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Posts Tagged ‘edinburgh’

BONE REPAIR THROUGH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 10, 2013 at 8:41 am

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The use of bone stem cells combined with a degradable rigid material that inserts into broken bones and encourages real bone to re-grow has been developed at the Universities of Edinburgh and Southampton.

Researchers have developed the material with a honeycomb scaffold structure that allows blood to flow through it, enabling stem cells from the patient’s bone marrow to attach to the material and grow new bone. Over time, the plastic slowly degrades as the implant is replaced by newly grown bone.  Scientists developed the material by blending three types of plastics. They used a pioneering technique to blend and test hundreds of combinations of plastics, to identify a blend that was robust, lightweight, and able to support bone stem cells. Successful results have been shown in the lab and in animal testing with the focus now moving towards human clinical evaluation.

“Fractures and bone loss due to trauma or disease are a significant clinical and socioeconomic problem.  This collaboration between chemistry and medicine has identified unique candidate materials that support human bone stem cell growth and allow bone formation. The collaborative strategy offers significant therapeutic implications.  We were able to make and look at a hundreds of candidate materials and rapidly whittle these down to one which is strong enough to replace bone and is also a suitable surface upon which to grow new bone.” said Professor Mark Bradley, of the University of Edinburgh’s School of Chemistry

“We are confident that this material could soon be helping to improve the quality of life for patients with severe bone injuries, and will help maintain the health of an aging population.”

The study, published in the journal Advanced Functional Materials.

Sources:

http://www.sciencedaily.com

http://www.southampton.ac.uk/

University of Edinburgh study paves way for stem cell library » The Journal

In VICTORIES & SUCCESS STORIES on October 29, 2009 at 2:15 am

University of Edinburgh study paves way for stem cell library

https://i0.wp.com/www.hepfoundation.org.nz/images/liver2.jpg

Research could revolutionise the development of drugs to treat diseases and pave way for the creation of a library of liver cells

by Chris Grainger –  Wednesday 28 October 2009, The Journal Issue 26

Scientists have, for the first time, produced liver cells from adult stem cells using technology called iPSC, or induced pluripotent stem cell.

Using either embryonic or induced pluripotent stem cells, the Gamm lab created aggregates of early retinal cells (green spheres). The blue spheres are early brain cells. Photo: Special arrangement - University of Wisconsin

Using induced pluripotent stem cells, aggregates of early retinal cells (green spheres) are created. The blue spheres are early brain cells. Photo: Special arrangement - University of Wisconsin

The liver cells were created by manipulating the skin cells to resemble embryonic stem cells, which have the ability to become different cells within the body.

The study, led by the University of Edinburgh’s Medical Research Council Centre for Regenerative Medicine, makes possible the creation of a liver cell library, which could revolutionise the development of drugs, making them more efficient and safe.

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University of Edinburgh

via University of Edinburgh study paves way for stem cell library » The Journal.

New breakthrough ‘could prevent hereditary diseases’ – Health | Bounty

In SCIENCE & STEM CELLS on August 27, 2009 at 8:44 pm

New breakthrough ‘could prevent hereditary diseases’

Couples could be able to have their own biological child, but have the embryo altered at the very early stages to ensure it is born with no hereditary medical conditions.

At least that is what a new research breakthrough has suggested, after experiments were successfully carried out on pregnant monkeys at the Oregon National Primate Research Centre and Oregon Health and Science University.

The proposed procedure could see scientists remove the nucleus from extracted maternal eggs that carry the DNA defects that cause certain diseases and transplant it into a healthy egg, which would then be transplanted back into the pregnant woman’s uterus.

Commenting on the findings, Professor Ian Wilmut, head of the Medical Research Council’s Centre for Regenerative Medicine at the University of Edinburgh, told the Times: “This brings us an important step nearer to being able to prevent the birth of children with a particular type of inherited disease.”

Meanwhile, scientists at the University of Auckland in New Zealand recently revealed that women who gain too much weight while pregnant could give birth to children who enter puberty at a younger than usual age.

via New breakthrough ‘could prevent hereditary diseases’ – Health | Bounty.

Stem Cell Research – Hyperbaric Oxygen Therapy to stimulate stem cell formation

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 23, 2009 at 1:37 pm

Move over Michael Jackson!

23 Feb 2009 12:09 pm

Hyperbaric Oxygen Therapy to stimulate stem cell formation

hyperbaric-oxygen-therapy HBOT involves breathing pure oxygen to higher than atmospheric pressures in an enclosed chamber This treatment is used to treat divers who suffer from bends or decompression sickness.

The experts of Edinburgh University will conduct a clinical trial to study whether HBOT can improve liver functions and stimulate bone marrow stem cells.

via Stem Cell Research Blog » Hyperbaric Oxygen Therapy to stimulate stem cell formation.

STEM CELLS & HIV (Part 4) University Of Edinburgh And Castle Craig Hospital Launch Pilot Study For Hyperbaric Oxygen Therapy In The Treatment Of Alcoholic Liver Disease

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 20, 2009 at 5:45 pm
stem-cells-hiv

stem-cells-hiv

University Of Edinburgh And Castle Craig Hospital Launch Pilot Study For Hyperbaric Oxygen Therapy In The Treatment Of Alcoholic Liver Disease

Main Category: Liver Disease / Hepatitis

Article Date: 20 Feb 2009 – 3:00 PST

A pilot study to treat alcoholic liver disease with Hyperbaric Oxygen Therapy (HBOT) is being launched by Castle Craig Hospital and the Department of Hepatology at The University of Edinburgh, after obtaining Ethical Committee approval.

The Phase I study aims to show whether bone marrow stem cells are mobilised into the bloodstream following HBOT, in patients who recently drank alcohol to excess[1], with or without chronic liver disease. The trial will also examine whether there is an improvement in liver function following HBOT.

via University Of Edinburgh And Castle Craig Hospital Launch Pilot Study For Hyperbaric Oxygen Therapy In The Treatment Of Alcoholic Liver Disease.

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