DAVID GRANOVSKY

Posts Tagged ‘EYE’

BENNY HILL IS ALIVE AND WELL AS BRITAIN GOES BLIND

In ALL ARTICLES on September 23, 2011 at 7:00 am

Remember in the final scene of every episode of Benny Hill where he does something really scandalous and then gets chased by the entire cast around and around in circles?  Turns out, Benny Hill is ALIVE AND WELL and advising Britain on their medical protocols!  http://www.webtvwire.com/wp-content/uploads/2010/06/the-benny-hill-show-logo.jpg

You see, Britain, like the USA, is chasing this fleet footed “embryonic stem cell treatment comedy of errors” around and around in circles just like in the Benny Hill episodes.  Every week, the same scene is played out with Benny running, the entire cast chasing and he never gets caught.  So in Art, so in life.  Britain is chasing embryonic stem cells used for treatment of optic diseases.  And remember…

  • Embryonic stem cells STILL have ZERO successful clinical trials
  • Embryonic stem cells STILL cause cysts and tumors that can become cancerous (wait 20 years and ask again though)
  • Embryonic stem cells STILL have rejection issues that require immunosuppressive drugs
  • Embryonic stem cells STILL carry the genetic anomalies of the donor
ON THE OTHER HAND…

So on top of wasting time chasing a cure with no prior history of success and huge negative side effects, thy are running right past a treatment with a huge history of success and safety and trials.

So cue up the cameras, get everyone in costume and let’s start that famous music going as everyone chases embryonic stem cell treatments around and around.  Wait! STOP! Hold it! CUT!

How on earth can we explain the entire medical community and government running right past what already works?  Got it! Give them all blindfolds!  That way they can be assured to miss the forest but they will hit every damn tree in it and so will the patients, patiently waiting for treatments which will never come!

…annndddd   ACTION!!!

Iris of a human eye

First trial of embryonic stem cell treatment in Europe gets green light

Patients in Britain with an eye disease that leads to blindness will take part in Europe’s first human embryonic stem cell trial

British surgeons are to take part in the first trial in patients of a human embryonic stem cell therapy to gain approval from regulators in Europe.

Surgeons at Moorfields Eye Hospital in London will inject cells into the eyes of 12 patients with an incurable eye disease called Stargardt’s macular dystrophy, one of the main causes of blindness in young people…

Read more

14-month old can see, thanks to stem cells

In ALL ARTICLES on September 13, 2011 at 1:01 pm

JAMES WOODCOCK/Gazette Staff – Kaile Milton plays with her 14-month-old daughter, Skylie. Skylie recently had stem cell surgery in China to correct blindness caused by septo-optic dysplasia. Skylie and her family spent 28 days in China for her treatment.

Skylie Milton’s grandma held out a cracker while standing on the other side of the room.

“Come on, Skylie, come get a cracker,” she said.

The 14-month-old Billings girl whipped her head around, smiled from ear to ear and hobbled across the living room toward the snack.

Once Skylie got within its grasp, she reached out, took the cracker and brought it to her mouth.

It’s something she couldn’t have done just a few months ago when she could see only about a foot away.

Thanks to stem cell research, and $40,000 raised by the community to send Skylie to China for stem cell injections, the giggling girl can now see just beyond 25 feet.

“It’s just amazing, it’s awesome,” said Skylie’s mom, Kaile Milton.

Lying beside Skylie on the floor as she played with blocks, Milton still seemed to not believe her girl could see.

The doctors in China shared her amazement, Milton said.

“They were surprised she took to it so well,” Milton said. “Usually they don’t see that much progress that quickly.”

Because the type of stem cell therapy the family settled on is considered experimental in the United States, the family had trouble finding a doctor in the area who would support them. It was further research that led them to China.

Skylie received seven stem cell injections geared toward improving the her eyesight.

Skylie was born missing her septum pellucidum, the part of the brain that separates the right and left hemispheres. Without it, her optic nerves never fully developed, diminishing her eyesight.

In addition, doctors determined that Skylie suffers from septo-optic dysplasia, which affects both her eyesight and the hormones related to the pituitary gland. It affects about 1 in 10,000 births, according to the National Library of Medicine.

To improve their daughter’s eyesight, the Miltons settled on stem cell injections and then looked to the community for help. The response was overwhelming.

