rigid as we thought.  Can someone have the chromosomal variant of Down Syndrome but have no indicators and no symptoms?   Something very worthwhile to work towards.  Perhaps we have to expand our view of what it means to recover from an illness beyond just reversing the criteria we currently use to define the disease.  

What if  everything else in the body works better due to the stem cells?  The circulatory system, the GI, the neurological, the lymph and all of ancillary parts and pieces work better resulting in a greater capacity for learning, growth, development, etc.  We know the central nervous system does regenerate as well as the brain, though very slowly; so if you can improve the workings of every part of the body, even without addressing the additional chromosome issue of Down Syndrome, wouldn’t that potentially result in the smartest, strongest, healthiest person with Down Syndrome?  Isn’t that significant improvement?

If you were diagnosed with cancer but there was a simple treatment which would allow you to have no symptoms and you could live a full and complete life; curing cancer wouldn’t really matter to you, would it?  That goal would cease to be our priority.  Now we are shifting from disease mitigation to quantifiable improvements in the measurable criteria by which the Down Syndrome patient is defined.  Maybe negating the symptoms and the ramifications of a disease is equal in importance to curing it.  Maybe it is even easier to do and the patient won’t be able to tell the difference between the two.   The patient; healthier, better, with fewer or no symptoms.  Isn’t that what we are all working towards anyway?

IS that what we are all working towards?  Survey says…
The Purist says: “Scam!  You can’t fix genetic conditions.  You didn’t fix the Down Syndrome!”
The Parent says: “My child’s ability to xyz has improved!  They are at age level in school and on height and weight and on and on…”
The Prognosis says: “Patient presents with fewer or none of the indicators and symptoms commonly associated with Down Syndrome and what is exhibited is more mild in nature.”
The Pragmatist says:  “This advancement in therapies for Down Syndrome allows the patient to live a normal life, unburdened by the symptoms and long term ramifications of the disease.”
The Future says: “We have seen a lower incidence of the common conditions associated with this Down Syndrome – various congenital and progressive medical conditions such as mental retardation, congenital heart disease, gastrointestinal anomalies, skeletal anomalies, leukemia and Alzheimer’s disease.”

Adverse side affects?  The cells used were Human Embryonic stem cells.  Now, they are very powerful as they have the capacity to differentiate into the hundreds of cells in the human body…but they also have a history of rejection and cysts and tumors which can become cancerous.  This is an area of great concern and I am very curious as to how the doctors addressed these issues or felt they were insignificant.  This issue needs more research…

Taoist philosophy says: ‘“Water always seeks the easiest path, the common level of life. When it reaches a spot where there is a blockage, water finds the easiest path around the blockage. Or, if it can’t find a way around the blockage, it continues to assemble. The water gets deeper and deeper until finally the level increases and it flows over the blockage. It uses itself to go beyond whatever it needs to go beyond.” Eventually, water wears down even the hardest rock. Proof of this is seen in the Grand Canyon. The power of water may not be evident right away; over time, though, the massive mountain is worn away while the stream remains.’  Go around.  Go over.  Go through.  Each has it’s merits and disadvantages. Let’s pursue all as viable paths for the healing of the patient.

Most would argue that stem cells encompass the most significant change to disease treatment and medicine in all history.  Stem cells are a game changer.  THE game changer.

If stem cells are the game changer…

maybe it’s past time we changed HOW WE KEEP SCORE.

down-syndrome-chromosome

Clinic claims it has used stem cells to treat Down’s syndrome

A clinic in India says it has used stem cells to treat Down’s syndrome in up to 14 people, but the announcement has alarmed independent researchers

By Andy Coghlan

A CLINIC claims it has used stem cells to treat Down’s syndrome in up to 14 people. “As far as we know, it’s the first time that stem cells have been used to treat Down’s syndrome,” says Jyoti Titus, manager at Nutech Mediworld clinic in New Delhi, India.

The announcement has set alarm bells ringing. It’s not clear to independent stem cell or Down’s experts how stem cells – which can form many types of tissue – might treat Down’s, a genetic disorder caused by having an extra chromosome.

Down'sDown’s: an extra chromosome 21 – Department of Clinical Cytogenetics, Addenbrookes Hospital/Science Photo Library

“The use of these cells does not make biological sense and may place the babies at considerable risk of side effects,”says John Rasko of the International Society for Cellular Therapy.

