DAVID GRANOVSKY

Posts Tagged ‘recover’

STEM CELLS FOR MS

In STEM CELLS IN THE NEWS on September 17, 2011 at 9:42 am

MORE CONFIRMATION IT WORKS!

Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2 Suppl 2):72-6.

[Transplantation of mesenchymal

stem cells in multiple sclerosis].

Abstract

To assess safety and tolerability of treatment with autologic multipotent mesenchymal stem cells (MSC) in multiple sclerosis (MS), we have obtained autologic red bone marrow-derived MSC from 8 patients. Proliferation, immunophenotype and caryotype of MSC, their sterility, the absence of hemopoetic cells, chromosomal aberrations and signs of aging were controlled during the cell growth. The inverse injection of MSC in patient’s blood was conducted in accordance to the elaborated protocol in a short intravenous infusion in dose 2.0 x 10(6)/kg of body mass once in 30 days.

  • The duration of treatment was from 4 to 8 months.
  • The efficacy of treatment was assessed after 4, 8 and 12 months.
  • All patients tolerated repeated intravenous infusions of autologic MSC well with no significant side-effects as in the early as well in the remote periods of treatment.
  • The distinct positive effect was seen in some cases 2 months after the beginning of treatment.
  • The improvement of 0.5 point on EDSS was seen in 5/8 patients after 4 months.
  • After 12 months, the improvement of 0.5-1 point on EDSS was seen in 6/8, stabilization in 1/8, progression in 1/8.
  • These results revealed the safety of the elaborated protocol of treatment and the moderate clinical efficacy of treatment in non-curable patients or those with poor response to treatment that suggested continuing the study and enrollment of new patients.

STEM CELLS FOR RECONSTRUCTIVE + PLASTIC SURGERY

In VICTORIES & SUCCESS STORIES on February 10, 2011 at 8:54 pm

Maxillary and mandibular radionecrosis (stage IIIR) with pathologic fracture presented early osteogenesis:

  • total recovery from alveolar nerve anesthesia, facial nerve reinnervation, and skin regeneration.
  • nonhealed fracture, bone loss, and bilateral paresthesia demonstrated callus formation, bone regeneration, and nerve recovery.
  • maxillary bone regenerated after massive deficiency
  • oral functional restoration with implants and fixed prosthesis was accomplished in all cases

Plast Reconstr Surg. 2010 Nov;126(5):1699-709.
Regenerative facial reconstruction of terminal stage osteoradionecrosis and other advanced craniofacial diseases with adult cultured stem and progenitor cells. – Mendonça JJ, Juiz-Lopez P.

Lugo, Spain From the Head and Neck Surgery Unit, POLUSA Hospital.

Abstract
BACKGROUND: Treatment options in cases of severe craniofacial disorders with bone loss and tissue damage are usually limited to vascularized and nonvascularized tissue transfers, allografts, mechanical devices and, more recently, facial transplantation. Despite the therapies available, the demand for new approaches is realized in cases where current therapies are unable to resume form and function. This study presents the feasibility of alternative treatments based on cultured bone marrow cells that yield mixed populations of mesenchymal, hematopoietic, and endothelial lineages at very early stages implemented as part of a novel regenerative procedure.

METHODS: One hundred milliliters of a bone marrow aspirate was inoculated into the automated single-pass perfusion technology system, AastromReplicell, for the development of the cellular product, tissue repair cells. After 12 days of incubation, cells were exposed to a specially designed osteogenic environment in an autogenous fibrin-rich and platelet-rich clot and membrane with a mineral base of ?-tricalcium phosphate and hydroxyapatite.

RESULTS: A case of maxillary and mandibular radionecrosis (stage IIIR) with pathologic fracture presented early osteogenesis, total recovery from alveolar nerve anesthesia, facial nerve reinnervation, and skin regeneration. Another case with nonhealed fracture, bone loss, and bilateral paresthesia demonstrated callus formation, bone regeneration, and nerve recovery. Finally, maxillary bone regenerated after massive deficiency. Oral functional restoration with implants and fixed prosthesis was accomplished in all cases.

