DAVID GRANOVSKY

Posts Tagged ‘muscle’

Pluristem stem cell trial to treat muscle injury meets main goal | Reuters

In STEM CELLS IN THE NEWS on January 22, 2014 at 5:32 pm
  • cells were safe and well tolerated
  • one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group.
  • Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.
  • An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated…versus the placebo group.

Pluristem stem cell trial to treat muscle injury meets main goal

TEL AVIV Tue Jan 21, 2014 3:07am EST

(Reuters) – Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided evidence the cells might be effective in treating orthopedic injuries.

\”Patients treated with PLX-PAD had a greater improved change of maximal voluntary muscle contraction force than the placebo group,\” Israel-based Pluristem said in a statement on Tuesday.

The trial was conducted at the Orthopedic Clinic of the Charite University Medical School under the auspices of the Paul-Ehrlich-Institute, Germany\’s health authority.

\”This was a very important study not only for Pluristem but for the cell therapy industry in general,\” Pluristem chief executive Zami Aberman said. \”Based on these results, we intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma.\”

The injured muscle studied was the gluteus medius muscle in the buttock. Total hip replacement surgery via the standard transgluteal approach necessitates injury of the gluteus medius muscle, and post-operative healing is crucial for joint stability and function.

\”The study showed that PLX-PAD cells were safe and well tolerated,\” the statement said.

The primary efficacy endpoint of the study was the change in maximal voluntary isometric contraction force of the gluteal muscle six months after surgery.

Efficacy was shown in two groups treated with the cells, with one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group. Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.

An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated with PLX-PAD cells versus the placebo group.

via Pluristem stem cell trial to treat muscle injury meets main goal | Reuters.

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STEM CELL TREATMENTS TO BATTLE DMD (DUCHENNE MUSCULAR DYSTROPHY)

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 15, 2013 at 9:00 am

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Stem-Cell Approach Shows Promise for Duchenne Muscular Dystrophy

“Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD.”

Their findings appear in the journal Stem Cells Translational Medicine.

Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without dystrophin, muscle contractions tear cell membranes, leading to cell death. The lost muscle cells must be regenerated, but in time, scar tissue replaces the muscle cells, causing the muscle weakness and heart problems typical of DMD.

The U.S. Centers for Disease Control and Prevention estimates that DMD affects one in every 3,500 males. The disease is more prevalent in males because the dystrophin mutation occurs on the X chromosome; males have one X and one Y chromosome, so a male with this mutation will have DMD, while females have two X chromosomes and must have the mutation on both of them to have the disease. Females with the mutation in one X chromosome sometimes develop muscle weakness and heart problems as well, and may pass the mutation on to their children.  Although medical advances have extended the lifespans of DMD patients from their teens or 20s into their early 30s, disease-related damage to the heart and diaphragm still limits their lifespan.

“Almost 100 percent of patients develop dilated cardiomyopathy,” in which a weakened heart with enlarged chambers prevents blood from being properly pumped throughout the body, said University of Illinois comparative biosciences professor Suzanne Berry-Miller, who led the study. “Right now, doctors are treating the symptoms of this heart problem by giving patients drugs to try to prolong heart function, but that can’t replace the lost or damaged cells,” she said.

In the new study, the researchers injected stem cells known as aorta-derived mesoangioblasts (ADM) into the hearts of dystrophin-deficient mice that serve as a model for human DMD. The ADM stem cells have a working copy of the dystrophin gene.  This stem cell therapy prevented or delayed heart problems in mice that did not already show signs of the functional or structural defects typical of Duchenne muscular dystrophy, the researchers report.

Berry-Miller and her colleagues do not yet know why the functional benefits occur, but proposed three potential mechanisms. They observed that some of the injected stem cells became new heart muscle cells that expressed the lacking dystrophin protein. The treatment also caused existing stem cells in the heart to divide and become new heart muscle cells, and the stem cells stimulated new blood vessel formation in the heart. It is not yet clear which of these effects is responsible for delaying the onset of cardiomyopathy, Berry-Miller said.

“These vessel-derived cells might be good candidates for therapy, but the more important thing is the results give us new potential therapeutic targets to study.  Activating stem cells that are already present in the body to repair tissue would avoid the potential requirement to find a match between donors and recipients and potential rejection of the stem cells by the patients.”

Despite the encouraging results that show that stem cells yield a functional benefit when administered before pathology arises in DMD mouse hearts, a decline in function was seen in mice that already showed the characteristics of dilated cardiomyopathy. One of these characteristics is the replacement of muscle tissue with connective tissue, known as fibrosis.

