DAVID GRANOVSKY

Posts Tagged ‘PALSY’

PARENTS WHO WILL STOP AT NOTHING TO HEAL THEIR OWN

In ALL ARTICLES, OFF THE BEATEN PATH on April 24, 2013 at 11:00 am

Dedicated to the amazing women (and men) who are doing everything in their power to heal their children…

Do not confuse them for a distracted and solitary parent sitting alone in a dark corner on a laptop, sipping a spritzer and dangling a toe into stem cell treatments.

These are parents who are researching for years, they network and talk to everyone they can get their hands on, they create pages and sites and media campaigns, they compare data with each other and they do it better than a super computer, more relentlessly than a pit-bull and they do not give up and do not surrender.

They are intense and even fanatical researchers with passion, drive, motivation, education and intelligence and they are going to change the entire stem cell industry from the inside out.  You can love them or hate them but do NOT get in their way.  They are blind to bureaucracy, oblivious to obstacles and dismissive of despair.  Their engines run on the nova hot burning jet fuel of a parent’s love for their child, they wield weapons built on research and science and wear impervious suits of armor forged in hope.

They are stem cell moms and they are organized and aggressive and nothing will stand in their way.

They are…

THE STEM CELL MOMFIA

wgun4

CEREBRAL PALSY AND STEM CELLS

In STEM CELLS IN THE NEWS on April 10, 2012 at 10:24 am

https://repairstemcell.wordpress.com/2011/02/22/little-lucass-stem-cell-hope/
https://repairstemcell.wordpress.com/2010/08/28/cord-blood-wakes-up-drowning-victim%e2%80%99s-brain/

https://repairstemcell.wordpress.com/2010/07/12/shiu-sisters-cp-and-rop-adult-stem-cell-patients/

Duke U. CLINICAL TRIAL for Cerebral Palsy & other newborn brain injuries – http://www.clinicaltrials.gov/ct2/show/NCT00593242?term=hypoxic+ischemic+encephalopathy&rank=3 – for more information – http://parentsguidecordblood.org/content/usa/medical/autocbt.shtml or for anecdotal info – Abby , Chloe, Dallas

Dallas Hextell, a 2-year-old from Sacramento, California, received an infusion of his own umbilical cord blood as part of the Duke University clinical trial. Within five days, he showed improvements in the limitations imposed by the condition.  video: http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985
via http://www.youhavealawyer.com/blog/2008/03/26/cerebral-palsy-improvement/

“a toddler with cerebral palsy, who experienced dramatic improvements in his disability following an experimental procedure involving a stem cell transplant.” – http://pediatrics.duke.edu/modules/dept_peds_annc/index.php?id=79\

Cerebral Palsy: Cord Blood Stem Cell Research and Treatment in Clinical Trials – Update

Thursday, April 29th, 2010

For those of  you who follow our blogs, you know well that this is a topic of interest for us.  It bears repeating – our job as lawyers is to properly investigate potential claims of malpractice in areas such as cerebral palsy and seek redress for our clients when the evidence demonstrates a connection between birth injuries and medical care, but the much more important topic for our clients and victims of cerebral palsy is in the field of medical research. It is through research efforts – including clinical trials – that this dreaded condition will be ameliorated and hopefully eradicated. Trust me, after practicing law for over 35 years, I’m not worried about job security – the frailties of the human condition will more than suffice to fill our file cabinets with people to help due to the negligence of others.

We have reported previously on various topics involving cord blood and stem cell research as they relate to a number of conditions, including cerebral palsy.  It seems that months have passed since there has been any significant news about two programs underway: one at the Medical College of Georgia and the other at Duke.  Earlier this month, an update came across the social media network via a post by Singularity Hub – Cord Blood Stem Cell Treatment for Cerebral Palsy in Clinical Trial | Singularity Hub.

Here’s our encapsulated version regarding the studies and Singularity Hub’s report.

