DAVID GRANOVSKY

Posts Tagged ‘immune’

LONG TERM REMISSION OF MULTIPLE SCLEROSIS WITH STEM CELLS

In Daily Dose of Stem Cells, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 16, 2017 at 12:36 pm

While high-dose immunosuppressive therapy is not without complications, we must remember that research is rarely linear and every step closer is a step closer – we learn a bit more and refine the process with each step as our understanding of all of the elements which make up our health, recover and illness are slowly puzzled together like a patch-work quilt…

ms-recovery

Stem cell transplants may induce long-term remission of multiple sclerosis

Encouraging results help set stage for larger studies.

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person’s own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

Five years after receiving the treatment, called high-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT), 69 percent of trial participants had survived without experiencing progression of disability, relapse of MS symptoms or new brain lesions. Notably, participants did not take any MS medications after receiving HDIT/HCT. Other studies have indicated that currently available MS drugs have lower success rates.

The trial, called HALT-MS, was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and conducted by the NIAID-funded Immune Tolerance Network (ITN). The researchers published three-year results from the study in December 2014, and the final five-year results appear online Feb. 1 in Neurology, the medical journal of the American Academy of Neurology.

Related:

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?

20 MINUTES EXERCISE = INFLAMMATION REDUX

In DISEASE INFO, HEALTH AND WELLNESS on January 23, 2017 at 11:17 am

Does exercise increase or reduce inflammation?  One look at Arnold Schwarzenegger’s  incredibly pumped physique and you might think exercise increases inflammation…but this is a different KIND of inflammation.
Scientists have found that just
one session of moderate exercise can stimulate the immune system, producing an anti-inflammatory cellular response.  “The findings have encouraging implications for chronic diseases like arthritis, fibromyalgia and for more pervasive conditions, such as obesity.”
schwarzenegger

Exercise … It does a body good: 20 minutes can act as anti-inflammatory

One moderate exercise session has a cellular response that may help suppress inflammation in the body

Date:January 12, 2017 – Source: University of California – San Diego
Summary:
It’s well known that regular physical activity has health benefits, including weight control, strengthening the heart, bones and muscles and reducing the risk of certain diseases. Recently, researchers have found how just one session of moderate exercise can also act as an anti-inflammatory. The findings have encouraging implications for chronic diseases like arthritis, fibromyalgia and for more pervasive conditions, such as obesity.

It’s well known that regular physical activity has health benefits, including weight control, strengthening the heart, bones and muscles and reducing the risk of certain diseases. Recently, researchers at University of California San Diego School of Medicine found how just one session of moderate exercise can also act as an anti-inflammatory. The findings have encouraging implications for chronic diseases like arthritis, fibromyalgia and for more pervasive conditions, such as obesity.

The study, recently published online in Brain, Behavior and Immunity, found one 20-minute session of moderate exercise can stimulate the immune system, producing an anti-inflammatory cellular response.

“Each time we exercise, we are truly doing something good for our body on many levels, including at the immune cell level,” said senior author Suzi Hong, PhD, in the Department of Psychiatry and the Department of Family Medicine and Public Health at UC San Diego School of Medicine. “The anti-inflammatory benefits of exercise have been known to researchers, but finding out how that process happens is the key to safely maximizing those benefits.”

The brain and sympathetic nervous system — a pathway that serves to accelerate heart rate and raise blood pressure, among other things — are activated during exercise to enable the body to carry out work. Hormones, such as epinephrine and norepinephrine, are released into the blood stream and trigger adrenergic receptors, which immune cells possess.

This activation process during exercise produces immunological responses, which include the production of many cytokines, or proteins, one of which is TNF — a key regulator of local and systemic inflammation that also helps boost immune responses.

exercise

“Our study found one session of about 20 minutes of moderate treadmill exercise resulted in a five percent decrease in the number of stimulated immune cells producing TNF,” said Hong. “Knowing what sets regulatory mechanisms of inflammatory proteins in motion may contribute to developing new therapies for the overwhelming number of individuals with chronic inflammatory conditions, including nearly 25 million Americans who suffer from autoimmune diseases.”

The 47 study participants walked on a treadmill at an intensity level that was adjusted based on their fitness level. Blood was collected before and immediately after the 20 minute exercise challenge.

