DAVID GRANOVSKY

Posts Tagged ‘neuron’

YOUR BRAIN, THE EMPTY CUP

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on June 4, 2014 at 8:40 am

empty-cup  819px-Complete_neuron_cell_diagram_en.svg

15 years ago, modern science was confronted with the premise that HEART type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results (The first clinical trial of a novel therapy was conducted unintentionally by the Renaissance surgeon Ambroise Parè in 1537).  Ask your doctor if heart cells can regenerate.  There is still ENORMOUS resistance.

10 years ago, modern science was confronted with the premise that BRAIN type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results.  Ask your doctor if brain cells can regenerate.  There is still ENORMOUS resistance.

3 days ago Duke researchers published a study in the peer reviewed journal Nature about how they “found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons.”

While this is incredible news, science is still moving too slowly for those suffering from chronic and terminal diseases, dementia, TBI and other neurological disorders.  Is it time to revamp the system?  Is it time to approach healing and science with the premise that the human body has regenerative capabilities and we should tap into those systems to heal disorders instead of treating symptoms far removed from the original disorders?  What other premises are in place which are blocking medical advancements?

A story from Zen Buddhism:
Nan-in served tea. He poured his visitor’s cup full, and then kept on pouring.  The professor watched the overflow until he no longer could restrain himself. “It is overfull. No more will go in!”  “Like this cup,” Nan-in said, “you are full of your own opinions and speculations. How can I show you Zen unless you first empty your cup?”

Regenerative medicine is a new frontier.  Already around for decades, most have yet to recognize it as the huge paradigm shift which necessitates our emptier our cups and approaching medicine from a completely new perspective.  A new perspective which includes an empty cup.

Is your thinking, holding you back?

via
http://www.sciencedaily.com/releases/2014/06/140602102006.htm
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3734.html

Advertisements

Parkinson’s patients fund their own stem cell research

In BUSINESS OF STEM CELLS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 19, 2013 at 9:00 am

parkinsons

Healing Parkinson’s patients with their own stem cells

Up to 1 million Americans have Parkinson’s, according to the Parkinson’s Disease Foundation. Because aging is the chief risk factor for the disease, the patient population is expected to increase as the baby boom generation gets older.  Parkinson’s selectively kills brain cells that make the neurotransmitter dopamine, which enables movement. No one knows how it happens, or how to stop it. Researchers expect that transplanted dopamine-producing brain cells will eventually die, but perhaps not for 10 to 15 years.

The most visible symptoms of Parkinson’s include tremors, slowed movement, stooped posture and loss of balance, and trouble speaking. People sometimes walk with a shuffling gait, and they may experience severe and chronic pain. Patients’ faces can assume a mask-like expression.  Drugs that provide dopamine or mimic its effects can partially relieve the symptoms, but they produce side effects such as uncontrolled movement. Also, their effectiveness decreases over time.

A groundbreaking stem cell treatment for Parkinson’s disease is getting close to moving from lab research in La Jolla to therapy for patients. The research, funded by the patients and their supporters, could also pioneer a new model for moving medical advances from the lab into the clinic.

Eight Parkinson’s patients have allied with scientists from The Scripps Research Institute and medical professionals from Scripps Clinic for the project, which involves creating new brain cells from other cells in their own bodies. Because of the unusual, personalized nature of the research, the patients are participating with scientists and doctors as equals, meeting regularly to review the progress.

The ambitious goal is to relieve the movement difficulties Parkinson’s causes by replacing the brain cells the disease destroys. In theory, it would restore near-normal movement for a decade or more, and the procedure could be repeated as needed.

Research is far enough along that scientists and health care professionals in the project are talking to regulators about beginning clinical trials, perhaps as soon as next year.

The replacement brain cells are now being grown in a lab at The Scripps Research Institute. Patches of skin the diameter of a pencil eraser were removed from the patients’ arms and turned into a new kind of stem cell that acts like embryonic stem cells. Called induced pluripotent stem cells, they were discovered in 2006, a feat honored by a Nobel Prize last year.