CONCLUSION: After nerve, bone, skin, and vessel formation in three patients with severe abnormality, bone marrow-derived mixed cultured stem cell lineages could be considered a new paradigmatic approach to advanced disease.

AUTISM RETROSPECTIVE

In ALL ARTICLES on February 16, 2010 at 2:38 pm

WHAT ARE THE ADVERSE REACTIONS FROM MMR VACCINES?
http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf
(The warnings from the manufacturer are scary enough, even if it doesn’t cause autism.)

WHY NO STEM CELLS IN THE US (FOR AUTISM)?
https://repairstemcell.wordpress.com/why-no-stem-cells-in-the-us/

STEM CELLS FOR AUTISM – PROGRESS TO DATE
https://repairstemcell.wordpress.com/2009/10/26/stem-cells-for-autism/

Potential of Stem Cell Treatments for Autism
https://repairstemcell.wordpress.com/2009/10/16/potential-of-stem-cell-treatments-for-autism/

Clinical trial of adult stem cells in heart attack reports on safety and efficacy

In VICTORIES & SUCCESS STORIES on January 13, 2010 at 5:17 am

SLOWLY Catching Up…

Sections:

Phase I trial of bone marrow stem cells in patients who had suffered a myocardial infarction. Safety was good and patients receiving the stem cell injections appeared to recover better.

The results of a Phase I trial looking at outcomes for heart attack patients treated with adult stem cells have concluded that the treatment is safe and should go forward to Phase II efficacy trials.

  • 53 patients from ten centers across the USA
  • received one of three doses of bone marrow stem cells or placebo
  • a purified formulation of mesenchymal stem cells
  • injected intravenously into the leg or arm within 10 days of the heart attack
  • patients were then monitored over 2 years to assess any side effects and recovery was measured using a variety of imaging techniques, measures of heart function and symptom scores.

“The results point to a promising new treatment for heart attack patients that could reduce mortality and lessen the need for heart transplants,” commented Gary Schaer, principal investigator at Rush University.

There was no evidence of any increase in adverse events in the stem cell- versus placebo-treated patients. Hematological parameters and markers of kidney and liver function were not different between the groups. Patients receiving stem cells showed greater improvement in symptoms, better heart function and fewer arrhythmias than patients receiving placebo after 6 months. There was also evidence of better lung function in the treatment group.

These results, recently published in the Journal of the American College of Cardiology, were considered sufficiently positive to proceed to a Phase II efficacy trial, which is currently recruiting.

“It is suspected that these stem cells may take part in the growth of new blood vessels to bring more oxygen to the heart and help reduce the scarring from a heart attack,” stated Dr Schaer.

The cells used in this study were mesenchymal stem cells harvested from the bone marrow of healthy unrelated adult donors. The researchers involved in the study feel that mesenchymal stem cells have advantages for clinical use in that they do not provoke immune reaction, are easy to prepare and have been extensively tested for this indication in animal studies.

“This study suggests that adult bone marrow derived stem cells are more flexible than previously thought … if the benefits and safety are confirmed in the ongoing Phase II trial, we may soon have a remarkable new therapy.”

via Future Medicine – Regenerative Medicine – 5(1):7 – Full Text.

CATCH UP!! – US HEART TRIAL YEARS BEHIND

In CATCH UP! on November 24, 2009 at 6:33 pm

THE LATEST B.S. ARTICLE FOR YOU TO LAUGH AT.  I MEAN REALLY, IT’S GETTING RIDICULOUS ALREADY. YOU CAN NOT CITE SOMETHING AS THE “first evidence” WHEN THERE IS ALMOST A DECADE OF SOLID RESEARCH THAT PREDATES IT.  FOR PETE’S SAKE, THERE’S EVEN A CHILDREN’S BOOK ABOUT ADULT STEM CELLS TREATING HEART DISEASE – • SUPER STEMMYS – DORIS & THE SUPERCELLS!  –   https://www.createspace.com/3391680

THE TIMELINE FOR STEM CELLS VS HEART DISEASE IS BELOW AND HERE ARE SOME HUMOROUS  STATS:

Google the title as keywords [Your Own Stem Cells Can Treat Heart Disease] and you get over 7 million hits…And this is first evidence?!