Clinically proven stem cell therapies are only just starting to become available. The first off-the-shelf stem cell treatment to gain regulatory approval was launched in Japan last year, and prevents transplanted organs from attacking their recipients. A number of research teams are putting other experimental stem cell therapies through stringent clinical trials.

But hundreds of clinics worldwide already offer stem cell treatments unvetted by regulatory authorities. A patent held by the clinic’s medical director, Geeta Shroff, from 2007 suggests that the cells offered by Nutech Mediworld could be helpful for over 70 types of conditions, from Down’s syndrome to Alzheimer’s disease, and even vegetative states.

“The use of stem cells doesn’t make sense and may place the babies at considerable risk”

Most treatments for children with Down’s syndrome centre on support – including speech and behavioural therapies. But in a study published last year Shroff, reported that a baby with Down’s syndrome developed better understanding, improved limb muscle tone, and the ability to recognise his relatives after receiving stem cells (Journal of Medical Cases, doi.org/bx3v).

No controls

“There’s no comparison to similar individuals with Down’s syndrome, and no indication this therapy had any effect whatsoever, so the author has no basis at all for saying the injections were beneficial,” says Elizabeth Fisher at University College London.

But since no other treatment was given, it is evident that the child’s improvements were due to stem cell treatment, says Titus. “He started babbling and crawling, and his facial features underwent a change.” The boy, who lives in Singapore, is now 3 years old. “He continues to develop age-appropriate skills,” says Titus.

Shroff’s study says she injected the cells, developed from a donated embryo, into his blood, back muscles and under his skin, as well as giving them as a nasal spray. “Stem cells have an innate ability to repair and regenerate, and that is how the baby’s condition improved,” says Titus.

“There’s no obvious way in which this treatment would have worked,” says Victor Tybulewicz at the Francis Crick Institute in London. To have any effect, neural stem cells would need to be injected into the brain, he says.

“The author appears to have no idea of where [the cells] are going, or what they’re doing,” says Fisher. “It’s even worse now we know they’ve treated 14 patients, not just one.”

Titus says that the way the cells were developed means recipients don’t need immunosuppressants. But Tybulewicz disagrees. “I expect the most likely outcome of the injections would have been that they were recognised as foreign and eliminated by the immune system,” he says. More details of the biological impact of the stem cells will be revealed in a study that has been submitted for publication, says Titus.

Nutech Mediworld isn’t the only clinic offering stem cells. An analysis led by Rasko last year identified 417 unique websites advertising stem cell treatments directly to patients. Of these, 187 were linked to 215 clinics in the US. Thirty-five websites were linked to organisations in India.

Although India introduced national guidelines on clinical stem cell research and treatments a decade ago, these are not legally binding.

This article appeared in print under the headline “Clinic claims stem cells treat Down’s syndrome”

 

ZEROING IN ON LEUKEMIA SMART BOMBS

In PHARMA AND DRUGS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 31, 2017 at 1:30 pm

A little over a week ago, I posted an article that described:
Of the 100 million BULK CANCER CELLS in a 1-cm cancer tumor, there are about 1,000 to 10,000 CANCER STEM CELLS and those cells are up to 15 times more active and may be the only cells responsible for cancer cell reproduction and metastasis.

Scientists have zeroed in even deeper and targeted a new ‘CD99’ molecule expressed on certain stem cells that drive human leukemia malignancies.  They’ve designed antibodies that can directly kill human acute myeloid leukemia (AML) stem cells.

cd99-2164277470_3687e795d0_z

protein-sugar molecule, CD99

Researchers design antibody that recognizes and destroys blood cancer stem cells

Published on January 25, 2017 at 9:44 PM ·

Building on this discovery, the study authors designed an antibody that recognizes and destroys CD99-covered leukemia cells while sparing normal blood stem cells, a finding confirmed by experiments in human cells and in mice with AML cells. Antibodies are immune system proteins that stick to a specific target, like a protein on the surface of invading bacterium. In recent years, researchers have become capable of engineering antibodies so that they target disease-related molecules.

“Our findings not only identify a new molecule expressed on stem cells that drive these human malignancies, but we show that antibodies against this target can directly kill human AML stem cells,” says corresponding study author, Christopher Y. Park, MD, PhD, associate professor in the Department of Pathology at NYU Langone and its Perlmutter Cancer Center.

“While we still have important details to work out, CD99 is likely to be an exploitable therapeutic target for most AML and MDS patients, and we are working urgently to finalize a therapy for human testing,” says Park.

Direct Cell Killing

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) arise from abnormal stem cells that build up in bone marrow until they interfere with normal blood cell production. Patients struggle with anemia, increased risk for infection, and bleeding.

The study results are based on the understanding that cancers, like normal tissues, contain stem cells that give rise to all the other cells. Such “cancer stem cells” are known to be major drivers of many cancer types. In AML, a small group of leukemic stem cells become incapable of maturing into red or white blood cells as intended. Most leukemias respond initially to standard treatment, but relapse is common as standard treatments fail to kill leukemia stem cells, which continue to multiply.

leukemia-741px-symptoms_of_leukemia

The research team became interested in CD99 when they observed that it occurs frequently on AML and MDS cells, and then noted in the literature that CD99 is elevated in a rare bone cancer called Ewing’s Sarcoma. This prompted them to see if CD99 was important in the development of these blood diseases.

When researchers examined stem cell populations from 79 AML and 24 MDS patients, they found that approximately 85 percent of stem cells in both groups expressed high levels of CD99. The levels were so high that diseased stem cells could be cleanly separated from related, normal stem cells in AML patients.

Upon confirming that CD99 was abundant on leukemia stem cells, the research team then made several CD99 antibodies, and chose to focus on the one that most effectively killed those cells. Researchers found that when the study antibody attaches itself to CD99 on the surface of a cancer stem cell, it sends a signal inside the cell that increases the activity of enzymes called SRC-family kinases.

While the team does not yet know why, the binding of their antibody to CD99, and the subsequent activation of these enzymes, causes leukemia stem cells to die. Most cells with genetic mistakes leading to cancer “sense” they are flawed and self-destruct, but CD99, so the theory goes, may be part of a mechanism that prevents this. As the antibody binds to CD99, it appears to undo this block on self-destruction.

“With the appropriate support, we believe we can rapidly determine the best antibodies for use in patients, produce them at the quality needed to verify our results, and apply for permission to begin clinical trials,” says Park.

While the most common acute leukemia affecting adults (22,000 new cases each year) and expected to become more prevalent as the population ages, AML it is still relatively rare, accounting for 1.2 percent of U.S. cancer deaths. About 15,000 mostly elderly patients are diagnosed with MDS each year as well.

 

AUSTRALIAN OF THE YEAR, ‘NOSE’ STEM CELLS

In Doctors Practicing Excellence, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 27, 2017 at 1:50 pm

Biomedical scientist Alan Mackay-Sim is one of the pioneers in stem cell research, digging into (pun intended) the enormously productive (flowing?) area of “olfactoric mucosal stem cells” or neurological stem cells from inside your nose responsible for your sense of smell.

  1. Lu, J.; Feron, F.; Ho, S. H.; Mackay-Sim, A.; Waite, P. M. E. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 2001, 889, 344-357.
  2. Lu, J.; Feron, F.; Mackay-Sim, A.; Waite, P. M. E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002, 125, 14-21.

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Alan Mackay-Sim, the scientist whose miracle made a paraplegic walk again, named Australian of the Year

JANUARY 25 2017 – Biomedical scientist Alan Mackay-Sim, whose research helped achieve a feat described as “more impressive than man walking on the moon”, has been named the 2017 Australian of the Year for his pioneering stem cell research.

Professor Mackay-Sim’s work was central to the 2014 surgery that allowed Darek Fidyka, a Polish firefighter, to walk again and even ride a custom-built bicycle. This made him the first (well, not the first but no less significant) paraplegic in the world to recover mobility after the complete severing of the spinal nerves. The success was hailed by fellow researcher Geoff Raisman as more impressive than the moon landing.

Professor Mackay-Sim is a leading global authority on the human sense of smell and the biology of nasal cells. The successful surgery that allowed Mr Fidyka to walk again involved taking cells from his nose, growing them in a lab and injecting them into his spinal cord.

Prime Minister Malcolm Turnbull gives Alan Mackay-Sim his honour.

Professor Mackay-Sim, 65, himself relied on a stem cell transplant two years ago when he was diagnosed with myeloma, a rare form of blood cancer that develops in the bone marrow.

He was presented with his Australian of the Year award by Prime Minister Malcolm Turnbull on Wednesday night…

 

A history of stem cell treatments for spinal cord injury

(NOT) FIRST PARALYZED HUMAN TREATED WITH STEM CELLS FOR SCI

In ALL ARTICLES, DISEASE INFO, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, THIS IS SPINAL... on January 27, 2017 at 12:05 pm

First paralyzed human treated with stem cells has now regained his upper body movement http://theheartysoul.com/stem-cells-cure-paralysis/

stem-cell-patient

CONGRATS! But…
NOT the FIRST!

This is the sort of article which makes me crazy because on the one hand, it is a triumph!  A mainstream coverage of a stem cell success, increasing awareness and helping to erode our entrenched concepts of what can be done with medicine and what is and isn’t really “incurable.”

On the other….it grossly misrepresents the long history of stem cell successes versus spinal cord injury. It devalues the patients who have recovered, the loved ones who supported them during their treatments and the doctors who worked their butts off developing the protocols and pushing the envelops, often in the face of massive popular skepticism.

 
These people, these patients and loved ones and doctors who risked everything; life, limb, money, time and more…they are the mavericks, the trail blazers, the ones who sacrificed everything for the one pure goal of advancing medicine, of advancing healing. They deserve to be honored and credited with their barrier breaking work, not dismissed in some ill conceived misinformation campaign, weakly relying upon the un-sturdy columns of anti-Piaget-ian Object Permanence.

hear_speak_see_no_evil_toshogu_cropped_enhanced

And no mention of Spinal Cord Injury and Stem Cell Treatment should be made without a HUGE nod to the God-Fathers, Prof Mackay-Sim and Dr Carlos Lima.

Dr Mackay-Sim was researching olfactoric mucosal stem cell applications for spinal cord injury in murine models as far back as 2001:

  1. Lu, J.; Feron, F.; Ho, S. H.; Mackay-Sim, A.; Waite, P. M. E. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 2001, 889, 344-357.
  2. Lu, J.; Feron, F.; Mackay-Sim, A.; Waite, P. M. E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002, 125, 14-21.

Dr Lima was “improving” and “recovering” Spinal Cord Injury patients with stem cells derived from their own noses as far back as…wait for it…2003.

“Olfactory stem cells have been shown to be most versatile. Indeed, Adult stem cells from the nose have now helped paraplegic patients walk. From the primary source, Carlos Lima et al., Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury, Neurorehabil Neural Repair 24(1):10–22 | doi: 10.1177/1545968309347685.”

“Of the 13 patients assessed by functional studies, 1 paraplegic patient (patient 9) can ambulate with 2 crutches and knee braces with no physical assistance and 10 other patients can ambulate with walkers with or without braces with physical assistance.

One tetraplegic [paralyzed in both arms and legs] patient (patient 13) ambulates with a walker, without knee braces or physical assistance.”

Why haven’t you heard of this?  I don’t know.  Perhaps you missed the “Testimony of Ms. Laura Dominguez, delivered at a hearing held by the United States Senate Subcommittee on Science, Technology, and Space on July 14, 2004. Accessed at: http://commerce.senate.gov/hearings/testimony.cfm?id=1268andwit_id=3673

If that doesn’t work, go here and skip ahead to 1 hour, 16 minutes to 2hrs 21min: https://www.c-span.org/video/?182693-1/stem-cell-research-treatment

Laura Dominguez, also featured in the article  here, was treated in 2004.  By then,

Dr “Lima’s procedure had proven successful in 26 patients, states Dr. Jean D. Peduzzi-Nelson, a co-researcher at the University of Alabama in Birmingham. [9] Dominguez was the tenth person in the world and the second American to undergo the surgery.

Completion of the surgery permitted a return to the United States, which ushered in the continuation of the therapeutic process and the resumption of home life in San Antonio. After an MRI was conducted, physicians informed her that her spinal cord had begun healing and that 70 percent of the lesion had recovered into normal spinal tissue. Within six months she had acquired sensation down to the abdominal region. By 2004, she had gained upper body agility and the ability to stand for extended periods of time with the aid of a walker. In addition, she reported improved motor skills, including the ability to stand on her toes and contract her quadriceps and hamstring muscles. She also announced that she had walked more than 1400 feet with the use of braces and outside help. Laura is inspired by the results and hopes to walk unassisted by the time she turns 21. [10]

Not first.  Missed it by just a baker’s dozen of years.

Here are just a small selection of more stem cell heroes from the past:

SPINAL CORD SUCCESSES

 https://repairstemcell.wordpress.com/2009/03/25/spinal-cord-injury-success/

 

MORE SPINAL CORD SUCCESSES

https://repairstemcell.wordpress.com/2009/03/25/more-spinal-cord-injury-success-from-adult-stem-cells/

 

STEM CELLS FOR SPINAL CORD

https://repairstemcell.wordpress.com/2009/03/20/stem-cell-surgery-spinal-cord-injury/

 

16 YEAR OLD PARALYZED KARTING CHAMP

https://repairstemcell.wordpress.com/2009/09/07/16-year-old-paralyzed-karting-champ-undergoing-stem-cell-treatment/

 

PARALYZED WOMAN WALKS ON 21ST BIRTHDAY
https://repairstemcell.wordpress.com/2009/04/23/strength-and-determination-help-paralyzed-woman-walk-on-21st-birthday/

 

QUEST TO CURE HIS DAUGHTER

https://repairstemcell.wordpress.com/2009/04/14/a-father%e2%80%99s-quest-to-cure-his-daughter-well-blog-nytimescom/

 

PARALYSIS IN RATS REVERSED

https://repairstemcell.wordpress.com/2009/04/02/adult-spinal-stem-cells-reverse-paralysis-in-rats/

 

ADULT STEM CELL PROGRAMS

https://repairstemcell.wordpress.com/2009/03/30/il-sussidiarionet-raisman-the-best-results-are-coming-from-the-adult-stem-cell-research-programmes/

 

IMPROVED QUALITY OF LIFE FOR THE PARALYZED

https://repairstemcell.wordpress.com/2009/03/26/adult-stem-cell-study-demonstrates-improved-quality-of-life-for-patients-suffering-from-spinal-cord-injury/

 

A PERSONAL NOTE

http://reflectionsofaparalytic.com/?p=2052

 

FUNDRAISING FOR SPINAL CORD/STEM CELL THERAPY

https://repairstemcell.wordpress.com/2009/03/20/fundraiser-for-spinal-cord-injury-patient-for-stem-cell-treatment/

 

STEM CELLS HELP 52 SPINAL CORD INJURY PATIENTS

https://repairstemcell.wordpress.com/2009/03/19/stem-cell-research-helps-52-spinal-cord-injury-patients-stem-cell-research-adult-stem-cell-research-spinal-cord-injury/

 

PARALYZED LAWMAKER MAKES STEM CELL DECISION

https://repairstemcell.wordpress.com/2009/03/11/paralyzed-ri-lawmaker-hails-stem-cell-decision-international-herald-tribune/

 

JAPAN AHEAD OF USA IN STEM CELLS FOR SCI

https://repairstemcell.wordpress.com/2009/02/10/spinal-cord-injury-sci-stem-cell-trials-japan-plays-catch-up/

 

CHINA AHEAD OF USA FOR STEM CELL TREATMENTS/SCI

https://repairstemcell.wordpress.com/2009/02/27/stem-cell-research-yields-benefits-for-american-man-traveling-to-china/

 

WHY DO WE PRETEND STEM CELLS DON’T WORK?

https://repairstemcell.wordpress.com/2009/02/18/adult-stem-cells-get-the-shaft-none-are-so-blind-as-those-who-will-not-see/

 

IRAN AHEAD OF USA IN STEM CELLS

https://repairstemcell.wordpress.com/2009/02/12/stem-cells-in-iran-catch-up/

 

 

TODDLER, CANCER, STEM CELLS, SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/02/08/toddler-helps-bring-about-a-medical-miracle-cancer-spimal-cord-injury/

 

REGENERATING THE CENTRAL NERVOUS SYSTEM https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

 

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6…-C7 injury

https://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

 

Paraplegic – Adult Stem Cell Success Stories – Laura Dominguez

https://repairstemcell.wordpress.com/2010/05/05/paraplegic-adult-stem-cell-success-stories-laura-dominguez/

 

PARALYZED COUSINS PLEASED WITH STEM CELL TREATMENT

https://repairstemcell.wordpress.com/2010/02/15/paralyzed-cousins-pleased-with-stem-cell-treatment/

 

Successful Stem Cell Treatment of Spinal Cord Injury in Dogs

https://repairstemcell.wordpress.com/2010/02/08/successful-stem-cell-treatment-of-spinal-cord-injury-in-dogs/

 

Spinal Cord Injury Patient Wins…and Loses

https://repairstemcell.wordpress.com/2010/02/08/spinal-cord-injury-patient-wins-and-loses/

 

STEM CELLS FOR SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/12/31/stem-cells-for-spinal-cord-injury/

 

Adult Stem Cell Grafts Help Paralyzed Heal

https://repairstemcell.wordpress.com/2009/10/21/adult-stem-cell-grafts-help-paralyzed-heal/

 

Medical hope as paralysed dog cured by stem cell therapy

https://repairstemcell.wordpress.com/2009/10/08/medical-hope-as-paralysed-dog-cured-by-stem-cell-therapy-mirror-co-uk/

 

and even, Major the Roseville police dog gets stem cell treatment

http://blogs.citypages.com/blotter/2011/01/major_police_dog_stem_cell.php

 

Time to set the record straight.  Too many have waited too long to get news which blacks out a dozen years of research and progress.

WHAT WILL TOM PRICE MEAN TO PATIENTS?

In BUSINESS OF STEM CELLS, HEALTH AND WELLNESS, STEM CELLS IN THE NEWS on January 24, 2017 at 11:45 am

tom_price_official_transition_portrait

“Who is Tom Price, Trump’s pick for HHS?

Washington (CNN) While some Republicans have signaled major changes to Obamacare are a long time in the making, President-elect Donald Trump has sent a strong signal that the law’s days are numbered, no matter what.

That signal is Rep. Tom Price, Trump’s pick to head the Department of Health and Human Services.
The Georgia Republican and medical doctor is among the law’s most studied and determined opponents.” via

On ABORTION

  • Voted YES on banning federal health coverage that includes abortion. (May 2011)
  • Voted NO on expanding research to more embryonic stem cell lines. (Jan 2007)
  • Voted NO on allowing human embryonic stem cell research. (May 2005)
  • Voted YES on restricting interstate transport of minors to get abortions. (Apr 2005)
  • Rated 100% by the NRLC, indicating a pro-life stance. (Dec 2006)
  • Bar funding for abortion under federal Obamacare plans. (Jul 2010)
  • Prohibit federal funding for abortion. (May 2011)
  • Prohibit federal funding to groups like Planned Parenthood. (Jan 2011)
  • No family planning assistance that includes abortion. (Jan 2013)
  • Grant the pre-born equal protection under 14th Amendment. (Jan 2007)

On DRUGS

  • Voted NO on more funding for Mexico to fight drugs. (Jun 2008)
  • Rated -10 by NORML, indicating a “hard-on-drugs” stance. (Dec 2006)
  • Rated 0% by NORML, indicating an anti-legalization stance. (Jan 2014)

On ENVIRONMENT

  • Voted NO on $2 billion more for Cash for Clunkers program. (Jul 2009)
  • Voted NO on protecting free-roaming horses and burros. (Jul 2009)
  • Voted NO on environmental education grants for outdoor experiences. (Sep 2008)
  • Voted NO on $9.7B for Amtrak improvements and operation thru 2013. (Jun 2008)
  • Voted NO on increasing AMTRAK funding by adding $214M to $900M. (Jun 2006)
  • Voted NO on barring website promoting Yucca Mountain nuclear waste dump. (May 2006)
  • Voted YES on deauthorizing “critical habitat” for endangered species. (Sep 2005)
  • Stop considering manure as pollutant or hazardous. (Sep 2011)
  • Rated 13% by HSLF, indicating an anti-animal welfare voting record. (Jan 2012)
  • Strengthen prohibitions against animal fighting. (Jan 2007)

On HEALTH CARE

  • Republicans have offered ideas and solutions on healthcare. (Jan 2010)
  • Address lawsuit abuse; it doesn’t raise taxes by a penny. (Jan 2010)
  • More Medical Savings Accounts; less medical malpractice. (Nov 2004)
  • Voted YES on the Ryan Budget: Medicare choice, tax & spending cuts. (Apr 2011)
  • Voted YES on repealing the “Prevention and Public Health” slush fund. (Apr 2011)
  • Voted NO on regulating tobacco as a drug. (Apr 2009)
  • Voted NO on expanding the Children’s Health Insurance Program. (Jan 2009)
  • Voted YES on overriding veto on expansion of Medicare. (Jul 2008)
  • Voted NO on giving mental health full equity with physical health. (Mar 2008)
  • Voted NO on Veto override: Extend SCHIP to cover 6M more kids. (Jan 2008)
  • Voted NO on adding 2 to 4 million children to SCHIP eligibility. (Oct 2007)
  • Voted NO on requiring negotiated Rx prices for Medicare part D. (Jan 2007)
  • Voted YES on denying non-emergency treatment for lack of Medicare co-pay. (Feb 2006)
  • Repeal any federal health care takeover. (Jul 2010)
  • Deauthorize funding for Obamacare. (Jul 2010)
  • Repeal the Job-Killing Health Care Law. (Jan 2011)

Via 

 

On HEALTH ISSUES
Benjamin says that Price’s record in public-health policy is particularly worrying. In 2008, for instance, Price voted against allowing the FDA to regulate tobacco as a drug.

Price has also pushed to repeal the Public Health and Prevention Fund (PHPF), a roughly $1 billion to $2 billion fund provided yearly to the CDC to support public-health programmes. Owing to past budget cuts, the agency has used this money to bolster spending on existing programmes, such as research on lead toxicity. Price has criticized the PHPF as a “slush fund”, but Benjamin says that it has been essential for the agency. “Should he be confirmed, we’d be working very hard to try and change his mind to convince him that prevention is an important issue he should champion,” he says.

And Price has also consistently opposed embryonic stem cell research, saying in 2009 that Obama’s executive order to permit such research would “force taxpayers to subsidize research that will destroy human embryos”.

He has also supported numerous efforts to defund the reproductive non-profit healthcare group Planned Parenthood” Via

 

“On STEM CELL RESEARCH

Price has been outspoken against research that involves embryonic stem cells.
In 2005, Price spoke with Georgia’s Athens Banner-Herald newspaper about the “ethical dilemma” of stem cell research. Embryonic stem cells, which have the potential to treat myriad medical conditions, are controversial because they derive from early embryos.
The cells are of interest for research because they have the potential to develop into many different cell types, and so scientists believe they can be used to generate cells and tissues that could be used for cell-based therapies.

See the latest news and share your comments with CNN Health on Facebook and Twitter.

“There are people who believe any form of embryonic stem cell research necessitates the destruction of human life,” Price said. “I can’t overestimate the importance of that statement.” And for people who believe that, “stem cell scientists are threatening your fundamental principles,” he said.
According to the National Institutes of Health’s current guidelines on human stem cell research, embryonic stem cells are eligible for research with NIH funding if they were created using in vitro fertilization and are no longer needed or were donated by individuals seeking reproductive treatment.
Price has voted against expanding embryonic stem cell research. As HHS secretary he would oversee NIH grants to research on embryonic stem cells.” Via
On LGBT, DOMESTIC VIOLENCE, HUMAN RIGHTS, PERSONHOOD STATUS of EMBRYOS
Last year Price joined other Georgia Congressmen in signing a letter of support for fired Atlanta fire chief Kelvin Cochran, who was terminated after not obtaining permission to use his official capacity to promote a book he wrote that disparages LGBT people under the cloak of religion. The letter falsely described both Cochran’s actions and the reason for his termination.Price, as On The Issues details, voted against reauthorizing the Violence Against Women Act and against prohibiting job discrimination based on sexual orientation. He voted to constitutionally define marriage as one-man-one-woman and to amend the Constitution to define traditional marriage. He’s earned a 0% rating from the Human Rights Campaign and a 17% rating from the NAACP.

Rep. Price, 62, opposes a woman’s right to choose, he opposes stem cell research, and supports banning all federal funding of Planned Parenthood. He also supports granting embryos personhood status and thus equal protection under 14th Amendment.” Via 

 

What will Tom Price as head of the Department of Health and Human Services mean to you?  Please comment below.

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