DAVID GRANOVSKY

Posts Tagged ‘DOCTOR’

New Stem Cell Therapy For Dogs Launched In NZ | Voxy.co.nz

In VICTORIES & SUCCESS STORIES on April 26, 2010 at 7:29 pm

Tuesday, 27 April, 2010 – 10:22

A breakthrough stem cell therapy is being launched in New Zealand – offering a new lease on life for dogs suffering from degenerative joint disease.

New Zealand’s largest companion animal veterinary group, Pet Doctors, has announced a national license agreement to treat dogs with a stem cell technology called AdiCellTM.

Pet Doctors has partnered with Regeneus Pty Ltd, a Sydney-based pioneering biotech company, to distribute AdicellTM here. New Zealand will be only the third country in the world, following the US and Australia, to offer this type of therapy commercially…

via New Stem Cell Therapy For Dogs Launched In NZ | Voxy.co.nz.

PFIZER, CELEBREX, BEXTRA + VIOXX CLINICAL TRIAL RESULTS WERE FAKE- FRAUD

In ALL ARTICLES on February 18, 2010 at 1:55 pm

“It’s being called the largest research fraud in medical history. Dr. Scott Reuben, a former member of Pfizer’s speakers’ bureau, has agreed to plead guilty to faking dozens of research studies that were published in medical journals. Now being reported across the mainstream media is the fact that Dr. Reuben accepted a $75,000 grant from Pfizer to study Celebrex in 2005. His research, which was published in a medical journal, has since been quoted by hundreds of other doctors and researchers as “proof” that Celebrex helped reduce pain during post-surgical recovery. There’s only one problem with all this:

No patients were ever enrolled in the study!”


Big Pharma researcher admits to faking dozens of research studies for Pfizer, Merck

Sources for this story include:

Also see http://en.wikipedia.org/wiki/Scott_Reuben#cite_note-nyt0311-1

References

Mike Adams, Natural News
Thursday, February 18th, 2010

It’s being called the largest research fraud in medical history. Dr. Scott Reuben, a former member of Pfizer’s speakers’ bureau, has agreed to plead guilty to faking dozens of research studies that were published in medical journals.

Now being reported across the mainstream media is the fact that Dr. Reuben accepted a $75,000 grant from Pfizer to study Celebrex in 2005. His research, which was published in a medical journal, has since been quoted by hundreds of other doctors and researchers as “proof” that Celebrex helped reduce pain during post-surgical recovery. There’s only one problem with all this:

No patients were ever enrolled in the study!

Dr. Scott Reuben, it turns out, faked the entire study and got it published anyway.

It wasn’t the first study faked by Dr. Reuben: He also faked study data on Bextra and Vioxx drugs, reports the Wall Street Journal.

As a result of Dr. Reuben’s faked studies, the peer-reviewed medical journal Anesthesia & Analgesia was forced to retract 10 “scientific” papers authored by Reuben. The Day of London reports that 21 articles written by Dr. Reuben that appear in medical journals have apparently been fabricated, too, and must be retracted.

After being caught fabricating research for Big Pharma, Dr. Reuben has reportedly signed a plea agreement that will require him to return $420,000 that he received from drug companies. He also faces up to a 10-year prison sentence and a $250,000 fine.

He was also fired from his job at the Baystate Medical Center in Springfield, Mass. after an internal audit there found that Dr. Reuben had been faking research data for 13 years. (http://www.theday.com/article/20100…)

Business as usual in Big Pharma

What’s notable about this story is not the fact that a medical researcher faked clinical trials for the pharmaceutical industry. It’s not the fact that so-called “scientific” medical journals published his fabricated studies. It’s not even the fact that the drug companies paid this quack close to half a million dollars while he kept on pumping out fabricated research.

The real story here is that this is business as usual in the pharmaceutical industry.

Dr. Reuben’s actions really aren’t that extraordinary. Drug companies bribe researchers and doctors as a routine matter. Medical journals routinely publish false, fraudulent studies. FDA panel members regularly rely on falsified research in making their drug approval decisions, and the mainstream media regularly quotes falsified research in reporting the news.

Fraudulent research, in other words, is widespread in modern medicine. The pharmaceutical industry couldn’t operate without it, actually. It is falsified research that gives the industry its best marketing claims and strongest FDA approvals. Quacks like Dr Scott Reuben are an important part of the pharmaceutical profit machine because without falsified research, bribery and corruption, the industry would have very little research at all.

Pay special attention to the fact that the Anesthesia & Analgesia medical journal gladly published Dr. Reuben’s faked studies even though this journal claims to be a “scientific” medical journal based on peer review. Funny, isn’t it, how such a scientific medical journal gladly publishes fraudulent research with data that was simply invented by the study author. Perhaps these medical journals should be moved out of the non-fiction section of university libraries and placed under science fiction.

Remember, too, that all the proponents of pharmaceuticals, vaccines and mammograms ignorantly claim that their conventional medicine is all based on “good science.” It’s all scientific and trustworthy, they claim, while accusing alternative medicine of being “woo woo” wishful thinking and non-scientific hype. Perhaps they should have a quick look in the mirror and realize it is their own system of quack medicine that’s based largely on fraudulent research, bribery and corruption.

You just have to laugh, actually, when you hear pushers of vaccines and pharmaceuticals claim their medicine is “scientific” while natural medicine is “unproven.” Sure it’s scientific — about as scientific as the storyline in a Scooby Doo cartoon, or as credible as the medical license of a six-year-old kid who just received a “let’s play doctor” gift set for Christmas. Many pharmaceutical researchers would have better careers as writers of fiction novels rather than scientific papers.

For all those people who ignorantly claim that modern pharmaceutical science is based on “scientific evidence,” just give them these three words: Doctor Scott Reuben.

Drug companies support fraudulent research

Don’t forget that the drug companies openly supported Dr. Scott Reuben’s research. They paid him, in fact, to keep on fabricating studies.

The drug companies claim to be innocent in all this, but behind the scenes they had to have known what was going on. Dr. Reuben’s research was just too consistently favorable to drug company interests to be scientifically legitimate. If a drug company wanted to “prove” that their drug was good for some new application, all they had to do was ask Dr. Reuben to come up with the research (wink wink). “Here’s another fifty thousand dollars to study whether our drug is good for post-surgical pain (wink).”

And before long, Dr. Reuben would magically materialize a brand new study that just happened to “prove” exactly what the sponsoring drug company wanted to prove. Advocates of western medicine claim they don’t believe in magic, but when it comes to clinical trials, they actually do: All the results they wish to see just magically appear as long as the right researcher gets paid to materialize the results out of thin air, much like waving a magician’s wand and chanting, “Abra cadabra… let there be RESEARCH DATA!”

Shazam! The research data materializes just like that. It all gets written up into a “scientific” paper that also magically gets published in medical journals that fail to ask a single question that might exposed the research fraud.

I guess these people believe in magic after all, huh? Where science is lacking, a little “research magic” conveniently fills the void.

The whole system makes a mockery of real science. It is a system operated by criminals who fabricate whatever “scientific evidence” they need in order to get published in medical journals and win FDA approval for drugs that they fully realize are killing people.

What is “Evidence-Based Medicine?”

The fact that a researcher like Dr. Reuben could so successfully fabricate fraudulent study data, then get it published in peer-reviewed science journals, and get away with it for 13 years sheds all kinds of new light on what’s really behind “evidence-based medicine.”

The recipe for evidence-based medicine is quite simple: Fabricate the evidence! Get it published in any mainstream medical journal. Then you can quote the fabricated evidence as “fact!”