The person who stands out the most to Milton’s mind is Dana Lariviere of Billings, who volunteered to head a fundraiser that helped raise more than $11,000.

“We wouldn’t have made the trip without them all,” Milton said.

In China

The family was able to stay in a room at the hospital, putting them close to Skylie during her 28 days abroad.

Most of the injections were given through her arm, though a few had to be given through her head.

“Watching the IV was horrible,” Milton said. “One day they had to poke her seven times, then eventually just had to put it in her head. But she took to it really well.”

To help soothe the child, the doctors would sing her “Old MacDonald” — in Chinese.

When she wasn’t receiving an injection, Skylie was undergoing rehabilitation treatments to help keep her blood flowing and the stem cells stimulated, including acupressure, electrical stimulation, walking training and cup therapy five times a week.

To continue her progress, Milton said they make sure to massage around her eyes and her head.

It’s unknown whether Skylie will need additional stem cell injections through the procedure, which is not available in the United States.

Not alone

During Skylie’s treatment, the Miltons met two other couples going through the same procedure, both from the United States.

When they weren’t waiting in the hospital, the group was able to go into the city and take in the culture.

It was quite a shock, especially seeing strangers’ adoration for Skylie.

“We couldn’t even go to the store, it would take an hour to get down the aisle,” said Rel, the grandmother. “People were taking pictures with her.

“They were very warm and loving toward her; we couldn’t keep her away from everyone.”

Suffering from jet lag and exhausted from the daily procedures, the family mostly stuck to the hotel, watching movies and having pizza — and McDonalds — delivered to the room.

“It was definitely close quarters,” Rel said. “You don’t get to venture off too much by yourself.”

Coming home

Skylie came home on Aug. 1, and not a moment too soon. The last few weeks of treatment were miserable.

It wasn’t because of the injections. Skylie was teething.

“She was not feeling good at all,” Milton said. “She was cranky.”

Now when she is fussy, all Milton has to do is start counting, holding up her fingers for her daughter to see.

Her crying calms down and changes to laughter as she starts clapping her hands, gets up and moves on to her next adventure.

SCOTLAND JUMPS INTO STEM CELL CLINICAL TRIALS

In ALL ARTICLES on July 29, 2010 at 12:11 pm

This video shows the Health Minister of Scotland discussing current stem clinical trials in Scotland for stroke and for eye repair.  It’s significant that they are in the stem cell game.  One more country recognizing the power of stem cells.

p.s.  It’s a short video and armed with my explanation above, you probably know everything you need to know without even watching it – http://video.forbes.com/fvn/tech/scotland-stem-cell-edge

 

And now for your viewing pleasure…a pic of Cuillin Mountains in Scotland

http://www.1adventure.com/archives/images/cuillin-mountains-scotland-backside.jpg

Other STROKE articles:

  1. https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
  2. https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
  3. http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
  4. http://www.sciencedaily.com/releases/2011/08/110831160216.htm

CHEMICALLY BURNED EYES REPAIRED WITH STEM CELLS

In VICTORIES & SUCCESS STORIES on June 24, 2010 at 12:47 pm

BRIEF SUMMARY OF METHODS

  1. used autologous limbal stem cells cultivated on fibrin
  2. treated 112 patients with corneal damage
  3. most had burn-dependent limbal stem-cell deficiency

BRIEF SUMMARY OF RESULTS

  1. Permanent restoration of a transparent, renewing corneal epithelium was attained in 76.6% of eyes.
  2. Restored eyes remained stable over time, with up to 10 years of follow-up (mean, 2.91±1.99; median, 1.93).
  3. Cultures in which p63-bright cells constituted more than 3% of the total number of clonogenic cells were associated with successful transplantation in 78% of patients.

—————————————-

MORE DETAILED INFORMATION:

http://content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f3.jpeg

Figure 3. Regeneration of a Functional Corneal Epithelium and Restoration of Visual Acuity.

[Brief: "All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left).  In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium."]

