DAVID GRANOVSKY

Posts Tagged ‘gehrig’

A history of Amyotrophic Lateral Sclerosis (ALS) and stem cells

In STEM CELLS IN THE NEWS on April 11, 2012 at 1:43 am

YEARS AWAY FROM A STEM CELL ETA AND ALL WE CAN HOPE FOR TODAY IS DOA…

A history of Amyotrophic Lateral Sclerosis (ALS)

aka Lou Gehrig’s disease

and stem cell treatments for humans going back to 2001.

OVERVIEW:

More stem cells in Lou Gehrig’s disease

29 Sep 2009 | 19:51 BST | Posted by Monya Baker | Category:

Shortly after my coverage of the FDA’s approval for NeuralStem’s stem-cell trial for amyotrophic lateral sclerosis appeared on the Niche, Letizia Mazzini and Franca Fagioli of Eastern Piedmont University contacted me to tell me about their team’s work using mesenchymal stem cells for the same disease. While Neuralstem is moving forward with neural stem cells, Mazzini and colleagues have been exploring the use of mesenchymal stem cells derived from the patient who will receive them. She has recently published results of a Phase I trial as well as a review of stem-cell approaches in ALS. Unfortunately, I learned of this work only after I’d posted.
Here is their letter:

We have just read, not without some interest, the NeuralStem communicate. The trial is presented as if it were the first clinical study with stem cells in ALS (“This is the first stem-cell approach for ALS” says Lucie Bruijin). However, this needs to be rectified as we conducted two phase 1 clinical trials one in 2001 (Mazzini et al., 2008)) and the other in 2007 (Mazzini L et al., 2009). The trials were approved respectively by the regional Ethical Committee and by the Italian Institute of Health and by the and were designed to test the safety and the feasibility of mesenchymal stem cell transplantation into the spinal cord of ALS patients.

MSC were isolated from patients’ bone marrow, in vitro expanded for 3-4 passages and evaluated for quality control as requested by national rules on advanced therapies. In neither of our trials were there any immediate or delayed transplant related toxicities. Stem cells were transplanted into the spinal cord at the thoracic levels with a surgical approach. Clinical, laboratory, and radiographic evaluations of the patients showed no serious transplant related adverse events. Magnetic resonance images (MRI) showed no structural changes (including tumor formation) in either the brain or the spinal cord.

Furthermore, we also demonstrated that expanded MSCs can survive and migrate after transplantation in the lumbar spinal cord of SOD1-G93A mice, where they prevent astrogliosis and microglial activation and delay the ALS-related decrease in the number of motor neurons, resulting in an amelioration of motor performance (Vercelli A et al., 2008 ). Therefore we concluded that MSCs represent a good source of stem cells for future ALS cell based clinical trials.

Thus, the NeuralStem trial, as it appears, shows this experimental design to be no different to our studies except for the cell type: neural stem cell derived from a 8-week fetus.

Letizia Mazzini, MD ALS Centre, Dpt of Neurology ,Eastern Piedmont University Maggiore della Carità Hospital Novara, Italy

Franca Fagioli, MD Stem Cell Transplantation and Cellular Therapy Unit Pediatric Onco-Hematology Department Regina Margherita Children’s Hospital Torino. Italy

References

1.Mazzini, L. & Mareschi, K.& Ferrero, I.& Vassallo, E.& Oliveri, G.& Nasuelli, N.& Oggioni, GD.& Testa, L.& Fagioli F. Stem cell treatment in Amyotrophic Lateral Sclerosis. Journal of the Neurological Sciences 265 (2008) 78–83 (PubMed link)

2. Mazzini L, Ferrero I, Luparello V, Rustichelli D, Gunetti M, Mareschi K, Testa L, Stecco A, Tarletti R, Miglioretti M, Fava E, Nasuelli N, Cisari C, Massara M, Vercelli R, Oggioni GD, Carriero A, Cantello R, Monaco F, Fagioli F Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial.Exp Neurol. 2009 Aug 13. (PubMed link)

3. Alessandro Vercelli, Oana M Mereuta, MD; Diego Garbossa, MD; Giuseppe Muraca; Katia Mareschi; Deborah Rustichelli; Ivana Ferrero; Letizia Mazzini, MD; Enrico Madon, MD; Franca Fagioli, MD Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

Neurobiology of disease. 31 (2008) 395–405 (PubMed link)