Photo provided by MSNBC

Duke University

According to the website ClincalTrials.gov, Duke began a clinical therapeutic trial – identifier: NCT00593242 - in January 2008 (estimated completion date of January 2011) whose primary purpose is listed as treatment of newborns with hypoxic ischemic encephalopathy (HIE) – inadequate oxygenation in the perinatal period for purposes of this study – through the controlled “collection, preparation and infusion of a baby’s own (autologous) umbilical cord blood in the first 14 days after birth if the baby is born with signs of brain injury.” For information concerning the inclusion and exclusion criteria for participation in this clinical trial, see the online posting. Essentially, the babies are then to be “followed for neurodevelopmental outcome at 4 – 6 and 9 – 12 months at Duke’s Special Infant Care Clinic. MRI’s will be obtained between postnatal weeks 1 and 4, and, for study purposes at 4 – 6 postnatal months.”

While other aspects of processing and administration are no doubt part of the key components of this project, it is readily apparent that the end-point goal is discovery of an effective treatment of cerebral palsy for the identified neonates in the study and then development of a second stage clinical trial to take such treatment modality to a greater number of potential beneficiaries.

Medical College of Georgia

For detailed information on this study, which began in February of this year, similar information is available through ClinicalTrials.gov under identifier NCT01072370.  This clinical trial investigation has a patient population consisting of children from ages of 2 to 12, “whose parents have saved their infant’s cord blood, who have non-progressive motor disability, and whose parents intend to have a cord blood infusion.”  Again – for full details regarding inclusion and exclusion criteria, see the full online posting.

For those parents who may be interested in determining if their child would qualify to participate, the study is still recruiting participants.  The contact information is also available at this link: Contact: James E Carroll, M.D.     706-721-3371     jcarroll@mcg.edu

Today’s report from Singularity Hub provides some encouraging – albeit anecdotal – news of potential progress.

The anecdotal evidence in support of treating cerebral palsy with cord blood stem cells is astounding. Much of it has actually been been performed at Duke University by one of the investigators in the pilot study: Joanne Kurtzberg. Among those that have been successfully treated at Duke include Ryan Schneider, Maia Friedlander, Chloe Levine, and Dallas Hextell. All had CP or CP-like symptoms and all made remarkable recoveries after cord blood stem cell treatments. Dallas Hextell, who showed improvements just 5 days after his therapy was featured on the Today show (the original report contains video compliments of MSNBC).

In addition to the early good news coming out of these projects, one other lesson is learned – for the time being, the storage of cord blood is an important component for those hoping to participate in such studies – particularly that being conducted at the Medical College of Georgia.  We have earlier reported on this topic as well.  You may want to refer to our early posting for some basic information if you are interested.

Obviously, the implications – if these projects prove to be successful – are far-reaching. The enthusiasm of the participants in these research projects is not limited to them alone. The words of the author, Aaron Saenz, from Singularity Hub somewhat tells it all:

So we have some exciting news for cerebral palsy, and some exciting news for those thinking about cord blood. What about the rest of us? Well the MCG and Duke work has some far reaching implications. Neurological damage, whether it’s caused by oxygen deprivation or some other injury, is one of the most difficult things to heal in the body. Work in animals (like that done by Carroll on rats) show that stem cells can not only help damaged brain cells recover, but they can also replace cells that have died. We may find that stem cells therapies have a wide range of applications for many different forms of brain damage. Kurtzberg is researching many different ways cord blood could be used (autologous or through donors) to treat a variety of conditions. In other words, today stem cells conquer cerebral palsy…tomorrow, the world.

Let’s all hope that Mr. Saenz is a prophet.

 

https://repairstemcell.wordpress.com/2010/10/24/the-challenging-life-of-a-young-man-with-cp-neil-barron/

Little Lucas’s stem-cell hope

In VICTORIES & SUCCESS STORIES on February 22, 2011 at 7:17 pm

LUCAS Garland has spent more time in hospital than most.

The three-year-old from Morayfield spent the first 116 days of his life in intensive care.

Born at just 25 weeks and weighing just 910g, his mother Louisa and father Nathan were told their newborn son was not expected to live.

UNCONDITIONAL: Louisa Garland has organised a fundraiser for son Lucas, 3. Picture: RUSSELL BROW

UNCONDITIONAL: Louisa Garland has organised a fundraiser for son Lucas, 3.

Picture: RUSSELL BROW

“We have a picture just after he was born and he was slightly larger than my hand,’’  Mrs Garland said.

After defying the odds to survive, Lucas was diagnosed with spastic quadriplegia cerebral palsy in August 2009.