These IPS cells can become nearly any kind of cell in the body… Another potential advantage of IPS cells over embryonic stem cells is that they should be less prone to rejection by the patients’ immune systems, because the transplanted cells come from the individuals themselves.

Patient Cassandra Peters, 57, learned of the reality of Parkinson’s and the hope of a new treatment in a visit with Dr. Houser, her neurologist.  “Interestingly, when I first had a conversation with her, when she definitively told me I had Parkinson’s, she said to me, quote, “You will have a stem cell procedure in your lifetime.”  I took that ball and held it in my heart, thinking, this is going to be my ‘get out of jail free’ card.  Not a day goes by when I don’t have an opportunity to share what I’m going through now and what the future might hold,” Peters said.

Ileana Slavin, a research associate in the lab of Jeanne Loring, and Suzanne Peterson, a staff scientist, discuss what it means for scientists to directly meet the people they’re trying to help.  Diabetes researcher Matthias von Herrath of the La Jolla Institute for Allergy & Immunology said the work could help scientists developing stem cell therapies for diabetics,” von Herrath said. “And that’s going to open the door for these type of stem cells.”

Loring’s researchers are reaching the final stages of their part of the project. They have made induced pluripotent stem cells from all eight patients, and have turned those into the needed brain cells for two of them. The work continues for the other six.

Parkinson’s represents the “low-hanging fruit” of neurological diseases for stem cell therapy.  We know what cell types are lost in Parkinson’s disease,” Bratt-Leal said in a March 8 meeting of the group. “We can make them from stem cells.  And now we can make stem cells from adult tissues.  The next logical step is to make these cells from people and put them back into them.”

“With IPS cells grown from the patient, rejection should be less of a worry”, Bratt-Leal said.

Now that the research side of the project has overcome its greatest hurdles, the focus is shifting to medicine, Loring said. The replacement brain cells will be grown in a clinical grade facility at the City of Hope in Los Angeles.  As part of the transition to the medical side, Houser will provide expertise in setting up the clinical trial, assuming approval is granted by the U.S. Food and Drug Administration.

Beyond the potential benefit to the eight patients, the project may provide an answer to what Loring and other researchers call the “Valley of Death,” the period that halts promising research before it can become a medical treatment.  Most scientific research is federally funded, but commercialization is left to the private sector. If companies don’t see a way to make money, they won’t pursue a therapy, even if it works.  This problem is especially forbidding for treatments customized to individual patients. These don’t produce economies of scale, and hence are not attractive to pharmaceutical companies.  Advocates of the customized Parkinson’s therapy said it will pay off in the long run. Patients will require less medical care, and find it easier to maintain their jobs.

To Read Full Article click HERE.

STEM CELLS REDUCE BRAIN DAMAGE AFTER STROKE

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 7, 2013 at 9:00 am

stroke

Stroke – Stem Cells Can Reduce Brain Damage

Rescuing a patient from a stroke and restoring cognitive functions are two significant medical challenges today. Blockage of a brain artery, usually by a clot or atherosclerotic plaque, results in reduction in oxygen supply to brain cells. If the supply of oxygen is interrupted for a long time, brain cells die resulting in severe loss of motor and cognitive functions. Therapeutic approaches to prevent the formation of plaques or blood clots are not a hundred percent successful in preventing a stroke. Recent research has focused on aiding regeneration of brain cells after an ischemic stroke and stem cells have been used with reasonable success.

Experiments conducted on rats show that intravenous injection of stem cells derived from adipose tissues as well as mesenchymal stem cells derived from bone marrow supported the recovery of brain cells after a stroke. In these experiments, rats were subjected to a stroke by blocking their middle cerebral artery permanently. Stem cells from bone marrow as well as fat cells were injected 30 minutes after induction and the health of the animals was assessed at 24 hours and 14 days after stroke. In the recovery period, animals injected with stem cells showed increased levels of vascular endothelial growth factor and synaptophysin. The injected stem cells did not migrate to the site of the lesion but presumably acted as a source of neurotrophic growth factors.