 

ADDITIONAL STUDIES IN CHRONOLOGICAL ORDER (may be some repetition)

2003 – Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans
Our results appear to demonstrate that the procedures of ex vivo expansion of autologous mesenchymal stem cells and of transplantation into the spinal cord of humans are safe and well tolerated by ALS patients.  Read More: http://informahealthcare.com/doi/abs/10.1080/14660820310014653

 

2003 – Amyotroph Lateral Scler Other Motor Neuron Disord  – Letizia Mazzini and colleagues (Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4: 158—61) injected autologous bone-marrow-derived stem cells into the spinal cord of seven ALS patients. These investigators reported that the procedure had a reasonable margin of clinical safety. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2804%2916634-8/fulltext

 

2007 – Stem cell treatment in Amyotrophic Lateral Sclerosis

Journal of the Neurological Sciences xx (2007) xxx– xxx – The results of the long term follow-up (more than 4 years) confirm that intraspinal injection of MSCs in ALS patients is safe as previously reported. – http://fondazionevialliemauro.it/eng/PDF/JNS.pdf


2008 – Stem cell treatment in Amyotrophic Lateral Sclerosis

Journal of the Neurological SciencesVolume 265, Issue 1 , Pages 78-83, 15 February 2008 – Our results seem to demonstrate that MSCs represent a good chance for stem cell cell-based therapy in ALS and that intraspinal injection of MSCs is safe also in the long term. A new phase 1 study is carried out to verify these data in a larger number of patients.


2009 – Stem Cell treatment of ALS has a history of success since Feb

“In a [February, 2009] published clinical stem cell research study, adult stem cells were shown to help delay Amyotrophic Lateral Sclerosis (ALS) progression and improve an ALS patient’s quality of life. This research study was believed to be the first published study comparing ALS patients who had their own stem cells injected into their brain vs a control group…

The initial two year clinical test study results of the stem cell procedure was published in Cytotherapy, February, 2009. Positive results were confirmed through both clinical observation and MRI tractography.  It is considered by many within the international neurological community to be the foremost procedure available for minimizing or abrogating ALS symptoms and extending the lifespan of ALS patients. The procedure is a state of the art use of autologous CD-133 (+) stem cells injected into the frontal cortices for the effective replacement of motor neurons.”

 

ALS adult stem cell trial = safe and effective

The initial two year clinical test study results of the stem cell procedure instituted by Hospital San Jose Tecnologico de Monterrey, was published in Cytotherapy, February, 2009. Positive results were confirmed through both clinical observation and MRI tractography. It is considered by many within the international neurological community to be the foremost procedure available for minimizing or abrogating ALS symptoms and extending the lifespan of ALS patients. The procedure is a state of the art use of autologous CD-133 (+) stem cells injected into the frontal cortices for the effective replacement of motor neurons.
Via https://repairstemcell.wordpress.com/2012/01/19/als-adult-stem-cell-trial-safe-and-effective-reuters/
THE TRIAL: http://www.alsworldwide.net/pdfs/monterey_hospital.pdf

 

2012 – BrainStorm sees positive data in ALS stem cell trial

TEL AVIVTue Jan 17, 2012 12:07am EST –  (Reuters) – Data from the first ALS patients in a clinical trial treated with BrainStorm Cell Therapeutics adult stem cell therapy did not show significant side effects and the treatment has so far proven to be safe, the company said on Tuesday…http://www.reuters.com/article/2012/01/17/us-brainstorm-trial-embargoed-idUSTRE80G07Q20120117?feedType=nl&feedName=ushealth1100

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely

In VICTORIES & SUCCESS STORIES on April 11, 2012 at 12:16 am

WELCOME US MEDIA!!! WOO HOO!!

11 YEARS LATE TO THE PARTY:

A history of Amyotrophic Lateral Sclerosis (ALS) aka Lou Gehrig’s disease and stem cell treatments for humans going back to 2001.

https://repairstemcell.wordpress.com/amyotrophic-lateral-sclerosis-als/

https://i1.wp.com/upload.wikimedia.org/wikipedia/commons/thumb/2/2f/GehrigCU.jpg/200px-GehrigCU.jpg

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely, New Research Shows

ANN ARBOR, Mich., April 10, 2012 /PRNewswire-USNewswire/ — The first published results from an early-stage clinical trial show that spinal cord stem cells can be delivered safely into the spines of patients with the condition commonly known as Lou Gehrig‘s disease, opening the door for further research on this innovative approach.

In a paper published online ahead of print publication in the peer-reviewed journal Stem Cells, a team from the University of Michigan, Emory University and study sponsor NeuralStem, Inc. report the results from 12 patients who took part in a study being conducted at Emory.

All had amyotrophic lateral sclerosis, the inevitably fatal degenerative disease of the nervous system that many call Lou Gehrig‘s disease. None experienced any long-term complications related to either the surgical procedure or the implantation of stem cells, or showed signs of rejecting the cells. And in the months following the surgery to inject the cells, none showed evidence that their ALS progression was accelerating..

Stem Cell Injections in Lou Gehrig’s Disease can be Given Safely,… — ANN ARBOR, Mich., April 10, 2012 /PRNewswire-USNewswire/ —.


ALS adult stem cell trial = safe and effective | Reuters

In VICTORIES & SUCCESS STORIES on January 19, 2012 at 9:28 am

(Reuters) – Data from the first ALS patients in a clinical trial treated with BrainStorm Cell Therapeutics adult stem cell therapy did not show significant side effects and the treatment has so far proven to be safe, the company said on Tuesday.

Israel-based BrainStorm is developing NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

The U.S. Food and Drug Administration last year granted orphan drug designation to NurOwn. The FDA’s orphan drug program encourages the development of treatments for rare diseases by providing financial incentives.

“There have been no significant side effects in the initial patients we have treated with BrainStorm’s NurOwn technology,” said Dimitrios Karussis, the head of Israel’s Hadassah Medical Center’s Multiple Sclerosis unit, who is leading the clinical trial.

“In addition, even though we are conducting a safety trial, the early clinical follow-up of the patients treated with the stem cells shows indications of beneficial clinical effects, such as an improvement in breathing and swallowing ability as well as in muscular power.”

Patients in the trial are transplanted with stem cells derived from their own bone marrow and treated with the NurOwn stem cell technology.

The initial phase of the study is designed to establish the safety of NurOwn and will later be expanded to assess efficacy.

“Based on the interim safety report, the hospital ethical and safety committee granted the company approval to proceed with treating the next patients,” said Chaim Lebovits, president of BrainStorm.

According to the ALS Association, 5,600 people in the United States are diagnosed with the disease each year. It is estimated that as many as 30,000 Americans may have the disease — which has severely disabled British physicist Stephen Hawking — at any given time.

BrainStorm sees positive data in ALS stem cell trial | Reuters.

60 Minutes, Stem Cell Treatments – Snake Oil Salesmen

In STEM CELLS IN THE NEWS on April 18, 2010 at 9:17 pm

I would like to draw your attention to the recent 60 Minutes segment that made comparisons to Stem Cell Treatment Centers as “snake oil salesmen.”

This blog was created to help navigate the misinformation and confusion associated with the almost 500 treatment centers around the world.  Many of these treatments centers are inexperienced, use untested protocols or are merely “in it for the money.”  This blog was created to assist the patient interested in stem cell treatment but daunted and worried by the overwhelming mass of information and misinformation.  I helped create a set of rigorous standards by which these treatments centers have been assessed.  Only those facilities that have a proven history of success, safety, service and integrity meet the exceedingly high standards.

Stem Cell therapy is a young and rapidly evolving science.  New information appears everyday and the typical patient has no hope of wading through and evaluating the plethora of information that has come before and continues to be generated by doctors and scientists around the world.  I can help to find the best treatment center for you, your condition and your situation and give you the confidence to make an educated and informed decision when choosing stem cell treatment protocols, treatment centers and doctors that will perfectly cater to your needs and concerns.

The problem was not the concept of treating ALS with stem cells…in fact, Stem Cell treatment of ALS has a history of success since Feb, 2009 –

“In a [February, 2009] published clinical stem cell research study, adult stem cells were shown to help delay Amyotrophic Lateral Sclerosis (ALS) progression and improve an ALS patient’s quality of life. This research study was believed to be the first published study comparing ALS patients who had their own stem cells injected into their brain vs a control group…

The initial two year clinical test study results of the stem cell procedure was published in Cytotherapy, February, 2009. Positive results were confirmed through both clinical observation and MRI tractography.  It is considered by many within the international neurological community to be the foremost procedure available for minimizing or abrogating ALS symptoms and extending the lifespan of ALS patients. The procedure is a state of the art use of autologous CD-133 (+) stem cells injected into the frontal cortices for the effective replacement of motor neurons.”

(There are also a number of other clinical trials currently ongoing to further test the safety and efficacy of Stem Cell treatment of ALS.)

For stem cell clinical trials and studies that have proven safe and effective treatments for heart disease, contact me at dsgrano@gmail.com

For more information on treatments for heart disease, go here: https://repairstemcell.wordpress.com/heart-disease-treatment/

For ALS (Lou Gehrig’s disease), contact me at dsgrano@gmail.com

For MS, go here: https://repairstemcell.wordpress.com/multiple-sclerosis-stem-cells/
For Autism/Asperger’s, go here: https://repairstemcell.wordpress.com/autismaspergers-stem-cells/

Warm Regards
David Granovsky, Author

•  SUPER STEMMYS – DORIS & THE SUPERCELLS!  •  http://bit.ly/StemCellBook4Kids

•  THE STEM CELL BLOG  •  http://bit.ly/TheStemCellBlog

Can Stem Cell Research Really Defeat the 1927 Yankees and Lou Gehrig’s Disease (ALS) | Adult Stem Cell Research

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on June 19, 2009 at 10:56 am
babe ruth and lou gehrig - 1927 yankees

babe ruth and lou gehrig - 1927 yankees

Can Stem Cell Research Really Defeat the 1927 Yankees and Lou Gehrig’s Disease (ALS)

Posted 18 June, 2009 in Amyotrophic Lateral Sclerosis (ALS) |

Stem Cell Research Shown To Improve ALS

In a recent published clinical stem cell research study, adult stem cells were shown to help delay Amyotrophic Lateral Sclerosis (ALS) progression and improve an ALS patient’s quality of life. This research study was believed to be the first published study comparing ALS patients who had their own stem cells injected into their brain vs a control group.

Thank you very much to ALS Worldwide for providing us with this exciting stem cell research breakthrough in humans- not mice! Any clinical studies like this in the United States? I can’t hear you….

Without further ado- here is the published stem cell research study on ALS.

Summary of Adult Stem Cell Therapy for ALS Study

This summary is provided by the good people at ALS Worldwide as well as they went to observe this tremendous stem cell treatment using Adult Stem Cells!

HOSPITAL SAN JOSE TECNOLOGICO DE MONTERREY STEM CELL PROCEDURE

The initial two year clinical test study results of the stem cell procedure instituted by Hospital San Jose Tecnologico de Monterrey, was published in Cytotherapy, February, 2009. Positive results were confirmed through both clinical observation and MRI tractography. It is considered by many within the international neurological community to be the foremost procedure available for minimizing or abrogating ALS symptoms and extending the lifespan of ALS patients. The procedure is a state of the art use of autologous CD-133 (+) stem cells injected into the frontal cortices for the effective replacement of motor neurons.

Representing the ALS WORLDWIDE patient community, we were at Hospital San Jose Tecnologico de Monterrey in Mexico from June 6-14 to observe the hospitalization and procedures for the first two international patients being provided this stem cell therapy. In a sentence, the official message delivered is clear: “This stem cell procedure is not a cure. We offer nothing more than the promise of stability and extended life expectancy. The opportunity, however, exists for improvement. “

Process of Stem Cells for Lou Gehrig’s Disease

The stem cell preparation procedure is sophisticated and complicated but in the simplest terms, the patient’s blood is purified, extracted and cleansed. Stem cells are extracted and then the one kind of stem cell that can be best coaxed into becoming a neuron is injected into two places in the brain. The patient experiences no pain and very little discomfort during the procedure. A mild sedative is provided and within hours, the patient is back in his or her room, enjoying dinner.

The team effort at Hospital San Jose Tecnologico de Monterrey embraces a cooperative spirit that pervades every aspect of their efforts. Patients and their families are treated with the highest level of concern, respect and support. The hospital itself resembles the finest hotel and provides exemplary care. A more detailed, scientific explanation of the Monterrey experience is currently being prepared and will be posted to ALS WORLDWIDE within the next week.

I hope to post these updates on this breakthrough in stem cell research as well.

via Can Stem Cell Research Really Defeat the 1927 Yankees and Lou Gehrig’s Disease (ALS) | Adult Stem Cell Research.

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