Being born premature, Lucas’s developmental age is estimated at 12 months.

He has only just started to crawl, and is still unable to communicate through speech with his family.

“He has his own way of letting us know what he wants but we can see him getting frustrated sometimes when he isn’t able to communicate with us,’’  Mrs Garland said.

But despite the numerous setbacks in his short life, the Garland family has begun a journey to try and give Lucas a chance at a normal life.

The Quest for Lucas aims to raise $35,000 for the Garland family to travel to Europe for Lucas to undergo stem cell therapy.

“We would hope that the therapy could improve his balance and walking, allow him to speak clearly and reduce spasticity,’’  Mrs Garland said. “There would be no better feeling than to finally see Lucas mobile.

“It would mean a lot to us … we prefer him to be able to do things physically for himself. It will get to a point that we can no longer move him.’‘

The first event in the Quest for Lucas will be a fashion show held this Friday at the Strathpine Community Centre.

“It’s a very exciting time for us to see it starting to come together,’’  Mrs Garland said.

Will The Catholic Church sponsor a CP patient’s Medical Treatment?

In STEM CELLS IN THE NEWS on November 19, 2010 at 3:43 pm
Will The Catholic Church sponsor a CP patient’s Medical Treatment?

The Catholic Church has taken notice of the challenging life of a young
29 year old man with cerebral palsy. The Catholic Churches recent
endorsement of adult stem cells is a true blessing for Neil Barron of Phenix
City, AL. Neil has Mixed Cerebral Palsy, he is a quadriplegic destined to live
out his deteriorating life in a wheelchair.

The recent advancements in medical therapies using adult stem cells has shown
significant improvements in the quality of life of several cerebral palsy patients
treated in China. Neil has been accepted for adult stem cell therapies in China
so he has been desperately seeking financial support.

Neil’s constant prayers and reaching out for help was answered by the Catholic
Church. Reverend Thomas Weise splits his time between two Roman Catholic
Churches, St. Patrick’s Church and the Mother Mary Parrish, both of Phenix City,
AL. Reverend Thomas Weise, a theologian with four degrees, is dedicated to
helping his community. After meeting Neil and introducing him to the church
community Reverend Weise is heading the fund raising for Neil’s adult stem cell
therapies in China. Neil’s treatments are scheduled for next month, December 28, 2010.

Our Sincere thanks to Reverend Thomas Weise and the church community of Phenix City,
Alabama.

https://mail.google.com/mail/?ui=2&ik=8217d5dacc&view=att&th=12c606ab71302f67&attid=0.1&disp=inline&zw

God Bless!

Carol Petersen
Stem Cell Advocate
Awareness Program Coordinator
Ph: 1-941-235-0088
Fx: 1-941-624-6133
Email: carolptrsn@msn.com
http://www.youtube.com/user/carolptrsn
http://stemcellsadvct.weebly.com
http://www.cameronsmiraclofsight.com
http://www.stemcellsforhope.org
http://www.stemcellaware.com

Shiu Sisters – CP and ROP Adult Stem Cell Patients

In ALL ARTICLES on July 12, 2010 at 11:27 am

Shiu Sisters – Cerebral Palsy and ROP – Adult Stem Cell Treatment

Tuesday, 29 June 2010 11:34

Sisters from Hong Kong, both Celia and Angelica have CP. Angelica also has ROP–a common retinal problem common in premature births. They received adult stem cell therapy together.

Celia: 2 years old, Cerebral Palsy

Angelic: 4 years old, Cerebral Palsy and Retinopathy of Prematurity (ROP)

Condition Before Treatment

Angelica was born prematurely, and as a result suffered a brain injury which lead to Cerebral Palsy and ROP. Her mother, Eileen describes her condition, “we have found that her speech is quite delayed and so is her interaction with other people. Her vision is pretty bad because she has ROP”

Her sister, unfortunately, was also diagnosed with CP at the age of one and a half. Her mother describes her symptoms, “the major problem with Celia is related to motor problems, her gross motor skills are lacking and there is some delay with her fine motor skills… She could not walk before she came here, and her balance was very poor so her alignment was off when standing, so she had very poor posture.”