In another study, stem cells from the dental pulp of human deciduous teeth (milk teeth) were grafted in the brains of mice one day after induction of a stroke. In some animals, the culture medium in which these cells were grown was used instead of the cells. Mice treated with human dental pulp stem cells and conditioned medium from these cells showed better recovery and neurological outcome than untreated mice. Grafted stem cells as well as the conditioned medium inhibited death of neurons in the recovery period and prevented cell destruction resulting from inflammation. In these experiments, the actual integration of human dental pulp stem cells into the brain tissue occurred at very low frequency.

Both studies present important insights in the process of regeneration of brain cells followed hypoxic and ischemic stroke. Stem cells secrete a number of growth factors which help to promote generation of new neurons post a stroke. The results presented by Yamagata and colleagues where just the culture medium from dental pulp stem cells was effective in restoring brain tissue and neurological functions indicate that a suitable “growth factor cocktail” can be derived from cultures of stem cells to treat stroke. Since intravenous injection of stem cells also helps recovery from stroke, it is easy to deliver such a therapeutic intervention. A xenograft of human dental pulp stem cells was successful in helping mice recover from a stroke. It would be interesting to know whether stem cells from other animal systems have a similar beneficial effect on human neurons as well.

References

Gutierrez-Fernandez M, Rodriguez-Frutos B, Ramos-Cejudo J, Vallejo-Cremades MT, Fuentes B, Cerdan S, & Diez-Tejedor E (2013). Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem cell research & therapy, 4 (1) PMID: 23356495

Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, Sawamoto K, & Ueda M (2013). Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke; a journal of cerebral circulation, 44 (2), 551-4 PMID: 23238858

Brain Blogger

Gastrointestinal motility disorders addressed with Stem Cells

In ALL ARTICLES, BUSINESS OF STEM CELLS, STEM CELLS IN THE NEWS on February 2, 2013 at 8:08 am

Zhang_neural_stem_cells04

Neural stem cell transplantation shows promise against gastrointestinal motility disorders

Proper function of the digestive system requires coordinated contraction of the muscle in the wall of the intestinal tract, regulated by the enteric nervous system. Damage or loss of these neurons can result in intestinal motility disorders, such as Hirschsprung’s disease, for which there is a dearth of effective treatments. In principle, disorders of the enteric nervous system could be treated by cell therapy, but it was previously unknown whether transplanted stem cells could migrate to the appropriate location in the gut and then become neurons that could properly innervate the bowel.

In the article, “Transplanted progenitors generate functional enteric neurons in the postnatal colon”, Journal of Clinical Investigation, Heather Young and colleagues at the University of Melbourne, isolated neural stem cells from mice, cultured them to promote the formation of neural precursor cells, and implanted them into the muscle in the colons of recipient mice. Young and colleagues found that these cells were able to migrate away from the transplantation site and develop into neurons that provided stimulation to the portions of the gut the regulate motility. These findings suggest that the transplantation of neural stem cells is a promising therapeutic avenue for the treatment of gastrointestinal motility disorders.

 www.news-medical.net

www.jci.org

Can MS be treated with stem cells?

In ALL ARTICLES on October 25, 2011 at 2:13 pm

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

I did some digging and would like to present the preliminary results to answer the question:

Can MS be treated with stem cells?

https://i1.wp.com/www.msconnections.org/ms-myelin.gifSOME MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” – January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

————————————-

Can MS be treated with stem cells?