“Our study shows a workout session doesn’t actually have to be intense to have anti-inflammatory effects. Twenty minutes to half-an-hour of moderate exercise, including fast walking, appears to be sufficient,” said Hong. “Feeling like a workout needs to be at a peak exertion level for a long duration can intimidate those who suffer from chronic inflammatory diseases and could greatly benefit from physical activity.”

Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. However, chronic inflammation can lead to serious health issues associated with diabetes, celiac disease, obesity and other conditions.

“Patients with chronic inflammatory diseases should always consult with their physician regarding the appropriate treatment plan, but knowing that exercise can act as an anti-inflammatory is an exciting step forward in possibilities,” said Hong.


Story Source:

Materials provided by University of California – San Diego. Original written by MIchelle Brubaker. Note: Content may be edited for style and length.


Journal Reference:

  1. Stoyan Dimitrov, Elaine Hulteng, Suzi Hong. Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation. Brain, Behavior, and Immunity, 2016; DOI: 10.1016/j.bbi.2016.12.017

SALT in FAST FOOD = IMMUNE DISORDERS? MULTIPLE SCLEROSIS?

In ALL ARTICLES on September 16, 2015 at 6:39 pm

In the last article we discovered that we don’t know everything there is to know about the human body.  Far from it.

“In contradiction to decades of medical education, a direct connection has been reported between the brain and the immune system….It seems astonishing that, after centuries of dissection, a system of lymphatic vessels could have survived undetected.” via https://repairstemcell.wordpress.com/2015/09/16/system-connecting-brain-to-immune-system-found/

So what about processed foods?  Could the foods you are eating be a contributing factor to immune diseases like Multiple Sclerosis?

A study [Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells ] showing that “mice fed with a high-salt diet develop a more severe form of (experimental autoimmune encephalomyelitis) EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells.”  In other words, “…increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.”  via 

In the latest study, scientists discovered that exposing these cells in a lab to a table salt solution made them act more ‘aggressively.’  They found that mice fed a diet high in refined salts saw a dramatic increase in the number of Th17 cells in their nervous systems that promoted inflammation.  They were also more likely to develop a severe form of a disease associated with multiple sclerosis in humans.  The scientists then conducted a closer examination of these effects at a molecular level.  Laboratory tests revealed that salt exposure increased the levels of cytokines released by Th17 cells 10 times more than usual. Cytokines are proteins used to pass messages between cells.  via 

More and more we realize that all the systems of the body are connected and everything we eat and do and don’t eat and don’t do has an affect.

Bare this in mind the next time you decide to “treat yourself” with some junk food.

SYSTEM CONNECTING BRAIN TO IMMUNE SYSTEM FOUND – AUTISM RECONSIDERED?

In ALL ARTICLES on September 16, 2015 at 11:47 am
“In contradiction to decades of medical education, a direct connection has been reported between the brain and the immune system….It seems astonishing that, after centuries of dissection, a system of lymphatic vessels could have survived undetected.”

EVERY time I have a conversation with someone who is 100% sure, I laugh inside and remember that everything we know for sure will be disproved within our lifetimes.
 
Medical science was 100% sure:
the heart doesn’t regenerate…wrong
the brain and central nervous system doesn’t regenerate…wrong
all of the ligaments have been found…wrong
butter is healthier, margarine is healthier, butter, margarine…wrong
stem cells don’t work…wrong
cholesterol is bad…wrong
and on and on and on and now…
 
This changes everything.

“It changes entirely the way we perceive the neuro-immune interaction,” says Kipnis. “We always perceived it before as something esoteric that can’t be studied. But now we can ask mechanistic questions.”

MS is known to be an example of the immune system attacking the brain, although the reasons are poorly understood. The opportunity to study lymphatic vessels that link the brain to the immune system could transform our understanding of how these attacks occur, and what could stop them. The causes of Alzheimer’s disease are even more controversial, but may also have immune system origins, and the authors suggest protein accumulation is a result of the vessels failing to do their job.

Indeed, Kipnis claims, “We believe that for every neurological disease that has an immune component to it, these vessels may play a major role.”

This changes everything.

Every single study dealing with brain and immune and GI systems must be revisited and re-evaluated.