Though both girls were receiving conventional therapy in Hong Kong and doing well, their parents were afraid that they were not reaching the proper developmental milestones. After careful research, they decided that stem cell therapy would help their daughters meet their goals.

Treatment

Both Sisters received 6 umbilical cord blood stem cell injections along with physical therapy, occupational therapy, electric wave therapy, and acupuncture.

Condition After Treatment

After receiving stem cell treatment, both sisters started experiencing changes in their condition.

Celia, in particular, saw dramatic improvement in her strength and mobility. Her mom explains, “After the second treatment, she got more power. She was willing to stand more and she asked me to help her to stand up and she wants to walk. And she can. She is starting to walk! I am very happy to see this result. She stands and walks, I think, around 4 hours a day. And before she came here she could not stand for so long. Probably a half hour a day is all she could do.”

Eileen also saw improvements in Angelica’s behavior and vision,
“Well she has more interaction with people and I think there is some improvement in her vision, because when I take pictures of her and I tell her to look at the camera she really is able to look at the camera. So I am pleased to see this result too.

“When I talk to her and ask her to do something, it seems like she really hears it and she does what I tell her. She is actually listening. So I am pleased to see her behaviors change. I think it helps my elder daughter catch up in her development.”

New trial tests cord blood in regenerating neuro damage

In STEM CELLS IN THE NEWS on March 13, 2010 at 11:23 pm
New trial tests cord blood in regenerating neuro damage

By Joe Pangburn, Inside Tucson Business
Published on Saturday, March 13, 2010

Cord Blood Registry and Tucson Medical Center want to help newborns at-risk for neurological injury avoid the pain of diseases such as cerebral palsy.

The two organizations, along with the Save the Cord Foundation and the Watching Over Mothers and Babies Foundation, have begun Newborn Possibilities – a first-of-its-kind program which may offer new options for children who are at risk of developing cerebral palsy.

For every 1,000 children born in the U.S. today, two to three are at risk for developing cerebral palsy because of injuries to the brain that may have occurred prior to or during birth. There is currently no cure for cerebral palsy. Premature and underweight babies have a higher risk of neurological damage and are examples of the kind of children who  would be eligible to enroll in this program.

The delivering doctor would explain to the mother the risk and the program, but it is the parent’s decision to have the cord blood saved or not.

Tucson Medical Center (TMC) began collecting the newborn cord blood stem cells of children born at risk for neurological damage last fall. About 240 samples have been collected. Cord Blood Registry (CBR) anticipates collecting 780 samples in the first year of the program at no cost to the families of the children.

If a child is diagnosed with the neurological damage – after around a year to a year and a half – he or she may be eligible to receive a new treatment being researched under approval from the U.S. Food and Drug Administration (FDA) using the child’s own cord blood stem cells.

“This program is a way for us to provide a safety net to children at-risk for cerebral palsy and other forms of neonatal brain injury while helping to advance the science of regenerative medicine,” said Tom Moore, chief executive officer of CBR. “CBR and our collaborators in this unique program share a commitment to advance cord blood stem cell research, expand education about the value of cord blood banking, and improve outcomes for children with neurological disabilities.”

A growing body of published data suggests that a child’s own newborn stem cells from the umbilical cord may play an important role in helping the body repair damage to nerve and brain tissue. In studies using animals, research has shown that cord blood stem cells have the ability to migrate to the site of injury in the brain and, in certain cases, have been shown to prevent neurological deterioration and even cause cognitive improvement.

This research has led the FDA to approve a human clinical trial evaluating the safety and efficacy of using a child’s own newborn blood stem cells to treat cerebral palsy.

The first FDA-approved human clinical trial evaluating the use of a child’s own newborn stem cells in the treatment of cerebral palsy has just been initiated at the Medical College of Georgia. CBR is the only cord blood bank to participate in this trial to ensure consistency and quality of the stem cells used.

The procedure is a 15-minute transfusion from the child’s stem cells. Moore said he is working with several researchers in Tucson to establish a local trial working with cord blood stem cells so families won’t have to travel to Georgia for the procedure.

Moore also said some of the kids will never present any neurological problems. But that most trauma in children’s lives happens in the first four years and that the cord blood stem cells could be used in cases where the child has a near-death experience that causes neurological damage.

