“I tried to find out how to get this [reversing MS with stem cells] done and all the companies I called require you to pay $15,000 for stem cells they already have and go to Mexico for the procedure. I wanted to use the baby’s cord tissue stem cells”
Posts Tagged ‘DISEASE’
“[Bob] received an infusion of cells called allogeneic human mesenchymal stem cells (hMSC), adult stem cells collected from the bone marrow of healthy volunteers”
“CF’s main effect is on the lungs. They fill with a sticky mucus as a reaction – really an over-reaction – by the body’s immune system to bacteria. The lungs are the source for much of the illness and shortened lifespan seen in CF.”
CYSTIC FIBROSIS The_fluorescent_microscopy_image_of_CFTR_tagged_with_EYFP
First stem cell study could lead to development of therapy to reduce inflammation caused by CF
Published on January 31, 2017 at 3:24 AM ·
A 39-year-old man with cystic fibrosis (CF) made history by becoming the first person to receive human adult stem cells in a new research study that researchers hope will someday lead to the development of a therapy to reduce the inflammation and infection caused by CF.
The pioneering subject in the study is Bob Held from Alliance, Ohio, who on Jan. 26 received an infusion of cells called allogeneic human mesenchymal stem cells (hMSC), adult stem cells collected from the bone marrow of healthy volunteers. Mr. Held was diagnosed with CF when he was 16 months old.
Currently, there is no cure for CF, and life expectancy for patients who survive into adulthood is approximately 41 years of age.
“It was a very exciting day for us with the very first participant in the first stem cell trial for cystic fibrosis,” said James Chmiel, MD, the principal investigator of the study at University Hospitals Rainbow Babies & Children’s Hospital.
The Phase 1 trial will assess the safety and tolerability of hMSCs in adult patients with CF.
“This is an early phase trial, and the most important thing is to ensure safety,” said Dr. Chmiel. “This study consists of a single infusion of stem cells. We will follow the study participants for a year to make sure it’s safe. Before applying any therapy on a broad basis, we want to make sure that it’s safe.”
While the goal of the study is safety, Dr. Chmiel hopes this is a first step towards the ultimate goal of developing a therapy to reduce lung inflammation and infection, resulting in longer and healthier lives for people with CF.
“While there’s been a tremendous increase in survival for people with CF from when I entered the field in the 1990s, that’s still not good enough,” said Dr. Chmiel, Director of the Cystic Fibrosis Therapeutics Development Center at UH Rainbow Babies & Children’s Hospital and Professor of Pediatrics at Case Western Reserve University School of Medicine. “While we’ve made great progress, we still have a long way to go.”
The stem cells that Mr. Held received were collected from the bone marrow of a healthy adult volunteer. UH is a national leader in the use of stem cell therapy with hMSCs. Researchers from UH, along with the CWRU School of Medicine, discovered hMSCs. The hMSCs possess many properties that are ideal for the treatment of inflammatory and degenerative diseases, and they possess natural abilities to detect changes in their environment, such as inflammation. The hope is that hMSCs can reduce the inflammation in the lungs caused by CF.
CF’s main effect is on the lungs. They fill with a sticky mucus as a reaction – really an over-reaction – by the body’s immune system to bacteria. The lungs are the source for much of the illness and shortened lifespan seen in CF.
“One of the issues in CF is that people with the disease get bacterial infections in their lungs, and these bacteria incite a vigorous and excessive inflammatory response,” explained Dr. Chmiel. “It’s actually the body’s inflammatory response that damages the lungs. The inflammatory response tries to eliminate the bacteria, but it’s not successful. Instead, the inflammatory system releases molecules that damage the individual’s own airways. The lung disease causes much of the illness and is responsible for the majority of the mortality of the disease.”
The stem cells are donated by healthy adult volunteers who go through a rigorous screening process. The stem cells are cultured in the UH stem cell facility. Volunteers with CF who are in the study receive an infusion through an IV.
“Once in the patient’s body, the stem cell tracks to the area where there’s a significant amount of inflammation, and they take up residence there. The stem cells then respond to the environment, and hopefully reverse some of the abnormalities,” said Dr. Chmiel. “We hope in future studies to demonstrate that the stem cells reduce the infection and inflammation and return the lungs to a more normal state.”
“This therapy aims to turn down the inflammatory response, not eliminate it because we still have to keep the bacteria in check. We want to reduce inflammation and the subsequent lung damage caused by inflammation without allowing the bacteria to proliferate,” said Dr. Chmiel.
A total of 15 clinically stable adults with CF will be enrolled in the study. Support for the study is from the Cystic Fibrosis Foundation.
The patient, Mr. Held, considers himself fortunate to be close to 40 with CF. When he was growing up, he said he’d miss 50 days of school each year because of the disease. Every day, he needs to breathe in aerosols for about two hours in the morning and 1-1/2 hours before bed to keep his lungs functioning. While he hasn’t been sick from the illness since his late teens, he does check himself into the hospital a couple of times a year for precautionary measures and to prevent himself from “getting into a valley” with CF.
His late wife, Michelle, died of CF seven years ago. They had met when they were kids, but didn’t get married until 2012. She died from the disease suddenly 28 days after they married.
“My only regret is that I didn’t ask her out sooner,” said Mr. Held.
He is participating in the study to carry on Michelle’s legacy, and “I am hoping the future generations of CF patients can get better treatments and that eventually a cure will be found for them,” he said.
Lung cancer is responsible for almost one-quarter of all cancer deaths in the nation.
Although this type is especially common in people who smoke cigarettes, it is possible for the disease to occur in non-smokers and yes, sometimes even in those who aren’t often breathing secondhand smoke.
A Texas A&M College of Medicine Radiation Oncologist breaks down the science behind lung cancer and the environmental hazards that could result in a diagnosis.
The American Cancer Society (ACS) estimates 224,000 new cases of lung cancer will be diagnosed in 2016.
“This means up to 13 percent of all projected cancers this year could be lung cancer,” said Niloy J. Deb, MD, Assistant Professor of radiology with the Texas A&M College of Medicine and Chairman.
“The leading cause of diagnosis is due to smoking cigarettes, but there are other instances where the cancer can occur.”
Secondhand smoke—like breathing car exhaust into your lungs
Do you live with friends or family who smoke cigarettes? If so, you’re at a much higher risk for developing lung cancer.
“Exposure to secondhand smoke is the number one cause of lung cancer in non-smokers,” Deb said. “Non-smokers who are constantly exposed to secondhand smoke increase their likelihood of getting lung cancer by 20 percent.”
So, how exactly does secondhand smoke up your chances for lung cancer? Deb said even smoke indirectly inhaled from a cigarette is damaging to the lungs.
“Chronic smoking impairs the tiny alveoli (small sacs that move oxygen and carbon dioxide between the lungs and bloodstream) in our lungs, and these alveoli start ‘trapping’ air,” he said.
“Cigarette smoke, with all the dissolved carcinogens, will then ‘sit’ in the alveoli, which causes the genetic mutations (changes) that cause cancerous transformation.”
Important to know: The most harmful part of cigarette smoke comes from the burning paper. This is because compounds are added to the wrapping to allow the tobacco and paper to burn at the same rate.
“To do this, companies add tar and other petroleum derivatives to the paper around cigarettes,” Deb said. “So, when you inhale smoke from a cigarette, it’s essentially like breathing car exhaust directly into your lungs.”
Carcinogens activate the ‘switch’ for cancer cell mutation
Cancer happens when a cell’s DNA is changed, and there are certain known substances and exposures that can lead to cancer; these are called carcinogens.
According to the ACS, carcinogens don’t always cause cancer in every case, but they may predispose to cancer in other ways.
“Some environmental carcinogens like asbestos, silica, benzene, ethylene oxide, and exposure to nickel compounds and by-products of petroleum distillation from vehicle exhaust and fossil fuels, can lead to lung cancer,” Deb said.
“These substances flip the genetic switches in our body by turning on a cancer activator or turning off a cancer suppressor.”
For example: For a cancer cell to form in our lungs, there must be an on/off switch flipped in the genetic code of the lung cells. “When a carcinogen flicks the ‘on’ switch, it turns on a gene that converts a normal cell into a cancer cell,” Deb said.
“When a carcinogen hits the ‘off’ switch, it’s turning off a gene that has been preventing a cancerous process or cancer cell formation. These switches can be flipped because of exposure to environmental carcinogens.”
Why lung cancer is a killer
Lung cancer is almost always fatal because it is asymptomatic. “Symptoms of lung cancer (chronic cough, shortness of breath, phlegm in lungs) are very similar to common respiratory illnesses,” Deb said.
“Most patients (both smokers and non-smokers) do not know their symptoms may be caused by cancer instead of a relatively benign illness.”
Most people who are diagnosed with lung cancer live with symptoms for years before seeking any medical opinion, and by then, it’s too late.
“This is why most lung cancers are diagnosed at Stage 3 or Stage 4 and the reason approximately 158,000 people die from lung cancer each year,” Deb said.
“The death rate increases when you can’t catch the cancer at an earlier stage, when there are more treatment options available.”
Science has poo-pooed the effect of environmental toxins for years citing that the miniscule concentrations of toxins couldn’t possibly cause harm to the human body. Everything from GMOs to toxins in vaccines were ignored based on this premise. New science reveals though that the environment can not only effect the human body but it can change DNA and contribute to diseases. Now that there’s proof, it’s time to get the crap out of our lives. -David Granovsky HOW ENVIRONMENT CONTRIBUTES TO SEVERAL HUMAN DISEASES National Institute of Environmental Health Sciences (NIEHS) Using a new imaging technique, researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures. These damaged molecules trigger cell death that produces some human diseases, according to the researchers. The work provides a possible explanation for how one type of DNA damage may lead to cancer, diabetes, hypertension, cardiovascular and lung disease, and Alzheimer’s disease… Samuel Wilson, M.D., senior NIEHS researcher on the team, explained that the damage is caused by oxidative stress, or the generation of free oxygen molecules, in response to environmental factors, such as ultraviolet exposure, diet, and chemical compounds in paints, plastics, and other consumer products… “When one of these oxidized nucleotides is placed into the DNA strand, it can’t pair with the opposing nucleotide as usual, which leaves a gap in the DNA,” Wilson said. “Until this paper, no one had actually seen how the polymerase did it or understood the downstream implications.” http://www.niehs.nih.gov/news/newsroom/releases/2014/november25/index.cfm http://www.sciencedaily.com/releases/2014/11/141125101703.htm
REDUCING STEM CELL MIGRATION/ADHD TO FOCUS HEALING
“Stem cells are smart and will only stay in one place to repair damaged cells and tissues until called away for more dire situations requiring attention. Like little ADHD multi-tasking mechanics/repairmen, they run all over the body where the body has decided (through a very complex set of devices) they are most needed. This results in stem cells dedicated to mending bones, suddenly running off to fix the heart, pancreas, etc before finishing the job on the broken bone. While this is a great holistic and triage approach (paying attention and dedicating resources to that which needs it most), it makes it difficult to access how powerful and successful stem cells are at resolving a single issue/condition in the body.
A lot can be said for repairing many areas in the entire body simultaneously, in fact, this is one of stem cells’ greatest strengths…but it doesn’t sit well with the concept of “completing one job before moving on to another.” Scientists have devised a new way to make stem cells stay put and finish the job they were directed to do. No more stem cell ADHD.
In the case of serious and terminal diseases, this is an excellent innovation. If you can fix that which is going to fail first, you can then move on to what’s next. It also makes commercialization of stem cells easier. Nobody picks up their car with the damaged exhaust from the mechanic and he says: ‘I got the exhaust half done but realized your distributor, struts and alternator were shot so I fixed them instead.’ But your body is not a car.
This may be a wonderful innovation or it may be another instance of scientists trying to aggressively control a natural healing system in the body. I think it’s both and the result is we now have one more extraordinary tool for fighting disease…and like any tool, it will be used well and for the right reasons and results and also used poorly for the wrong reasons and results. Ultimately, our understanding of the modus operandi of stem cells has increased, our ability to manipulate stem cells has increased and the everyday miracles of stem cell treatment results are getting better and better understood and more common place all the time.” – David Granovsky
Delivering Capsules of Stem Cells Helps Repair Injured Bones
“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.
Researchers, and a couple of renegade doctors in Colorado, have shown that stem cells do help bones heal. While bones, even the intricately shaped jawbone, have been grown in the lab, researchers have been somewhat stymied in their efforts at the seemingly more banal task of using stem cells and grafts to help heal major fractures, bones removed in surgery and other hard-to-fix injuries inside the body.
That’s where materials science comes in.
University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone…”
15 years ago, modern science was confronted with the premise that HEART type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results (The first clinical trial of a novel therapy was conducted unintentionally by the Renaissance surgeon Ambroise Parè in 1537). Ask your doctor if heart cells can regenerate. There is still ENORMOUS resistance.
10 years ago, modern science was confronted with the premise that BRAIN type cells could regenerate, overturning hundreds of years of empirical knowledge including over 400 years of clinical trial results. Ask your doctor if brain cells can regenerate. There is still ENORMOUS resistance.
3 days ago Duke researchers published a study in the peer reviewed journal Nature about how they “found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons.”
While this is incredible news, science is still moving too slowly for those suffering from chronic and terminal diseases, dementia, TBI and other neurological disorders. Is it time to revamp the system? Is it time to approach healing and science with the premise that the human body has regenerative capabilities and we should tap into those systems to heal disorders instead of treating symptoms far removed from the original disorders? What other premises are in place which are blocking medical advancements?
A story from Zen Buddhism:
Nan-in served tea. He poured his visitor’s cup full, and then kept on pouring. The professor watched the overflow until he no longer could restrain himself. “It is overfull. No more will go in!” “Like this cup,” Nan-in said, “you are full of your own opinions and speculations. How can I show you Zen unless you first empty your cup?”
Regenerative medicine is a new frontier. Already around for decades, most have yet to recognize it as the huge paradigm shift which necessitates our emptier our cups and approaching medicine from a completely new perspective. A new perspective which includes an empty cup.
Is your thinking, holding you back?
Let’s be careful out there guys. While every word in the below article MAY be true, there is no association whatsoever between this list and John Hopkins. The first clue is that there are no references, no footnotes, no backlinks. Then you go to Hopkins and see they have called it a hoax – http://m.hopkinsmedicine.org/kimmel_cancer_center/news_events/featured/cancer_update_email_it_is_a_hoax.html and finally, Snopes shoots it down –
What’s very frustrating to me is that the dissemination of unreferenced data damages the hard work of “non-traditional” healers and healing techniques and makes anything with “alternative”, “holistic”, “natural”, etc seem to be a scam via guilt by association. Is there truth in the above? Maybe, but finding it out just got set back significantly as the baby gets thrown out with the bathwater.
Science is a tool. It’s neither good nor evil. And there are many, many studies showing huge benefits from “alternative”, “holistic”, “natural”, therapies. Science is also slow and there typically needs to be a huge $ sign and a mass producible and patentable pill at the end of the road (7-10 yrs and $250 million) for a study/trial to happen. These are some of the reasons stem cell treatments are taking so long to get into mainstream Western medicine. https://repairstemcell.wordpress.com/why-no-stem-cells-in-the-us Part1/
Techniques described as “alternative”, “holistic” and “natural” are essentially working with a huge handicap on many levels. I am all for ‘changing the system’ as it is fundamentally broken. https://repairstemcell.wordpress.com/why-are-there-still-no-stem-cells-in-the-us Part2/ but this is not the way. Ultimately, sharing this info without references damages those looking for real healing options.
Big Hospital Finally telling the truth about Cancer, Johns Hopkins
LATEST CANCER INFORMATION
from Johns Hopkins
AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY AND ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERNATIVE WAY …
1. Every person has cancer cells in the body. These cancer cells do not show up in the standard tests until they have multiplied to a few billion. When doctors tell cancer patients that there are no more cancer cells in their bodies after treatment, it just means the tests are unable to detect the cancer cells because they have not reached the detectable size.
2. Cancer cells occur between 6 to more than 10 times in a person’s lifetime.
3. When the person’s immune system is strong the cancer cells will be destroyed and prevented from multiplying and forming tumors.
4. When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.
5. To overcome the multiple nutritional deficiencies, changing diet and including supplements will strengthen the immune system.
6. Chemotherapy involves poisoning the rapidly-growing cancer cells and also destroys rapidly-growing healthy cells in the bone marrow, gastro-intestinal tract etc, and can cause organ damage, like liver, kidneys, heart, lungs etc.
7. Radiation while destroying cancer cells also burns, scars and damages healthy cells, tissues and organs.
8. Initial treatment with chemotherapy and radiation will often reduce tumor size. However prolonged use of chemotherapy and radiation do not result in more tumor destruction.
9. When the body has too much toxic burden from chemotherapy and radiation the immune system is either compromised or destroyed, hence the person can succumb to various kinds of infections and complications.
10. Chemotherapy and radiation can cause cancer cells to mutate and become resistant and difficult to destroy. Surgery can also cause cancer cells to spread to other sites.
11. An effective way to battle cancer is to STARVE the cancer cells by not feeding it with foods it needs to multiple.
What cancer cells feed on:
a. Sugar is a cancer-feeder. By cutting off sugar it cuts off one important food supply to the cancer cells. Note:Sugar substitutes like NutraSweet, Equal, Spoonful, etc are made with Aspartame and it is harmful. A better natural substitute would be Manuka honey or molasses but only in very small amounts. Table salt has a chemical added to make it white in colour. Better alternative is Bragg’s aminos or sea salt.
b. Milk causes the body to produce mucus, especially in the gastro-intestinal tract. Cancer feeds on mucus. By cutting off milk and substituting with unsweetened soy milk, cancer cells will starved.
c. Cancer cells thrive in an acid environment. A meat-based diet is acidic and it is best to eat fish, and a little chicken rather than beef or pork. Meat also contains livestock antibiotics, growth hormones and parasites, which are all harmful, especially to people with cancer.
d. A diet made of 80% fresh vegetables and juice, whole grains, seeds, nuts and a little fruits help put the body into an alkaline environment. About 20% can be from cooked food including beans. Fresh vegetable juices provide live enzymes that are easily absorbed and reach down to cellular levels within 15 minutes t o nourish and enhance growth of healthy cells.
To obtain live enzymes for building healthy cells try and drink fresh vegetable juice (most vegetables including bean sprouts) and eat some raw vegetables 2 or 3 times a day. Enzymes are destroyed at temperatures of 104 degrees F (40 degrees C).
e. Avoid coffee, tea, and chocolate, which have high caffeine. Green tea is a better alternative and has cancer-fighting properties. Water–best to drink purified water, or filtered, to avoid known toxins and heavy metals in tap water. Distilled water is acidic, avoid it.
12. Meat protein is difficult to digest and requires a lot of digestive enzymes. Undigested meat remaining in the intestines will become putrified and leads to more toxic buildup.
13. Cancer cell walls have a tough protein covering. By refraining from or eating less meat it frees more enzymes to attack the protein walls of cancer cells and allows the body’s killer cells to destroy the cancer cells.
14. Some supplements build up the immune system (IP6, Flor-ssence, Essiac, anti-oxidants, vitamins, minerals, EFAs etc.) to enable the body’s own killer cells to destroy cancer cells. Other supplements like vitamin E are known to cause apoptosis, or programmed cell death, the body’s normal method of disposing of damaged, unwanted, or unneeded cells.
15. Cancer is a disease of the mind, body, and spirit. A proactive and positive spirit will help the cancer warrior be a survivor.
Anger, unforgiving and bitterness put the body into a stressful and acidic environment. Learn to have a loving and forgiving spirit. Learn to relax and enjoy life.
16. Cancer cells cannot thrive in an oxygenated environment. Exercising daily, and deep breathing help to get more oxygen down to the cellular level. Oxygen therapy is another means employed to destroy cancer cells.
As you are tracking through the woods, are you concerned about lyme disease? LYME DISEASE IS THE #1 WORLD EPIDEMIC. And you can and probably will get it in your own backyard. Time to learn. http://vimeo.com/95647143
TIcks sit at the top of blades of grass for weeks till they find a victim. You, a mouse, a deer, your dog.
The password to view movie is capital LD
November 8, 2012
Vitamin C boosts the reprogramming of adult cells into stem cells 1
Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.
Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.
“The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated,” explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.
Dr. Pei and colleagues measured the production of reactive oxygen species or ROS during reprogramming and discovered a potential link between high ROS and low reprogramming efficiency. They became particularly interested in antioxidants, hypothesizing that they might suppress ROS and cell senescence, which seems to be a major roadblock for the generation of iPSCs.
The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.
“Our results highlight a simple way to improve iPSC generation and provide additional insight into the mechanistic basis of reprogramming,” concludes Dr. Pei. “It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level. It is likely that our work may stimulate further research in this area as well.”