DAVID GRANOVSKY

Posts Tagged ‘italy’

CHEMICALLY BURNED EYES REPAIRED WITH STEM CELLS

In VICTORIES & SUCCESS STORIES on June 24, 2010 at 12:47 pm

BRIEF SUMMARY OF METHODS

  1. used autologous limbal stem cells cultivated on fibrin
  2. treated 112 patients with corneal damage
  3. most had burn-dependent limbal stem-cell deficiency

BRIEF SUMMARY OF RESULTS

  1. Permanent restoration of a transparent, renewing corneal epithelium was attained in 76.6% of eyes.
  2. Restored eyes remained stable over time, with up to 10 years of follow-up (mean, 2.91±1.99; median, 1.93).
  3. Cultures in which p63-bright cells constituted more than 3% of the total number of clonogenic cells were associated with successful transplantation in 78% of patients.

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MORE DETAILED INFORMATION:

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Figure 3. Regeneration of a Functional Corneal Epithelium and Restoration of Visual Acuity.

[Brief: “All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left).  In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium.“]

Panel A shows the left eye of Patient 93 (see Table 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org), who had total limbal stem-cell deficiency due to an acid burn (image at left). His visual acuity was reduced to counting fingers. A graft of autologous limbal cultures was sufficient to regenerate functional corneal epithelium (image at right) and to restore normal vision (visual acuity, 0.7), since the eye had no stromal scarring. Panel B shows the eyes of Patients 22, 26, and 46 (see Table 1 in the Supplementary Appendix), which were damaged by alkali burns and were treated with unsuccessful surgery 13, 30, and 3 years before admission, respectively. All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left). Vision was reduced to counting fingers (in Patient 22) or perceiving hand movements (in Patients 26 and 46). In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium. To improve their visual acuity after grafting, the patients underwent penetrating keratoplasty. In all three eyes, the engrafted limbal stem cells resurfaced the donor stroma. At the last follow-up visits (at 6, 6.5, and 4 years, respectively), all eyes were covered by stable corneal epithelium (images at right). The keratoplasty resulted in complete restoration of visual acuity in Patients 22 and 46 (0.9 and 0.8, respectively). The visual acuity of Patient 26 increased to only 0.3 because of a concomitant amblyopia (the alkali burn had occurred 30 years before admission). In Patient 46, the follow-up image shows that the conjunctival vessels stop at the conjunctival–corneal boundary (arrowheads); they do not invade the restored corneal surface.

https://i2.wp.com/content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f1.jpeg

Figure 1. Kaplan–Meier Estimates of Grafted Limbal Stem-Cell Survival.

[Brief: “the final clinical outcome was deemed a success in 76.6% of the eyes treated“]

Panel A shows the survival estimates for the cultures after one graft was placed, with partial or total success attained in 68.2% of the eyes treated. Panel B shows survival estimates after a second graft was placed in 11 eyes (a total of 12 additional grafts, since 1 eye was regrafted twice), indicating either partial success or failure. After regrafting, 9 of these eyes regenerated normal epithelium. Thus, the final clinical outcome was deemed a success in 76.6% of the eyes treated. All failures occurred within the first year after grafting, whereas successful cultures remained stable for up to 10 years of follow-up.

THIS POST IS AN ADDENDUM TO EARLIER STORY:  Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg – VIA

THE IMAGES AND TEXT ARE VIA: http://content.nejm.org/cgi/content/full/NEJMoa0905955v1#F3

First Ever Multicellular Animals Found In Oxygen-Free Environment | Popular Science

In OFF THE BEATEN PATH on April 7, 2010 at 3:48 pm

First Ever Multicellular Animals Found In Oxygen-Free Environment

Unnamed Loriciferan:   via Nature

By Stuart Fox Posted 04.06.2010 at 5:30 pm

In the 236 years since oxygen was identified as a life-giving necessity, no scientist anywhere has discovered a multicellular animal capable of living without the stuff. Until now. Researchers from the Polytechnic University of Marche in Ancona, Italy, have discovered three new species that live their entire life in an anoxic pit beneath the Mediterranean Sea. This discovery drastically revises science’s understand of where animals can thrive.Prior to this discovery, the only organisms capable of life in oxygen-free environments were viruses and bacteria.

via First Ever Multicellular Animals Found In Oxygen-Free Environment | Popular Science.

JANET JACKSON HAS AIDS COVERED – Stem Cells + amfAR

In ALL ARTICLES on October 15, 2009 at 3:10 pm

Janet Jackson MILAN, ITALY – SEPTEMBER

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Janet Jackson recently arrived in Milan, Italy to chair at an amfAR charity event, as they try to raise funds and awareness. There are a lot of organizations that operate on the frontlines of the battle against AIDS and are proportionately well funded, providing things like housing, counseling and the essentials to better living.

However, amfAR (The Foundation for AIDS Research) is disproportionately under-funded receiving a small amount of the money spent on AIDS Research. Whereby if there was an intelligence department in AIDS Research they are it, as in over a period about 25 years founded in 1985 they spent about $300 million on their mission. However there were over 25 million deaths due to the complications of AIDS and at least 33 million infected as of this day. People are living longer with AIDS now, but it is still for most a death sentence.

Janet Jackson arrives in Milan, Italy for amfAR Charity event

Yes it is important to serve those underserved in society such as People Living with AIDS, but the only real hope is in finding a cure to eradicate this dreadful disease. And that is the mission of amfAR. I think with the promises of Stem Cell Research there should be a resurgence of enthusiasm and not settling for just treatments that ultimately leads to death, but an actual cure.

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There was a recent BUZZ stating that there is a female contraceptive ring that can prevent the transmission of AIDS, so there has been real progress in AIDS research. Hopefully a cure will be found in the life time of the many infected people as of this day.

Adult stem cell discovery

In VICTORIES & SUCCESS STORIES on August 25, 2009 at 9:41 pm

…better late than never! – dg

Published: 30 August 2009

VATICAN CITY (CNS): Italian researchers have developed a method to repair a damaged heart using adult stem cells, and said it confirmed that the adult cells were more therapeutically useful than embryonic stem cells.

“The adult stem cell is already prepared to differentiate in the tissue we want to repair. And it is certainly more productive, less wasteful and less dangerous – beyond the ethical aspects – to work with adult stem cells instead of embryonic stem cells,” Settimio Grimaldi, who is an expert at the Institute of Neurobiology and Molecular Medicine in Rome, which carried out the research, said.

via Adult stem cell discovery – The Catholic Leader: World News.

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