For example, it begs the question…With so many people saying Autism is a neurological malfunction and so many people saying Autism is immune system caused and so many saying it is nutritional and heavy metal toxin caused…if these systems are all interconnected, perhaps they are all right.  Is it time to reconsider the cause (causes!) of Autism?

http://www.iflscience.com/brain/vessels-found-connect-immune-system-and-brain

FDA APPROVES FIRST CORD BLOOD PRODUCT

In STEM CELLS IN THE NEWS on April 6, 2012 at 2:06 am

Finally some good news!  I guess its true, even monkeys fall out of trees sometimes!

https://i2.wp.com/mymommymanual.com/wp-content/uploads/2009/10/cord-blood-300x225.png

FDA APPROVES FIRST CORD BLOOD PRODUCT

The U.S. Food and Drug Administration today approved HEMACORD, the first licensed hematopoietic progenitor cells-cord (HPC-C) cell therapy.

HEMACORD is indicated for use in hematopoietic stem cell transplantation procedures in patients with disorders affecting the hematopoietic (blood forming) system. For example, cord blood transplants have been used to treat patients with certain blood cancers and some inherited metabolic and immune system disorders.

“The use of cord blood hematopoietic progenitor cell therapy offers potentially life-saving treatment options for patients with these types of disorders,” said Karen Midthun, M.D., director, FDA’s Center for Biologics Evaluation and Research.

HEMACORD contains hematopoietic progenitor cells (HPCs) from human cord blood. Cord blood is one of three sources of HPCs used in transplants; the other two are bone marrow and peripheral blood..

Read more: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm279575.htm.

Reuters Health Update

In ALL ARTICLES on April 22, 2011 at 3:38 pm

New studies point to clot risk of Bayer’s Yasmin
April 21, 2011 06:34 PM ET
FRANKFURT (Reuters) – New evidence emerged on Friday that women taking Bayer’s best-selling contraceptive Yasmin may run a higher risk of dangerous blood clots than those using older birth-control pills. | Full Article
No evidence coffee ups risk of high blood pressure
April 22, 2011 07:52 AM ET
NEW YORK (Reuters Health) – Despite earlier concerns, downing lots of coffee doesn’t seem to increase the risk of high blood pressure, according to a new report — but the evidence isn’t conclusive. | Full Article
Many kids with diabetes have other immune diseases
April 21, 2011 05:29 PM ET
NEW YORK (Reuters Health) – A third of children with type 1 diabetes have signs of other immune system disorders when they get diagnosed with diabetes, according to a new study. | Full Article

New Disease Identified By Australian Researchers

In VICTORIES & SUCCESS STORIES on May 27, 2010 at 9:40 am

And now, stem cells are treating disease that we don’t even know about yet! – dg

New Disease Identified By Australian Researchers

Researchers at the Queensland Institute of Medical Research (QIMR) and the Royal Brisbane Women’s Hospital have identified a previously undiagnosed condition and successfully treated it by performing an experimental stem cell transplant.

Having spent her late teenage years in and out of hospital Katie Pulling had almost given up hope. “It was very confusing and very daunting. I kept hearing the doctors say, ‘We don’t know what is wrong’, ‘We don’t know why you are so sick’,” said Katie, who lives in north-eastern NSW.

With no options left Katie agreed to an experimental stem cell transplant – a transplant which ultimately saved her life.

“Katie presented with a range of symptoms when she was eleven. No one could identify her condition and no treatment had been successful. She did not respond to regular treatments and she continued to get sick, often complicated by life-threatening infections,” said Dr Maher Gandhi head of QIMR’s Clinical Immunohaemotology Laboratory.

The key to unlocking the reason for Katie’s reoccurring symptoms came when she contracted the common teenage virus that causes glandular fever. Usually most people come down with only a mild infection. However, Katie developed a full-blown version known as fulminant infectious mononucleosis (FIM)…

via New Disease Identified By Australian Researchers.

Bone Marrow Cells May Improve Stem Cell Therapy, Study Finds

In STEM CELLS IN THE NEWS on February 2, 2010 at 3:03 am

Why would they burden the amazing healing properties of bone marrow stem cells with the rejection and tumors associated with embryonic stem cells?  Bone marrow stem cells work already; they don’t need embryonic stem cells…cord blood stem cells work, umbilical cord cells, fat cells, neuro cells….all work already.  ADULT & REPAIR STEM CELLS WORK!  Even Embryonic Stem Cell focused California has finally realized where their efforts should be…

It’s like tying an arsonist to someone with a puritan work ethic in the hopes that more work gets done.  Ok, bad analogy but you get the point…

…so, anyone who can come up with an appropriate analogy to illustrate this point gets a free one year subscription to the Stem Cell Newsletter.-dg

Bone Marrow Cells May Improve Stem Cell Therapy, Study Finds??

