DAVID GRANOVSKY

Posts Tagged ‘multiple sclerosis’

SALT in FAST FOOD = IMMUNE DISORDERS? MULTIPLE SCLEROSIS?

In ALL ARTICLES on September 16, 2015 at 6:39 pm

In the last article we discovered that we don’t know everything there is to know about the human body.  Far from it.

“In contradiction to decades of medical education, a direct connection has been reported between the brain and the immune system….It seems astonishing that, after centuries of dissection, a system of lymphatic vessels could have survived undetected.” via https://repairstemcell.wordpress.com/2015/09/16/system-connecting-brain-to-immune-system-found/

So what about processed foods?  Could the foods you are eating be a contributing factor to immune diseases like Multiple Sclerosis?

A study [Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells ] showing that “mice fed with a high-salt diet develop a more severe form of (experimental autoimmune encephalomyelitis) EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells.”  In other words, “…increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.”  via 

In the latest study, scientists discovered that exposing these cells in a lab to a table salt solution made them act more ‘aggressively.’  They found that mice fed a diet high in refined salts saw a dramatic increase in the number of Th17 cells in their nervous systems that promoted inflammation.  They were also more likely to develop a severe form of a disease associated with multiple sclerosis in humans.  The scientists then conducted a closer examination of these effects at a molecular level.  Laboratory tests revealed that salt exposure increased the levels of cytokines released by Th17 cells 10 times more than usual. Cytokines are proteins used to pass messages between cells.  via 

More and more we realize that all the systems of the body are connected and everything we eat and do and don’t eat and don’t do has an affect.

Bare this in mind the next time you decide to “treat yourself” with some junk food.

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:25 pm
Milan, Italy study used stem cells derived from mouse skin tissue to treat MS

 

An experiment was published Tuesday in Nature Communications by researchers at San Raffaele Scientific Institute in Milan and the University of Milan in Italy, that showed they were able to reduce nervous system damage in mice.

Milan, Italy study used stem cells derived from mouse skin tissue to treat MS – Lima multiple sclerosis | Examiner.com.

STEM CELL TRAIL BLAZER RICHARD HUMPHRIES WILL BE MISSED

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 21, 2013 at 4:44 pm

richard humphries

Richard Davis Humphries was a trail blazer in the area of adult stem cell treatments and his strength and passion will be missed. His successful treatment and recovery from secondary progressive multiple sclerosis in 2007 enlightened untold numbers to the benefits and safety of adult stem cell treatments. If you didn’t know him, here’s a small piece of his battle and recovery from MS:

In March of 2007, “Humphries, a 54-year-old Alexandria native who lives in Fort Worth, Texas, was bedridden and suffering from excruciating pain with secondary progressive multiple sclerosis.

“Very few people know this,” he said, “but I prayed to die every day and night, for the pain was off the charts.”…

…”The night after the second injection, I started to feel better and the fog had lifted. The time was midnight, and I had not been able to stay up that late in some time. The pain was gone….

HUMPHRIES WAS THE FIRST ADIPOSE (FAT TISSUE) DERIVED STEM CELL RECIPIENT IN THE WORLD.  STEM CELLS FROM FAT HAVE SOME OF THE HIGHEST REGENERATIVE CAPABILITIES AND ARE FOUND IN SUPER ABUNDANCE, MAKING THEM AN IDEAL SOURCE FOR TREATMENT.


…In February (2008?), Humphries underwent another experimental stem cell treatment to regrow inner ear nerve hairs. It not only improved his hearing but helped him tolerate heat, which can be a problem for people with MS…

“It’s an amazing recovery,” Ichem said (Dr. Tom Ichem of San Diego, a scientist). “I was with him in (Washington) D.C. and spent three days with him, and I was, honestly, bona fide flabbergasted. It’s one thing to read about recoveries like this, but to see it first hand — I hate to say ‘miracle,’ but it was absolutely something very, very stunning. Usually when we develop new treatments, we see results with some impact, but I’ve never seen this kind of stunning impact. It literally shocked me.”

