DAVID GRANOVSKY

Posts Tagged ‘PATIENT’

Higher bleeding risk seen in J&J, Bayer clot drug – Reuters Health Report

In OFF THE BEATEN PATH on April 5, 2011 at 9:43 pm
Higher bleeding risk seen in J&J, Bayer clot drug
April 05, 2011 09:35 AM ET
NEW ORLEANS (Reuters) – A blood clot preventer from Johnson & Johnson and Bayer caused a surprisingly high rate of bleeding in a trial of patients with acute illnesses, representing a significant setback for the drugmakers. | Full Article

https://i0.wp.com/boogey.me/wp-content/themes/mixedmediared/images/DrippingBlood.png

Gmail – Reuters Health Report – dsgrano@gmail.com.

Adult Stem Cells Help Patients with Aggressive Multiple Sclerosis

In VICTORIES & SUCCESS STORIES on April 1, 2011 at 1:12 pm

Adult Stem Cells Help Patients with Aggressive Multiple Sclerosis
by David Prentice – March 22, 2011

A team of scientists from Thessaloniki, Greece, have shown that chemotherapy followed by adult stem cell transplant can stop progression of aggressive multiple sclerosis (MS). The team observed a group of 35 patients who received transplants of their own bone marrow adult stem cells after being treated with chemotherapy to wipe out the rogue immune cells that were attacking their nervous system and causing their MS. An average of 11 years after their transplants, 25% of the patients in Greece have not seen their disease progress, the researchers report. Among patients with active lesions on MRI scans before their transplants, indicating that they were in an inflammatory phase of the disease, 44% have not progressed. For 16 people, symptoms improved by an average of one point on their disability scale after the transplant, and the improvements lasted for an average of two years. The participants also had a reduction in the number and size of lesions in their brains. But two patients died from transplant-related complications. The results are published in the journal Neurology, the journal of the American Association of Neurology. Co-author Dr. Vasilios Kimiskidis said:

“Keeping that in mind, our feeling is that stem cell transplants may benefit people with rapidly progressive MS. This is not a therapy for the general population of people with MS but should be reserved for aggressive cases that are still in the inflammatory phase of the disease.”

Other researchers not associated with the current study commented that this was still a big step forward in the use of adult stem cells to treat MS Dr. Richard Nash of the Fred Hutchinson Cancer Research Center in Seattle noted:

“This is the first long-term paper that’s being published on this.”

Nash is part of a National Institutes of Health trial of stem cell transplants for MS, but he was not involved in the Greek study.

Dr. Richard Burt, Chief of the Division of Medicine-Immunotherapy for Autoimmune Diseases at Northwestern University’s Feinberg School of Medicine in Chicago, points out:

“It’s the only therapy to date that has been shown to reverse neurologic deficits. But you have to get the right group of patients.”

Burt published a study in 2009 in The Lancet in which 17 out of 21 patients with relapsing-remitting MS improved after stem cell transplants.

In a gentler method of treatment, Prof. Neil Scolding and colleagues published positive results in 2010 for stabilization of MS patients using their own adult stem cells.

Adult stem cells continue to lead the way, showing published evidence of positive benefits for thousands of patients with dozens of diseases and conditions.

FRC Blog » Adult Stem Cells Help Patients with Aggressive Multiple Sclerosis.

Gene therapy shows promise for Parkinson’s | Reuters

In VICTORIES & SUCCESS STORIES on March 17, 2011 at 11:02 am

I’m glad to see other therapies are producing benefits to Parkinson’s patients.

There now seems to be 3 options for Parkinson’s patients:
Gene therapy = 23.1 % improvement
Placebo effect = 12.7 % improvement

Adult Stem Cells = 60 % improvement*

* 60% PARKINSON’S PATIENTS IMPROVE AFTER REPAIR STEM CELL TREATMENT – PHYSICIANS CONFIRM RESULTS! https://repairstemcell.wordpress.com/2010/02/06/60-parkinsons-patients-improve-after-repair-stem-cell-treatment-physicians-confirm-results/

-dg

Gene therapy article below pic


“The treated group showed a 23.1 percent improvement on a scale of Parkinson’s symptoms six months after treatment, compared to a 12.7 percent improvement for patients who received sham surgery, according to the published research.”