When pushers of pharmaceuticals and vaccines resort to quoting “evidence-based medicine” as their defense, keep in mind that much of their so-called evidence has been entirely fabricated. When they claim their branch of toxic chemical medicine is based on “real science,” what they really mean is that it’s based on fraudulent science but they’ve all secretly agreed to call it “real science.” When they claim to have “scientific facts” supporting their position, what they really mean is that those “facts” were fabricated by criminal researchers being paid bribes by the drug companies.

“Evidence-based medicine,” it turns out, hardly exists anymore. And even if it does, how do you know which studies are real vs. which ones were fabricated? If a trusted, well-paid researcher can get his falsified papers published for 13 years in top-notch science journals — without getting caught by his peers — then what does that say about the credibility of the entire peer-review science paper publishing process?

Here’s what is says: “Scientific medicine” is a total fraud.

And this fraud isn’t limited to Dr Scott Reuben, either. Remember: he engaged in routine research fraud for 13 years before being caught. There are probably thousands of other scientists engaged in similar research fraud right now who haven’t yet been caught in the act. Their fraudulent research papers have no doubt already been published in “scientific” medical journals. They’ve been quoted in the popular press. They’ve been relied on by FDA decision makers to approve drugs as “safe and effective” for widespread use.

And yet underneath all this, there’s nothing more than fraud and quackery. Sure, there may be some legitimate studies mixed in with all the fraud, but how can we tell the difference?

How are we to trust this system that claims to have a monopoly on scientific truth but in reality is a front for outright scientific fraud?

Keep up the great work, Dr Reuben

Thank you, Dr Scott Reuben, for showing us the truth about the pharmaceutical industry, the research quackery, the laughable “scientific” journals and the bribery and corruption that characterizes the pharmaceutical industry today. You have done more to shed light on the true nature of the drug industry than a thousand articles on NaturalNews.com ever could.

Keep up the good work. After paying your fine and serving a little jail time, I’m sure your services will be in high demand at all the top drug companies that need yet more “scientific” studies to be fabricated and submitted to the medical journals.

You may be a dishonest, disgusting human being to most of the world, but you’re a huge asset to the pharmaceutical industry and they need you back! There are more studies that need to be fabricated soon; more false papers that need to be published and more dangerous drugs that need to receive FDA approval. Hurry!

Because if there’s one place that extreme dishonesty is richly rewarded, it’s in the pharmaceutical industry, where poisons are approved as medicines and fiction is published as the truth.

Also see http://en.wikipedia.org/wiki/Scott_Reuben#cite_note-nyt0311-1

References

Double transplant for type 1 diabetes brings troubles, gifts

In ALL ARTICLES on January 11, 2010 at 3:05 pm

Double transplant for type 1 diabetes brings troubles, gifts
Updated 1/11/2010 12:05 PM ET    E-mail | Save | Print

Enlarge    By Dan MacMedan, USA TODAY

Immersing himself in a hot bath while taking anti-nausea pills brings Scott Bowles some relief from cyclic vomiting syndrome.

By Scott Bowles, USA TODAY

Ten years ago Tuesday, USA TODAY’s Scott Bowles had a kidney and pancreas transplant to treat his juvenile diabetes. He kept a journal of the experience, which ran as a series in the newspaper and in his book, The Needle and the Damage Done. Bowles, 44, a film reporter in Los Angeles, looks back at the decade and life after the surgery.

Albuquerque, April 7, 2009
Denzel Washington is going to have to wait.
The star is on a nearby stage, rehearsing

But I’m not going to make it. I’m on the floor of a publicist’s darkened office, on my back, trying to slow my breathing and fight off the nausea and heart palpitations that are racking my body.
READ MORE: Type 1 diabetes’ effect on daily life
Again.

It has been 10 years since I opted to treat my diabetes with a kidney and pancreas transplant, a decision that, for the first time, I’m beginning to question.

I find myself on a hospital gurney with frightening regularity lately. Where once I was going to the hospital every six to eight months, now I’m there every six to eight weeks. My weight is down to 139, lighter than I was in college. Three days without nausea or a racing heart feels like a good stretch of health.

More frightening, doctors aren’t sure how to keep my body from breaking down. They’ve diagnosed me with two post-transplant illnesses: cyclic vomiting syndrome (CVS) and atrial fibrillation. CVS is a powerful wave of nausea that hits without warning and can last hours, leaving me heaving long after my stomach is empty.
The nausea depletes me of electrolytes and minerals, which sends my body into the more dangerous complication: atrial fibrillation, a condition in which the heart pumps twice as fast as normal but circulates only 60% of the blood, raising the risk of a blood clot and stroke.

Today, I’m in the throes of both complications. I’m rushed to New Mexico University Hospital, where nurses are having trouble finding a vein. I’ve had so many blood draws over the decade that my veins have scarred and it’s difficult to find one that’s usable.

They try two sticks in the left arm. No luck. One in the right. Same result.
A nurse suggests mining my neck. I close my eyes: This is the one place I thoroughly feel the needle. The vein works all right; it’s dashing us both in arterial spray, too much for her to secure an intravenous tube. Finally, she sinks the needle between the fingers of my right hand and finds a vein.
After a bit, I feel the medications open my lungs and nudge me toward sleep.
But not before I think to myself: I can’t keep doing this.

Los Angeles, July 14
My doctor for the past 10 years, Michael Brousseau, has me in his office. My mother is here, too. She has traveled from Atlanta to meet with physicians and brainstorm.

Brousseau is frustrated. I’m on a dozen anti-nausea medications — some of them designed for cancer patients on chemotherapy — yet nothing works with consistency.
He connects me with two more specialists, who will focus on my stomach and heart. “Something has to work,” he says. “Because right now, you’re not functional.”

The words throw me. I had this surgery Jan. 12, 2000, as a salvo against the disease, which over 20 years claimed both kidneys, one-third of my sight and almost all hope that I’d reach 50 with my vision and limbs intact.
And for five years, it seemed, the transplant was the solution. To this day I’ve had no rejection episodes and not a drop of insulin.

But the new complications are frighteningly quick and forceful. I was never staggered by an insulin reaction or high blood sugar as I am by these side effects.

We drive home, and I excuse myself to the bathroom. I run a hot bath (the one treatment that seems to settle my nausea) and turn up the radio so Mom can’t hear me lose my composure in the tub.
Maybe I don’t beat my body’s demons. Maybe I already was as healthy as I’m ever going to be.

July 16
Mom and I are walking through the mall when I lose my balance. The new medications are interacting poorly, leaving my head swimming and my legs unreliable. I flop in a mall seat while Mom goes for something to drink.
A woman who has been watching from a nearby bench walks toward me. She holds a package of gum and offers me a piece.

I’m not sure how to respond, so I take it and thank her. She shakes her head — she doesn’t speak English — but smiles and offers another piece.
The gum does nothing, the gesture everything. By the time Mom is back, I’m already feeling better, energized by the random kindness of the woman, who nods and smiles as Mom and I pad off.
This disease can offer such odd, sweet consolation prizes.

Sept. 16
A nurse calls me at home, the first time I’ve heard from my insurance company unsolicited.
“It appears you’ve been having some complications of late,” she says. “Is there anything we can do?”
I’m cautious. I’m getting two dozen bills, letters from hospitals and benefits explanations every month now, and I must be signaling a red flag with the insurance company. My anti-rejection drugs have jumped from $1,200 a year to $2,800. And that doesn’t include hospital stays, ER visits or nausea medications that run $150 a week.
No, thank you, I tell her. We have specialists working on it.

She presses a little more, asking for some details of my recent hospitalizations. She gently asks whether this is a new problem or something “that might have been pre-existing.”
I freeze. I know what that phrase means. It means you’ve become too expensive to keep healthy. No, I say flatly before getting off the phone, it’s a new problem.

Fortunately, I didn’t have to lie. This is new. I could use help. But I’m not sure she’s offering it, and I would have told her my nose wasn’t a pre-existing condition if my insurance were at stake.

Nov. 1
My good friend Jocelyn Smith is visiting when I feel my hands and feet go numb — the surest signal I’m headed into atrial fibrillation.

Without a word, she jumps into action. She eases me into her car, drives me to the hospital and gives the doctors the rundown on my medications and symptoms. She stays the duration of the six-hour wait for a bed.
Somehow, this trip to the hospital is easier than the others.

Maybe it’s seeing Jocelyn oversee the chaos like a M.A.S.H. nurse. I’ve watched as my friends and family turn into a team of first responders: paramedics, doctors, ambulance drivers. All without asking or asking anything in return.
Not that there’s any way to repay what they’ve given me.

Dec. 11
I’m beginning to understand how dogs improve and lengthen the lives of the elderly. Mine are making this place more homey.

When I’m ill in the bath, I notice, they quit roaming the house and cram into the bathroom. My golden retriever, Teddy, curls up by the tub. Esmé, a diminutive Boston terrier who acts as his orbiting moon, nestles into his belly.
I don’t want to be that crazy dog guy, but I’m convinced their company helps. It’s comforting to reach over the tub and bury my hands into that warm, tangled fur pile, something that could have sprung from Where the Wild Things Are.

I’ve read the studies that say domestic animals have learned over the years to befriend humans to maximize food and shelter from us.
But I prefer to think they can’t stand the thought of me being alone or sick.

Dec. 25
This could be a strange Christmas. Because the nausea and A-fib can strike so suddenly, I can’t risk being on a plane for five hours to visit my family in Atlanta. This will be the first Christmas I don’t make it home for some part of the holiday season.

I wake up ready to dread the day, but my body has surprised me. No nausea, no heart-skipping.
I decide to spend the day visiting people dear to me: Anthony Breznican, who cooks for me more than I do; Luz Elena Avitia, who has become a surrogate parent to my dogs when I’m sick; and Michael Ingram, an old friend who offered me one of his kidneys 10 years ago.

The trip isn’t without risk. Luz and Michael are in San Diego, and the complete drive will take at least five hours — as long as a flight.
But I’m tired of my body caging me. I stuff a few meds in my jeans and hit the road.
The day flies. Everyone is in good spirits, my heart is behaving and by the time I’m driving back, I’ve forgotten how long I’d gone without a moment of nausea.

When I get home, I realize that I haven’t opened any presents under the tree. I know it’s corny, but this Christmas — filled only with people I love — has a Seuss-ian feel to it. I go to bed without touching a gift. I’ll do that tomorrow.
Tonight, I’d like to remain that Who in Whoville.

Jan. 9, 2010
Tuesday marks what I consider my 10th birthday: the day I received my organs.

It also marks the day Valerie and Leroy Flegel took their 21-year-old son, Samuel, off life support.
I have trouble reconciling this. How does that much despair create that much hope?

Samuel was, by all accounts, an extraordinary young man. Born with a learning disability similar to dyslexia, he overcame it to earn his GED and become an engineer for Red River Valley and Western Railroad in Wahpeton, N.D.
He was riding home from a New Year’s party in Fargo in 2000 when he hit a parking lot abutment hidden in snow. By the time police found him, he was brain-dead, though the subzero temperatures kept his body alive.
Now I carry him.

For some reason, I rarely get sick around the anniversary date, and this time is no different. I wake up hungry, energized. Healthy. I hop in the car and drive for a doughnut, something I could never have eaten as a diabetic.
On the drive back, I’m a little angry at myself for being so self-pitying, for questioning this fight. There is no beating diabetes, just changing the complications. But at least I have a chance for better health, something Samuel never got.

And perhaps more than any other anniversary, this one reminds me that I do not fight alone. Through all this, friends have become family and family has become closer than it has ever been. Strangers have offered whatever they have. I think of them and it propels me, literally.
I am awake now, opening up the accelerator as I drive home. Music rattles the windows of the car. I don’t want the drive to end.

I speed past the exit for my house. The morning is bleeding into afternoon, and it’s too warm, too nice to stop moving. I’m going to drive until I run out of gas.
For every day I spend sick or in a hospital, it seems, I receive one that is equally fine. That’s where I discovered the unexpected gift of diabetes, one that I would never return: the capacity to recognize and enjoy the moment.
A nausea-free morning. A symptom-free afternoon. A good day.
Like this one.

Prospects rosy for adult stem-cell treatments

In VICTORIES & SUCCESS STORIES on January 4, 2010 at 2:25 pm

Prospects rosy for adult stem-cell treatments

Medical ResearchThe past decade spelled success in research with adult stem cells.

The one area in stem-cell research where there have been no successful treatments is research on human embryos, which involves killing a tiny human being. Dr. David Prentice of the Family Research Council tells OneNewsNow there has been progress in a related field, that of induced pluripotent stem cells that can be developed by taking, for example, skin cells and adding a few genes and reprogramming the cell so it looks and acts like an embryonic stem cell.

But the real success, says Prentice, has been with adult stem cells.

“We’ve got stem cells in all of these tissues from the moment we’re born,” he explains. “They’re in the umbilical cord blood that we cut off the newborn baby — and these are the cells that actually can repair and replace damaged tissue.”

Research on adult stem cells is already helping thousands of people, treating such things as spinal cord injury, heart damage, stroke, and juvenile diabetes. “And the list keeps growing,” Prentice adds.

Almost 80 diseases and medical conditions are now treated with many success stories, so Dr. Prentice believes adult stem-cell research now and in future years will produce even more cures and treatments.

via Prospects rosy for adult stem-cell treatments (OneNewsNow.com).

STEM CELLS HEAL HEARING LOSS

In VICTORIES & SUCCESS STORIES on November 19, 2009 at 11:52 pm

Watch the video here:

Vodpod videos no longer available.

more about “Rescues a College Student fro…“, posted with vodpod
Captioned version of that video of Chloe’s miraculous recovery.
STEM CELLS CURE HEARING LOSS…WHAT?

A music student is encouraged by her parents (both of whom are doctors) to get stem cell treatment for her hearing loss with spectacular results.  Is the increase in her ability to hear the results of the stem cell treatment…or is this another example of the placebo effect gone wild?

So far, the deceived include the girl, her parents, the doctors and the measuring devices!  Beware, you may be next!  One of those people that think her improvement is due to the placebo effect was quoted dismissing the results with the comment:  “You gotta be kidding me! From stem cells?  Stop pulling my leg!  She’s just hearing things!”

Read the story here:

An American college student who was suffering from autoimmune hearing loss and she gained her hearing back in two months after (repair stem cell) treatment.

Chloe Sohl, an 18-year old college student who majors in music at University of Arizona was suffering from autoimmune hearing loss since the age of 15.  Although there is no known cause of her diagnosis, it is a serious disease that slowly damages the organs. Chloe’s father, Dr. Bertram Sohl is a director of Obstetrics and Gynecology at St. Mary’s Medical Center in Long Beach, California and her mother, Dr. Veronique Jotterand is an ophthalmologist and Vice Chief of Staff at Miller Children’s Hospital in Long Beach, California.

Even though Chloe’s parents are medical doctors, they felt helpless and devastated about their daughter’s progressive condition. They tried every possible medication, but Chloe’s condition got worse. The only options they had were for Chloe to use a hearing aid and for her to take medication to slow down her autoimmune system. Dr. Tai June Yoo, a professor from University of Tennessee and a medical advisor of (the treatment facility),  explained as specialist in immune diseases, that if Chloe continues to take strong medication like Methotrexate and Humira, there will be high chances for further serious complications without guarantee of improvement. Her doctors even recommended Chloe to receive Cochlea implant that would enable Chloe to hear some sound, but would irreversibly destroy the middle ear, which scared her parents.

The principle of adult stem cell therapy is actually simple because it utilizes the natural healing ability of our own body…

“Every part of our body already contains stem cells that play a key role in maintaining and repairing our own structural and functional system. Due to aging, the amount of stem cells decrease and that’s why the time and ability to recover from cellular damage slow down and chronic and degenerative symptoms develop as time goes by. The principle of our stem cell treatment is to make enough amount of stem cells and to bring them back to the patient’s own body. Surprisingly, we found that stem cell therapy has great potential to treat autoimmune diseases,” explained Dr. Ra.

Many stem cell researchers have demonstrated that mesenchymal stem cells modulate the immune system and suppress inflammation as a major therapeutic effect. Chloe’s hearing loss falls into this example. This treatment was supposed to soothe any hypersensitive immune response and repair damaged organs so that she might hear again.

Dr. Sohl was very intrigued for his daughter to receive stem cell treatment, but his wife was skeptical about Chloe getting stem cell therapy at first. Chloe’s physicians even discouraged Chloe from receiving stem cell treatment. (What else is new?) However, they were able to decide to try this treatment for Chloe from seeing (the treatment facility’s) successful outcomes. The great safety profile of (the treatment facility’s) stem cell therapy made them comfortable. Chloe felt assured to accept the therapy.

Chloe said, “I felt very good about it. I felt very optimistic. I’ve had IV’s every month since I started to lose my hearing. It was good because I knew this could work unlike the other ones. I just felt very optimistic about the whole procedure.”

Currently, stem cell transplant is not allowed in some countries like the United States, some European countries, and South Korea unless it gets a market approval through clinical trials as new pharmaceutical drugs undergo. Chloe had to travel outside of the United States and to Japan or China where (the treatment facility) established stem cell clinics. More than 2,000 patients with various diseases have been treated with stem cell therapeutics through (the treatment facility) since 2008.

hearing test

Chloe’s hearing was tested two months after the procedure was completed on October 16, 2009. The results were spectacular. The left ear improved to 50% from 0%. The right ear gained almost complete hearing.  Dr. Jotterand could not bear her excitement, “Now it’s just been a 180 degree turnaround. She’s just enjoying life and enjoying being a freshman at the university.

She’s just having a great time and it’s just wonderful to see the joy in her own face and in her life.”

Chloe’s parents invited members of (the treatment facility) to their home in Long Beach to celebrate her miracle. They expressed their gratitude and felt like they received a gift of miracle. Thus, they promised to support (the treatment facility) promoting stem cell business in the United States.

To find out if you are a candidate for stem cell therapy for your hearing disorder, contact me at dsgrano@gmail.com  – The information is free and there is no obligation.

HEARING LOSS + STEM CELLS – A BRIEF HISTORY

In VICTORIES & SUCCESS STORIES on November 16, 2009 at 12:23 am

http://meredith007.files.wordpress.com/2009/02/mouse-human-ear.jpg

HEARING LOSS – A BRIEF HISTORY

Progress in Hair Cell Regeneration – January 2001

As most of our readers probably know, most hearing loss is caused by deterioration of the hair cells in the cochlea. The hair cells move in response to acoustic energy entering the ear, and stimulate the auditory nerve with information regarding the characteristics of the incoming sound. Drugs, heredity, or loud noises can damage or destroy the hair cells, resulting in hearing loss.

We have known for some time that some animals (including many birds) can spontaneously regenerate damaged hair cells, but regeneration has never been observed in mammals – until now. The August 26, 2000 Issue of the British medical Journal Lancet reported successful regeneration of hair cells in a postnatal rat cochlea by introducing a particular gene (Math1) to the cochlea. Researcher Wei-Qiang Gao (Genentech, San Francisco, CA,USA) points out, “It wasn’t just a few hair cells–we had several hundred, so it’s robust production”.

The next step in the investigation is to determine whether similar techniques can regenerate hair cells in mature rats. Success in these experiments would bode well for eventual hair cell regeneration in humans.

Another possibility to replace damaged hair cells is transplantation. Matthew Holley (University of Bristol, UK) and his colleagues have developed an “ear in a test tube”, in which they have successfully grown mouse hair cells. Future advances may allow growth and transplantation of human hair cells.

Hair Cell Regeneration Update from the House Ear Institute – August 2001

The House Ear Institute has been actively involved in the research on hair cell regeneration. They are pursuing two complementary strategies in hopes of understanding the regeneration process and how to induce it in humans. Here’s a link to an article describing their recent work. http://www.hei.org/research/projects/cmb/haircellchall.htm

In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme

  • aGonda Department of Cell and Molecular Biology, House Ear Institute,
  • bCenter for Basic Neuroscience, University of Texas Southwestern Medical Center,
  • cDepartment of Cell and Neurobiology, University of Southern California Medical School,

24 September 2003; The sensory hair cells and supporting cells of the organ of Corti are generated by a precise program of coordinated cell division and differentiation. Since no regeneration occurs in the mature organ of Corti, loss of hair cells leads to deafness. To investigate the molecular basis of hair cell differentiation and their lack of regeneration, we have established a dissociated cell culture system in which sensory hair cells and supporting cells can be generated from mitotic precursors. By incorporating a Math1-GFP transgene expressed exclusively in hair cells, we have used this system to characterize the conditions required for the growth and differentiation of hair cells in culture. These conditions include a requirement for epidermal growth factor, as well as the presence of periotic mesenchymal cells. Lastly, we show that early postnatal cochlear tissue also contains cells that can divide and generate new sensory hair cells in vitro.

Europe Issues Patent on Hearing Loss Treatment – October 2003

Editor: Here’s more breaking news on hair cell regeneration. Sound Pharmaceuticals has been issued a European patent for its hair cell regeneration treatment. Note that this development is only part of the required solution, and it doesn’t mean that a treatment will be widely available next week. But I think it is a big step towards viable hair cell regeneration. Here’s the press release: Sound Pharmaceuticals, Inc. (SPI) announced that its patent “Method for the treatment of diseases or disorders of the inner ear” has issued in Europe, effective Oct. 1, 2003.

SPI has developed a novel strategy to stimulate auditory hair cell regeneration using proprietary cell cycle inhibition technology. Typically, auditory hair cells in mammals are not replaced when injured or lost. This results in permanent and often progressive sensorineural hearing a disease that affects over 30 million in the US. In non-mammals like birds, hair cell regeneration occurs through the spontaneous proliferation of the adjacent supporting cell. These newly proliferating supporting cells can go on to become replacement hair cells. However in mammals, auditory supporting cells do not proliferate or regenerate into hair cells even in the presence of growth factors.

SPI identified that p27Kip1, a cyclin dependent kinase inhibitor, prevents supporting cells from proliferating after embryogenesis. Compounds developed by SPI to inhibit p27Kip1 have been shown to stimulate supporting cell proliferation after drug or noise induced hair cell loss. “We are the only group that has demonstrated the ability to stimulate proliferative regeneration in the cochlea of mammals” says Dr. Jonathan Kil, President & CEO. “It is anticipated that this revolutionary technology will be critical in developing treatments to restore hearing in humans.”

Sound Pharmaceuticals, Inc. is a drug development company focused on treating hearing loss. To date, Sound Pharmaceuticals’ drug discovery program has identified targets for the prevention of hearing loss and for the improvement of hearing in individuals with hearing loss. For more information please visit http://www.soundpharmaceuticals.com

Transplantation of bone marrow stromal cells into the cochlea of chinchillas – 19 January 2004 – Volume 15 – Issue 1 – pp 1-4, Auditory and Vestibular Systems – Survival, migrational mobility and differentiation of autologous marrow cells in damaged cochlea suggest their potential as transplants for treatment of various degenerative inner ear diseases.

Promising Research on Hair Cell Regeneration – October 2004

Editor: For people interested in hearing loss “cures”, hair cell regeneration is the current best bet. It appears that virtually all animals except mammals regenerate hair cells on a routine basis. Dr. Edwin W. Rubel [Virginia Merrill Bloedel Professor of Hearing Science, Virginia Merrill Bloedel Hearing Research Center, Otolaryngology-Head and Neck Surgery, Physiology and Biophysics, Psychology (Adjunct)] and his colleagues are among the researchers on the forefront of this exciting technology. “Hearing Review” recently published an interview of Dr. Rubel along with a synopsis of the research status. Here’s one question and answer from the interview. The complete article is available at: http://www.hearingreview.com/Articles.ASP?articleid=H0410F01

Hearing Review: If hair cell regeneration is indeed possible, do you think this science will ever progress to a point where there will be full restoration of hair cells, or do you think that it’s far more likely we would see a partial restoration of hair cells in the inner ear?

Rubel: In my opinion, it’s not a question of if we will regenerate, restore, or protect hair cells, it’s a question of when. Because we now know that it’s possible, it’s only a matter of time until we can apply this science to humans. My best prediction is 10-20 years. I certainly hope to see it in my lifetime.

With respect to the degree of hair cell regeneration or restoration, my gut feeling is that it will all depend on what type of hearing loss a person has to begin with. One possibility for regeneration are people who have complete loss of hair cells due to some genetic anomaly, ototoxins, aminoglycosides, etc. In these cases, hearing care professionals may someday have a choice between recommending a cochlear implant versus an approach for growing enough hair cells where hearing aids could be used more effectively and provide much more acoustic information to that patient. As another example, you might see a patient who has a 50% loss of their outer hair cells. In this case, maybe we will be able to stimulate the regrowth and replacement of these “cochlear amplifier” cells.

Stem-cell researchers hope for deafness cure within 15 years – November 2004

Editor: “The Scotsman” is reporting on research at Sheffield University that may enable hearing restoration in the foreseeable future. Here are excerpts from the story. For the complete article, please point your browser to http://news.scotsman.com/uk.cfm?id=1346202004 SCIENTISTS hope that stem-cell research could lead to a cure for deafness in as little as ten years. Researchers from Sheffield University are using embryonic stem cells in efforts to grow new cells in the inner ear. Although in its early stages, the team from Sheffield University hopes it could lead to a cure for deafness in ten to 15 years. Dr Rivolta added that his team hoped to undertake the first tests on animals in two years. “It could then be possible to do human trials in three to four years, but that would depend on the animal trials.”

Stem cells could cure deafness in ten years.

Scientists at Britain’s Sheffield University are hoping that stem cell research could lead to a cure for deafness within ten years! Laboratory tests have demonstrated that embryonic stem cells have the capability to regrow in damaged areas; animal testing is planned within two years. Here’s the full story.

Survey and research on acute severe hearing disorders. Study on the expression of cells similar to internal ear stem cell after acute acoustic trauma using a nestin GFP rat. – 2005 Rats that co-expressed nestin and GFP (green fluorescent protein) were used to study whether the presence of cells similar to internal ear stem cell could be identified using nestin, a filament of an intermediate size, as a marker. In the cochlea of 4-week-old nestin-GRP rats, nestin-positive cells were observed only in spiral ganglion cells but not in the sensory epithelial cell layer comprising hair cells and supprt cells of Corti organ. A very small number of nestin-positive cells were observed inside the Corti organ in the cochlea of the rats loaded with band noise at 4 kHz and 125 dB for two hours. Cells similar to internal ear stem cell are deemed likely to differentiate to support cells or hair cells. Regeneration therapy of cochlea hair cells was suggested to be possible.

Stem Cells May Be Key To Deafness Cure – August 2006

In a dusty, cluttered lab at Stanford University, a team of young scientists is on a quest. Curing deafness is the goal, reports CBS News correspondent Elizabeth Kaledin, and Stefan Heller says stem cells hold the key. Heller and his entire team were recruited away from Harvard, and they’ve made a breakthrough discovery: They’ve found that stem cells have the capacity to regenerate in the inner ear.  Full Story

Stem cell based therapy to restore nearly normal hearing Nov 2006hearing in humans. The current review focuses on stem cellbased therapy with particular emphasis to summarize …. restored hearing loss, which demonstrates their potential ….

First blood and bone stem cell research on deafness – December 2006 – Deafness Research UK is funding a new research programme that will be the first to try and develop a cure for deafness using stem cells taken from umbilical cord blood or bone marrow. This three-year project will be based in the Centre for Stem Cell Biology at the University of Sheffield and has been made possible by a £126,000 charitable donation from GlaxoSmithKline (GSK).  It will be the first research to use these promising new lines of stem cells, which are less controversial than stem cells derived from human embryos, in the search for a cure for deafness.   Full Story

COSM 2007: Triological Society – Stem Cell and Genetic Therapies for Hair Cell-Related Hearing Loss

Neil Segil, PhD, from the House Ear Institute, discussed the potential of hair cell regeneration with endogenous progenitor cells—specifically supporting cells.  In mice, Dr. Segil’s team tested the capacity of cochlear supporting cells to divide and transdifferentiate by using green fluorescent markers expressed only in supporting cells in the inner ear. With the resulting purified supporting cells, the scientists discovered that the cells were still capable of self-division. And, although these cells normally wouldn’t actively divide, under the culture conditions in the lab, they did.

“If we keep these cells in culture for six days, some of the cells begin to differentiate as hair cells,” he said, adding that they have not yet identified the stimulus for the division. What they did determine is that self-division is age-dependent, in early cells. It is important, Dr. Segil said, to further test whether self-division can be stimulated in mature cells. In another study, Dr. Segil’s team is targeting one pathway that keeps cells next to each other from differentiating as the same cell type. They believe that supporting cells are being actively inhibited from becoming hair cells by this pathway. Additional projects look at cell differentiation to better understand the process by which the supporting cell differentiated state is maintained.

Tech Could End Deafness – February 2007

“We have a good chance of getting normal hearing back in normal ears,” said Richard Schmiedt, an otolaryngology professor at the Medical University of South Carolina. The stem-cell approach involves restoring the tiny “hair cells” in the ear that convert sound into electrical impulses. When the cells die, people permanently lose their hearing. Bringing back the cells through stem-cell transplants, along with a shock of electricity, could restore hearing, scientists say. At Stanford University, professor Stefan Heller, who discovered stem cells in the inner ear, believes they can be used to cure deafness in mice within five years. Heller and his colleagues are trying to learn from birds, which do not become deaf, the secret genetic recipe for warding off hearing loss.  Full Story

The Miracle of Hair Cells and Prospects for Regrowth – June 2007

Here’s a great article that explains the structure and function of inner and outer hair cells and also looks at some of the research into regrowing these cells. If you’re interested in this topic, it’s very much worth the read! Full Story

Stem Cell Therapy Recovers Lost Hearing – June 2007

Stem cells injected into the inner ear survived in half of the injured rats, where they migrated away from the site of injection toward the injured region within the inner ear. These stem cells divided in the new environment and expressed several proteins necessary for hearing, suggesting tissue-specific differentiation. Further, transplanted cells that migrated to the damaged area of the inner ear displayed shape similar to that of cochlear fibrocytes. Importantly, transplanted rats exhibited faster recovery from hearing loss, particularly in the high frequency range, which is difficult to restore by natural regeneration. Stem cell migration into the damaged area of the inner ear improved hearing of high frequency sound (40 kHz) by 23% compared to natural recovery in untreated animals.  Full Story

Genes In Human Inner Ear Cells Restored – June 2007

Dr. Jeffrey Holt, associate professor of neuroscience and otolaryngology at UVa, and his research team, including Dr. Bradley Kesser, an assistant professor of otolaryngology, targeted a gene known as KCNQ4, which causes genetic hearing loss in humans when mutated. They engineered a correct form of the gene and created a gene therapy delivery system that successfully transferred the KCNQ4 gene into human hair cells harvested from the inner ears of patients with hearing loss. “Our results show that gene therapy reagents are effective in human inner ear tissue. Taken together with the results from another group of scientists who showed that similar gene therapy compounds can produce new hair cells and restore hearing function in guinea pigs suggest that the future of gene therapy in the human inner ear is sound,” Holt said.  Full Story

Researchers Develop New Method of Growing Hair Cells – November 2007 – Researchers at the University of Virginia have developed a new method of growing inner-ear hair cells that will aid research to help people regain their hearing. Dr. Jeffrey T. Corwin, a professor of neuroscience at the UVa Health System, and Dr. Zhengqing Hu, a neuroscience research assistant, have been growing cells from inner ears of chicken embryos. They hope to extend that knowledge to re-grow the inner-ear hair cells of humans. Mammals grow inner-ear hair cells only before they are born, unlike amphibians and birds, which can re-grow damaged or lost cells. These unique structures are lost over time as mammals age, or if they contract certain infections or undergo trauma. The loss of inner-ear hair cells results in hearing loss and balance impairment. Hu and Corwin’s process is able to grow chicken inner-ear hair cells in a laboratory setting.  Full Story

Mesenchymal Stem Cell Transplantation Accelerates Hearing Recovery through the Repair of Injured Cochlear Fibrocytes(American Journal of Pathology. 2007;171:214-226.) DOI: 10.2353/ajpath.2007.060948 – From the Laboratory of Auditory Disorders* and Division of Hearing and Balance Research, National Institute of Sensory Organs, and the Department of Plastic Surgery, National Tokyo Medical Center, Tokyo, Japan – Cochlear fibrocytes play important roles in normal hearing as well as in several types of sensorineural hearing loss attributable to inner ear homeostasis disorders. Recently, we developed a novel rat model of acute sensorineural hearing loss attributable to fibrocyte dysfunction induced by a mitochondrial toxin. In this model, we demonstrate active regeneration of the cochlear fibrocytes after severe focal apoptosis without any changes in the organ of Corti. To rescue the residual hearing loss, we transplanted mesenchymal stem cells into the lateral semicircular canal; a number of these stem cells were then detected in the injured area in the lateral wall. Rats with transplanted mesenchymal stem cells in the lateral wall demonstrated a significantly higher hearing recovery ratio than controls. The mesenchymal stem cells in the lateral wall also showed connexin 26 and connexin 30 immunostaining reminiscent of gap junctions between neighboring cells. These results indicate that reorganization of the cochlear fibrocytes leads to hearing recovery after acute sensorineural hearing loss in this model and suggest that mesenchymal stem cell transplantation into the inner ear may be a promising therapy for patients with sensorineural hearing loss attributable to degeneration of cochlear fibrocytes.

Directed differentiation of mouse cochlear neural progenitors in vitro– 18 June 2008 – Departments of 1Otolaryngology and 2Neurosurgery, 3Graduate Program in Neuroscience, 4Stem Cell Institute, and 5Bioengineering, University of Minnesota, Minneapolis, Minnesota – Multipotent cochlear neural progenitors (CNPs) in the organ of Corti hold the promise for cell replacement in degenerative hearing disorders. However, not much is known about the CNPs and the specific conditions for their differentiation. Here we isolate the CNPs from the postnatal day 1 organ of Corti in mice and demonstrate their capability to self-renew and to differentiate into hair cell-like and neuronal cell-like phenotypes under the guidance of sonic hedgehog (SHH), epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic factor (BDNF), herein termed SERB (abbreviation of SHH, EGF, RA, and BDNF) in an asymmetric or symmetric manner from clonal isolates. Differentiation of CNPs into hair cells by SERB was dependent on the ERK signaling pathway, whereas the differentiation of CNPs into neurons by SERB was not. This work develops a new in vitro methodology for the maintenance and self-regeneration of CNPs for future design of regenerative strategies for hearing disorders.

Novel approaches to treating sensorineural hearing loss. Auditory genetics and necessary factors for stem cell transplant. 2008 Aug;14(8):RA114-25.  Sensorineural hearing loss is a chronic disease, with a serious impact on human communication and quality of life. Exposure to various factors can lead to irreversible hearing impairment, as the auditory epithelium in humans comprises terminally differentiated cells. By contrast, the inner ear of lower vertebrates and invertebrates shows regenerative capacity. Efforts to regenerate the damaged human inner ear may involve renewed cell proliferation, or transplanting cells that can differentiate into sensory cells. Literature review. Animal studies, in vitro studies, retrospective-cohort studies, community-based case-controls, clinical guidelines, and review articles. Embryonic stem cells, inner ear stem cells, and stem cells from other tissues (i.e., neural tissue, hematopoietic system) may be candidates for restoring the auditory epithelium.

Transcriptional regulation of p27kip1 is the primary determinant of terminal mitosis and the final number of postmitotic progenitors of hair and supporting cells. Basic helix-loop-helix transcription factor Math1 was found to be necessary and sufficient for the production of auditory hair cells. Notch signaling seems to play a major role in the regulation of Math1, through lateral inhibition. Brn3c, Gfi1, and Barhl1 are also specific transcription factors that have been implicated in hair cell maintenance and consequent survival. Evidence concerning development, maintenance, and regeneration of hair cells is still at an embryonic stage. Combined data, as attempted in the present study, will lead to a more successful management of deafness.

Sensory Cell Regeneration and Stem Cells: What We Have Already Achieved in the Management of Deafness – Otology & Neurotology: September 2008 – Volume 29 – Issue 6 – pp 758-768, doi: 10.1097/MAO.0b013e31817fdfad – There is an already exciting progress in the fields of sensory cell regeneration and SC research in an attempt to restore hearing or prevent deafness. However, further understanding of the underlying mechanisms of auditory genetics, continuing investigation of the human genome, refinement of the delivering techniques, and specification of the therapeutic strategies have to be developed before functional regeneration of the cochlea can be achieved in clinical practice.

Umbilical Stem Cells May Repair Damaged Cochlear Hair Cells – September 2008

According to an Italian research team publishing their findings in the current issue of Cell Transplantation (17:6), hearing loss due to cochlear damage may be repaired by transplantation of human umbilical cord hematopoietic stem cells (HSC) since they show that a small number migrated to the damaged cochlea and repaired sensory hair cells and neurons. For their study, the team used animal models in which permanent hearing loss had been induced by intense noise, chemical toxicity or both. Cochlear regeneration was only observed in animal groups that received HSC transplants. Researchers used sensitive tracing methods to determine if the transplanted cells were capable of migrating to the cochlea and evaluated whether the cells could contribute to regenerating neurons and sensory tissue in the cochlea.  Full Story

Researchers Make in Vitro Inner Ear Hair Cells – November 2008

Iranian researchers managed to successfully extract bone marrow stem cells from rodents and produce in vitro inner ear hair cells. “In this two-year project, researchers cultured and produced inner ear hair cells, a procedure which is not commonly performed in other countries,” research team-leader, Mohammad Farhadi told the Iranian students news agency. Farhadi reported that injecting the resulted cells into deaf mice has successfully tackled hearing loss in them.  Full Story

New Stem Cell Therapy May Lead To Treatment For Deafness – ScienceDaily (Mar. 23, 2009) — Deafness affects more than 250 million people worldwide. It typically involves the loss of sensory receptors, called hair cells, for their “tufts” of hair-like protrusions, and their associated neurons. The transplantation of stem cells that are capable of producing functional cell types might be a promising treatment for hearing impairment, but no human candidate cell type has been available to develop this technology. A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons…”The results are the first in vitro renewable stem cell system derived from the human auditory organ and have the potential for a variety of applications, such as studying the development of human cochlear neurons and hair cells, as models for drug screening and helping to develop cell-based therapies for deafness,” say the authors.

Stem cells may help deaf people hear – April 2009 – Stem cells may help deaf people hear again, according to early stage research by British scientists. A team at the University of Sheffield said on Thursday they had discovered how to turn stem cells into ones that behave like sensory hair cells or auditory neurons, which could then be surgically inserted into the ear to restore lost hearing. Lead researcher Marcelo Rivolta said the approach, which is being tested on animals, held significant potential but was a long way from being offered to patients.  Full Story

Hair Cell Regeneration – How It Works and What It Means for Audiologists – May 2009 – Twenty years have passed since the discovery of hair cell regeneration in birds (Corwin & Cotanche, 1988; Ryals & Rubel, 1988). The initial excitement caused by this discovery has been followed by steady progress in understanding the fundamental mechanisms that recently culminated in research evidence of hair cell regeneration in both the auditory and vestibular portions of the mammalian inner ear (Kawamoto et al., 2003; Izumikawa et al., 2005; Staecker et al., 2007). Clinical audiologists are faced with the responsibility of translating these basic science findings into potential patient application. They raise important questions: When will hair cell regeneration be a reality for my patients? What will be the measures of candidacy? What will the impact of hair cell regeneration be in my patients who use or are candidates for hearing aids or other amplification devices? Will hearing aids or cochlear implants continue to be needed in the face of hair cell regeneration?  Full Story

Regrowing Hair Cells in the Human Cochlea – June 2009

More than 20 years ago, Douglas Cotanche, PhD, then at the Medical University of South Carolina and now affiliated with Children’s Hospital Boston, discovered that the hair cells within the chick cochlea were capable of a “significant amount of recovery and regeneration” following acoustic trauma.1 His unexpected discovery began a cascade of research on the question of whether hair cells within the human cochlea could someday achieve the same regenerative results. If and when this happens, many of the causes of hearing loss in humans, from noise to aging, can finally be resolved without the need for hearing aids or cochlear implants. Although steady progress has been made in understanding the mechanisms underlying hair cell regeneration, human subjects have yet to participate in clinical trials concerned with regrowing hair cells. Such trials may still be years away. Let’s look at a sampling of the research in 2008, which moves us ever closer to the goal of restoring hearing in this most natural way.  Full Story

Can a Tiny Fish Save Your Ears? – August 2009

For many people, loss of hearing is irreversible. For scientists trying to figure out what can be done about that, one answer may lie-or swim, actually-in freshwater aquariums. About one of every 10 Americans suffers from hearing impairment, according to a survey conducted by the Better Hearing Institute, a nonprofit advocacy group. By far the most common cause of hearing loss is damage to the so-called hair cells in the inner ear as a result of excessive noise, certain illnesses and drugs, and simple aging. The problem is that once hair cells die, humans (like other mammals) aren’t able to grow new ones. In recent years, a research team at the University of Washington in Seattle has been working on finding a way to resolve that problem in experiments involving the zebrafish, a common aquarium denizen. The zebrafish, like many aquatic creatures, has clusters of hair cells running along the outside of its body that help sense vibrations in the water, working in a similar way to hair cells in the human inner ear. But unlike humans, zebrafish are able to regenerate their damaged hair cells. Researchers hope their work can unlock secrets to protect human hair cells from becoming damaged and to stimulate the cells to regenerate.   Full Story

Cord Blood Stem Cells Repair Mouse Inner Ear – August 2009

Results: The authors found that HSC migrated and engrafted into the cochlea of the deaf mice and that the levels of engraftment correlated with both the severity of damage and the treatment dose. Analysis at 60 days post-treatment showed that the mice in the HSC treatment group had well-repaired cochlea with dramatic hair cell regrowth, while control mice showed no sign of repair or hair cell regeneration.

Conclusion: The study shows dramatic repair of cochlear damage in mice after intravenous infusion of cord blood HSC, suggesting a potential therapeutic strategy using cord blood stem cells in hearing rehabilitation therapies.  Full Story

Regeneration of the mammalian inner ear sensory epithelium – Oct 2009 – …focus on ‘self-repair’ of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation

and finally…

Stem Cells Cure Hearing Loss? – November 2009 – Chloe had to travel outside of the United States for stem cell treatment for her hearing disorder.  Chloe’s hearing was tested two months after the procedure was completed on October 16, 2009. The results were spectacular. The left ear improved to 50% from 0%. The right ear gained almost complete hearing.   https://repairstemcell.wordpress.com/2009/11/05/stem-cells-heal-hearing-loss/

(much thanks to hearinglossweb.com for compiling many of these articles!)

To find out if you are a candidate for stem cell therapy for your hearing disorder, contact me at dsgrano@gmail.com  – The information is free and there is no obligation.

DIABETES AWARENESS MONTH 16 PART SPECIAL SERIES

In ALL ARTICLES on November 5, 2009 at 11:24 pm

DIABETES AWARENESS MONTH 16 PART SPECIAL SERIES ON:

“THE DIABETES PANDEMIC – An inconvenient Truth”

by Don Margolis, Founder, Repair Stem Cell Institute

[ CLICK HERE TO READ ]

* Part 1 of 16: THE GROWING PANDEMIC
Errata?

* Part 2 of 16: REFINED WHEAT DEFINED
Refined Wheat

* Part 3 of 16: HOW SWEET IT IS (NOT)
Refined Sugar, The Sweetest Poison of All

* Part 4 of 16: MODERN FOOD = MODERN ALCHEMY
Why McDonald’s Fries Taste So Good

* Part 5 of 16: DO YOU (REALLY) WANT FRIES WITH THAT?
California Wants to Serve a Warning With Fries

* Part 6 of 16: SUGAR CAUSES DENTAL DECAY & DISEASE
Sugar and Science

* Part 7 of 16: MEXICAN OBESITY
Mexico Pushes National Campaign to Lose Weight

* Part 8 of 16: MEXICAN DIABETES
Mexico warns diabetes may bankrupt health system

* Part 9 of 16: THE CIGARETTE CONNECTION
From the list of 599 approved cigarette additives

* Part 10 of 16: ADA REQUESTS MORE FUNDING TO FIGHT DIABETES
American Diabetes Association Urges Congress to Increase CDC Diabetes Prevention Funding By $20.8 Million: One Dollar for Every American With Diabetes

* Part 11 of 16: THE PANDEMIC…TOMORROW
Effect of current factor 1.035 annual increase in WHO diabetes prevalence

* Part 12 of 16: LEARNING FROM DIABETIC MICE
Mouse study points researchers toward early trigger for type-1 diabetes

* Part 13 of 16: THE COST OF THE PANDEMIC
Effect of 1.04 annual increase of USA diabetes prevalence coupled with 6% annual medical inflation rate for care and medical costs per diabetic combined

* Part 14 of 16: SPANISH DIABETES REFORM
Why Spain leads the world in fighting obesity and diabetes

* Part 15 of 16: YOUR PLASTIC IS KILLING YOU
Higher urinary levels of chemical used in plastic food and beverage containers associated with cardiovascular disease, diabetes

* Part 16 of 16: INSULIN AND DIABETES
War On Diabetes

[ CLICK HERE TO READ ]

THINKING ABOUT STEM CELL TREATMENT?

In OFF THE BEATEN PATH on November 1, 2009 at 4:41 pm

THINKING ABOUT STEM CELL TREATMENT?

A friend sent me the following comment and it got me thinking a lot about how someone makes the decision to get treated with stem cells.

Here’s his comment:

I know two [people with multiple sclerosis] personally who did the autogolous stem cell treatment procedure (stem cells are pulled from your on body and then implanted after being multiplied etc.- dg). One felt it helped a lot. The other said it helped minimally if at all.

Here’s my reply:

You always have to weigh your options when considering getting any kind of medical treatment.  Getting educated on the issues and variables is (IMO) the direct responsibility of the patient (although there are patient advocates who will help in this process).  There is no way that doctors (especially from the US) can keep up with the advances occurring around the world today.  Add the embryonic controversy pulling eyes away from the stem cells (adult or repair stem cells) that are making all the advancements and it’s no wonder the patient is on their own to find stem cell treatment information.

But in consideration of  your friend’s results:

The success rate for “significant therapeutic benefits” seem to be around 74% at this time which is pretty amazing IMO. SO one friend was one of the lucky 3/4 and the other was one of the unlucky 1/4.  Luckily there are virtually no negative side effects (soreness at the injection site treated with ibuprofen is typically the most extreme side effect if you can believe it!)

SO the worst that can happen is you get minimal response to the treatment, you take an advil andand you lose your money (which is a considerable issue considering so many people are doing fund raisers, etc on a limited budget in a bad economy).  Perhaps facilities should offer a return treatment at no or minimal cost for those that do not have benefit from the first treatment.  I work with one ‘future planned’ treatment center that is offering exactly that when they open their doors.  We’ll have to wait and see.

moore's law

To make the question more difficult to answer, you must factor this in…the field of stem cell treatments IS in it’s infancy and changes are occurring on par or faster than Moore’s law (computing hardware – the # of transistors/integrated circuit doubles every two years). I personally know of 2 separate innovations that will advance the field significantly in the next 3 months.

Point is, things are changing and improving every day.  The problem is (besides that none of us are getting any younger) neurological disease gets increasingly harder to treat the longer you wait.  SO where’s the magic window?  It’s different for each person.  Combine severity of symptoms, impact of your disease on what your lifestyle was prior to the disease, quality of life reduction/missed opportunities due to the disease and of course, your wallet.

There are no absolute answers…but there are people who are willing to help you sort through the variables and put together a game plan.  Surprisingly, these services are free.

Whatever your decision, do the research.  With over 800 articles, my blog [ https://repairstemcell.wordpress.com ] is a good place to get started.  The info is constantly updated and I am in touch with the top stem cell docs in the world who both feed me new advances and make sure I don’t make any errors in my info.   (btw, I don’t make any money from it, this is just my way of sharing what I know).

I am also happy to help people find what they are looking for.  You can email me at dsgrano@gmail.com I get about one or two dozen emails per day of people asking where to get treated, what is the current status of treatment for their disease, etc.  Feel free to bother me, I enjoy it 😉

ok, this reply got very long…they sometimes get away from me when I am writing and my fingers and brain get into a zone.  lol!  but there’s good info in here.  I hope it is helpful.

TREATMENT INFO NOW!

Regards
david

LeBron Had Cancer Scare Last Season

In CELEBRITIES & STEM CELLS on October 23, 2009 at 2:27 pm

LeBron Had Cancer Scare Last Season

Lebron James thankful to be finished with cancer scare

NBA Star Feared Growth Was Malignant

POSTED: 9:38 am CDT October 20, 2009

In an interview with the Cleveland Plain Dealer, Cavaliers star LeBron James admits that his biggest worry last season wasn’t basketball. It was waiting to hear if he had cancer.

https://i0.wp.com/c2.api.ning.com/files/WKqwCyAi1sDqXZ8SXtn*dPTwovP0NReZC9F0eCGFQTw_/lebron_wallpaper.jpg

Lebron James

James had a biopsy on a growth on his parotid gland, which produces saliva, in January. According to the newspaper, doctors told James that 70 to 80 percent of tumors like his were benign, but still, they needed to be sure.

“It was a nerve-racking experience, but I knew at that point I had to get it done,” James told the Plain Dealer. “I was on edge for those few days; I was lucky the season was going on and we were playing really well so I could concentrate on basketball. My family was nervous.”

The biopsy showed that the mass was benign, but according to the Plain Dealer, James was told that it could become cancerous if it were allowed to grow. The NBA star made arrangements to have the growth removed after the season on June 3, just two days after the Cavaliers were eliminated from the playoffs.

https://i0.wp.com/www.psu.com/media/themes/82954_9917-Background5.jpg

The Kid Can Play

According to the newspaper, the procedure took more than six hours, which was more than twice as long as doctors expected the surgery would take. The Plain Dealer reported that Dr. Frank Papay performed the procedure, which ended up being so time consuming because he needed to work around nerves and muscles that controlled James’ facial movements.

The Cavaliers’ star needed to stay in bed for about a week to recover and he told the Plain Dealer that during that time he didn’t want to talk or eat very much.

“I just relaxed and got some of the best sleep I’ve had in my life,” James told the Plain Dealer.

James now has a thin scar around his right ear.

via LeBron Had Cancer Scare Last Season – Sports News Story – KHBS NW Arkansas.

Swine flu vaccine linked to deadly nerve disease – a response

In ALL ARTICLES on August 17, 2009 at 10:35 pm

In the previous post you saw this:

Swine flu jab link to killer nerve disease: Leaked letter reveals concern of neurologists over 25 deaths in America

Here is a response to this from a third party:

I have been saying for six months that the swine flu “hoax” is a ploy to sell a toxic vaccine that will kill more people than it helps.

Doctors say: “How dare I give medical advice!?”
My response to them is: “How can you call a disease that has killed only 2000 in six months an epidemic when EVERY YEAR flu kills 35,000 Americans?”
I don’t give a crap about those who are so stupid and believe their govt actually wants to help them, but I repeat for the Nth time:
“DO NOT ALLOW THE BASTARDS TO FORCE THIS POISON UPON YOUR KIDS.”
Thank God you don’t live in corrupt NJ which will kill 10-20 of its kids with this crap.   AND, you will see that NJ will NOT have a lower prevalence of swine flu than the rest of the country.
.
Time will prove whether this is correct.  Personally, I hope it isn’t…but…as J. B. S. Haldane, the Scottish biologist, said:

My own suspicion is that the universe is not only queerer than we suppose, but queerer than we can suppose… I suspect that there are more things in heaven and earth than are dreamed of, or can be dreamed of, by any philosophy.

What do you think? -dg
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