DAVID GRANOVSKY

Posts Tagged ‘CURE’

SHOULD STEM CELLS BE USED ONLY AS A LAST RESORT?

In ALL ARTICLES on January 12, 2015 at 1:49 pm

https://i2.wp.com/upload.wikimedia.org/wikipedia/commons/e/e8/Last_Resort_Logo_Noir.png

Should stem cells be used only as a last resort? 

Two reasons why the answer is NO!

1.  Last week I saw someone with no education on stem cells stating that stem cells should be used only as a last resort.
The presentation of stem cell therapies as a last resort is tragic. Unfortunately, most people do come to me asking for information as a last resort.  They have been advised by their friends, family, medical professionals and media that they should try everything else and not try stem cells.  When all else fails and they finally approach me, “I’ve tried everything,” is a common explanation. Again, tragic. In many cases, the sooner stem cells are used, the faster patients can improve their quality of life, relieve their suffering and mediate their symptoms.
The CEO of a well known stem cell company made this analogy: “Most people renovate their homes just before selling them.  What a missed opportunity!  If they renovated them earlier they would derive years of pleasure from the renovation instead of fixing things up for the next owner.”  But what if you used stem cell therapies to improve your health and fix your body BEFORE you exhausted all other resources, money, energy, your immune system and your health?   What a concept.
2.  A new study is investigating the question: Is stem cell therapy less effective in older patients with chronic diseases?
Let’s over-simplify…
When was the last time a piece of equipment in your car failed and another one didn’t fail soon after.  This is because they are dependent upon each other for optimum efficiency.  The older the patient and the more advanced their disease, the odds are, the more there are other organs and systems being taxed beyond their capabilities.  And many people believe one pill will fix their disease but it’s far from true.  We must change the one pill for one one disease, one size fits all, magic cure belief which is rampant in the USA.  There is no evidence to support it.
Look at it another way.  Consider your body a battleground and the disease is the enemy.  The surest way to fight the enemy is to send wave after wave of soldiers (stem cells) into battle.  But many of the same issues in battle restrict maximizing the success of your therapy.  If you cut off the supply routes to the soldiers carrying food and ammunition (a weakened or restricted circulatory system), your soldiers’ ability to move to the battle will be ineffective.  If you wipe out their communications (cytokines/messenger cells), your soldiers won’t know where to go or what is needed to fight.
Time is always against us.  The longer we wait, the more our resources will be depleted and our other organs and systems will be taxed, both to support the failing areas and due to the natural deterioration associated with aging.  “Aging and chronic diseases including CVD and diabetes substantially affect stem/progenitor cells of adult organism. Such conditions could restrict the effectiveness of autologous cell therapy in aged patients with CAD, lower limb ischemia, T2DM and other chronic pathologies, although these patients are some of the most obvious candidates for cell therapy.”

Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells – http://online.liebertpub.com/doi/full/10.1089/biores.2014.0042

It is my hope that people do real research or talk to someone who has so they can make an educated decision about reclaiming their health. There is a great deal of misinformation out there and many people are trying to sabotage the real info and data getting to those whom need it most. Let’s work together to get rid of misinformation and not perpetuate the confusion which may lead to unnecessary suffering.  DON’T WAIT.

LORI MILLS WINS BATTLE WITH BLUE CROSS IN WAR ON CIDP

In ALL ARTICLES, BUSINESS OF STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 9, 2015 at 8:08 pm

“A journey of a thousand miles begins with a single step.”Lao-tzu,

Lori Mills’ story is now mainstream and may affect millions of people in years to come.  You may have seen her in the dictionary under “persistence” or next to the quote: “be the change you want to see in the world.”  Certainly she is a very lucky woman.  Or maybe it’s simpler than that.  Maybe she is simply a mother and a wife who wants to live her life as best as she can without simultaneously carrying the burden of a debilitating illness.

Lori has chronic inflammatory demyelinating polyneuropathy or CIDP and she was denied insurance coverage by Blue Cross Blue Shield in the Summer of 2014.  One week ago, believe it or not, they reversed their decision. This is a huge victory for Lori in the battle with Blue Cross Blue Shield.  This is also the first of many skirmishes in her war on CIDP and a minor victory for those that follow her.  Here’s how it breaks down:

  • Be excited for Lori as she now has a chance at a better life.  She has defeated the one thing standing in her way of getting treated.
  • Don’t expect insurance companies to start caving tomorrow as BCBS has already stated with conviction that this is not to be seen as a precedent.
  • The treatment she is approved for is a clinical trial with exclusionary criteria, not from a treatment center so this is not available to the general public.