Gene therapy shows promise for Parkinson’s | Reuters.

PETITION to make ADULT STEM CELL TREATMENTS AVAILABLE in the USA NOW!

In VICTORIES & SUCCESS STORIES on March 10, 2011 at 12:45 pm
You can help make this petition a success – please share this petition with your friends and family. Petitions will succeed only by word of mouth, and every signature makes a difference! Forward our email, or simply send your friends this link:
http://www.thepetitionsite.com/1/ADULT-STEM-CELLS-NOW/

Make ADULT STEM CELL TREATMENTS

AVAILABLE in the USA NOW!

*ADULT STEM CELLS are the natural healing device in the human body.
*ADULT STEM CELL derived treatments are some of the greatest therapies know to modern medicine.
*ADULT STEM CELLS have all of the benefits and none of the side effects or controversy of embryonic stem cells. StemCells101:https://repairstemcell.wordpress.com/stem-cells-for-newbies/

There is only one problem…

ADULT STEM CELLS ARE NOT AVAILABLE TO PATIENTS IN THE USA!

ADULT STEM CELLS have allowed patients outside the USA to reap huge rewards of life extension and improved quality of life. In many cases, 60-70% of patients experience RECOVERY from so-called incurable diseases like Autism, Multiple Sclerosis, Spinal Cord Injury, Parkinson’s, Diabetes, Heart Disease and many others.

Millions of patients are struggling with diseases and the treatment options available to them are not helping them. Perhaps you have a friend or loved one with an incurable or debilitating disease. Perhaps you are a patient fighting for your own life. Shouldn’t patients in the USA be allowed to access one of the greatest treatments in the history of medicine?

Please sign this petition:

*To help put the MIRACLE of ADULT STEM CELLS into the political, scientific and public spotlight.

*So dying and debilitated patients can have a chance at recovery, life extension and the increased quality of life they so desperately need.

*So our own dying and incurable patients can be offered

ADULT STEM CELL TREATMENTS NOW!

Thank you!

For more information about the current state of adult stem cell treatments around the world, feel free to contact me at: dsgrano@gmail.com

OPTION A:  CLICK HERE TO SIGN THE  “ADULT STEM CELL TREATMENTS NOW!” PETITION

 

OPTION B:  IF YOU HAVE A TWITTER ACCOUNT YOU CAN SIGN & TWEET IT THERE


FEDERAL FUNDING FOR EMBRYONIC RESEARCH…SO WHAT?

In ALL ARTICLES on September 9, 2010 at 4:50 pm

FEDERAL FUNDING FOR EMBRYONIC RESEARCH…SO WHAT?

Embryonic Stem Cells come from embryos and have 1 goal only. They split + split through cell mitosis for 7 weeks until there is a fetus the size of a thumbnail. When they are manipulated to be used for treatment, they often revert back to their original goal. This means that they will start splitting uncontrollably at the site of injection, disease or injury. The natural result of this uncontrolled splitting is the development of cysts + tumors that often become cancerous. Because of this, Embryonic stem cells have NOT been used to treat any diseases in humans to date. Because embryonic stem cells are very likely to be rejected by the body, patients are frequently required to take immunosuppressive drugs. The ineffectiveness of embryonic stem cells for treating patients is the main issue that has stymied their research + use around the world, while the ethical + moral dilemmas further delay research in the USA. The FACT remains that Embryonic Stem Cells are considered a dead end in regard to treatments by some of the top Stem Cell minds in science (including the top embryonic stem cell scientists!).

To date, Embryonic research has been 100% fruitless (in regard to generating treatments) for well-funded + government supported scientists around the world for the last 11 years.

Dr James Thomson, father of embryonic research said: “…embryonic stem cells are not being used in any clinical applications yet, while alternatives such as adult stem cells figure in scores of therapies.”