You decide. Here are 11 articles from my blog,  28,000 from google news and there are a total of 20 clinical trials from clinicaltrials.gov

From my blog…

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

***https://repairstemcell.wordpress.com/2010/05/18/ms-and-stem-cells-time-is-brain-in-ms/

*** https://repairstemcell.wordpress.com/2009/09/02/my-ms-pain-is-gone/

* * * https://repairstemcell.wordpress.com/2009/04/26/fat-derived-stem-cells-might-treat-ms-us-news-and-world-report/

* * * https://repairstemcell.wordpress.com/2009/04/15/britt%e2%80%99s-fight-against-multiple-sclerosis-hits-home-for-uncw-starnewsonlinecom-star-news-wilmington-nc/

* * * https://repairstemcell.wordpress.com/2009/04/09/stem-cell-breakthrough-may-lead-to-ms-treatments-forbescom/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-2/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-1/

* * * https://repairstemcell.wordpress.com/2009/03/07/study-stem-cell-transplants-could-reverse-ms-cloning-and-stem-cells-msnbccom/

* * * https://repairstemcell.wordpress.com/2009/02/23/foxnewscom-college-student-with-multiple-sclerosis-symptom-free-after-stem-cell-treatment-health-news-current-health-news-medical-news/

* * * https://repairstemcell.wordpress.com/2009/02/12/stem-cells-ms-multiple-sclerosis-cured-by-adult-stem-cells-video-stem-cell-research-and-stem-cell-therapy/

* * * https://repairstemcell.wordpress.com/2009/02/11/multiple-sclerosis-ms-stem-cell-trials-us-is-starting-to-%e2%80%9ccatch-up%e2%80%9d/

* * * https://repairstemcell.wordpress.com/2009/02/10/the-us-is-playing-catch-up-with-stem-cells-ms/

* * * https://repairstemcell.wordpress.com/2009/02/08/stem-cell-transplants-help-ms-victims/

…and about 28,000 scholarly papers/studys on “MS stem cell” here:
http://scholar.google.com/scholar?q=multiple%20sclerosis%20trial%20stem%20cell&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=ws\

…and 20 responses from clinicaltrials.gov on “multiple sclerosis stem cell”
http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

NEW MS TREATMENT INFO!!!

In BEST OF THE BEST on October 6, 2011 at 1:02 am

NEW MULTIPLE SCLEROSIS TREATMENT INFO!!!!

For those interested, I just received 13 pages of Stem Cell Treatments of MS info. There is editing and translation and I am trying to get fully substantiated results for these treatments. I will have it to those of you who are interested shortly.

https://i0.wp.com/www.quicktrimbody.com/wp-content/uploads/2011/02/multiple-sclerosis-and-sunshine8.gif

Stem cells may hold secret to multiple spinal injury repair

In VICTORIES & SUCCESS STORIES on February 8, 2011 at 9:40 am

CATCH UP!  They’ve been treating SCI patients successfully with stem cells for years now!

Stem cells may hold secret to multiple spinal injury repair

21 January 2011

Scientists may soon be able to repair multiple aspects of a spinal cord injury in humans, using adult stem cells.

A Case Western Reserve University School of Medicine study involving rats showed that use of multipotent adult progenitor cells (mapc) could prevent neuron retraction, promote new neuron re-growth and reduce inflammation in spinal injury.

Researchers will no doubt be hopeful that the development of such treatment can contribute significantly to reducing the costs of spinal injury treatment, which can range between $500,000 (£312,000) and $3 million (£1.9 million) in the US.

Commenting on the findings, published in the Journal of Neuroscience, university professor Jerry Silver explained: “Using preclinical models of spinal cord injury, we found that MAPC can both dynamically regulate macrophages, which cause inflammatory damage, and stimulate neuron growth simultaneously.

“Our results demonstrate that MAPC convey meaningful therapeutic benefits after spinal cord injury.”

Meanwhile, recent research conducted at Otago University suggests that cell tissue extracted from the nose could be transplanted to the site of spinal cord injury.

Scientists are hopeful the procedure could overcome blocks that prevent nerve cells regenerating following damage.