Panel A shows the left eye of Patient 93 (see Table 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org), who had total limbal stem-cell deficiency due to an acid burn (image at left). His visual acuity was reduced to counting fingers. A graft of autologous limbal cultures was sufficient to regenerate functional corneal epithelium (image at right) and to restore normal vision (visual acuity, 0.7), since the eye had no stromal scarring. Panel B shows the eyes of Patients 22, 26, and 46 (see Table 1 in the Supplementary Appendix), which were damaged by alkali burns and were treated with unsuccessful surgery 13, 30, and 3 years before admission, respectively. All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left). Vision was reduced to counting fingers (in Patient 22) or perceiving hand movements (in Patients 26 and 46). In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium. To improve their visual acuity after grafting, the patients underwent penetrating keratoplasty. In all three eyes, the engrafted limbal stem cells resurfaced the donor stroma. At the last follow-up visits (at 6, 6.5, and 4 years, respectively), all eyes were covered by stable corneal epithelium (images at right). The keratoplasty resulted in complete restoration of visual acuity in Patients 22 and 46 (0.9 and 0.8, respectively). The visual acuity of Patient 26 increased to only 0.3 because of a concomitant amblyopia (the alkali burn had occurred 30 years before admission). In Patient 46, the follow-up image shows that the conjunctival vessels stop at the conjunctival–corneal boundary (arrowheads); they do not invade the restored corneal surface.

http://content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f1.jpeg

Figure 1. Kaplan–Meier Estimates of Grafted Limbal Stem-Cell Survival.

[Brief: "the final clinical outcome was deemed a success in 76.6% of the eyes treated"]

Panel A shows the survival estimates for the cultures after one graft was placed, with partial or total success attained in 68.2% of the eyes treated. Panel B shows survival estimates after a second graft was placed in 11 eyes (a total of 12 additional grafts, since 1 eye was regrafted twice), indicating either partial success or failure. After regrafting, 9 of these eyes regenerated normal epithelium. Thus, the final clinical outcome was deemed a success in 76.6% of the eyes treated. All failures occurred within the first year after grafting, whereas successful cultures remained stable for up to 10 years of follow-up.

THIS POST IS AN ADDENDUM TO EARLIER STORY:  Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg – VIA

THE IMAGES AND TEXT ARE VIA: http://content.nejm.org/cgi/content/full/NEJMoa0905955v1#F3

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg

In VICTORIES & SUCCESS STORIES on June 22, 2010 at 3:00 am

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows

Patients blinded in one or both eyes by chemical burns regained their vision after healthy stem cells were extracted from their eyes and reimplanted, according to a report by Italian researchers at a scientific meeting.

Patient's Own Stem Cells Fix Damaged Eyes

The tissue was drawn from the limbus, an area at the junction of the cornea and white part of the eye. It was grown on a fibrous tissue, then layered onto the damaged eyes. The cells grew into healthy corneal tissue, transforming disfigured, opaque eyes into functioning ones with normal appearance and color, said researchers led by Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine.

The stem-cell treatment restored sight to more than three- quarters of the 112 patients treated, Pellegrini said yesterday in a presentation at the International Society for Stem Cell Research meeting. She estimated the work may benefit 1,000 to 2,000 patients in Europe whose eyes have been damaged by chemical burns and many more in developing countries where the use of chemicals is less regulated. Her patients were followed for an average of three years and some for as long as a decade…..

via Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg.

Charlestown boy’s sight improves after stem cell treatment

In VICTORIES & SUCCESS STORIES on May 25, 2010 at 10:00 am

IMPROVEMENT: Connor Wink, 11, and his mother Tracey.

Charlestown boy’s sight improves after stem cell treatment

BY DONNA SHARPE – 18 May, 2010 10:44 AM

A CHARLESTOWN boy is showing marked signs of improvement in sight after his first round of stem cell treatment.

Connor Wink, 11, and his mother Tracey recently returned from China where he received a round of injections, which are not available in Australia.

The treatment appears to have had dramatic results.

Connor has gained light perception, a sign the treatment is working.

Born blind, he also suffers nystagmus, a condition which means Connor has poor muscle control causing his eyes to move frequently.

“That has slowed right down so it’s certainly a big plus,” Mrs Wink said.

Connor is the second Hunter child to undergo stem cell treatment in China.

Holly Arvidson, 12, of Denman, is having a second round of the procedure in a bid to restore her sight.

For the past 12 months, The Herald has been following the progress of Holly, who is in China with her family for the treatment which involves stem cell injections, acupuncture and bone marrow cultivation.

The treatment is only available in a handful of hospitals worldwide. It has an 80 per cent success rate but since Holly’s first round her condition has not changed.

Mrs Wink said she is praying Holly receives a positive result this time.

“Connor was lucky and we have seen improvements. We were sitting in front of a fire at the weekend and he could tell when someone was putting logs on it,” she said.