Ian Wilmut, who led the team that cloned Dolly the sheep, abandoned his license to attempt human cloning, saying that the researchers “may have achieved what no politician could: an end to the embryonic stem cell debate.”

Dr. Bernadine Healy, former director of the National Institutes of Health, was quoted in U.S. News & World Report: “…embryonic stem cells, once thought to hold the cure for Alzheimer’s, Parkinson’s, and diabetes, are obsolete….. In fact, adult stem cells, which occur in small quantities in organs throughout the body for natural growth and repair, have become stars despite great skepticism early on.”

Embryonic stem cells MAY be researched further with federal funding + may provide great insights into medicine + disease but will NOT generate treatments for decades to come, if ever.

Adult stem cells, on the other hand, are the body’s natural healing cells. Their one job is to heal damaged organs and tissues. Adult stem cells have been used in bone marrow transplants for 40 years and have over a half decade of treatment in humans. Adult stem cells have virtually no side effects…in fact, a stem cell treatment using cells from your own body, when following standard quality controls, carries about the same amount of risk as drawing blood. To date, 130+ diseases have been treated with Adult Stem Cells with approximately 2/3 of patients deriving therapeutic benefits.

“Stem Cell Awareness Seminar” Tampa, FLA. Aug 28, 2010

In STEM CELLS IN THE NEWS on June 22, 2010 at 6:40 pm

“Stem Cell Awareness Seminar”


August 28,2010 1:00pm – 5:00pm
Free Admission – open to the public

SEMINAR FOCUS:

Learn the Truth regarding the differences between embryonic and adult stem cell treatments. Doctors, patients and others will share their knowledge and experiences with you and answer any questions you may have on stem cells.

Regenerative stem cell therapies for diseases, disorders and injuries will be discussed: ALS, Alzheimer’s disease, Ataxia, Autism, Cerebral Palsy, Diabetes, Heart disease, Lupus, Multiple Sclerosis, Muscular Dystrophy, ONH & optic disorders, Parkinson’s disease, Spinal Cord Injury and Stroke patients have shown significant improvements after treatment.

Several doctors will speak about the progress they have noted in their patients. They will share information with you both pre and post stem cell therapies. You will also hear from several stem cell patients who will share their personal experiences and views of this regenerative therapy. You can also read documented case studies of adult stem cell patients.

David Granovsky, author of “The Stem Cell Blog” and the 1st children’s book on stem cells  “Super Stemmys Doris and the Super Cells” will begin the discussions.

We look forward to meeting you!

LOCATION:

Marriott Tampa Airport Hotel
Tampa International Airport
4200 George J. Bean Pkwy.
Tampa, Florida 33607

Hotel Reservations 800-564-3440 , ask for Stem Cell awareness room block or Http://www.marriott.com/hotels/travel/tpaap? group Code= STCSTCA

SIGN UP:

Please RSVP by filling out the following survey:

STEM CELL AWARENESS SEMINAR SIGN UP SHEET/SURVEY

ORGANIZER’S CONTACT INFO:

Carol Petersen
Stem Cell Advocate
Ph: 1-941-235-0088
carolptrsn@msn.com

THE CLINICAL TRIAL MUSE SPOUTS OFF

In BUSINESS OF STEM CELLS on May 25, 2010 at 3:56 pm

My new friend, Dan just posted –

Can Web 2.0 Really Save Clinical Trial Participation Rates?

It never ceases to amaze me that people think that technology alone can improve clinical trial participation rates. What they need to understand is that potential study participants want to actually LEARN more about clinical trials before they sign up for a study. Having an app that can find open studies available for your phone is not going to encourage anyone to actually join a study. What is missing is the human touch, and research professionals doing more education themselves and not outsourcing study participant recruitment to third party vendors.  Via: Save Clinical Trial

-Dan

————————————————————————————————————–

Dan poses an interesting question that got me thinking. In support and response, here are a few of my thoughts…

THE CLINICAL TRIAL MUSE SPOUTS OFF


A few thoughts…

  • ***I fully support and applaud Dan’s movement/efforts to re-evaluate and reform the clinical trial parameters and process so it is more patient friendly.
  • ***Changing the trial process to help those within the trial is a great step in the right direction.
  • ***I would further like to see the process changed to help those patients outside of the trials who are sick, desperate and with no available options ‘to get better’ within our current medical practices.