Rest In Peace my friend. You will be missed.

WHY TRAVEL ABROAD FOR STEM CELL TREATMENTS???

In ALL ARTICLES, CELEBRITIES & STEM CELLS, VICTORIES & SUCCESS STORIES on February 12, 2013 at 9:00 am
sunny-day-in-cheshire_std
“Woke up this morning and am “aware” of my surroundings. I guess in other words I’m not a zombie. Haven’t been this clear in years. And the headache i’ve had all week is GONE!”

A women who has been battling Multiple Sclerosis, wheel chair bound for two years, unable to grasp objects due to severe shaking, and dealing with daily Brainfog, was treated with stem cells here in the United States two weeks ago.   For the first time in two years she was walking with the assistance of a cane and able to grasp her morning coffee cup and this was ONLY AFTER TEN DAYS!!!

Jack Osbourne

It’s a shame that Son of rocker Ozzy Osbourne, Jack Osbourne has had to travel to Germany to ­undergo stem cell replacement therapy to treat his Multiple Sclerosis, when he could have been treated here in the United States..  Jack, who went public about his health crisis last summer, said he is currently feeling well and getting plenty of rest – despite being a new dad to nine-month-old daughter Pearl.

“There are odd restrictions here in America because everybody still thinks it’s, like, what it isn’t. So I’m going to Germany. They pull stem cells from your own blood then inject them back into you.  Hopefully it will repair any damaged cells and nerves and things like that.” said Jack.

For more articles related to Stem Cell treatments for Multiple Sclerosis click HERE.

 

RESEARCHERS DISCOVER KEY TO STEM CELL THERAPY FOR MS PATIENTS

In STEM CELLS IN THE NEWS on November 30, 2012 at 9:00 am

 clinical trial capsules

We know stem cells work on MS, we just hadn’t figured out exactly how yet…and now we have!

– DG

CLEVELAND, Ohio — One of the most promising and exciting treatment avenues for multiple sclerosis is the use of a patient’s own stem cells to try to stop — or even repair — some of the disease’s brain tissue damage.

But injecting a patient with a dose of his or her own bone-marrow stem cells was actually a pretty crude method of treating the disease, because no one was quite sure how or why it worked. Last year, doctors at the Cleveland Clinic, University Hospitals Seidman Cancer Center and Case Western Reserve University began trying this for MS patients in a Phase 1 clinical trial after positive results were seen in mice.

Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheaths that surround and protect nerve cells. When myelin is damaged, the nerve cells are exposed and unable to do their job, which is sending signals to the brain and back. This results in the loss of motor skills, coordination and cognitive abilities.

Like many other researchers using stem cells, the local group didn’t know exactly how their treatment worked, but they knew that when they gave these human mesenchymal stem cells, or MSCs, to mice with a mouse version of the disease, the mice got better.

Figuring out why the mice improved could help researchers see if the MSC injection will work well in a particular patient before the patient is injected, and possibly augment or improve the treatment as well.

In May, the research group at CWRU, headed up by neurosciences professor Robert Miller, discovered exactly what it is in the stem-cell soup that has a healing effect: a large molecule called hepatocyte growth factor, or HGF. The team published their results in Nature Neuroscience.

Miller’s group knew that it could be the stem cells themselves, by coming in physical contact with the myelin damage, that were having a healing effect. Or it could be something the stem cells secreted into the surrounding liquid culture, or media, they were grown in, that was key. HGF is secreted by the stem cells, Miller said.

The team identified the HGF by first injecting only the liquid the stem cells were grown in, but not the stem cells themselves, into the mice they were studying. The mice got better, so the team knew whatever was helping was in the media.

Next, they isolated the small, medium and large molecules from the media and tried each size on the mice. Only the large-molecule treatment had the healing effect, meaning that whatever was helping was somewhere in that mix, Miller said.

“The molecule that jumped out at us was HGF,” he said, because it is the right size, is made by MSCs, and in a couple of studies had been shown to be involved in myelin repair.

So the scientists took a purified sample of HGF and injected it into the sick mice. They got better. When they blocked the receptor for HGF in the mice, they stayed sick. It was pretty compelling evidence that they’d found what they’d been looking for, Miller said.

“We went on to show that HGF, like the MSCs, is regulating both the immune response, and it is independently promoting myelin repair in the brain,” he said.

MSCs, taken from the bone marrow, are currently being tested in more than 150 clinical trials in the United States and around the world to treat conditions such as osteoarthritis, diabetes, emphysema and stroke.

The local Phase 1 trial has enrolled 16 of 24 total patients, and eight of them have completed the trial protocol, said Dr. Jeffrey Cohen, Cleveland Clinic neurologist and lead investigator of the trial.

So far, the treatment seems to be working, Cohen said.

“It’s a little early to be saying it, but things have looked encouraging.”

And there have been no safety concerns and almost no side effects. There has also been no activation — an aggravation or return of symptoms — of this relapsing disease in the patients involved, which has happened unexpectedly with other types of MS treatments.

Miller’s discovery won’t change the course of the trial currently under way at the Clinic and UH, but it may change the future of MSC treatment.

While they don’t know yet what the outcome of that trial will be, it’s possible that if a patient doesn’t respond to the treatment, it could mean that his stem cells aren’t producing enough HGF to be effective at healing, Miller said. Miller will be studying MSC samples from all the patients in the trial to find out if those who are better at producing HGF fare better.

He’ll also be trying to see if they can predict how well a patient will do based on his HGF levels in the MSC sample.

“Finally, though we’re a long way from this, maybe we could augment the expression of HGF in patients whose stem cells aren’t that effective to enhance their effectiveness,” he said.

But why not just inject the HGF alone? Miller said there are two reasons. First, the receptor for HGF in the cells, called c-MET, has been implicated in liver and breast cancer. Injecting HGF by itself into the body may stimulate the c-MET pathway, he said, and the research team is not willing to risk that.

“The stem cells have the advantage that they tend to home to the area of insult, so they don’t stick around in other parts of the body,” he said. “They target the treatment where it’s needed.”

Miller said his group is experimenting with a way of delivering HGF directly into the area of injury in the brain to minimize its contact with the rest of the body. HGF and c-MET are not associated with brain tumors.

They are also trying to test small fragments of the growth factor as a treatment, to see if they can eliminate some of the cancer concerns.

Cohen’s group hopes to have results from the Phase 1 trial available in the spring and has already started planning a larger study based on those results.

http://www.cleveland.com/healthfit/index.ssf/2012/09/cleveland_researchers_find_key.html

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells

In VICTORIES & SUCCESS STORIES on June 21, 2012 at 1:54 pm

https://i1.wp.com/static.ddmcdn.com/gif/multiple-sclerosis-demyelinization.gif

Recovery From Multiple Sclerosis By Growth Factor In Stem Cells
http://www.medicalnewstoday.com/articles/245816.php

Multiple Sclerosis and stem cells – need more info?
https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

In STEM CELLS IN THE NEWS on October 25, 2011 at 1:49 pm

Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of the scale of their disability.”

With these “encouraging” results, the researchers decided to perform another study involving more patients, and compared their results with traditional treatments. The experiment involved the removal and freezing of bone marrow after treating the marrow with drugs to remove the lymphocytes of the immune system which are responsible for attacking nerve system fibers in MS patients.

At the end of the process, doctors implanted stem cells, which proved to be able to give the MS patients a normally functioning immune system. The time factor, underlined neurologists, seems crucial in the efficiency for stem cells because “if we intervene quickly, we are able to exploit the body’s ability to repair itself, which in the long term is lost”. In any case, scientists say that “ it is not a definitive cure for muscular sclerosis”.

DO STEM CELL TREATMENTS WORK?

In VICTORIES & SUCCESS STORIES on October 10, 2009 at 10:43 am

DO STEM CELL TREATMENTS WORK?

Do not take one step further in your plans for treatment or read one more word about stem cells anywhere else until you believe that we have answered this question, unequivocally and without a shadow of a doubt:

DO STEM CELL TREATMENTS WORK?

Ask most US doctors if repair stem cell treatments work and they will tell you “NO!”  You may also get condescending retorts, misinformation and derisive abuse.  But if you press them on the question, eventually they will give you the reason why they believe repair stem cells don’t work.  The top answer WHY STEM CELLS DON’T WORK is… (Survey Says!):

There have been no clinical trials to date that prove they do work.

When all is said and done, in the end, there is nothing that will convince a western doctor of the effectiveness of stem cell treatments besides clinical trials.  So have there been any stem cell clinical trials? Is all of the evidence supporting the benefits of stem cell treatments anecdotal as virtually every western doctor says? NOT ON YOUR LIFE! Have there been clinical trials?  The answer is a resounding “YES!”

According to the National Institutes of Health, there were and are ~2600 stem cell clinical trials around the world – http://www.clinicaltrials.gov/

  • Of those ~2600 trials, there are only nine mentions of embryonic stem cells.
  • Of those 9, there are no actual embryonic clinical trials.
  • Of those ~2600, there are ~2591 mentions of adult stem cells.
  • Of those ~2591, about half of them (~1300) are actual adult stem cell clinical trials.

Let’s look at (only) a few of those ~1300 clinical trials:

HEART DISEASE CLINICAL TRIALS

  • 2002 – clinical trial led by Dr. Hans Dohmann plus six colleagues in Brazil took 21 transplant candidates and gave 14 of them bone marrow cells. The results were so spectacular that the American Heart Association accepted the paper and it was presented in 2003. Five of the seven in the control group opted in to make a total of 19 stem cell transplants. The mortality rate for transplant candidates is about 35% per year. At that rate there would be, of those 19, only 2.2 patients still alive without a transplant after five years. There were, in fact, 12 alive as of Dec. 31, 2007; more than five years down the road.
    • In 2002, if you did not want or could not get a heart transplant (as is true of 90%+ of dying heart patients in North America) then you had to make a choice between stem cell treatment or standard Western Cardiology methodology.
  1. Western Cardiology methodology in 2002 kept 12% of transplant-waiting-patients alive for five years.
  2. Adult/repair Stem cell treatments in 2002 kept 63% of transplant-waiting-patients alive for five years.  More than 5 times more heart transplant candidates lived for 5 years with stem cell treatments than the typical heart transplant recipient! Btw, stem cell science has made huge advancements in treating heart disease over the past seven years.
  • 2003 – Dr. Andreas Zeiher of the Goethe Institute in Frankfurt began much larger trials. As of 2007, he has overseen more ASC implants into hearts than anyone, both in and out of clinical trials and he was the first to prove that timely implant of RSC in new heart attack victims improves future mortality and morbidity – http://circ.ahajournals.org/cgi/search?journalcode=circulationaha&fulltext=zeiher
  • 2004 – Dr. Amit Patel of Pittsburgh completed two of the most successful trials ever.  In Uruguay, he proved, on a group of ischemic heart failure patients, that a bypass plus cells was infinitely better than a bypass only. That same year, TheraVitae, in Israel, developed a new, powerful blood-derived stem cell and dared to treat the sickest patients no clinical trial (except Brazil) would consider.
  • 2004 – One of the Brazilians, Dr. Perin, came to Texas, used the Brazil results to get the first ASC heart clinical trial approved by the FDA. Over a dozen such approvals were granted in the next 12-18 months.
  • Clinical trials at the Mayo Clinic in Florida have seen successes in reversing and curing pulmonary hypertension using adult stem cells from patients’ own blood.

diabetes-RED

DIABETES CLINICAL TRIALS

  • FIRST USE OF CORD BLOOD TO ALTER COURSE OF TYPE 1 DIABETES, June 25, 2007 – (I’ll bet nobody heard of this one!)transfusion of stored, autologous (i.e. the person’s own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association’s 67th Annual Scientific Sessions. –http://parentsguidecordblood.org/content/media/m_pdf/ADA_T1D_PR-06-25-07.pdf(The ADA in 2007 knew stem cells can treat Diabetes type 1 in children!)
  • Diabetes type 1 stem cell clinical trial – Enrollment 11/2003-4/2008, follow-up until December 2008 – https://repairstemcell.wordpress.com/2009/09/14/type-1-diabetes-stem-cells-clinical-trial/
  • Why no diabetes clinical trial s in the US when mice were cured of diabetes type 1 in the 1990’s? –  Weissman, a professor of pathology and developmental biology at Stanford University, states: “Stem cells are rare, self-renewing, and can regenerate body tissues.” He repeatedly expressed frustration that while many of his discoveries seemed to hold remarkable potential for life-saving treatments, commercial or regulatory hurdles have prevented his scientific research from benefiting human beings. One example is, his mid-’90s research on type I diabetes, in which he demonstrated the ability to fully cure type I diabetes in mice using stem cells. Even though the experiments avoided political controversy by using adult/repair stem cells, which do not come from embryos, Weissman ran into a road block when pharmaceutical companies refused to sponsor clinical trials. The therapy went nowhere. “The pharmaceutical companies had put profit over principle, preferring to keep diabetes sufferers dependent on costly insulin than to cure them once and for all.” – https://repairstemcell.wordpress.com/2009/09/13/research-from-90s-cures-type-1-diabetes/

CerebralPalsy

CEREBRAL PALSY CLINICAL TRIALS

AMPUTATION CLINICAL TRIAL

  • Bone Marrow Stem Cell Treatment Saves Legs – The results of a clinical trial to save volunteers’ leg from amputation by injecting (autologous bone marrow) stem cell concentrate to the limb affected by thrombo angitis obliterance (TAO) have been encouraging. The clinical trial is being conducted on patients suffering from blocks in the artery of the leg. Sixty patients enrolled, all of them were smokers. Some had diabetes.  “We have got very good results,”said Dr. K.S. Vijayaragavan, head of the Department of Vascular Surgery, Sri Ramachandra University, Chennai, who is conducting the trial. “The legs of 89 per cent of the patients have been saved.”

stroke

STROKE CLINICAL TRIALS

  • “The stem cells had excellent safety profile. After carrying out Pet scans and MRIs thrice in a year on patients who received stem cells, we found no side effects. This study shows that stem cells are a safe and feasible therapy in acute stroke. https://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
  • The University of Texas, Health Science Center at Houston July 1, 2009       Several months after becoming the first patient in the United States to undergo a revolutionary new stroke treatment, Roland “Bud” Henrich continues to improve. Doctors intravenously injected Henrich, 61, with stem cells taken from his own bone marrow…”The stem cells, we believe, may help repair the damage to his brain caused by the stroke,” said Sean Savitz, M.D., assistant professor of neurology at The University of Texas Medical School at Houston and the study’s lead investigator. “Animal studies have shown that when you administer stem cells after stroke, the cells enhance the healing. We know that stem cells have some kind of guidance system and migrate to the area of injury. They’re not making new brain cells but they may be enhancing the repair processes and reducing inflammatory damage.” http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

Other stroke articles:

MyelinGraphic

MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” – January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

What is clear is that the overwhelming majority of Repair Stem Cell vs Disease clinical trials have been successful.

  • The majority of patients treated with stem cells get better.

Not all, but the majority.

  • The majority of patients treated with stem cells get better.

Not cured, but better.

No western doctor in the world can come to matching the statistical success of stem cell treatments with pill-based “cures” for diseases that they define as “untreatable” and “incurable.”

WHAT HAVE WE LEARNED?

What have we learned?

  • Now you know there are 1300 real adult/repair stem cell clinical trials.
  • Now you know that adult/repair stem cell treatments work on most patients.
  • Now you know that while the disease is not cured, their condition does improve considerably.
  • Now you know that stem cell treatments are a significantly better choice than pill after pill after pill.
  • Now you know that stem cell treatments can provide more benefit to patients with so-called “incurable” diseases like Diabetes, Heart Disease, Stroke, Multiple Sclerosis and Cerebral Palsy.

Based upon this information, can you now answer the question DO STEM CELL TREATMENTS WORK?

OF COURSE YOU CAN!

Based upon this information, can you now answer the question DO STEM CELL TREATMENTS WORK unequivocally and without a shadow of a doubt?

OF COURSE YOU CAN!

Well do they?

OF COURSE THEY DO!

Green light!

Green light means go!  You may now take the next step in your plans for treatment!

—————————————————————–

Helping those with so-called “untreatable” medical conditions make educated choices and connect with the world’s finest, most advanced stem cell doctors.

“Give them nothing! But take from them everything!”

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on May 12, 2009 at 9:12 am
In the movie 300, King Leonidas rallies his troops for the clash with the insurmountable odds of the Persian forces.  Just before the armies slam into each other, Leonidas shouts: “Give them nothing! But take from them everything!”
leonidas
Imagine an army of brilliant doctors who oppose the seemingly insurmountable forces of both Multiple Sclerosis AND the regulatory boards that refuse to allow patients to receive adult stem cell treatments in the US.

Their battle is a difficult one and not all patients will benefit from the treatment (~74% do) so the doctors must “promise them nothing.”

But the doctors WILL give the patients the beneficial treatments, WILL give them their own stem cells, NONE shall stand in the way of treating their patients and MOST patients will be SYMPTOM FREE and get their lives back…in short, they will be given EVERYTHING!

“Promise them NOTHING,

but give them EVERYTHING!”

Multiple Sclerosis Patients Promised Nothing But Are Symptom Free After Stem Cell Treatment | Culture11

May 11, 2009

Multiple Sclerosis Patients Improve After Stem Cell Research and Therapy Preston Walker and Richard Humphries are shining examples of how stem cell research using Adult Stem Cells are improving lives right now. Preston and Richard were the first two Multiple Sclerosis patients to receive stem cell treatment with their own cells derived from their fat. Stem […]…read more

via Multiple Sclerosis Patients Promised Nothing But Are Symptom Free After Stem Cell Treatment | Culture11.

Fat-Derived Stem Cells Might Treat MS – US News and World Report

In ALL ARTICLES, CATCH UP! on April 26, 2009 at 5:08 pm

There are probably more than a dozen articles on here to speak of stem cells treating MS successfully over the past 4-6 years.  One day the US might catch up but it doesn’t look promising.

-dg

ms-multiple sclerosis

Fat-Derived Stem Cells Might Treat MS

Small study suggests they inhibit runaway immune system response

Posted April 26, 2009

SUNDAY, April 26 (HealthDay News) — Stem cells taken from the fat tissue of people with multiple sclerosis (MS) may help treat the disease, suggests a preliminary study that included three patients.

The successful use of the stromal vascular fraction (SVF) cells in these patients shows that further clinical studies should be conducted into the use of SVF cells to treat multiple sclerosis and other autoimmune diseases, the researchers said.

“All three patients in our study showed dramatic improvement in their condition after the course of SVF therapy. While obviously no conclusions in terms of therapeutic efficacy can be drawn from these reports, this first clinical use of fat stem cells for treatment of MS supports further investigation into this very simple and easily-implementable treatment methodology,” Dr. Boris Minev, division of neurosurgery at the University of California, San Diego, said in a news release.

In people with MS, the immune system attacks and destroys the myelin sheath that surrounds and protects nerves cells. It’s believed that SVF cells, and other stem cells, may limit this immune reaction and promote the growth of new myelin.

“None of the presently available MS treatments selectively inhibit the immune attack against the nervous system, nor do they stimulate regeneration of previously damaged tissue. We’ve shown that SVF cells may fill this therapeutic gap,” Minev said.

The study was published in the Journal of Translational Medicine.

via Fat-Derived Stem Cells Might Treat MS – US News and World Report.

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