Posts Tagged ‘gut’


In ALL ARTICLES, BUSINESS OF STEM CELLS on July 5, 2014 at 10:20 am
It May Take Guts to Cure Diabetes -Human GI Cells Retrained to Produce Insulin

Imagine taking cells from your gastrointestinal tract and then switching off one gene, the FOXO1 gene, and then ending up with insulin producing cells.  From gut cell to diabetes fighter in one easy gene switch-off.  Scientists did this successfully in 2012 in mice and recently in humans.  What does the FOXO1 say? ‘Here’s more insulin!’  Awesome.

The next step is where it gets…awkward.  I’d like this information to generate a gene therapy protocol or to improve success rates in stem cell/Diabetes treatment protocols,  etc.  But that’s not the way our system works.  The next step is to find a drug that inhibits the FOXO1 gene so it “…could retrain cells inside a person’s GI tract to produce insulin…”  Unfortunately, this drug will also have side effects as all drugs do which will create other symptoms requiring other drugs to mitigate.  And so it goes.

When will US Diabetes patients be able to benefit from a medical protocol based on this discovery?  An educated guess puts it at:
7-10 years for clinical trials and drug development for a name brand Pharma product and then 10-15 years for the drug patent to open up to an affordable generic.
Sorry Diabetes patients.

New York, NY (June 30, 2014) “By switching off a single gene, scientists at Columbia University’s Naomi Berrie Diabetes Center have converted human gastrointestinal cells into insulin-producing cells, demonstrating in principle that a drug could retrain cells inside a person’s GI tract to produce insulin…The Columbia researchers were able to teach human gut cells to make insulin in response to physiological circumstances by deactivating the cells’ FOXO1 gene.”


In ALL ARTICLES, OFF THE BEATEN PATH on June 23, 2014 at 4:04 pm


 For Best Results: Increase Gut Bacteria


“A healthy and balanced diet, as well as probiotics, have been known to be helpful in preserving gastrointestinal health for quite a long time. But it is only recently that the underlying mechanisms have become somewhat clearer. A rapidly increasing body of knowledge promises to further clarify the effects of our daily food on the gut microbiota and to indicate more targeted applications of probiotics in the near future. This was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL, USA. On March 8-9, 2014, internationally leading experts discussed the latest advances in gut microbiota research and its impact on health.”  –‘Feeding gut microbiota: Nutrition, probiotics key factors for digestive health.’ ScienceDaily

We’ve all heard of probiotics and their dietary benefits. Now let’s use that knowledge and put it to good use when it comes to stem cell transplantation. According to the article we posted earlier, increased gut microbiota can increase the success and survival rate of patients post transplant. Now here’s the big question… ‘how do we increase these helpful suckers early and get them working ASAP?!’ Well, you probably guessed it–  eating foods rich in probiotics (such as yogurt)  is one way to do this! Click the links and find out why you should be feeding the little helpers alive in your gut and how to increase their diversity– and increase your chances of success!!


Other benefits of increased gut microbiota and why that’s good

Related Links:

Exercise and healthy diet and how that helps

What are probiotics anyway?


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