A few facts…

  • ***1938 – the Federal Food, Drug, and Cosmetic Act was the first attempt to regulate cosmetics and medical devices requiring that drugs be proven safe prior to marketing.
  • ***It typically costs 500-700 million dollars and 7-10 years to bring a drug public, including the clinical trial process.
  • ***The current clinical trial process severely limits the available treatments for thousands of disorders because there just is no hope of recouping the expenditure to study them properly.  For ex: A very effective drug for treating a rare form of glioblastoma drug was abandoned because there was only 23,000 people in the US with the disease [ $500mil/$23k = ~$22k per patient just to break even on the expenditure!! ]
  • ***The clinical trial process is based on an outdated and “broken” paradigm that has let many drugs pass only to be pulled off of the market when patients started developing serious complications or dying from the “safe and approved” drugs.
  • ***New technologies like stem cells are now available all over the world except in the US because the FDA is trying to force stem cells to be a “clinical trial drug” which they are not.


A few conclusions…

  • 1.  The clinical trial process from soup to nuts MUST be revamped…perhaps with many of the ideas Dan proposed.
  • 2.  The clinical trial process must be reformed based on the goal of “treating more patients and more diseases safely and well”…not the goal of “recouping expenditures for the trials.”
  • 3.  The clinical trial process must be torn down and rebuilt anew for those procedures that exist outside of the historic and pre-conceived notions of medicine…those that are not “DRUGS,” like adult or repair stem cell treatments.

CATCH UP ALREADY!! Heart Stem Cells Move Closer to Human Treatments

In VICTORIES & SUCCESS STORIES on February 25, 2010 at 3:29 pm

It’s nice they are recognizing the benefits of adult stem cells finally.  But they are still slow to catch up to the UNDENIABLE SCIENTIFIC PROOF.

Heart Stem Cells Move Closer to Human Treatments

‘Patch’ for damaged heart is just one of several promising developments
By Amanda Gardner, HealthDay Reporter

WEDNESDAY, Feb. 24 (HealthDay News) — Researchers are moving ahead — although sometimes ploddingly — toward the goal of using stem cell therapies to rescue people with cardiovascular disease, the leading killer of men and women in the United States.

Although much of the gains thus far have been in basic science, stem cells do seem close to actually being able to help actual humans.

“We have seen consistent but modest effects of stem cells in improving heart function and reverse remodeling of heart,” said Dr. Gordon Tomaselli, a spokesman for the American Heart Association and an associate professor of medicine at the Johns Hopkins University School of Medicine in Baltimore.

“I think there’s great hope,” added Dr. Darwin J. Prockop, director of the Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White in Temple.

Several studies presented last November at the annual scientific sessions of the American Heart Association in Orlando serve as examples.

In one study, out of Germany, 35 patients who received bone-marrow stem cell transplantation during coronary artery bypass surgery achieved “excellent long-term safety and survival.”

Ten patients who received similar transplantations after repair of mitral valves also fared well, with improvements in the heart’s pumping capacity.

Slovenian investigators had similar success, with improvements seen in patients with advanced heart failure who received bone-marrow derived stem cells.

There were also advances in gene therapy reported, with Singaporean researchers using nanotechnology to deliver genetically modified cells to help heal heart attack damage in rabbits.

The stem cell promise hinges on the ability to produce unlimited supplies of human cardiac cells, experts say.

Kevin Eggan, chief scientific officer for the New York Stem Cell Foundation and associate professor of stem cell and regenerative biology at Harvard University, noted two breakthrough treatments that would require steady production of stem cells.

One is a future “patch” made out of these cells to fix a damaged heart after a heart attack. Researchers also hope to fashion blood vessels out of stem cells for use in bypass surgery and other procedures.

“People are making very substantial progress in being able to make those various vascular cells you would need,” Eggan said. “Transplanting those is something that will come from all of this.”