Google the title as a complete sentence Your Own Stem Cells Can Treat Heart Disease” and you get over 148,000 hits…And this is first evidence?!

Your Own Stem Cells Can Treat Heart Disease -November 17, 2009 | Research – By Marla Paul
 
Transplanting people’s own stem cells into heart lessens pain, improves ability to walk
 
CHICAGO — The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn’t receive stem cells.


https://i2.wp.com/www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/1097.jpg

THIS IS YEARS BEHIND!! HERE’S WHY:

“First came a year or two of (repair stem cell/cardiac) animal tests, then, in Paris, 2000, doctors gave a dying 70-year-old heart patient bone marrow cells and he lived four years, at which time the doctors ‘fessed up and released his name.

In 2001, USA pioneer Warren Sherman, MD (Columbia U, Mt. Sinai NY Hosp) went to Rotterdam and became the first American to implant ASC into a human heart. However, if you can believe it, the same Sherman, calls those that have taken forward what he did eight years ago, “snake oil salesmen.”

In 2002, a very daring clinical trial led by Dr. Hans Dohmann plus six colleagues in Brazil took 21 transplant candidates and gave 14 of them bone marrow cells. The results were so spectacular that the AHA accepted the paper and it was presented in 2003. Five of the seven in the control group opted in to make a total of 19 stem cell transplants. The mortality rate for transplant candidates is about 35% per year. At that rate there would be, of those 19, only 2.2 patients still alive after five years. There were, in fact, 12 alive as of Dec. 31, 2007; more than five years down the road.

In 2003, Dr. Andreas Zeiher of the Goethe Institute in Frankfurt began much larger trials. As of 2007, he has overseen more ASC implants into hearts than anyone, both in and out of clinical trials.

In 2004, Dr. Amit Patel of Pittsburgh completed two of the most successful trials ever, especially when, in Uruguay, he proved, on a group of ischemic heart failure patients, that a bypass plus cells was infinitely better than a bypass only. That same year, TheraVitae, in Israel, developed a new, powerful blood-derived stem cell and dared to treat the sickest patients no clinical trial would consider.

Also in 2004, one of the Brazilians, Dr. Perin, came to Texas and used the Brazil results to get the first ASC heart clinical trial approved by the FDA. Over a dozen such approvals were granted in the next 12-18 months.

Meanwhile, around the world, while USA stem cell research remains mired in politics instead of science, ASC advances in virtually every sector of medicine are rocketing forward without any sign of letting up.

In 2005, Drs. Vina & Saslavsky in Argentina completed the very first successful diabetes2 stem cell clinical trial in the world: 13 out of 16 successfully cured. Spinal problems and emphysema and renal failure and cirrhosis of the liver treatments will be moving to the forefront in 2008-9. (Yes, but mostly in China and elsewhere, while Americans die with those diseases without a chance of help from their “doctors.”

AND MORE:

More info on heart disease and stem cells treatment: https://repairstemcell.wordpress.com/2009/09/24/heart-disease-asc-a-brief-history/

Patients are being treated all over the world today with years of research and clinical trials behind the procedures.  For more information, go to: TREATMENT INFO NOW

STEM CELLS FOR AUTISM

In SCIENCE & STEM CELLS on October 26, 2009 at 6:49 pm

autism-ribbonautism-ribbonautism-ribbonautism-ribbonautism-ribbonautism-ribbon

“STEM CELLS FOR AUTISM – PROGRESS TO DATE”