News by Serious Law. Expert legal assistance for those affected by spinal injury

Posted by Timothy Walters

ReNeuron – PRESENTS NEW DATA – STEM CELLS REPAIR BRAIN DAMAGE

In BUSINESS OF STEM CELLS on July 19, 2010 at 2:44 pm

ReNeuron presents new data showing how its stem cells work to repair brain damage. 12/07/10

Guildford, UK, 12 July 2010: ReNeuron Group plc (LSE: RENE.L) today announces important new data regarding the mechanisms of action of its lead CTX stem cell line in pre-clinical models of brain damage. The results of these studies will be presented in two posters1 at the UK National Stem Cell Network Annual Scientific Conference, taking place on 12 – 14 July, 2010 at the University of Nottingham, East Midlands Conference Centre, Nottingham, UK.

Image of stroke in the brain

In one series of studies, the angiogenic potential of the CTX stem cell line was tested, both in vitro and in rodent models of stroke damage. Angiogenesis is a multiple-step process whereby new blood vessels develop from pre-existing vasculature, potentially contributing to the functional recovery of the brain from damage such as that caused by ischaemic stroke. The results of these studies showed that the CTX cells express several trophic and pro-angiogenic factors in culture and also induce endothelial cell markers associated with blood vessel formation in the host at both 72 hours and 7 days post-implantation of the cells into the brain. Taken together, these results suggest that the CTX cells may play a role in promoting the functional recovery of stroke patients through up-regulation of angiogenesis in the region of ischaemic brain damage.

In a series of further studies, the CTX cells were seen to inhibit T cell activation. This immunosuppressive activity was in part attributed to the up-regulation of the ligand CD274, a regulator of T cell function. T cells are a type of white blood cell associated with the mediation of immune responses in the body. These results suggest that the CTX cells may act to suppress the inflammatory response associated with brain damage, thereby aiding the natural healing processes in the brain. This anti-inflammatory characteristic opens up a number of exciting new potential applications for the CTX cell line as a cell-based therapy for certain inflammatory diseases both within and beyond the brain.

ReNeuron recently announced the commencement of a UK Phase I clinical trial of its lead ReN001 stem cell therapy for disabled stroke patients. The ReN001 therapy represents the initial therapeutic application of the Company’s CTX stem cell line. Due in part to the anti-inflammatory properties of the CTX cells, patients in this clinical trial will not require immunosuppressive drug treatments alongside their cell therapy.

via ReNeuron –.

Stem Cells and “Glue” Heal Stroke Damage

In VICTORIES & SUCCESS STORIES on November 18, 2009 at 10:11 pm

Stem-Cell Repair Kit for Stroke

A stem-cell matrix can repair brain damage in rodents.

By Michael Day – Monday, March 09, 2009

A novel matrix of neural stem cells and a biodegradable polymer can quickly repair brain damage from stroke in rats. Within just seven days of injecting the concoction directly into the damaged part of the brain, new nerve tissue grew to fill stroke-induced cavities.

Growing brain: Shown here is new nerve tissue created from stem cells forming in the area of the brain with a cavity caused by a stroke.

Credit: Bible E et al., The support of neural stem cells transplanted into stroke-induced brain cavities by PGLA particles, Biomaterials (2009), doi:10.1016/j.biomaterials.2009.02.012.

Scientists say that the key to the advance, published today in the journal Biomaterials, is the use of a biodegradable polymer called PLGA, which ensures that the stem cells remain in the area of stroke damage and establish connections with surrounding brain tissue. By reducing the number of stray stem cells, the system is likely to be safer as well as more effective than other methods, the researchers add.

via Technology Review: Stem-Cell Repair Kit for Stroke.

‘Bionic’ Nerve To Bring Damaged Limbs + Organs Back To Life

In VICTORIES & SUCCESS STORIES on September 8, 2009 at 10:13 pm

‘Bionic’ Nerve To Bring Damaged Limbs And Organs Back To Life (Oct. 18, 2007) — University of Manchester researchers have transformed fat tissue stem cells into nerve cells — and now plan to develop an artificial nerve that will bring damaged limbs and organs back to life. In a … > read more

via Injectable Biomaterial Regenerates Brain Tissue In Traumatic Injuries.

%d bloggers like this: