DAVID GRANOVSKY

Posts Tagged ‘mccarthy’

LEAKY GUT + BLOOD BRAIN BARRIER =AUTISM?

In DISEASE INFO, HEALTH AND WELLNESS, SCIENCE & STEM CELLS on January 24, 2017 at 10:55 am

leaking

Does leaking cause autism and schizophrenia?

Remember those hysterical soccer Moms who said Autism has to do with the gut, the immune system and the brain.  Guess what, they were pretty spot on…it looks like in ASD and schizophrenia patients, there is a significant incidence of leaking in both the intestines and the blood-brain barrier

  1. “Blood-brain-barrier integrity and function and with inflammation was detected in ASD tissue samples, supporting the hypothesis that an impaired blood-brain barrier associated with neuroinflammation contributes to ASD”
  2. Gut: “75 percent of the individuals affected by ASD had reduced expression of barrier-forming cellular components, compared with controls, and 66 percent showed a higher expression of molecules that increase intestinal permeability”

autism-awareness

Wednesday, January 18, 2017

Study finds alterations in both blood-brain barrier and intestinal permeability in individuals with autism

Autism spectrum disorder (ASD) has the dubious distinction of being the fastest-growing developmental disability in the U.S., according to the Centers for Disease Control and Prevention. With 1 in every 68 children born in this country diagnosed with ASD, parents are looking everywhere for answers about best treatments. Along with selective medication to treat certain symptoms, traditional treatments include intensive behavioral approaches. But with no “one-size-fits-all” treatment approach, parents often turn to diverse complementary and alternative therapies.

Just as parents are looking for answers, scientists are trying to tease out the causes of this multifactorial and complex condition. “Although we are fairly certain that there is a genetic component, there are many pathways for an individual to arrive at autism’s final destination,” says Alessio Fasano, MD, director of the Center for Celiac Research and Treatment at Massachusetts General Hospital (MGH) and co-senior author of a study published in the journal Molecular Autism. “What might dispose one person to develop ASD – either pre- or post-natally – might have no such effect on another person,” he adds.

Looking at the interconnectivity of the gut-brain axis – the biochemical signaling between the gastrointestinal and central nervous systems – researchers led by Maria Rosaria Fiorentino, PhD, of the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC), have opened up a new avenue of research into the pathophysiology of ASD and other neurodevelopmental disorders. “As far as we know, this is the first study to look at the molecular signature of blood-brain barrier dysfunction in ASD and schizophrenia in samples from human patients,” says Fiorentino. In collaboration with researchers from the University of Maryland School of Medicine and others, Fiorentino’s group found an altered blood-brain barrier in tissue samples from people with ASD when compared with healthy controls.

The group analyzed postmortem cerebral cortex and cerebellum tissues from 33 individuals – 8 with ASD, 10 with schizophrenia and 15 healthy controls. Altered expression of genes associated with blood-brain-barrier integrity and function and with inflammation was detected in ASD tissue samples, supporting the hypothesis that an impaired blood-brain barrier associated with neuroinflammation contributes to ASD.

In keeping with the hypothesis that the interplay within the gut-brain axis is a crucial component in the development of neurodevelopmental disorders, the group also analyzed intestinal epithelial tissue from 12 individuals with ASD and 9 without such disorders. That analysis revealed that 75 percent of the individuals affected by ASD had reduced expression of barrier-forming cellular components, compared with controls, and 66 percent showed a higher expression of molecules that increase intestinal permeability.

The study was driven in part by the high number of gastrointestinal problems that occur in people with ASD. Although considered controversial by some health care practitioners, a gluten- and casein-free diet has been shown to produce some improvement in behavioral and gastrointestinal symptoms in a subgroup of children with ASD. “This is the first time anyone has shown that an altered blood-brain barrier and impaired intestinal barrier might both play a role in neuroinflammation in people with ASD,” says Fiorentino.

Fasano adds, “As well as information on the blood-brain barrier, we were looking for more information on how increased intestinal permeability, otherwise known as a ‘leaky gut,’ might affect the development of ASD in the context of a dysfunctional gut-brain axis.”

Fiorentino’s next project involves looking more mechanistically at how microbiota – the collection of microorganisms in the gut – are linked with intestinal permeability and behavior. “There is definitely something going on between the gut and the brain with ASD and other neurodevelopmental disorders, and of course the microbiome has a big role to play,” she says. “It has already been shown that ASD kids have an altered composition of gut microbial communities. If we can figure out what is required or missing, then maybe we can come up with a treatment that might be able to improve some of the behavioral issues and/or the gastrointestinal symptoms.”

Fasano is a professor of Pediatrics, and Fiorentino is an assistant professor of Pediatrics at Harvard Medical School. Additional co-authors of the Molecular Autism paper are Anna Sapone, PhD, Stefania Senger, PhD, and Stephanie Camhi, MGHfC Mucosal Immunology and Biology Research Center; Sarah Kadzielski, MD, and Timothy Buie, MGHfC Gastoenterology and Lurie Center for Autism; Deanna L. Kelly, PharmD, BCPP, University of Maryland School of Medicine, and Nicola Cascella, MD, Sheppard Pratt Health System, Baltimore.

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $800 million and major research centers in HIV/AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, photomedicine and transplantation biology. The MGH topped the 2015 Nature Index list of health care organizations publishing in leading scientific journals and earned the prestigious 2015 Foster G. McGaw Prize for Excellence in Community Service. In August 2016 the MGH was once again named to the Honor Roll in the U.S. News & World Report list of “America’s Best Hospitals.”

MMR VACCINE AND AUTISM – THE SCIENCE

In ALL ARTICLES, OFF THE BEATEN PATH on April 30, 2013 at 6:56 pm

autism scientific america

TRYING TO GET A HANDLE ON THE MMR/VACCINE CONTROVERSY:

I don’t know what causes Autism but I believe in education, knowledge and research.

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Baby monkeys given standard doses of popular vaccines develop autism symptoms

“…a macaque monkey (primates) study of the very same vaccines given to children during 1994-1999, i.e., the Measles-Mumps-Rubella (MMR) vaccine and several Thimerosal mercury-containing vaccines injected into children during that time frame when the autism spectrum disorder skyrocketed.”

The original Study here:

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study   http://www.ane.pl/pdf/7020.pdf

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WHAT ARE THE ADVERSE REACTIONS FROM MMR VACCINES?
http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf
(The warnings from the manufacturer are scary enough, even if it doesn’t cause autism.)

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WORLD STUDIES ON MMR/AUTISM:

Here is a list of 28 studies from around the world from (mercola.com) that support Dr. Wakefield’s controversial findings:

  1. The Journal of Pediatrics November 1999; 135(5):559-63
  2. The Journal of Pediatrics 2000; 138(3): 366-372
  3. Journal of Clinical Immunology November 2003; 23(6): 504-517
  4. Journal of Neuroimmunology 2005 
  5. Brain, Behavior and Immunity 1993; 7: 97-103
  6. Pediatric Neurology 2003; 28(4): 1-3
  7. Neuropsychobiology 2005; 51:77-85
  8. The Journal of Pediatrics May 2005;146(5):605-10
  9. Autism Insights 2009; 1: 1-11
  10. Canadian Journal of Gastroenterology February 2009; 23(2): 95-98
  11. Annals of Clinical Psychiatry 2009:21(3): 148-161
  12. Journal of Child Neurology June 29, 2009; 000:1-6
  13. Journal of Autism and Developmental Disorders March 2009;39(3):405-13
  14. Medical Hypotheses August 1998;51:133-144.
  15. Journal of Child Neurology July 2000; ;15(7):429-35
  16. Lancet. 1972;2:883–884.
  17. Journal of Autism and Childhood Schizophrenia January-March 1971;1:48-62
  18. Journal of Pediatrics March 2001;138:366-372.
  19. Molecular Psychiatry 2002;7:375-382.
  20. American Journal of Gastroenterolgy April 2004;598-605.
  21. Journal of Clinical Immunology November 2003;23:504-517.
  22. Neuroimmunology April 2006;173(1-2):126-34.
  23. Prog. Neuropsychopharmacol Biol. Psychiatry December 30 2006;30:1472-1477.
  24. Clinical Infectious Diseases September 1 2002;35(Suppl 1):S6-S16
  25. Applied and Environmental Microbiology, 2004;70(11):6459-6465
  26. Journal of Medical Microbiology October 2005;54:987-991
  27. Archivos venezolanos de puericultura y pediatría 2006; Vol 69 (1): 19-25.
  28. Gastroenterology. 2005:128 (Suppl 2);Abstract-303

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Dr. Wakefield’s Latest: MMR And Autism

http://articles.mercola.com/sites/articles/archive/2008/01/02/mmr-and-autism-part-two.aspx

References/Notes

1. Plotkin SA, Mortimer EA. (eds.) Vaccines, Philadelphia, W. B. Saunders, 1994. This collection of articles has a wealth of medical information about vaccines.

2. See details at http://www.cdc.gov/nip/registry.

3. “The effect of routine infant vaccination on acute disease incidence may not be apparent for 20-30 years because currently most infections occur among young adults.” Morbidity and Mortality Weekly Report, Vol. 44, No. 30, Aug. 4, 1995.

4. “In a sudden reversal of health policy, France has decided to suspend Hepatitis B vaccinations in secondary schools because of fears that the vaccine causes neurological disorders.” New York Times, Oct. 3, 1998.

5. ACIP meeting minutes, Feb. 1998. Available from CDC.

6. The Economist 1998;344(8044):95(3). It suggested possible correlations between vaccines and other diseases such as asthma.

7. Patton CV, Sawicki DS. Basic Methods of Policy Analysis, Prentice Hall, 1993.

8. ACIP Policies and Procedures, July 1998. Available from the CDC or from Some other supporting evidence on immunization policy is also there.

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Measles-Mumps-Rubella (MMR) Vaccine as a Potential Cause of Encephalitis (Brain Inflammation) in Children

http://articles.mercola.com/sites/articles/archive/2008/01/02/mmr-vaccine-part-three.aspx

References for this article:

1. Statements by Bernard Rimland, PhD, were given at a conference on autism, sponsored by the Autism Research Institute in Chicago, June, 1996.

2. Information from the Developmental Delay Registry, 6701 Fairfax Road, Chevy Chase, Maryland 20815, Tel. 301652-2263.

3. From a paper distributed by Dawbarns Law Firm, Bank House, Kingrs Staithe Square, Lingrs Lynn, Norfolk PE30 IRD, Great Britain, Tel. 01553. 764373, Fax 01553-765226.

4. Singh VJ et al., Antibodies to myelin basic protein in children with autistic behavior, Brain, Behavior, and Immunity, Vol. 7, 97-1203, 1993.

5. Kumar S & Miller LK, Effects of serial passage of Autographs Californica nuclear polyhidrosis virus in cell culture. Virus Research, Vol. 7, 335-349, 1987.

6. Jahnke U et al., Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis, Science, Vol. 29, 282-284, July 19, 1985,

7. Presentation by Dr. Vijendra Singh, August 16, 1997, Allegro School, Cedar Knolls, New Jersey.

8. Scott HD et al., Physician reporting of adverse reactions: results of the Rhode Island adverse drug reaction reporting project, JAMA, Vol. 263, No. 13, 1785-1788, April 4, 1990.

9. Reporting side effects: signals or noise? (Editorial), ibid, page 1823.

10. Gupta S et al., Dysregulated immune system in children with autism; beneficial effects of intravenous globulin on autistic characteristics, J ofAutism and Develop Disorders, Vol. 26, No. 4, 439-452, 1996. (In this article on page 450, it is stated, “We theorized that the high titers of rubella antibody … present in mothers of children with autism would be transplacentally transferred and may persist for a prolonged period in the child. When such a child gets MMR immunization, rubella antigen may complex with preexisting antibodies and such complexes might play a role in pathogenesis of autistic features.”)

11. Dublin L & Lotka A, Twenty-five Years ofHealth Progress, New York: Metropolitan Life Insurance Company, 1937, page 48.

12. Dublin L, Health Progress 1936-1945, New York: Metropolitan Life Insurance Company, 1948, page 12.

13. Vaccination. 100 Years of Orthodox Research Shows that Vaccines Represent a Medical Assault on the Immune System, Viera Scheibner, PhD., 1993 (from pages 33 to 49 the author extensively reviews the Swedish and Japanese experiences with the pertussis vaccine, book available from New Atlantean Press, P.O. Box 9638-925, Santa Fe, New Mexico 87504).

14. Garenne M et al., Child mortality after high-titre measles vaccines; a prospective study in Senegal, Lancet, Vol. 338, 903-907, October 12, 1991.

15. Hussey GD et al., The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune responses in infants, J of Infect Diseases, Vol. 173, 1320-1326, 1996.

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Italian court reignites MMR vaccine debate after award over child with autism

http://www.independent.co.uk/life-style/health-and-families/health-news/italian-court-reignites-mmr-vaccine-debate-after-award-over-child-with-autism-7858596.html?origin=internalSearch

Original Articles in Italian:

MMR e Autismo: il caso Wakefield come emblema del “COVER-UP scientifico”

… per tutte sulla vicenda Wakefield e la correlazione fra MMR e Autismo. Innanzitutto vi segnaliamo il pregevole lavoro che il sito … i n discussione la procedura di valutazione dei vaccini MMR in Gran Bretagna fin dal lontano 1987 e conferma la sostanziale assenza di …

News – thinknew – 28/09/2012 – 08:05 – 0 comments – 1 allegato

MMR: la Vittoria di una Madre

… apparso il 16 giugno 2012 su “Daily Mail” con il titolo “MMR: A mother’s victory. The vast majority of doctors say there is no link …

Articolo – thinknew – 24/09/2012 – 13:17 – 0 comments – 0 allegati

Ascolta il Silenzio – Film

… i possibili legami tra la somministrazione del vaccino MMR, la malattia intestinale cronica e l’autismo.   Nonostante tutte le …

Argomento di discussione del forum – yellowbrain – 26/03/2013 – 19:58 – 0 comments – 0 allegati

Re: VACCINI OMEOPATICI

… 7 th November 1997″ , che riporta : ” MMR e SSPE ****** In una conferenza negli Stati Uniti, … potrebbe essere utile. ” originale: “MMR and SSPE****** at a conference in the US had suggested that the measles …

Commento – Lucas – 16/01/2013 – 00:19 – 0 comments – 0 allegati

Chi ha paura dell’uomo nero?

… di Valentino ( http://www.comilva.org/danno_da_vaccino/mmr_vittoria_di_madre ) poi dà particolarmente fastidio perché sbugiarda …

News – thinknew – 28/01/2013 – 11:35 – 0 comments – 0 allegati

Anonimo:Autismo e vaccino di MMR (orecc.morb.rosolia)

… sul collegamento di tale malattia con il vaccino di MMR (orecchioni – morbillo – rosolia). di: VICKY COLLINS Gordon Bell, … molto stretta tra l’autismo ed il vaccino di MMR(orecchioni – morbillo – rosolia) indicando che i bambini autistici … volta presenti a livelli così elevati, causa il vaccino MMR, scatenano in un organismo così debole nel sistema immunitario come quello …

Argomento di discussione del forum – OldForum – 30/07/2002 – 00:00 – 0 comments – 0 allegati

Anonimo:Il legame tra MMR e autismo.

… prove schiaccianti relative al legame fra la vaccinazione MMR (orecchioni – morbillo – rosolia) l’autismo e le malattie intestinali nei … urgentemente nuovi parametri sulla sicurezza del vaccino MMR – la vaccinazione combinata per orecchioni, morbillo e rosolia che viene …

Argomento di discussione del forum – OldForum – 02/08/2002 – 00:00 – 0 comments – 0 allegati

Londra. 40 bambini uccisi dal vaccino MMR

… (Discussioni Libere) …

Argomento di discussione del forum – alsa – 11/12/2010 – 11:50 – 0 comments – 0 allegati

Anonimo:ProQuad il nuovo vaccino MMR+ sicuro.

… bambini sono stati sottoposti ad iniezione del vaccino di Mmr (morbillo parotite rosolia), e una seconda iniezione di Varivax …

Argomento di discussione del forum – OldForum – 15/04/2003 – 00:00 – 3 comments – 0 allegati

Richiamo vaccinazione MMR

Ho appena scoperto il vostro forum e ne approfitto subito per chiedervi un’opinione: ho ricevuto la lettera della ASL (provincia di Milano) in cui mi invitano a presentarmi con il mio bambino di 6 anni per il richiamo di Morbillo-Rosolia-Parotite. Allegan …

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RELATED ARTICLES:

FAKE AND FRAUDULENT SCIENCE

CDC VACCINE COVER UP – MERCURY ACTUALLY DOES CAUSE AUTISM?

AUTISM RETROSPECTIVE

Letters from Laura #1 – Autism, GI issues, chronic ear infections, breast cancer and Jenny McCarthy

AUTISM/ASPERGER’S + STEM CELLS

AUTISM RETROSPECTIVE

In ALL ARTICLES on February 16, 2010 at 2:38 pm

WHAT ARE THE ADVERSE REACTIONS FROM MMR VACCINES?
http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf
(The warnings from the manufacturer are scary enough, even if it doesn’t cause autism.)

WHY NO STEM CELLS IN THE US (FOR AUTISM)?
https://repairstemcell.wordpress.com/why-no-stem-cells-in-the-us/

STEM CELLS FOR AUTISM – PROGRESS TO DATE
https://repairstemcell.wordpress.com/2009/10/26/stem-cells-for-autism/

Potential of Stem Cell Treatments for Autism
https://repairstemcell.wordpress.com/2009/10/16/potential-of-stem-cell-treatments-for-autism/

AUTISM & STEM CELLS – A brief history

In VICTORIES & SUCCESS STORIES on October 1, 2009 at 1:37 pm

autism-ribbon

Can REPAIR STEM CELLS treat AUTISM?

You tell me:

OPEN LETTER TO PRESIDENT OBAMA – STEM CELLS FOR AUTISM

AUTISM RUNAROUND – TREATMENT

STEM CELLS CURE AUTISM

POTENTIAL OF STEM CELL TREATMENTS FOR AUTISM

AUTISM RESISTANCE AND STEM CELLS

AUTISM, JENNY MCCARTHY AND LAURA’S STORY

HELP FIGHT IGNORANCE OF AUTISM TREATMENTS

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