More immediately, perhaps, is the use of stem cells to screen heart drugs, sort of like test-driving the drugs in preclinical trials, Eggan said.//

“You can do this in a couple of different ways,” Eggan said. Researchers could determine in a laboratory dish if a drug actually works on heart cells, he said. The other method would involve manufacturing heart cells for a variety of people to find out which cells the drugs work on.

“One of the tricky things about drug trials is they often don’t work on all people equally well,” Eggan explained. “You have to study a whole lot of people to be able to see any sort of effects. This would screen out people that the drug doesn’t work on. It would enable personalized medicine.”

One innovation that is close to market, Eggan said, is a method for identifying and eliminating toxic drugs before they go into clinical trials.

A system is in the works that would involve testing drugs on heart muscle cells in a lab dish.

“This could save enormous time and money in clinical trials,” Eggan said.

Gene therapy has not advanced as far, he added, but predicts that it will combine with stem cell therapies in the future.

“The one good thing that really has come out is that nobody has been harmed by [the stem cell] therapies,” Prockop pointed out.

More information

http://www.healthscout.com/news/1/635506_2/main.html

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DR REUBEN FAKE TRIAL RESULTS FOR PFIZER

In BUSINESS OF STEM CELLS on February 18, 2010 at 3:29 pm

“It’s being called the largest research fraud in medical history.

————————————————

[Click here for larger image of list.]

https://repairstemcell.wordpress.com/2010/02/18/pfizer-celebrex-bextra-vioxx-clinical-trial-results-were-fake-fraud/

Yes, We Need a Different Conversation, Surgeon General…

In ALL ARTICLES on February 16, 2010 at 9:40 pm

“American is straight-jacketed in western-empirical medicine doctrines, summed up, quite unspectacularly as: “if it ain’t broke, don’t fix it.”  We eat poorly, don’t exercise, make bad choices and only when we have a heart attack or other significant medical event do we seek professional help.  This leads to a lifetime of decline in one’s health, energy and vitality with no pro-active efforts towards maintaining health, increasing longevity, making decisions that will have positive repercussions in the long term.

Only when the symptoms of disease become so pervasive that they are readily identifiable by the patient do they even consider going to their doc, questioning how they got there, changing there lifestyle choices and begin the process of “fixin what’s broke.”  More often than not, by that time, it is already to late for any intervention but the most drastic and then the cure is often equal to or worse than the disease – radiation, chemo, surgery, etc..

Not only does the conversation have to change, the entire attitude must change.  There must be a shift in how we perceive our lifestyles and act on our own behalf.  We must shift from patient dependent on others giving us our options to self-advocate, working hard to lead healthy lifestyles.  There must be a shift towards healthy living and prevention and away from post-diagnosis invasive intervention.

What is your role in your health?  Are you a patient?  Are you a self-advocate for your won health?  Can these things coincide?  The word “Patient is derived from the Latin word patiens, the present participle of the deponent verb pati, meaning “one who endures” or “one who suffers”. I think it is extremely telling when the expectation of anyone seeking medical help is that they will have to endure and suffer. Was this what Hippocrates had in mind? Not likely.”
via https://repairstemcell.wordpress.com/2009/03/22/on-patients-and-patience/

Redefine the conversation, sure…but redefine your attitude, your own role in the conversation, your goals for your health and life, your longevity and vitality, your attitude towards your health.  It’s time to be an active player in the script of your life and your health, not a sometimes pawn taking no responsibility for your well-being until you get ill, at which point your options are extremely limited and you have to give up that responsibility to someone else.” -dg

Yes, We Need a Different Conversation, Surgeon General. But In More Ways Than One

I’m not going to weigh in on whether the new Surgeon General, Regina M. Benjamin, should be thinner. Of course you’d have had to expect that controversy to erupt nano-seconds after she assumed office on January 11, and it did.

Instead, I want to push Benjamin’s platform even further forward. Benjamin talks about changing the national conversation. I say we have to change how we conduct that conversation…

http://www.huffingtonpost.com/riva-greenberg/yes-we-need-a-different-c_b_464537.html?just_reloaded=1

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