DAVID GRANOVSKY

Posts Tagged ‘head’

Heads, Shoulders, Knees and Toes

In ALL ARTICLES, STEM CELLS IN THE NEWS on October 25, 2016 at 10:17 am

Heads, Shoulders, Knees and Toes

head, shoulders, knees and toes

Building on the revolutionary work of Dr Lima, who used nose stem cells to recover spinal cord injuries:

“Investigators took biopsy specimens that were 6 mm in diameter from the nasal septum, under local anaesthetic.

Then they grew the harvested cells in the lab for two weeks. The cartilage grafts were further prepared and then cut into the right shapes.

Finally, surgeons used the engineered grafts to replace damaged cartilage that was removed.

..Even though the level of repaired tissue appeared to vary among patients and over time, MRI scans at two years showed new tissue developed with similar properties to the original cartilage.

The nine recipients reported improvements in use of their knees and better pain scores compared to before their surgeries.

No side-effects were reported.”

Heads and Knees – Check!
Shoulders and Toes just around the corner.

Spinal Cord Injury and Stem Cells:
https://repairstemcell.wordpress.com/2011/02/07/spinal-cord-injury-and-repair-stem-cell-treatments/

Read more:
http://www.cbc.ca/news/health/knee-repair-nose-1.3814647

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Stem Cells Improve Cognition After Brain Injury | Beyond the Dish

In STEM CELLS IN THE NEWS on November 5, 2013 at 2:20 pm
https://repairstemcell.files.wordpress.com/2013/11/8c5a1-strokebrainimage.jpg
Stem Cells Improve Cognition After Brain Injury

Research led by Charles Cox at the University of Texas Health Science Center has shown that stem cell therapy given during the critical time window after traumatic brain injury promotes lasting cognitive improvement. These experiments, which were published in the latest issue of the journal Stem Cells Translational Medicine, provide a pre-clinical model for experiments with larger animals.

After the brain has suffered a traumatic injury, there are few treatment options. Damage to the brain can be severe, and can also cause ongoing neurological impairment. Approximately half of all patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

In this work from Cox’s lab, stem cells from bone marrow known as multipotent adult progenitor cells (MAPCs) were used. MAPCs seem to be a subpopulation of mesenchymal stem cells, and they have a documented ability to reduce inflammation in mice immediately after traumatic brain injury. Unfortunately, no one has measured the ability of MAPCs to improve the condition of the brain over time.

Cox, Distinguished Professor of Pediatric Surgery at the UTHealth Medical School and in collaboration with the Children’s Fund, Inc., injected two groups of brain-injured mice with MAPCs two hours after injury and then once again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times greater.

After four months, those mice that had received the stronger dose not only continued to have less inflammation, but they also showed significant gains in cognitive function. Laboratory examination of the brains of these rodents confirmed that those that had received the higher dose of MAPCs had better brain function than those that had received the lower dose.

According to Cox, “Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs.” Cox also indicated that this study indicates that intravenous injection of MAPCs might very well become a viable treatment for people with traumatic brain injury in the future.

 

Stem Cells Improve Cognition After Brain Injury | Beyond the Dish.

TRAUMATIC BRAIN INJURY and STROKE

In DISEASE INFO on March 26, 2012 at 1:17 am

TO SEE IF YOU ARE A CANDIDATE FOR STEM CELL TREATMENT, PLEASE FILL OUT THE FOLLOWING FORM:  STEM CELL PATIENT QUESTIONNAIRE

I was told this was a con…here is my response:

My Stem Cells vs. Stroke page:
https://repairstemcell.wordpress.com/stroke-stem-cells/

Additional articles sorted by date (YEAR/MONTH/DAY):
https://repairstemcell.wordpress.com/2012/03/06/stem-cells-safe-for-young-traumatic-brain-injury/
https://repairstemcell.wordpress.com/2012/01/22/cellnews-scientists-learn-how-stem-cell-implants-help-heal-traumatic-brain-injury/

http://www.sciencedaily.com/releases/2011/08/110831160216.htm
https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
https://repairstemcell.wordpress.com/2010/08/28/cord-blood-wakes-up-drowning-victim%e2%80%99s-brain/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
https://repairstemcell.wordpress.com/2010/07/12/stem-cell-gel-helps-repair-traumatic-brain-injuries-smartplanet/
http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
https://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/

https://repairstemcell.wordpress.com/2009/04/20/stem-cell-research-shows-adult-stem-cells-help-stroke-victims-adult-stem-cell-research/
http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

A con? Ok my skeptical friends, I understand. You’ve been researching stroke treatments for so long and been so disheartened you don’t believe your condition can ever improve. You’ve read all the outdated literature saying the central nervous system can not regrow (except for the most recent studies which prove it can be.) You’ve skimmed my articles and realize they are uncorroborated by “hard science.”

Fair enough. Ignore the 14 articles above which show the positive benefits of adult stem cells on stroke. You’re right, they are unsubstantiated. They are not peer reviewed medical journal articles. I appreciate your skepticism but know this:

*there are over 2,600 peer reviewed medical journal clinical trials that utilized adult stem cells with a record of safety and efficacy,
*there are many trials that cover the use of adult stem cells for stroke, ataxia, TBI, etc
*there are 60 trials that have the key words “adult stem cell” and “stroke.”
*there are 14 “Completed” trials that have the key words “adult stem cell” and “stroke.”

Research it yourself if you like. http://clinicaltrials.gov/ct2/results?term=adult+stem+cell+stroke&pg=1&show_flds=Y

Here are only the 14 “completed” trials:

Completed Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients

Conditions: Stroke;   Middle Cerebral Artery Infarction
Interventions: Procedure: Intercerebral implantation of Autulogous Stem Cells;   Drug: convention therapy
Completed Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke

Condition: Acute Stroke
Intervention: Biological: Autologous bone marrow stem cell
Completed Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.

Conditions: Stroke, Acute;   Infarction, Middle Cerebral Artery
Intervention: Procedure: Infusion on autologous CD34+ stem cells into middle cerebral artery
Completed Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke

Condition: Infarction, Middle Cerebral Artery
Intervention: Other: Autologous cell transplantation
21 Completed Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke

Condition: Ischemic Stroke
Intervention: Drug: Filgrastim
31 Completed Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)

Condition: Sickle Cell Anemia
Intervention: Procedure: Angiography
34 Completed Investigating Endothelial Precursor Cells (EPCs)

Condition: Central Nervous System
Intervention:
38 Completed Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention: Procedure: Stem Cell Transplanataion
40 Completed Gene Therapy for Gaucher’s and Fabry Disease Using Viruses and Blood-Forming Cells

Condition: Gaucher’s Disease
Intervention: Genetic: human glucocerebrosidase cDNA
51 Completed Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189

Condition: Depression
Intervention: Drug: NSI-189 Phosphate
52 Completed Beta-hCG + Erythropoietin in Acute Stroke

Condition: Acute Stroke
Intervention: Drug: Beta-hCG + Erythropoietin
54 Completed Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study

Conditions: Autism;   Oxidative Stress;   Inflammation
Intervention: Drug: Hyperbaric Oxygen Therapy
59 Completed Effects of Enzyme Replacement in Gaucher’s Disease

Condition: Gaucher’s Disease
Intervention:
60 Completed Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)

Condition: Sturge – Weber Syndrome (SWS)
Intervention:

 

 

If you still feel this is a con, tell me what you would need to see to prove otherwise. Respectfully, David

Can MS be treated with stem cells?

In ALL ARTICLES on October 25, 2011 at 2:13 pm

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

I did some digging and would like to present the preliminary results to answer the question:

Can MS be treated with stem cells?

https://i1.wp.com/www.msconnections.org/ms-myelin.gifSOME MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” – January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

————————————-

Can MS be treated with stem cells?

You decide. Here are 11 articles from my blog,  28,000 from google news and there are a total of 20 clinical trials from clinicaltrials.gov

From my blog…

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

***https://repairstemcell.wordpress.com/2010/05/18/ms-and-stem-cells-time-is-brain-in-ms/

*** https://repairstemcell.wordpress.com/2009/09/02/my-ms-pain-is-gone/

* * * https://repairstemcell.wordpress.com/2009/04/26/fat-derived-stem-cells-might-treat-ms-us-news-and-world-report/

* * * https://repairstemcell.wordpress.com/2009/04/15/britt%e2%80%99s-fight-against-multiple-sclerosis-hits-home-for-uncw-starnewsonlinecom-star-news-wilmington-nc/

* * * https://repairstemcell.wordpress.com/2009/04/09/stem-cell-breakthrough-may-lead-to-ms-treatments-forbescom/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-2/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-1/

* * * https://repairstemcell.wordpress.com/2009/03/07/study-stem-cell-transplants-could-reverse-ms-cloning-and-stem-cells-msnbccom/

* * * https://repairstemcell.wordpress.com/2009/02/23/foxnewscom-college-student-with-multiple-sclerosis-symptom-free-after-stem-cell-treatment-health-news-current-health-news-medical-news/

* * * https://repairstemcell.wordpress.com/2009/02/12/stem-cells-ms-multiple-sclerosis-cured-by-adult-stem-cells-video-stem-cell-research-and-stem-cell-therapy/

* * * https://repairstemcell.wordpress.com/2009/02/11/multiple-sclerosis-ms-stem-cell-trials-us-is-starting-to-%e2%80%9ccatch-up%e2%80%9d/

* * * https://repairstemcell.wordpress.com/2009/02/10/the-us-is-playing-catch-up-with-stem-cells-ms/

* * * https://repairstemcell.wordpress.com/2009/02/08/stem-cell-transplants-help-ms-victims/

…and about 28,000 scholarly papers/studys on “MS stem cell” here:
http://scholar.google.com/scholar?q=multiple%20sclerosis%20trial%20stem%20cell&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=ws\

…and 20 responses from clinicaltrials.gov on “multiple sclerosis stem cell”
http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

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