January 28th 2010 12:00 AM

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* ‘Starving’ Fat May Be Newest Obesity Treatment

Researchers say they have devised a new strategy that increases the likelihood of a recipient’s immune system accepting embryonic stem cell transplants. The strategy involves fusing bone marrow cells to embryonic stem cells. Once fused, the hybrid cells have DNA from both the donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs. The findings appear in the February issue of the FASEB Journal

Although the study holds great promise for future embryonic stem cell therapies, the results may be even more far reaching. The team used two different mouse strains, one as the donor and the other as the recipient. When bone marrow cells were engrafted into the recipient, they tested for the presence of both donor and recipient cells and found three different types of cells: donor cells, recipient cells, and fused cells that had DNA from the donor and recipient…

via Bone Marrow Cells May Improve Stem Cell Therapy, Study Finds.

Stem Cells May Provide Cancer Vaccination

In SCIENCE & STEM CELLS on October 8, 2009 at 2:29 pm

Stem Cells Which ‘Fool Immune System’ May Provide Vaccination For Cancer

https://i1.wp.com/www.urmc.rochester.edu/news/story/uploadedimages/cancer%20stem%20cellUCLA3.jpg

cancer stem cell

ScienceDaily (Oct. 8, 2009) — Scientists from the United States and China have revealed the potential for human stem cells to provide a vaccination against colon cancer, reports a study published in Stem Cells.

This discovery, led by experts in immunology, Dr. Bei Liu and Dr. Zihai Li, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumour response. However, this theory has never before been advanced beyond animal research so the discovery that human stem cells are able to immunize against colon cancer is both new and unexpected.

“This finding potentially opens up a new paradigm for cancer vaccine research,” said Dr. Zihai Li. “Cancer and stem cells share many molecular and biological features. By immunizing the host with stem cells, we are able to ‘fool’ the immune system to believe that cancer cells are present and thus to initiate a tumor-combating immune program.”

via Stem Cells Which ‘Fool Immune System’ May Provide Vaccination For Cancer.

Molecular ‘Key’ To Successful Blood Stem Cell Transplants Discovered

In ALL ARTICLES, SCIENCE & STEM CELLS on April 25, 2009 at 11:10 pm

science

ScienceDaily (Apr. 25, 2009) — University of British Columbia researchers have discovered a “molecular key” that could help increase the success of blood stem cell transplants, a procedure currently used to treat diseases such as leukemia, Hodgkin’s lymphoma and aplastic anemia.

During a blood stem cell transplant, donor blood stem cells – which can produce red and white blood cells and platelets – are injected into the recipient to produce new blood. The stem cells then need to travel to the thymus – an organ near the heart – and produce T-cells, a type of white blood cell that orchestrates the body’s immune system.

A common problem with blood stem cell transplants is the failure of stem cells to repopulate the thymus and generate T-cells. Without T-cells the patient is unable to fight infection and post-transplant prognosis is poor.

Now Prof. Hermann Ziltener and his research team at UBC’s Biomedical Research Centre have identified a molecule called S1P that can tell the thymus to “open the gates” and accept more stem cells.

“This discovery gives us a handle on determining whether the thymus will be receptive to migrating stem cells,” says Ziltener, a professor in the Dept. of Pathology and Laboratory Medicine. “By treating patients with drugs that control S1P, scientists can now manipulate the thymic gates to either open or close.”

The same team had previously identified a number of molecules that function as the thymic gates for migrating stem cells. The new study, published in the April issue of The Journal of Experimental Medicine, is the first to hone in on the “key” molecule that can open the thymic gate.

Next steps in the research include finding the mechanism T-cells in blood use to control S1P formation. Researchers estimate that it would be at least five years before the discovery can be translated into a clinical test

via Molecular ‘Key’ To Successful Blood Stem Cell Transplants Discovered.

See also:

Health & Medicine

* Stem Cells

* Prostate Cancer

* Lymphoma

* Brain Tumor

* Immune System

* Anemia

Reference

* T cell

* Embryonic stem cell

* Somatic cell

* Bone marrow transplant

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