This difference may occur, Berry-Miller said, as a result of stem cells landing in a pocket of fibrosis rather than in muscle tissue. The stem cells may then become fibroblasts that generate more connective tissue, increasing the amount of scarring and making heart function worse. This shows that the timing of stem cell insertion plays a crucial role in an increase in heart function in mice lacking the dystrophin protein.

She remains optimistic that these results provide a stepping-stone toward new clinical targets for human DMD patients.

“This is the only study so far where a functional benefit has been observed from stem cells in the dystrophin-deficient heart, or where endogenous stem cells in the heart have been observed to produce new muscle cells that replace those lost in DMD, so I think it opens up a new area to focus on in pre-clinical studies for DMD,” Berry-Miller said.

The Illinois Regenerative Medicine Institute supported this research.

http://www.sciencedaily.com/releases/2013/01/130114133350.htm

SNOWMEN RECEIVING STEM CELLS

MS MS MS MS MS MS MS MS MS MS MS

In DISEASE INFO on September 19, 2011 at 9:36 am

some info on stem cell treatments for MS.

I can tell you where to go, costs, protocols, etc. No charge for my help, just trying to give you some info.

World Cup Soccer Players Could Benefit from Stem Cell “Repair Kit” – twitter moms: the influential moms network

In VICTORIES & SUCCESS STORIES on June 24, 2010 at 12:26 pm

A decade ago, stem cells and World Cup soccer would have been considered an unusual pairing yet today they can easily be found on the same playing field. Recent reports indicate that some players in top-tiered soccer leagues are storing their infants’ stem cells for possible use as a “repair kit” for future injuries.

http://rlisu.files.wordpress.com/2009/12/149.jpg

“As a footballer, if you’re prone to injury it can mean the end of your career, so having your stem cells – a repair kit if you like – on hand makes sense,” said one unnamed Premier League player from England in a 2006 story in the London Times. “We decided to store our baby’s stem cells for possible future therapeutic reasons, both for our children and possibly for myself.”

Stem cells defined as ‘mesenchymal’ stem cells are of increasing interest to the field of regenerative medicine because they are able to become many different types of cells including bone, cartilage, tendon and more. One example of a possible application for these cells would be for the treatment of damaged knee cartilage, which is a very common athletic injury that can occur while playing sports or exercising. As a result of the injury, the joint becomes inflamed and painful. Injection of stem cells can potentially lead to cartilage rejuvenation.

via World Cup Soccer Players Could Benefit from Stem Cell “Repair Kit” – twitter moms: the influential moms network.

Charlestown boy’s sight improves after stem cell treatment

In VICTORIES & SUCCESS STORIES on May 25, 2010 at 10:00 am

IMPROVEMENT: Connor Wink, 11, and his mother Tracey.

Charlestown boy’s sight improves after stem cell treatment

BY DONNA SHARPE – 18 May, 2010 10:44 AM

A CHARLESTOWN boy is showing marked signs of improvement in sight after his first round of stem cell treatment.

Connor Wink, 11, and his mother Tracey recently returned from China where he received a round of injections, which are not available in Australia.

The treatment appears to have had dramatic results.

Connor has gained light perception, a sign the treatment is working.

Born blind, he also suffers nystagmus, a condition which means Connor has poor muscle control causing his eyes to move frequently.

“That has slowed right down so it’s certainly a big plus,” Mrs Wink said.

Connor is the second Hunter child to undergo stem cell treatment in China.

Holly Arvidson, 12, of Denman, is having a second round of the procedure in a bid to restore her sight.

For the past 12 months, The Herald has been following the progress of Holly, who is in China with her family for the treatment which involves stem cell injections, acupuncture and bone marrow cultivation.

The treatment is only available in a handful of hospitals worldwide. It has an 80 per cent success rate but since Holly’s first round her condition has not changed.

Mrs Wink said she is praying Holly receives a positive result this time.

“Connor was lucky and we have seen improvements. We were sitting in front of a fire at the weekend and he could tell when someone was putting logs on it,” she said.

The Charlestown community and Connor’s school, Hillsborough Public, helped raise money for the China trip.

“We still have enough money to travel for Connor’s second round of treatment thanks to those earlier fund-raising efforts which Connor was a big part of, raising $6000 busking.”

via Charlestown boy’s sight improves after stem cell treatment – Local News – News – General – The Herald.

Caught on tape: Muscle stem cells captured on video

In STEM CELLS - 101 on May 6, 2010 at 1:21 pm

Caught on tape: Muscle stem cells captured on video

May 6, 2010

When muscle tissue experiences trauma or disease, such as muscular dystrophy, stem cells in the muscle known as “satellite cells” respond to repair and regenerate the muscle. These cells are particularly important in neuromuscular diseases, such as muscular dystrophy, which affect muscle stability and repair. Now, University of Missouri researchers have used time-lapse photography to document satellite cell movements and behaviors when they interact with their ‘host’ myofiber. Scientists hope that if they can understand more about what satellite cells do in healthy muscle, obstacles to cell or gene therapies for muscular dystrophy might be overcome.

“We have been trying to understand what’s happening in these cells using the technology we have, which basically lets us take one snap shot per cell,” said Dawn Cornelison, assistant professor of biological sciences in the College of Arts and Science and investigator in the Bond Life Sciences Center. “That’s like taking one picture per game of a series of different football games and trying to use them to figure out the rules of football. This new technology is like watching the football game on TV. Now, we can see what’s going on with groups of cells over time, how they move, how they’re related and what kinds of different things they do. We were really surprised by a lot of things we saw because we never expected them to act that way.”

TOO VIEW THE VIDEO, CLICK HERE

University of Missouri researchers have used time-lapse photography to document satellite cell movements and behaviors when they interact with their “host” myofiber. Credit: Video courtesy of Dawn Cornelison

are small and rare, and only become active in specific conditions associated with damage or disease. Once activated, they multiply, establishing a large population of replacement cells in the , then differentiate to replace or repair damaged muscle. Patients with Duchenne’s Muscular Dystrophy have so fragile that simply moving or breathing causes them to tear. While the satellite cells do a good job repairing this damage in early childhood, the cells eventually fall behind. Because this is a genetic disease, the new muscle made from the satellite cells has the same defect, so even the repaired doesn’t last long. Without repair, the muscles in these patients eventually stop working. In the severest form, this disease is fatal by early adulthood.

Since 1989, scientists and physicians have tried to use transplanted satellite cells from healthy donors as a therapy for , but have had very little success. One major problem with therapies being tried now is that the transplanted cells never move away from the site where they are injected, so patients require a large number of injections over a very small area, up to 4,000 injections in a single individual.

“Previous studies had little data about how satellite cells moved, and many scientists thought that satellite cells didn’t move,” Cornelison said. “The time-lapse videomicroscopy showed that they can and do move. Some cells travel a few centimeters in a day. Now, we can ask things like ‘is it important for them to be able to move?’, ‘where are they going?’, ‘what factors do they need to tell them where and how to move?’ and ‘what are the cells saying to each other?’ Hopefully, the answers to these questions will help us think of ways to improve satellite cell therapies. For example, it would be wonderful if we could just tell all the cells in a transplant to move away from where they were injected, so they wouldn’t be overcrowded and die.”

More information: The study, “3D Time-lapse Analysis of Muscle Satellite Cell Motility,” was published in Stem Cells.

Provided by University of Missouri-Columbia

via Caught on tape: Muscle stem cells captured on video.

FDA Warns about Increased Risk of Muscle Injury with Zocor

In OFF THE BEATEN PATH on March 24, 2010 at 8:14 pm

FDA NEWS RELEASE

For Immediate Release: March 19, 2010

Media Inquiries: Elaine Gansz Bobo, 301-796-7567; elaine.bobo@fda.hhs.gov

Consumer Inquiries: 888-INFO-FDA

FDA Warns about Increased Risk of Muscle Injury with Zocor

Highest approved dose of cholesterol-lowering medication could cause harm to muscles

The U.S. Food and Drug Administration today warned patients and healthcare providers about the potential for increased risk of muscle injury from the cholesterol-lowering medication Zocor (simvastatin) 80 mg. Although muscle injury (called myopathy) is a known side effect with all statins, today’s warning highlights the greater risk of developing muscle injury, including rhabdomyolysis, for patients when they are prescribed and use higher doses of this drug. Rhabdomyolysis is the most serious form of myopathy and can lead to severe kidney damage, kidney failure, and sometimes death.

“Review of simvastatin is part of an ongoing FDA effort to evaluate the risk of statin-associated muscle injury and to provide that information to the public as it becomes available,” said Eric Colman, M.D., Deputy Director of FDA’s Division of Metabolism and Endocrinology Products (DMEP). “It’s important for patients and healthcare professionals to consider all the potential risks and known benefits of any drug before deciding on any one therapy or dose of therapy.”

Simvastatin is sold as a single-ingredient generic medication and as the brand-name Zocor. It also is sold in combination with ezetimibe as Vytorin, and in combination with niacin as Simcor.

FDA’s review of new information on the risk of muscle injury is derived from clinical trials, observational studies, adverse event reports, and prescription use data. The agency also is reviewing data from the SEARCH (Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine) trial, which evaluated major cardiovascular events, such as heart attack, revascularization and cardiovascular death, in patients taking 80 mg compared to 20 mg of simvastatin. SEARCH also included data on muscle injury in patients taking simvastatin…

via FDA Warns about Increased Risk of Muscle Injury with Zocor.

Stem cell infusion shows promise for treating heart disease

In VICTORIES & SUCCESS STORIES on February 7, 2010 at 6:37 pm

Stem cell infusion shows promise for treating heart disease

DAVID WAHLBERG | dwahlberg@madison.com | 608-252-6125 | Posted: Sunday, February 7, 2010 2:00 pm | 1 Comment

After Bernie Treichel had a heart attack in December, she received the standard treatment: angioplasty, in which doctors propped open her clogged arteries with stents.

Then she tried something unusual. She signed up for a study in which stem cells are infused into the arm to potentially do what the body can’t do on its own: grow new heart muscle…

 

DO STEM CELL TREATMENTS WORK?!?!
https://repairstemcell.wordpress.com/do-stem-cell-treatments-work/

via Stem cell infusion shows promise for treating heart disease.

Heart Muscle Health Aspects | VesCell adult stem cell therapy

In VICTORIES & SUCCESS STORIES on February 2, 2010 at 4:23 pm

Heart Muscle Health Aspects You Should Consider

Stunned or Dying Tissue can be Rejuvenated by Adult Stem Cells Injected in the Patient’s Heart

Heart muscle health aspect from James Eilert story

Click here to see if your heart disease is treatable with Adult/Repair Stem Cells now

James Eilert, a young man, who was a victim of the heart disease epidemic that is increasingly taking hold around the world, has been given a second chance at a healthy life thanks to VesCell adult stem cell therapy.

In 2006, at the relatively young age of 34, James experienced a major heart attack. His left anterior descending artery (or what the doctors call the ‘widowmaker’) was 100% blocked. The heart attack left him with severe damage to his heart. A normal ejection fraction is generally considered to be 55-75%. At the tender age of 34, James’ ejection fraction had sunk to 20-25%. The doctors diagnosed him as being in Class III NYHA Heart Failure.

He didn’t want to die, but figured dying would be a better option than living as he was. That was when James stumbled upon VesCell on the internet. Already a patient at the world renowned Henry Ford Heart and Vascular Institute in Detroit, James was shocked to find out that Dr. Barbara Czerska, the Medical Director of the Heart Failure Transplant Program at Henry Ford was featured prominently on the VesCell website. That, along with reading that recent medical research indicates that dead heart tissue can be ‘awakened’ by the implantation of adult stem cells gave James new hope.

He contacted VesCell and Dr. Czerska and prepared for his trip to Bangkok, Thailand to receive a new shot of hope using his own adult stem cells.

After arrival in Bangkok, James along with his father, were well taken care of by the TheraVitae team and the doctors and nurses at Phyathai 2 Hospital. James was treated by Dr. Damras Tresukosol, the director of the Phyathai-Harvard Heart Center and also the lead investigator of TheraVitae’s clinical trial using adult stem cells which was presented at the American Heart Association annual meeting in 2006.

Treated on November 14, 2007, James received 41 million of his own adult stem cells via catheter to heal his damaged heart muscle.

Told by doctors that the stem cells would take approximately 6-8 weeks to take affect, James was pleasantly surprised that the doctors were mistaken – just 1½ weeks after his stem cell treatment,

James had an echocardiogram done and found out his previously dead part of his heart had life again….

Click [HERE] to see if your heart disease is treatable with Adult/Repair Stem Cells now

via Heart Muscle Health Aspects | VesCell adult stem cell therapy.

FIBROMYALGIA and STEM CELL TREATMENT

In VICTORIES & SUCCESS STORIES on February 2, 2010 at 3:31 pm

My Stem Cell Story

My name is E.A. I live in California. I’m 77 years old…After 45 years in the health care industry I have come to the conclusion that not only are the average American medical services substandard in quality and effectiveness but with overutilization of the current reimbursement system it tends to be from the patients perspective the best medicine in the world until they are exposed to the best medicine in the world.