“If we can keep a kid out of a wheelchair or help restore functions in their brain, that is the kind of thing that really gets me jazzed up.” Moore said.

Contact reporter Joe Pangburn at jpangburn@azbiz.com or (520) 295-4259.

Copyright © 2010 Inside Tucson Business

First FDA-approved stem cell trial in pediatric cerebral palsy

In VICTORIES & SUCCESS STORIES on February 12, 2010 at 1:04 am

Actually, I’m confused.  Here are the links to the Duke University and Northwestern University clinical trials on pediatric cerebral palsy with umbilical cord derived stem cells (story published 03/26/08 ) https://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/ plus, you can get treatments already if you are willing to leave the country: http://bit.ly/PATIENTQUESTIONNAIRE

So how is this one at the Medical College of Georgia the first? – dg

FOr example: “Dallas Hextell, a 2-year-old from Sacramento, California, received an infusion of his own umbilical cord blood as part of the Duke University clinical trial. Within five days, he showed improvements in the limitations imposed by the condition.  video: http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985
via http://www.youhavealawyer.com/blog/2008/03/26/cerebral-palsy-improvement/ “

Let’ not forget these trials… https://repairstemcell.wordpress.com/2009/10/10/do-stem-cell-treatments-work/

CEREBRAL PALSY CLINICAL TRIALS

CerebralPalsy

First FDA-Approved Stem Cell Trial in Pediatric Cerebral Palsy

ScienceDaily (Feb. 11, 2010) — Medical College of Georgia researchers are conducting the first FDA-approved clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy.

The study will include 40 children age 2-12 whose parents have stored cord blood at the Cord Blood Registry in Tucson, Ariz.

Umbilical cord blood is rich in stem cells, which can divide and morph into different types of cells throughout the body, said Dr. James Carroll, professor and chief of pediatric neurology in MCG School of Medicine and principal investigator on the study.

Cerebral palsy, caused by a brain injury or lack of oxygen in the brain before birth or during the first few years of life, can impair movement, learning, hearing, vision and cognitive skills. Two to 3 children in 1,000 are affected by it, according to the Centers for Disease Control.

Animal studies indicate that infused stem cells help injured brain cells recover and replace brain cells that have died, Dr. Carroll said.

“Autologous stem cell transplantation, in which the transplant recipient is also the donor, is the safest form of stem cell transplantation because it carries virtually no threat of immune system rejection,” he said.

While no controlled clinical trials have been conducted to date, previous studies have shown marked improvement in children with cerebral palsy about three months after an initial infusion of cord blood.

“Evidence up to this point has been purely anecdotal,” Dr. Carroll said. “While a variety of cord blood stem cell therapies have been used successfully for more than 20 years, this study is breaking new ground in advancing therapies for brain injury — a condition for which there is currently no cure.”

Children will begin the study with a neurological exam by MCG pediatric neurologists Elizabeth Sekul and Nicole Brockway. Then, half of the study participants will receive an infusion of their own cord blood while the other half receive a placebo. Three months later, the children will be evaluated without physicians knowing which group received the stem cell infusion. Afterward, children who didn’t get the cord blood initially will receive an infusion. Children will return three and six months later for evaluation.

Researchers will periodically assess the children’s motor skills and neurological development.

“For the purposes of this study, we’re not looking at stem cells as a possible cure; rather whether stem cells can help change the course of these types of brain injuries in children,” Dr. Carroll said.

Study participants must have been unable to sit independently by 12 months or unable to walk by 18 months and must be seizure-free or have seizures that are adequately controlled.

To ensure consistency in cord blood stem cell processing, storage and release for infusion, the Cord Blood Registry is the only family stem cell bank participating in the study.

The trial is also receiving support from the Associazione Figli Inabili Banca d’Italia, a private organization in Italy that provides financial assistance to parents who can’t pay for their children’s medical treatments.

via First FDA-approved stem cell trial in pediatric cerebral palsy.

DO STEM CELL TREATMENTS WORK?

In VICTORIES & SUCCESS STORIES on October 10, 2009 at 10:43 am

DO STEM CELL TREATMENTS WORK?

Do not take one step further in your plans for treatment or read one more word about stem cells anywhere else until you believe that we have answered this question, unequivocally and without a shadow of a doubt:

DO STEM CELL TREATMENTS WORK?

Ask most US doctors if repair stem cell treatments work and they will tell you “NO!”  You may also get condescending retorts, misinformation and derisive abuse.  But if you press them on the question, eventually they will give you the reason why they believe repair stem cells don’t work.  The top answer WHY STEM CELLS DON’T WORK is… (Survey Says!):

There have been no clinical trials to date that prove they do work.

When all is said and done, in the end, there is nothing that will convince a western doctor of the effectiveness of stem cell treatments besides clinical trials.  So have there been any stem cell clinical trials? Is all of the evidence supporting the benefits of stem cell treatments anecdotal as virtually every western doctor says? NOT ON YOUR LIFE! Have there been clinical trials?  The answer is a resounding “YES!”

According to the National Institutes of Health, there were and are ~2600 stem cell clinical trials around the world – http://www.clinicaltrials.gov/

  • Of those ~2600 trials, there are only nine mentions of embryonic stem cells.
  • Of those 9, there are no actual embryonic clinical trials.
  • Of those ~2600, there are ~2591 mentions of adult stem cells.
  • Of those ~2591, about half of them (~1300) are actual adult stem cell clinical trials.

Let’s look at (only) a few of those ~1300 clinical trials:

HEART DISEASE CLINICAL TRIALS

  • 2002 – clinical trial led by Dr. Hans Dohmann plus six colleagues in Brazil took 21 transplant candidates and gave 14 of them bone marrow cells. The results were so spectacular that the American Heart Association accepted the paper and it was presented in 2003. Five of the seven in the control group opted in to make a total of 19 stem cell transplants. The mortality rate for transplant candidates is about 35% per year. At that rate there would be, of those 19, only 2.2 patients still alive without a transplant after five years. There were, in fact, 12 alive as of Dec. 31, 2007; more than five years down the road.
    • In 2002, if you did not want or could not get a heart transplant (as is true of 90%+ of dying heart patients in North America) then you had to make a choice between stem cell treatment or standard Western Cardiology methodology.
  1. Western Cardiology methodology in 2002 kept 12% of transplant-waiting-patients alive for five years.
  2. Adult/repair Stem cell treatments in 2002 kept 63% of transplant-waiting-patients alive for five years.  More than 5 times more heart transplant candidates lived for 5 years with stem cell treatments than the typical heart transplant recipient! Btw, stem cell science has made huge advancements in treating heart disease over the past seven years.
  • 2003 – Dr. Andreas Zeiher of the Goethe Institute in Frankfurt began much larger trials. As of 2007, he has overseen more ASC implants into hearts than anyone, both in and out of clinical trials and he was the first to prove that timely implant of RSC in new heart attack victims improves future mortality and morbidity – http://circ.ahajournals.org/cgi/search?journalcode=circulationaha&fulltext=zeiher
  • 2004 – Dr. Amit Patel of Pittsburgh completed two of the most successful trials ever.  In Uruguay, he proved, on a group of ischemic heart failure patients, that a bypass plus cells was infinitely better than a bypass only. That same year, TheraVitae, in Israel, developed a new, powerful blood-derived stem cell and dared to treat the sickest patients no clinical trial (except Brazil) would consider.
  • 2004 – One of the Brazilians, Dr. Perin, came to Texas, used the Brazil results to get the first ASC heart clinical trial approved by the FDA. Over a dozen such approvals were granted in the next 12-18 months.
  • Clinical trials at the Mayo Clinic in Florida have seen successes in reversing and curing pulmonary hypertension using adult stem cells from patients’ own blood.

diabetes-RED

DIABETES CLINICAL TRIALS

  • FIRST USE OF CORD BLOOD TO ALTER COURSE OF TYPE 1 DIABETES, June 25, 2007 – (I’ll bet nobody heard of this one!)transfusion of stored, autologous (i.e. the person’s own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association’s 67th Annual Scientific Sessions. –http://parentsguidecordblood.org/content/media/m_pdf/ADA_T1D_PR-06-25-07.pdf(The ADA in 2007 knew stem cells can treat Diabetes type 1 in children!)
  • Diabetes type 1 stem cell clinical trial – Enrollment 11/2003-4/2008, follow-up until December 2008 – https://repairstemcell.wordpress.com/2009/09/14/type-1-diabetes-stem-cells-clinical-trial/
  • Why no diabetes clinical trial s in the US when mice were cured of diabetes type 1 in the 1990’s? -  Weissman, a professor of pathology and developmental biology at Stanford University, states: “Stem cells are rare, self-renewing, and can regenerate body tissues.” He repeatedly expressed frustration that while many of his discoveries seemed to hold remarkable potential for life-saving treatments, commercial or regulatory hurdles have prevented his scientific research from benefiting human beings. One example is, his mid-’90s research on type I diabetes, in which he demonstrated the ability to fully cure type I diabetes in mice using stem cells. Even though the experiments avoided political controversy by using adult/repair stem cells, which do not come from embryos, Weissman ran into a road block when pharmaceutical companies refused to sponsor clinical trials. The therapy went nowhere. “The pharmaceutical companies had put profit over principle, preferring to keep diabetes sufferers dependent on costly insulin than to cure them once and for all.” – https://repairstemcell.wordpress.com/2009/09/13/research-from-90s-cures-type-1-diabetes/

CerebralPalsy

CEREBRAL PALSY CLINICAL TRIALS

AMPUTATION CLINICAL TRIAL

  • Bone Marrow Stem Cell Treatment Saves Legs – The results of a clinical trial to save volunteers’ leg from amputation by injecting (autologous bone marrow) stem cell concentrate to the limb affected by thrombo angitis obliterance (TAO) have been encouraging. The clinical trial is being conducted on patients suffering from blocks in the artery of the leg. Sixty patients enrolled, all of them were smokers. Some had diabetes.  “We have got very good results,”said Dr. K.S. Vijayaragavan, head of the Department of Vascular Surgery, Sri Ramachandra University, Chennai, who is conducting the trial. “The legs of 89 per cent of the patients have been saved.”

stroke

STROKE CLINICAL TRIALS

  • “The stem cells had excellent safety profile. After carrying out Pet scans and MRIs thrice in a year on patients who received stem cells, we found no side effects. This study shows that stem cells are a safe and feasible therapy in acute stroke. https://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
  • The University of Texas, Health Science Center at Houston July 1, 2009       Several months after becoming the first patient in the United States to undergo a revolutionary new stroke treatment, Roland “Bud” Henrich continues to improve. Doctors intravenously injected Henrich, 61, with stem cells taken from his own bone marrow…”The stem cells, we believe, may help repair the damage to his brain caused by the stroke,” said Sean Savitz, M.D., assistant professor of neurology at The University of Texas Medical School at Houston and the study’s lead investigator. “Animal studies have shown that when you administer stem cells after stroke, the cells enhance the healing. We know that stem cells have some kind of guidance system and migrate to the area of injury. They’re not making new brain cells but they may be enhancing the repair processes and reducing inflammatory damage.” http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

Other stroke articles:

MyelinGraphic

MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” - January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

What is clear is that the overwhelming majority of Repair Stem Cell vs Disease clinical trials have been successful.

  • The majority of patients treated with stem cells get better.

Not all, but the majority.

  • The majority of patients treated with stem cells get better.

Not cured, but better.

No western doctor in the world can come to matching the statistical success of stem cell treatments with pill-based “cures” for diseases that they define as “untreatable” and “incurable.”

WHAT HAVE WE LEARNED?

What have we learned?

  • Now you know there are 1300 real adult/repair stem cell clinical trials.
  • Now you know that adult/repair stem cell treatments work on most patients.
  • Now you know that while the disease is not cured, their condition does improve considerably.
  • Now you know that stem cell treatments are a significantly better choice than pill after pill after pill.
  • Now you know that stem cell treatments can provide more benefit to patients with so-called “incurable” diseases like Diabetes, Heart Disease, Stroke, Multiple Sclerosis and Cerebral Palsy.

Based upon this information, can you now answer the question DO STEM CELL TREATMENTS WORK?

OF COURSE YOU CAN!

Based upon this information, can you now answer the question DO STEM CELL TREATMENTS WORK unequivocally and without a shadow of a doubt?

OF COURSE YOU CAN!

Well do they?

OF COURSE THEY DO!

Green light!

Green light means go!  You may now take the next step in your plans for treatment!

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Helping those with so-called “untreatable” medical conditions make educated choices and connect with the world’s finest, most advanced stem cell doctors.

‘No proof’ of benefit to children????

In ALL ARTICLES on September 23, 2009 at 11:26 am

The factual information is only half here and the conclusions are all wrong! My comments in red. -dg

No proof’ of benefit to children

By REBECCA TODD – The PressLast updated 05:00 23/09/2009

Stem-cell treatment is “highly experimental”, with “potential hazards“, the Paediatric Society of New Zealand warns.

Re: “highly experimental”
  • There have been thousands of adult/repair stem cell treatments with virtually no side effects and a significant proportion were successful.
Re: “potential hazards”
  • By not differentiating between the problematic embryonic stem cells with a history of causing tumors and the non-problematic adult stem cells with a history of treating people successfully, the author  effectively generalizes to the point of ridiculousness.  This is like saying: “all bacteria is bad.” (think pro-biotic and beneficial flora in the digetive tract)

… society president Rosemary Marks said the therapy (had) no controlled studies to back claims of dramatic improvements.

Re: “No controlled studies:”
  • 5,030 scholarly papers when you type “stem cell” and cerebral palsy into google’s scholarly papers
  • 2,572 clinical trials completed or in process when you type “stem cell” into clinicaltrials.gov (After “studies,” scientists perform even more rigorous clinical trials to back up their findings.)
  • 1,160,000 scholarly papers when you type “stem cell” into google’s scholarly papers

It said the stem-cell operation carried risks of introducing viral diseases or bacterial infections, and even malignant tumours developing after the transplant.

Re: “viral diseases, bacterial infections, malignant tumours”

  1. Any blood drawn that goes through a lab is at risk of “viral diseases or bacterial infections.”
  2. So too, any stem cell rich sample drawn that goes through a lab is at risk of “viral diseases or bacterial infections.”
  3. Evidence supports that the risk is the same for both and standard safe practice of lab protocols removes this risk almost entirely.
  4. ONLY embryonic stem cells have a history of creating tumors and malignant tumors.
  5. Adult stem cells have no history of generating tumors in thousands of studies, clinical trials and patients treated.

“…stem-cell treatment for children with cerebral palsy is unproven…

Re: “Unproven”

“Most centres offering this treatment also follow the treatment with intensive physical-therapy programmes,” the pamphlet said. “It is very difficult to know whether improvements are the result of the stem-cell treatment itself, or the intensive physical therapy, or are the result of the child growing and developing.”

Re: “It is very difficult to know whether improvements are the result of the stem-cell treatment itself, or the intensive physical therapy, or are the result of the child growing and developing.”

“…there was “no evidence” that using your own cord blood had benefits, he said.”

Re: “no evidence”
  • One stem cell center uses a treatment method involving any cord blood.  The cord blood does not have to be autologous or from the patient’s own body.  So far, it’s been effective in treating cerebral palsy with an 80 percent success rate in over 200 patients.

Cerebral Palsy Improvement seen after stem cells

In VICTORIES & SUCCESS STORIES on September 23, 2009 at 10:50 am

Cerebral Palsy

Dramatic cerebral palsy improvement seen after cord blood stem celll treatment

March 26th, 2008 by Donald Saiontz | PERMALINK

NBC’s Today Show recently reported on the story about a toddler with cerebral palsy, who experienced dramatic improvements in his disability following an experimental procedure involving a stem cell transplant. While still an unproven treatment, this provides hope that some children may be able to recover from cerebral palsy, or at least experience improvement of cerebral palsy symptoms.

Dallas Hextell, a 2-year-old from Sacramento, California, received an infusion of his own umbilical cord blood as part of a Duke University clinical trial. Within five days, he showed improvements in the limitations imposed by the condition, and his parents are hopeful that a cerebral palsy recovery, with no signs of the disability, may be possible for Dallas by the time he is 7-years-old.

video: http://www.msnbc.msn.com/id/21134540/vp/23569985#23569985
via http://www.youhavealawyer.com/blog/2008/03/26/cerebral-palsy-improvement/

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