I reached out to Lori today and both she and her friends responded with grace and respect:

Hi Lori,
I’m following your story with great interest. I am a 10 year stem cell educator and while Blue Cross is clear in stating that this shouldn’t be considered precedent setting I just wanted to personally thank you for your hard work to get the doors open just a little bit more for those people who are suffering needlessly with conventional drug and treatment protocols which do not work for them. Kudos to you and yours! Wishing you the best,
David

We wish her great success and hope to do a follow up on her progress at the end of her trial.

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I’d like to share something with you.  Look at the image below.  It jumped out at me.
A simple statement.  “I’m a CIDP Fighter.”
We can all understand what it means to fight a single adversary.
With awareness and education we can learn what it means to fight an invisible neurological illness like CIDP.
And that should be enough.  For anyone.  But it isn’t.

Today’s patients seek answers, seek cures, seek stem cell therapies…
but they are not just fighting their conditions…
they often are simultaneously fighting the medical establishment, fighting insurance companies, fighting ignorance and fighting resistance.
It should not be this hard.  We should do more to make it easier for patients to get the treatments they need.  We must do more.

https://i2.wp.com/api.ning.com/files/g3sZFdca7acig06FeFWUZqdRPlquxI2mTDs9uAFPDyLXkzcpRZ7I43vUcRg17SeZXVckqdfYklRANSSUHPFwBNvR9VB6NnHt/603671_10102191952132385_769765818_n1.jpg

Blue Cross overturns decision, approves stem cell transplant coverage

GREENVILLE, Mich. — Lori Mills has been approved to receive a stem cell transplant under her Blue Cross Blue Shield coverage.

The insurance company has overturned its previous denial from the summer of 2014.

In a letter Mills received January 2, 2015, Blue Cross states the company will now pay for the potentially life-changing procedure.

“I know it’s going to be a shot at a whole new life for me,” Mills said today.

She added, “I know that because of our previous interview, it really helped get this approval letter because whenever I call they talk about it.”

FOX 17 also interviewed Mills in October, questioned Blue Cross, and aired her story.

She suffers from chronic inflammatory demyelinating polyneuropathy or CIDP. Her immune system attacks her nervous system. She shakes, has numbness, and it impairs her movement.

Doctors told her a stem cell transplant could be the cure.

via

RELATED ARTICLES:

NONMYELOABLATIVE AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR REFRACTORY CIDP

http://www.neurology.org/content/69/18/1802.short

Haemopoietic stem cell transplantation—an evolving treatment for severe autoimmune and inflammatory diseases in rheumatology, neurology and gastroenterology

http://www.maneyonline.com/doi/abs/10.1080/10245330701255106

Autologous haemopoietic stem cell transplantation for autoimmune diseases
http://informahealthcare.com/doi/abs/10.1517/14712598.2011.580272

LATE STAGE OVARIAN CANCER CURED WITH STEM CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on July 7, 2014 at 1:03 pm

ovarian-cancer-symptoms
Hue Hospital Succeeds in Treating Cancer with Stem Cell

Saigon – Doctors of Hue Central Hospital have used stem cell transplantation to successfully treat a cancer patient of the last stage. The Hue Central Hospital announced on June 26 that its doctors have cured Le Thi Sau, 52, who was suffering ovarian cancer in the last stage, with stem cell transplant. The operation is the success of the scientific project “Using stem cell in breast cancer and cervical cancer” managed by Professor Nguyen Duy Thang, deputy head of the hospital. Adult stem cells have been used to treat certain cancers through bone marrow transplants. In this therapy, the stem cells that give rise to the different blood cells in the body are transplanted into the bone marrow of the patient, where they regenerate the blood. The project was given green light to carry out in the Hue Central Hospital by the Ministry of Science and Technology. Professor Nguyen Duy Thang said the success of this method will pave the way for next operations on breast and ovarian cancer patients. In the time ahead, the hospital continues to treat two other cancer female patients with the stem cell treatment. It is hoped that the treatment will save many cancer patients. (www.saigon-gpdaily.com.vn June 27)

HOPKINS CANCER UPDATE?

In STEM CELLS IN THE NEWS on May 28, 2014 at 11:42 am

​Let’s be careful out there guys.  While every word in the below article MAY be true, there is no association whatsoever between this list and John Hopkins.  The first clue is that there are no references, no footnotes, no backlinks.  Then you go to Hopkins and see they have called it a hoax – http://m.hopkinsmedicine.org/kimmel_cancer_center/news_events/featured/cancer_update_email_it_is_a_hoax.html and finally, Snopes shoots it down –
http://www.snopes.com/medical/disease/cancerupdate.asp

What’s very frustrating to me is that the dissemination of unreferenced data damages the hard work of “non-traditional” healers and healing techniques and makes anything with “alternative”, “holistic”, “natural”, etc seem to be a scam via guilt by association.  Is there truth in the above? Maybe, but finding it out just got set back significantly as the baby gets thrown out with the bathwater.

Science is a tool.  It’s neither good nor evil.  And there are many, many studies showing huge benefits from  “alternative”, “holistic”, “natural”, therapies.  Science is also slow and there typically needs to be a huge $ sign and a mass producible and patentable pill at the end of the road (7-10 yrs and $250 million) for a study/trial to happen.  These are some of the reasons stem cell treatments are taking so long to get into mainstream Western medicine.   https://repairstemcell.wordpress.com/why-no-stem-cells-in-the-us Part1/

Techniques described as “alternative”, “holistic” and “natural” are essentially working with a huge handicap on many levels.  I am all for ‘changing the system’ as it is fundamentally broken. https://repairstemcell.wordpress.com/why-are-there-still-no-stem-cells-in-the-us Part2/  but this is not the way.  Ultimately, sharing this info without references damages those looking for real healing options.

-David

 

Image
Big Hospital Finally telling the truth about Cancer, Johns Hopkins

LATEST CANCER INFORMATION
from Johns Hopkins

AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY AND ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERNATIVE WAY …

1. Every person has cancer cells in the body. These cancer cells do not show up in the standard tests until they have multiplied to a few billion. When doctors tell cancer patients that there are no more cancer cells in their bodies after treatment, it just means the tests are unable to detect the cancer cells because they have not reached the detectable size.

2. Cancer cells occur between 6 to more than 10 times in a person’s lifetime.

3. When the person’s immune system is strong the cancer cells will be destroyed and prevented from multiplying and forming tumors.

4. When a person has cancer it indicates the person has multiple nutritional deficiencies. These could be due to genetic, environmental, food and lifestyle factors.

5. To overcome the multiple nutritional deficiencies, changing diet and including supplements will strengthen the immune system.

6. Chemotherapy involves poisoning the rapidly-growing cancer cells and also destroys rapidly-growing healthy cells in the bone marrow, gastro-intestinal tract etc, and can cause organ damage, like liver, kidneys, heart, lungs etc.

7. Radiation while destroying cancer cells also burns, scars and damages healthy cells, tissues and organs.

8. Initial treatment with chemotherapy and radiation will often reduce tumor size. However prolonged use of chemotherapy and radiation do not result in more tumor destruction.

9. When the body has too much toxic burden from chemotherapy and radiation the immune system is either compromised or destroyed, hence the person can succumb to various kinds of infections and complications.

10. Chemotherapy and radiation can cause cancer cells to mutate and become resistant and difficult to destroy. Surgery can also cause cancer cells to spread to other sites.

11. An effective way to battle cancer is to STARVE the cancer cells by not feeding it with foods it needs to multiple.

What cancer cells feed on:

a. Sugar is a cancer-feeder. By cutting off sugar it cuts off one important food supply to the cancer cells. Note:Sugar substitutes like NutraSweet, Equal, Spoonful, etc are made with Aspartame and it is harmful. A better natural substitute would be Manuka honey or molasses but only in very small amounts. Table salt has a chemical added to make it white in colour. Better alternative is Bragg’s aminos or sea salt.

b. Milk causes the body to produce mucus, especially in the gastro-intestinal tract. Cancer feeds on mucus. By cutting off milk and substituting with unsweetened soy milk, cancer cells will starved.

c. Cancer cells thrive in an acid environment. A meat-based diet is acidic and it is best to eat fish, and a little chicken rather than beef or pork. Meat also contains livestock antibiotics, growth hormones and parasites, which are all harmful, especially to people with cancer.

d. A diet made of 80% fresh vegetables and juice, whole grains, seeds, nuts and a little fruits help put the body into an alkaline environment. About 20% can be from cooked food including beans. Fresh vegetable juices provide live enzymes that are easily absorbed and reach down to cellular levels within 15 minutes t o nourish and enhance growth of healthy cells.

To obtain live enzymes for building healthy cells try and drink fresh vegetable juice (most vegetables including bean sprouts) and eat some raw vegetables 2 or 3 times a day. Enzymes are destroyed at temperatures of 104 degrees F (40 degrees C).

e. Avoid coffee, tea, and chocolate, which have high caffeine. Green tea is a better alternative and has cancer-fighting properties. Water–best to drink purified water, or filtered, to avoid known toxins and heavy metals in tap water. Distilled water is acidic, avoid it.

12. Meat protein is difficult to digest and requires a lot of digestive enzymes. Undigested meat remaining in the intestines will become putrified and leads to more toxic buildup.

13. Cancer cell walls have a tough protein covering. By refraining from or eating less meat it frees more enzymes to attack the protein walls of cancer cells and allows the body’s killer cells to destroy the cancer cells.

14. Some supplements build up the immune system (IP6, Flor-ssence, Essiac, anti-oxidants, vitamins, minerals, EFAs etc.) to enable the body’s own killer cells to destroy cancer cells. Other supplements like vitamin E are known to cause apoptosis, or programmed cell death, the body’s normal method of disposing of damaged, unwanted, or unneeded cells.

15. Cancer is a disease of the mind, body, and spirit. A proactive and positive spirit will help the cancer warrior be a survivor.

Anger, unforgiving and bitterness put the body into a stressful and acidic environment. Learn to have a loving and forgiving spirit. Learn to relax and enjoy life.

16. Cancer cells cannot thrive in an oxygenated environment. Exercising daily, and deep breathing help to get more oxygen down to the cellular level. Oxygen therapy is another means employed to destroy cancer cells.

Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report

In STEM CELLS IN THE NEWS on January 24, 2014 at 8:05 am

November 8, 2012

Vitamin C boosts the reprogramming of adult cells into stem cells 1

https://i0.wp.com/www.nutraingredients-usa.com/var/plain_site/storage/images/publications/food-beverage-nutrition/nutraingredients-usa.com/research/vitamin-c-rda-should-be-doubled-says-linus-pauling-institute-researcher/6914603-1-eng-GB/Vitamin-C-RDA-should-be-doubled-says-Linus-Pauling-Institute-researcher_strict_xxl.jpg

Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.

Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.

“The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated,” explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.

Dr. Pei and colleagues measured the production of reactive oxygen species or ROS during reprogramming and discovered a potential link between high ROS and low reprogramming efficiency. They became particularly interested in antioxidants, hypothesizing that they might suppress ROS and cell senescence, which seems to be a major roadblock for the generation of iPSCs.

The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.

“Our results highlight a simple way to improve iPSC generation and provide additional insight into the mechanistic basis of reprogramming,” concludes Dr. Pei. “It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level. It is likely that our work may stimulate further research in this area as well.”

via Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report.

Stem cell scarring aids recovery from spinal cord injury

In VICTORIES & SUCCESS STORIES on November 5, 2013 at 2:45 pm

Scarring created by stem cells at the site of spinal cord injury actually assists in healing, instead of impeding it as previously thought! -dg

Stem Cell Scarring Aids Recovery from Spinal Cord Injury

Oct. 31, 2013 — In a new study, researchers at Karolinska Institutet in Sweden show that the scar tissue formed by stem cells after a spinal cord injury does not impair recovery; in fact, stem cell scarring confines the damage. The findings, which are published in the scientific journal Science, indicate that scar tissue prevents the lesion from expanding and helps injured nerve cells survive…

Stem cell scarring aids recovery from spinal cord injury.

AUTISM SPECTRUM, TREATMENTS AND CURES(?)

In ALL ARTICLES, OFF THE BEATEN PATH on April 30, 2013 at 10:13 am

autism-not-a-disease

What is the Autism Spectrum? What does it mean to Treat? Does treat mean Cure?

Let’s be clear, as clear as we can. Nothing applies to all but we speak of an autistic spectrum, a gross lumping together of many different variations.

“A spectrum (plural spectra or spectrums[1]) is a condition that is not limited to a specific set of values but can vary infinitely within a continuum…the autism spectrum. In these uses, values within a spectrum may not be associated with precisely quantifiable numbers or definitions. Such uses imply a broad range of conditions or behaviors grouped together and studied under a single title for ease of discussion.”

We use spectrum because it’s easier to do so and because we don’t have 100 different, perfectly defined types of Autism in the spectrum. We don’t have: “Jimmy Jones presents with ADS#72” and even if we did, it would probably look more like, “Jimmy Jones presents with ADS72 with non-specific characteristics of ADS34 and a dash of ADS9.” We are limited in that we have a spectrum, an umbrella of sorts with perhaps more dissimilarities than similarities between those on it but it’s the umbrella we have so let’s use it because it allows us to move forward on the discourse.

As for the term treat   and what I “mean” by it, now we are getting into strictly defined   terms.  Treat means:
1. To give medical aid to someone.
2. To give medical aid to counteract a disease or   condition.

Treat does not mean cure. .  Likewise, recovery does not mean remission. Asymptomatic does not mean therapeutic benefit.  A treatment, when applied to different people with the same condition or different people on a spectrum, may result in dissimilar responses or results. Some may recover, some may become asymptomatic, some may derive significant therapeutic benefit, some may derive lesser benefits and some may have no significant response to a treatment and some may have limited quantifiable change yet huge quality of life improvement.  I wish there were guarantees on treatments but there are not.

In addition, there are many different kinds of treatments stemming from different schools of thought on cause, affect, symptom alleviation, etc.  There is HBOC, MSC, Chelation Therapy, Nutritional Intervention, Gut Bacteria Proliferation, etc. and many studies showing their safety and efficacy and many swear by them.  Some of these treatments or therapies or interventions have worked for some on the spectrum and because it’s a spectrum, may not work on others. But we educate ourselves to what’s available and the new studies and advancements.

So, here are a few articles. Some will be relevant to your inquiries, some will not. I hope they are helpful and enlightening.  And this is not the sum total of the information out there, just a broad brush stroke collection.   I’ll keep looking and I’ll try to gather some more over the next few days to create a more comprehensive… spectrum…of data and information:  AUTISM AND STEM CELL TREATMENTS

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I’ll leave you with this one last thought.  I used the image at the top for a reason.  It is something I’ve been wrestling with quite a lot lately.  Is Autism an identity or a disability?  Should we search for a cure or try to understand it.  I wrote an article on the subject early this month – AUTISM: IDENTITY OR DISABILITY  

And a chicken and the egg scenario just occurred to me.  Simply put:

Stem cells are the body’s natural healing system.  If you implant stem cells into the body, it will begin to repair itself.  It is the job of the stem cell to assist your body in functioning as well as it possibly can.  Dead tissue can begin to regenerate, new tissue can begin to develop, genetic anomalies can begin to correct, etc.  The stem cells and the body “know” what needs to be done or even, what needs to be fixed.  We can force them to do ‘x’ but eventually they will go fix ‘y.’

So if stem cells ‘fix’ something, that means (at the very least) that the stem cells and your body believed it needed ‘fixing.’  So in the simplest of terms and the broadest of definitions, if stem cells fix Autism, was it not because it needed to be fixed?  I don’t know.  I’m asking.  Maybe you have a different view.  If you do, I’d love to hear it.

p.s. A “friend” noted that cure is perhaps not the best term to use and I agree.  We do need a new set of words. Both for that reason and because we need to start seeing people as people and not as patients and definitely not as diseases. 

Further, when I eat well it is not to cure, when I go to the gym it is not to cure, when I meditate or do yoga it is not to cure. All of these things are to maximize my life, my health, my soundness of body and mind, my time on this earth, not to cure. Part of the issue is that Western medicine treats illnesses not people…wait until someone is sick and then try to fix what’s wrong with them with zero ‘cures’ since Polio 1954.   A pretty backward way of thinking.  Eastern medicine prevents disease as a by product of the efforts taken to maximize one’s health, vitality and life. We could learn a lot from this attitude.

KIDNEY BREAKTHROUGH: COMPLETE LAB GROWN ORGAN WORKS IN RATS

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on April 19, 2013 at 4:00 pm
A brand new rat kidney being built on the scaffold of an old one <i>(Image: Ott Lab, Center for Regenerative Medicine, Massachusetts General Hospital)</i>

A brand new rat kidney being built on the scaffold of an old one

(Image: Ott Lab, Center for Regenerative Medicine, Massachusetts General Hospital)

Kidney breakthrough: complete lab-grown organ works in rats

 

  • 18:00 14 April 2013 by Andy Coghlan

 

For the first time, complete lab-grown kidneys have been successfully transplanted into rats, filtering and discharging urine as a normal kidney would.

 

The breakthrough paves the way for human-scale versions, which could potentially provide an inexhaustible supply of organs, eliminating the need for recipients to wait for a matching donor kidney Movie Camera.

 

Similar techniques have already been applied successfully in people with simpler tissue, such as windpipes. But the kidney is by far the most complex organ successfully recreated.

 

“If this technology can be scaled to human-size grafts, patients suffering from renal failure, who are currently waiting for donor kidneys, could theoretically receive an organ grown on demand,” says Harald Ott, head of the team that developed the rat kidneys at the Massachusetts General Hospital in Boston.

 

“In an ideal world, such grafts could be produced from patient-derived cells, enabling us to overcome both donor organ shortages and the need for long-term immunosuppression drugs,” says Ott. Currently in the US alone, 18,000 transplants are carried out each year, but 100,000 Americans remain on waiting lists.

 

Strip and coat

 

To make the rat kidneys, Ott and his colleagues took kidneys from healthy “donor” rats and used a chemical solution to wash away the native cells, leaving behind the organ’s scaffold. Because this is made of collagen, a biologically inert material, there is no issue of the recipient’s body rejecting it.

 

Next, the team set about regrowing the “flesh” of the organ by coating the inner surfaces of the scaffold with new cells. In the case of humans, these would likely come from the recipient, so all the flesh would be their own.

 

The kidney was too complex to use the approach applied to the windpipe – in which its scaffold was coated by simply immersing it in a bath of the recipient’s cells.

 

Instead, the team placed the kidney scaffolds in glass chambers containing oxygen and nutrients, and attached tubes to the protruding ends of the renal artery, vein and ureter – through which urine normally exits the kidney. They recoated the insides of the blood vessels by flowing human stem cells through the tubes attached to the artery and vein. Through the ureter, they fed kidney cells from newborn rats, re-coating the labyrinthine tubules and ducts that make up the kidney’s urine filtration system.

 

It took many attempts to establish the precise pressures at which to feed the cells into the organ, as if it was growing in an embryonic rat. Remarkably, given the complexity of the kidney, the cells differentiated into exactly those required in the different compartments of the organ. “We found the correct cell types homed in to specific regions in the organ matrix,” says Ott.

 

The kidneys, which took about a fortnight to fully recoat, worked both in the lab and when transplanted into rats. They filtered out and discharged urine, although they did not sieve it as well as a natural kidney would. Ott is confident that the function can be improved by refining the technique.

 

Humans and pigs

 

The team is now attempting the same procedure using human kidneys, and also pig kidneys, which could be used to make scaffolds if there were a scarcity of human donors. The team has already successfully repopulated pig kidneys with human cells, but Ott says further studies are vital to guarantee that the pig components of the organ do not cause rejection when transplanted into humans.

 

The fact that heart valves and other “inert” tissues from pigs are already successfully used in humans without rejection suggests that this will not be a big problem.

 

Other researchers working in the field hailed the team’s success at recreating such a complex organ. “The researchers have taken a technique that most in the field thought would be impossible for complex organs such as the kidney, and have painstakingly developed a method to make it work,” says Jamie Davies at the University of Edinburgh, UK, who was part of a team that last year made some headway in their attempts to grow kidneys from scratch in the lab. “By showing that recellularisation is feasible even for complicated organs, their work will stimulate similar approaches to the engineering of other body systems.”

 

Journal reference: Nature Medicine, DOI: 10.1038/nm.3154

BLOOD, HEART AND BRAIN STEM CELLS

In STEM CELLS IN THE NEWS on April 11, 2013 at 10:40 am

stem cell science

Science daily is an excellent source for medical article and studies.  I’ve received their feed for quite a while now.  Here, are 3 stem cell articles from today.

  1. Blood stem cells, besides turning into hema type cells can also become white blood cells.
  2. Cardiac stem cells from bone marrow can heal the heart.  This we’ve known since the late 90’s but additional confirmation is always appreciated.
  3. Brain stem cells not only can turn into brain and nerve cells but they also clear out the garbage in the brain and keep the cells in a perpetual stem cell state.

These are 3 good stem cell articles but also of note…

This is the first time Science Daily has had three stem cell articles in their feed.  The world is turning to stem cells.  Are you?

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Surprising ability of blood stem cells to respond to emergencies

http://www.sciencedaily.com/releases/2013/04/130410131227.htm 

Posted: 10 Apr 2013 10:12 AM PDT

Scientists have revealed an unexpected role for hematopoietic stem cells: They do not merely ensure the continuous renewal of our blood cells; in emergencies they are capable of producing white blood cells “on demand” that help the body deal with inflammation or infection. This property could be used to protect against infections in patients undergoing bone marrow transplants, while their immune system reconstitutes itself.

 

Cardiopoietic ‘smart’ stem cells show promise in heart failure patients

 http://www.sciencedaily.com/releases/2013/04/130410103349.htm

Posted: 10 Apr 2013 07:33 AM PDT

Therapy with cardiopoietic (cardiogenically-instructed) or “smart” stem cells can improve heart health for people suffering from heart failure. This is the first application in patients of lineage-guided stem cells for targeted regeneration of a failing organ, paving the way to development of next generation regenerative medicine solutions.

 

Spring cleaning in your brain’s stem cells?

http://www.sciencedaily.com/releases/2013/04/130410094120.htm

Posted: 10 Apr 2013 06:41 AM PDT

Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells when you need them. New research shows the vital role of a type of internal “spring cleaning” that both clears out garbage inside the cells, and keeps them in their perpetual stem-cell state.

STEM CELLS 101 – short

In ALL ARTICLES, SCIENCE & STEM CELLS on April 11, 2013 at 12:50 am

Transplanted adult dermal stem cells / Cellule...

STEM CELLS 101 – short

ADULT STEM CELL = ASC

  • SOURCE/DERIVED FROM•comes from
    blood, umbilical cords, bone marrow, placenta fat tissue, muscle, nasal
    neurological, breast milk, menstruation, dental pulp, lungs (new source!) and many more
  • PURPOSE IN BODY•they are the body’s natural healing cells
  • OBSTACLES+SIDE EFFECTS•~zero problems (virtually zero side effects)
  • TREATMENT HISTORY•used in bone marrow transplants to treat cancer for 40 years
  • TREATMENT HISTORY•can currently treat 130+ diseases safely and effectively (CP, MS, Autism, Diabetes, CHF, PAD, etc)

EMBRYONIC STEM CELL = ESC

  • SOURCE/DERIVED FROM•comes from embryos
  • PURPOSE IN BODY•split for 7 weeks until you have a fetus the size of a thumbnail
  • OBSTACLES+SIDE EFFECTS•they create
    cysts and tumors, rejection requires immunosuppressive drugs for the ill
    patient, they carry the genetic anomalies of the donor, etc
  • TREATMENT HISTORY•can currently treat zero diseases, probably need to cure cancer first to use them

INDUCED PLURIPOTENT STEM CELL = iPSC (“Embryonic Stem Cell Lite”)

  • SOURCE/DERIVED FROM•comes from regular adult cells like skin cells that are then transformed by scientists into stem cells
  • PURPOSE IN BODY•to be a skin cell or other tissue
  • OBSTACLES+SIDE EFFECTS•they create
    cysts and tumors, rejection requires immunosuppressive drugs for the ill
    patient, they carry the genetic anomalies of the donor…
  • TREATMENT HISTORY•no treatments to date, probably need to cure cancer first to use them
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