The Charlestown community and Connor’s school, Hillsborough Public, helped raise money for the China trip.

“We still have enough money to travel for Connor’s second round of treatment thanks to those earlier fund-raising efforts which Connor was a big part of, raising $6000 busking.”

via Charlestown boy’s sight improves after stem cell treatment – Local News – News – General – The Herald.

The Ray Romano + Kevin James Celebrity Golf Classic to Benefit Advancement in Vision Research

In VICTORIES & SUCCESS STORIES on October 2, 2009 at 8:49 pm

The Ray Romano and Kevin James Celebrity Golf Classic to Benefit Advancement in Vision Research

http://blogs.ajc.com/radio-tv-talk/files/2009/04/aug2006-ray_romano.jpgLA JOLLA, Calif.–(BUSINESS WIRE)–The Ray Romano and Kevin James Celebrity Golf Classic will be held on Monday, November 16, 2009 at the El Caballero Country Club in Tarzana, California. This year’s golf classic will benefit the advancement in vision science at The Scripps Research Institute in La Jolla, California.

The celebrity tournament is an annual event hosted by television and film stars Ray Romano (Everybody Loves Raymond, Ice Age) and Kevin James (The King of Queens, Paul Blart: Mall Cop). Each year, Romano and James choose a cause to support that is close to their hearts. Funds raised by this year’s golf tournament will support the research and treating of such debilitating vision diseases as retinitis pigmentosa and macular degeneration.

“My scientific team and I greatly appreciate Ray and Kevin for choosing The Scripps Research Institute as the beneficiary of this year’s golf tournament. The Ray Romano & Kevin James Celebrity Golf Classic’s contribution will be dedicated to research on stem cells for RP and MD patients,” said Scripps Research Professor Martin Friedlander, M.D./Ph.D., who is also a practicing ophthalmologist at the Scripps Clinic.

via The Ray Romano and Kevin James Celebrity Golf Classic to Benefit Advancement in Vision Research.

New insights on eye stem cells

In STEM CELLS IN THE NEWS on August 31, 2009 at 11:44 am

New insights on eye stem cells

Retinal stem cell - Wallace group

Retinal stem cell – Wallace group Retinal stem cells have now been created from human skin, adding yet another specialized cell type to a rapidly growing list of cells that can be created using induced pluripotent (iPS) methodology. The finding could prove to be an important method in the production of human retinal cells, which would help overcome one of the greatest obstacles to successful stem cell therapies to treat eye conditions. The announcement was made on Monday by a team from the University of Wisconsin-Madison.

via Stem Cell Network Blog: New insights on eye stem cells.

Retina Cells Created From Skin-derived Stem Cells

In VICTORIES & SUCCESS STORIES on August 26, 2009 at 1:58 pm

A team of scientists led by David Gamm, assistant professor of ophthalmology and visual sciences, and Jason Meyer, research scientist, has successfully grown multiple types of retina cells from two types of stem cells — suggesting a future in which damaged retinas could be repaired by cells grown from the patient’s own skin. Pictured here in a microscopic photograph are early retinal cells (green) and early brain cells (blue). (Credit: Courtesy David Gamm)

Retina Cells Created From Skin-derived Stem Cells

ScienceDaily (Aug. 25, 2009) — A team of scientists from the University of Wisconsin-Madison School of Medicine and Public Health has successfully grown multiple types of retina cells from two types of stem cells — suggesting a future in which damaged retinas could be repaired by cells grown from the patient’s own skin.

via Retina Cells Created From Skin-derived Stem Cells.

University of Louisville researchers make stem-cell discovery – Business First of Louisville:

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on May 22, 2009 at 6:48 pm
stem cell retina eye treat heal optic

stem cell retina eye treat heal optic

Thursday, May 21, 2009, 10:34am EDT

University of Louisville researchers make stem-cell discovery

Researchers at the University of Louisville have discovered that stem cells extracted from bone marrow can restore damaged retinal tissue by generating new cells.

The findings are an important step toward helping people who experience vision loss and blindness as a result of age-related macular degeneration and hereditary retinal degeneration, the university said in a news release.

Researchers found that stem cells removed from bone marrow were attracted to damaged retinal pigment epithelium, the pigmented cell layer just outside the retina.

via University of Louisville researchers make stem-cell discovery – Business First of Louisville:.

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