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Posts Tagged ‘lou gehrig’

STEPHEN HAWKING VISITS STEM CELL LAB

In ALL ARTICLES, STEM CELLS IN THE NEWS on April 10, 2013 at 4:57 pm
Stephen Hawking Visits LA Stem Cell Lab

Stephen Hawking toured a stem cell laboratory Tuesday where scientists are studying ways to slow the progression of Lou Gehrig’s disease, a neurological disorder that has left the British cosmologist almost completely paralyzed.

After the visit, the 71-year-old Hawking urged doctors, nurses and staff at Cedars-Sinai Medical Center to support the research.

Hawking recalled how he became depressed when he was diagnosed with the disease 50 years ago and initially didn’t see a point in finishing his doctorate. But his attitude changed when his condition didn’t progress quickly and he was able to concentrate on his studies.

“Every new day became a bonus,” he told a packed room.

Cedars-Sinai received nearly $18 million last year from California’s taxpayer-funded stem cell institute to study the debilitating disease also known as amyotrophic lateral sclerosis. ALS attacks nerve cells in the brain and spinal cord that control the muscles. People gradually have more and more trouble breathing and moving as muscles weaken and waste away.

There’s no cure and no way to reverse the disease’s progression. Few people with ALS live longer than a decade.

Diagnosed at age 21 while a student at Cambridge University, Hawking has survived longer than most. He receives around-the-clock care, can only communicate by twitching his cheek, and relies on a computer mounted to his wheelchair to convey his thoughts in a distinctive robotic monotone.

A Cedars-Sinai patient who was Hawking’s former student spurred doctors to invite the physicist to glimpse their stem cell work.

“We decided it was a great opportunity for him to see the labs and for us to speak to one of the preeminent scientists in the world,” said Dr. Robert Baloh, who heads the hospital’s ALS program.

During the tour, Hawking viewed microscopic stem cells through a projector screen and asked questions about the research, Baloh said.

Cedar-Sinai scientists have focused on engineering stem cells to make a protein in hopes of preventing nerve cells from dying. The experiment so far has been done in rats. Baloh said he hopes to get governmental approval to test it in humans, which would be needed before any therapy can be approved.

Renowned for his work on black holes and the origins of the universe, Hawking is famous for bringing esoteric physics concepts to the masses through his best-selling books including “A Brief History of Time,” which sold more than 10 million copies worldwide. Hawking titled his speech to Cedars-Sinai employees “A Brief History of Mine.”

Despite his diagnosis, Hawking has remained active. In 2007, he floated like an astronaut on an aircraft that creates weightlessness by making parabolic dives.

Space exploration is important “for the future of humanity,” he told the audience.

Hawking said he did not think Earthlings would survive “without escaping beyond your fragile planet.”

And he gave some advice: Look up at the stars. Stay curious.

“However difficult life may seem, there is always something you can do and succeed at,” he said.

Doctors don’t know why some people with Lou Gehrig’s disease fare better than others. Baloh said he has treated patients who lived for 10 years or more.

“But 50 years is unusual, to say the least,” he said.

 

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ALS TREATMENT THROUGH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS - 101, STEM CELLS IN THE NEWS on January 8, 2013 at 9:00 am

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Stem Cells Treat Lou Gehrig’s Disease, In Mice

“… just to see what stem cells would do in the nervous system of a mouse who had a model of this disease, in other words, was very rapidly and very progressively losing all muscular activity, including respiration. What we found – and this was a surprise at the time – in the early days, we thought, well, stem cells should simply replace these dying motor neurons. What, in fact, we found is – and this reflected a growing sophistication of our knowledge about stem cells as well as a growing sophistication about our knowledge about ALS – that the stem cells did make a difference in these animals. It slowed the onset of the disease, its progression and prolonged survival fairly significantly. But it did it by protecting the neurons of this animal and also kind of counteracting many of the other disease processes that we started learning were going on in this disease.”

http://www.npr.org/2012/12/21/167798232/stem-cells-treat-lou-gehrigs-disease-in-mice

“Injecting stem cells into the brains of mice that recently suffered a stroke can reduce nerve cell (neuron) damage by up to 60 percent, according to new research.  But the stem cells do not simply replace damaged tissue as previously believed. Instead, the immature cells trigger adult brain cells to switch gears and block a stroke-induced immune response that causes nerve damage.”

– Taken from 2008 article:  http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage

 

For all related  articles on (ALS) and the history of Amyotrophic Lateral Sclerosis (aka Lou Gehrig’s disease). Click HERE.

ALS Stem Cell Trial Gets FDA Go Ahead

In ALL ARTICLES on October 5, 2009 at 1:48 pm

ALS Stem Cell Trial Gets FDA Go Ahead The US Food and Drug Administration (FDA) said the first clinical trial to test a new stem cell treatment for the fatal neurodegenerative disease ALS (amyotrophic lateral sclerosis) this month (ALS) can go ahead.

US – ALS – ASC – BCLI

In ALL ARTICLES on August 25, 2009 at 8:22 am

— BrainStorm Cell Therapeutics Inc. (OTCBB: BCLI | Quote | Chart | News | PowerRating) opened Monday at $0.084 per share on trading volume of 2,680,000 shares.

In a press release out on Aug 24, 2009 — BrainStorm Cell Therapeutics Inc. (OTCBB: BCLI), a leading developer of adult stem cell technologies and therapeutics, announced today that the company has secured the funding required to complete pre-clinical trials underway for the treatment of ALS (Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s disease). The company expects to begin Phase I clinical studies in 2010.

BILL CLINTON BACKS MICHIGAN STEM CELL PROP 2

In ALL ARTICLES, RELIGION & STEM CELLS, STEM CELLS IN THE NEWS on February 22, 2009 at 3:45 pm
Bill Clinton backs Michigan’s Prop 2
By Alexa Stanard 10/13/08 6:52 AM
Former president Bill Clinton speaks Friday on behalf of CureMichigan. (photo: Alexa Stanard)

Former president Bill Clinton speaks Friday on behalf of CureMichigan. (photo: Alexa Stanard)

Former President Bill Clinton rallied a star-studded Michigan political crowd Friday to support a ballot proposal that would permit embryonic stem-cell research in the state.

Clinton appeared at the upscale fund-raiser hosted by CureMichigan, the organization backing Proposal 2, which will appear on the Nov. 4 ballot.  He called support for stem-cell research “the pro-life position” and cited the research’s potential benefits both to those facing health problems like Alzheimer’s and Lou Gehrig’s disease and to Michigan’s struggling economy.

“There isn’t a person here who doesn’t know someone who could be benefited by this work,” Clinton told the crowd of several hundred in Waterford Township, northwest of Detroit. “This is not about cloning. This is about letting Michigan do what can be done in almost any other state.”…

http://michiganmessenger.com/6192/bill-clinton-backs-michigans-prop-2

ALS CLINICAL TRIAL IN ISRAEL

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 9, 2009 at 10:58 pm

Lou Gehrig

BrainStorm Cell Therapeutics’ Consultant to Assist with Final Regulatory Preparations Towards Clinical Trials For ALS Patients Based on Stem Cells Treatment
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NEW YORK & PETACH TIKVAH, Israel – BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell (ASC) technology, announced today that the company has retained the services of Bio Medical Research Design (BRD) headed by Dr. Moshe Neuman to consult BrainStorm&rsq

Posted : Mon, 09 Feb 2009 15:32:28 GMT

Author : Brainstorm Cell Therapeutics Inc.

Category : Press Release

NEW YORK & PETACH TIKVAH, Israel – (Business Wire) BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell (ASC) technology, announced today that the company has retained the services of Bio Medical Research Design (BRD) headed by Dr. Moshe Neuman to consult BrainStorm’s regulatory team in its preparations for clinical trials of ALS patients in Israel.

BrainStorm previously announced its plan to proceed to clinical trials for ALS disease in Israel and therefore engaged BRD to assist with the various final pre-clinical studies and stem cells production process that will help fulfill the relevant regulatory requirements…

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