I was developing, with USC School of Medicine, a neurological hospital in Beijing, when by chance I was introduced to what I considered the medical miracles of Korea…not because American physicians and medical schools can not do as well in providing high quality medical services, but because our systems are based upon the German medical training where the interns and residents are actively involved in the medical procedures in the surgery suites and the diagnostic area. In Korea they are criticized for not allowing the residents to do the major part of very complicated surgeries such as gamma knife, liver transplants, or even something as simple as kidney transplants.

After discovering this new world of medicine I decided to use my own body to investigate the potential for de-aging. After completing an extensive CT, MRI and PET physical at Seoul National University Hospital and having a complete evaluation from top to bottom I discovered the research they were doing with stem cells. In looking at my own health challenges I decided to do a 365 day blog reporting each day how effective the research in adult stem cells has grown to the point at which it is truly possible to effect real change and help in a very short period of time.

Ten months ago we produced a reality TV show demonstrating how a man aged 77 could be 67. The name of the show is “10 Years Younger” (Please check out web site for a link to the TV show). The procedures involved plastic surgery and dental implants. I have discovered that with adult stem cells, through technology developed by the scientists who cloned the first dog and won the Korean Science Award in 2008, that I do not have to settle for my various diseases and health conditions. The changes that were brought about for the TV show, were external, making me look 10 years younger, but with stem cells, the changes are internal, including a cardiovascular make over, etc., which has the potential of making me effectivley 20 years younger.

My Current Health Status (prior to adult stem cell treatment):
-40% closed aorta…plaque
-excess fat around liver
-20 lbs overweight

According to the VA in Los Angeles I suffer from
-Anemia
-Mid level pain from fibromyalgia
-Skin Cancer
-Hypertension
-High Cholesterol
-PSA of 7.8
-Enlarged Prostate

These conditions have affected my current physical activies as follows:
-No Dancing
-No free weights
-reduced travel schedule
-waking 5-6 times per night with pain
-muscle atrophy

Compared to 1 year ago when I was:
-traveling 12 international flights per year/10 domestic flights
-walking/jogging 5 miles daily
-working out with weights 3 days per wk
-dancing 2 times per week

My goal is to get back to where I was a year ago or more.

In May 2009 I had 5 cc’s of fat removed from tummy fat which was sent to Maryland where the stem cells were separated from the fat cells. The stem cells were sent to the stem cell bank where they were frozen to -196 Celsius degrees. One month ago they grew my stem cells to over 400 million and implanted 100 million directly into my face and 200 million in my arm intravenously on August 24th….follow my progress toward my goal of having a body that is effectively 20 years younger than my 77 years of living.

August 24th-Stem cells implanted with a minimum of discomfort no different than the many times I’ve donated blood to the blood bank. The stem cells implanted in my face were very similar to a very sharp pinch. Not painful, but with a minimal level of discomfort…tolerable.

August 25th-Returned to Seoul feeling no adverse effect and no relief from the stem cell injections

August 26th-Flew back to Los Angeles on business class and was able to sleep better than I had in many months with the roar of the engines and people moving all around. Arrived US at LAX still not feeling any relief for the fibromyalgia or from my hypertension reading. I had difficulty removing my bags from the overhead bin on the airplane. I had low muscle strength.

August 27th-Still no relief, substantial jet lag, and a great deal of trouble sleeping but not as tired as I’d been before when returning from Asia.

August 28th-No improvement but hoping that something would happen soon very similar to John Cullison’s experience after just a few days of his first treatment.

August 29th-Sleeping better, not as stressed but no improvement. Taking a lot of medication for my fibromyalgia.

August 30th-Feeling better but nothing dramatic that I could measure in reference to my fibromyalgia.

August 31st-Feeling better but don’t know if it’s just jet lag going away but pain in my neck, arms, legs and hips still substantial. Taking heavy doses of Tylenol.

September 1st-Getting out of bed in the morning I noticed that the pain in my shoulders has disappated during the night. I’m almost pain free. Woke up only four times during the night. Went dancing tonight!!! No discomfort!

September 2nd- Neck no longer painful. Shoulders normal. Pillow that I was using in my automobile no longer needed. Hip pain almost all gone. Went dancing again! Did I ever cut the rug!!!

September 3rd-Pain in my legs very minimal and almost completely gone were the typical signs of fibromyalgia. The only thing I can hope is that the stem cells are also doing a good job on my prostate and heart.

September 4th-Drove to Palm Springs with virtually no discomfort in my neck, arms, legs, and hips. Woke up only one time last night with no real discomfort at all.

It seems to be somewhat of a miracle to me.

.

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Click [HERE] to see if your condition can be treated with Adult/Repair Stem Cells now.

 

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