A parent’s caution and skepticism when evaluating whether stem cell treatment for their child’s Autism is warranted given the number of times “miracle cure for autism” has been crammed down their throats.  Placebo and expectation effects are definitely a legit concern…but (you knew there was a but, didn’t you), if you look at the science of adult or repair stem cells (these are not embryonic btw), here’s what you will find:

1.  General results:

There have been ~1300 peer reviewed, FDA approved, clinical trials with adult stem cells to date and most (almost all) have shown that adult stem cell implantation is safe and effective and provides therapeutic benefit to the patient. https://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/

2.  Autism specific results:

As for Autism and stem cells, there haven’t been any FDA approved clinical trials completed to date, except for the hyperbaric chamber trial, which is weak and tangential at best.  The argument appears to be:

  • If hyperbaric chamber therapy helps autism
  • And hyperbaric chamber increases stem cell production
  • Then stem cells help Autism

http://clinicaltrials.gov/ct2/show/NCT00335790

3. Nonetheless, there is an excellent argument for the viability of stem cells to treat Autism.  Here is an exhaustive study gauging the potential of a clinical trial on the benefits of stem cells treating Autism: http://www.translational-medicine.com/content/5/1/30

4.  There is additional evidence that Stem Cells can treat Autism here: https://repairstemcell.wordpress.com/2009/10/01/autism-stem-cells-a-brief-history/

5.  Placebo/expectation effect:

Do stem cell treatments create a placebo/expectation effect?  Good question.  You can find the answer here: https://repairstemcell.wordpress.com/2009/10/12/the-stem-cell-placebo-effect/

6.  Clinic’s responsibility regarding claims of success:

Stem cell clinics must be up-front regarding the results of their therapy and unless you see this type of clear, open and honest disclaimer, I would be skeptical about going to a clinic: “We would like to point out from the start that there are still some questions concerning the function of stem cells that science has not yet been able to answer, and that despite the advances that have been made recently there is no guarantee for the success of stem cell therapy. Nevertheless, every week we see this new “medicine” helping a lot of people. Therefore, we offer therapies with adult stem cells whenever classical treatment does not yield the type of results that are satisfactory for the patient.”  In addition, this facility points out that only 70% of patients responded and they are up-front as to how they define improvement.  Personally, I would see this kind of clear definition of defining “improvement” than someone throwing out some empty and unsubstantiated claims.

7.  Costs of treatment:

Is it worth it?  Let’s put aside for the moment that “there is no price to great to secure your child’s health” because that does not factor in your financial situation and look at the comparative costs.

  1. Michael Ganz, an assistant Professor of Society, Human Development, and Health at Harvard School of Public Health, has examined the cost of autism for US society //and has found that the disease costs a person $3.2 million over the entire life span. – http://www.bio-medicine.org/medicine-news/The-Price-Of-Autism-9735-1/
  2. And “…a nearby school operated by the May Institute that practices behavior modification on its autistic students charges school districts $100,000 per year in tuition. And home-based ABA/behavior modification programs charge about $75,000 a year for 25 hours a week of therapy, supervision and team meetings. Parents have been known to remortgage their homes or go bankrupt in an attempt to fund these programs.” http://autismtomorrows.blogspot.com/2009/10/cost-effectiveness-and-autism-treatment.html

All the evidence and many, many patients treated successfully, reinforce that stem cells are a powerful and underutilized tool for Autism and Asperger’s patient recovery .

autism-ribbonautism-ribbonautism-ribbonautism-ribbonautism-ribbonautism-ribbon

My MS Pain is GONE!

In VICTORIES & SUCCESS STORIES on September 2, 2009 at 12:38 pm

Another adult stem cell miracle…CONGRATS to Richard + Laura Humphries for having the sight and the gumption to pursue non-conventional treatments!

…but is it truly a miracle? Let’s see:
mir·a·cle – Pronunciation: ˈmir-i-kəl Function: noun – Etymology: Middle English, from Anglo-French, from Late Latin miraculum, from Latin, a wonder, marvel, from mirari to wonder at – Date: 12th century
1 : an extraordinary event manifesting divine intervention in human affairs
2 : an extremely outstanding or unusual event, thing, or accomplishment

Nope. Definitely not a miracle. These kind of success stories of so called “incurable diseases” improving are happening every day, all over the world, with adult stem cells…EXCEPT in the US!

Richard, Laura, thanks for blazing the trail and getting the word out!  I wish you continued health and hope many, many people follow your example! -dg

———————————–

Richard Humphries, an Alexandria native from Fort Worth, Texas, has plans to play in the 2009 Deep South Four Ball golf tournament, despite suffering from secondary progressive multiple sclerosis.Seventeen months ago, Humphries, a 54-year-old Alexandria native who lives in Fort Worth, Texas, was bedridden and suffering from excruciating pain with secondary progressive multiple sclerosis.

“Very few people know this,” he said, “but I prayed to die every day and night, for the pain was off the charts.”…

…”The night after the second injection, I started to feel better and the fog had lifted. The time was midnight, and I had not been able to stay up that late in some time. The pain was gone….

…In February, Humphries underwent another experimental stem cell treatment to regrow inner ear nerve hairs. It not only improved his hearing but helped him tolerate heat, which can be a problem for people with MS…

Richard Humphries, an Alexandria native from Fort Worth, Texas, has plans to play in the 2009 Deep South Four Ball golf tournament, despite suffering from secondary progressive multiple sclerosis.

“It’s an amazing recovery,” Ichem  said (Dr. Tom Ichem of San Diego, a scientist). “I was with him in (Washington) D.C. and spent three days with him, and I was, honestly, bona fide flabbergasted. It’s one thing to read about recoveries like this, but to see it first hand — I hate to say ‘miracle,’ but it was absolutely something very, very stunning. Usually when we develop new treatments, we see results with some impact, but I’ve never seen this kind of stunning impact. It literally shocked me.”

via Pushing the limit: Alexandria native Humphries fights through MS to play in tourney | thetowntalk.com | The Town Talk.

Stem Cell Research A Miracle for Aussie Toddler with Cerebral Palsy

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on April 29, 2009 at 7:20 pm
Apr. 17, 2009 at 5:48 PM

Plenty to smile about: Rosanne de Gregorio (left) with Corey and dad Mark are pleased with the results of the stem cell therapy.Picture: CHRIS HYDE

Adult Stem Cells Improve Young Boy with Cerebral Palsy

Corey de Gregorio, a 3 year old boy from Gordonvale, Australia has improved tremendously after going to a Stem Cell research company which implanted Adult Stem Cells from cord blood into him.

Corey’s parents, Mark and Roseanne had doubts before going to China for the stem cell treatment, but they  wanted Corey to have every chance to live a better life and therefore, they made the journey to China for the stem cell therapy which used only Adult Stem Cells.

The miracle treatment consisted of six “therapies” of cord blood stem cells.

Before the Adult Stem Cells for Cerebral Palsy

  • Had very little use of his left arm/hand
  • Little movement in his torso

After the Stem Cell Treatment

  • Can now use his left hand, can use it to drink a cup by himself
  • Increased flexibility in torso

Amazed by the Stem Cell Research

According to the stem cell article:
More than six months after the stem cell treatment, Mr de Gregorio said the family was amazed at the improvements in his torso and his left arm.

Corey de Gregorio is not the only Aussie to go abroad for stem cell research using Adult Stem Cells. Last month, I featured Sierra Rose Hill, another young toddler from Australia who went to Germany for a successful stem cell treatment for her Cerebral Palsy as well.

Adult Stem Cells do seem to work well for Cerebral Palsy as I have posted many stories about children going to Duke University for stem cell research where they were treated with their own cord blood stem cells.

I am happy for Corey de Gregorio and a special kudos for his parents for taking an educated “risk” and going to China for stem cell treatment where hundreds of others have been helped as well.   It paid off for them.

 

%d bloggers like this: