DAVID GRANOVSKY

Posts Tagged ‘children’

Stem Cells Safe for Young Traumatic Brain Injury

In SCIENCE & STEM CELLS on March 6, 2012 at 4:02 am
Image showing potential uses of stem cell research with traumatic brain injuries checked.
A Phase 1 clinical trial studying the safety of using bone marrow stem cells to treat traumatic brain injuries in children is reported. The procedures look to be safe even after 6 months of being applied. The image is adapted from a public domain image

Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients

Saturday March 3rd 2012

A procedure involving stem cells taken from patients’ own bone marrow to treat traumatic brain injury in children is safe, according to the results of a Phase 1 clinical trial.

The trial included 10 children aged 5-14 with severe traumatic brain injuries. Within 48 hours of their injuries, the children received stem cells processed from their own bone marrow.

Six months following the procedures, the children are showing no signs of further damage caused by the use of the stem cells. Though this study only points out that the procedure is safe so far, all of the children from the study had significant improvements.

Stem cell research studies such as this one are producing more and more evidence that stem cell treatments can be safe and effective.

With very few effective treatments for brain injury patients, these studies provide great promise for the future of medicine.

The University of Texas Health Science Center at Houston press release below offers more details about this and other stem cell studies.

UTHealth study: Stem cells may provide treatment for brain injuries

Preliminary results show safety of bone marrow stem cells in traumatic brain injury

Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month’s issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

“Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe,” said Charles S. Cox, Jr., M.D., the study’s lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children’s Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth’s Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient’s own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a “good outcome,” meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Read more: Bone Marrow Stem Cells Safe for Young Traumatic Brain Injury Patients | Neuroscience News.

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital – MarketWatch

In STEM CELLS IN THE NEWS on January 15, 2012 at 9:25 am

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital – MarketWatch.

First FDA-Approved Study of Stem Cells to Treat Hearing Loss Begins at Children’s Memorial Hermann Hospital

HOUSTON, Jan. 12, 2012 /PRNewswire via COMTEX/ — Children’s Memorial Hermann Hospital and Cord Blood Registry® (CBR) are launching the first FDA-approved, Phase I safety study on the use of cord blood stem cells to treat children with sensorineural hearing loss.

To view the multimedia assets associated with this release, please visit: http://www.multivu.com/mnr/53686-cord-blood-childrens-memorial-hermann-fda-approved-stem-cells-hearing-loss

The study, which will use patients’ stem cells from their own stored umbilical cord blood, is the first of its kind, and has the potential to restore hearing. This follows evidence from published laboratory studies that cord blood helps repair damaged organs in the inner ear.

The year-long study will follow 10 children, ages 6 weeks to 18 months, who have sustained post-birth hearing loss. Children who are deaf as a result of a genetic anomaly or syndrome are not eligible. To ensure consistency in cord blood stem cell processing, storage, and release for infusion, CBR is the only stem cell bank providing clients for the study..

Reuters Health Update

In ALL ARTICLES on April 22, 2011 at 3:38 pm

New studies point to clot risk of Bayer’s Yasmin
April 21, 2011 06:34 PM ET
FRANKFURT (Reuters) – New evidence emerged on Friday that women taking Bayer’s best-selling contraceptive Yasmin may run a higher risk of dangerous blood clots than those using older birth-control pills. | Full Article
No evidence coffee ups risk of high blood pressure
April 22, 2011 07:52 AM ET
NEW YORK (Reuters Health) – Despite earlier concerns, downing lots of coffee doesn’t seem to increase the risk of high blood pressure, according to a new report — but the evidence isn’t conclusive. | Full Article
Many kids with diabetes have other immune diseases
April 21, 2011 05:29 PM ET
NEW YORK (Reuters Health) – A third of children with type 1 diabetes have signs of other immune system disorders when they get diagnosed with diabetes, according to a new study. | Full Article

Breathing Easier with Adult Stem Cells

In VICTORIES & SUCCESS STORIES on December 3, 2009 at 1:14 pm

Several recent reports, using animal models, provide evidence for treating lung disorders with adult stem cells.

Premature babies are often placed on ventilators to deliver oxygen and expand underdeveloped lungs, but the high oxygen and mechanical ventilation can lead to lung inflammation, inhibit proper lung growth, and lead to long-term complications. Work out of Children’s Hospital in Boston found that bone marrow stromal cells, a type of adult stem cell, can reduce inflammation in lung tissue. Using newborn mice as a model, the researchers injected adult bone marrow stem cells intravenously. The cells migrated to the lungs and prevented inflammation. The cells seem to work by secreting protective and stimulatory factors that help the lung cells and blood vessels; the same effects could be obtained by injecting the growth medium in which the adult stem cells had been grown. The results are published in the American Journal of Respiratory and Critical Care Medicine.

Similar results have been published by an international team, led by Canadian scientist Dr. Bernard Thébaud at the Stollery Children’s Hospital, Edmonton, Alberta. Using a rat model, the scientists found that adult stem cells from bone marrow could repair lung damage in newborn rats as well as prevent further damage. According to Dr. Thébaud:

“The really exciting thing that we discovered was that stem cells are like little factories, pumping out healing factors.”

These results are also published in the American Journal of Respiratory and Critical Care Medicine.

More breathable news comes from a team in South Korea led by Dr. Won Soon Park from the Samsung Medical Center. Using newborn laboratory rats with oxygen-deprived lung injury, the researchers found that mesenchymal stem cells, a type of adult stem cell from umbilical cord blood, had a protective effect against low-oxygen-induced lung injury. They noted that their findings could have important therapeutic potential for the currently untreatable hyperoxic neonatal lung disease, or bronchopulmonary dysplasia (BPD), in premature human infants. The easy availability of umbilical cord blood is also an associated benefit. The results are published in the journal Cell Transplantation.

And in a final breath of adult stem cell fresh air, a team at the University of Illinois at Chicago College of Medicine identified adult stem cells in the bone marrow of mice that could prevent and treat acute lung injury. The researchers discovered a way to grow and stimulate the adult stem cells, and when injected into mice with acute lung injury, the cells repaired the lung injury, prevented fluid build-up and improved survival of the mice. Results were published in the journal Stem Cells.

So take a deep breath in appreciation of adult stem cells.

via FRC Blog » Breathing Easier with Adult Stem Cells.

No More Chemo + Radiation For Kids Getting Stem Cells

In VICTORIES & SUCCESS STORIES on September 2, 2009 at 11:31 am

FINALLY!!

This novel approach represents a shift from the paradigm that intensive chemotherapy or radiotherapy is needed for donor stem-cell engraftment.

New Technique Reduces Toxicity Associated With Stem Cell Transplants in Children

NEW YORK — September 1, 2009 — A minimal-intensity conditioning (MIC) regimen using antibodies instead of high dose chemotherapy may reduce the short and long term toxicity associated with stem cell transplants in children, and enable successful transplantation even in the sickest children, according to a study published online first and in an upcoming edition of The Lancet…

This study analysed the results of antibody-based conditioning in 16 children with primary immunodeficiencies (PID) who were too sick to undergo a traditional stem cell transplant. The average age of these patients was 11 months and 11 of 16 had previously been ventilated on a life-support machine. The majority (11) were transplanted from unrelated donors and 5 from matched siblings.

The researchers found that antibody-based MIC was well tolerated despite the fact that most patients were extremely sick at the time of transplant, with only 2 cases of serious toxicity. The sickness and hair loss associated with high dose chemotherapy were not seen, and there was much less damage to the liver, lungs, and gut.

Patients recovered twice as quickly as those given standard treatment and the rates of graft-versus-host disease (GVHD were similar to with conventional transplant. Fifteen of the 16 patients (94%) engrafted, although in 2 cases this was not sufficient for cure.

At an average of 40 months post-transplant, 13 of 16 patients (81%) were alive and cured from their underlying disease. Almost all of these patients now have excellent quality of life and it is predicted that they will have very little in the way of late effects.

This novel approach represents a shift from the paradigm that intensive chemotherapy or radiotherapy is needed for donor stem-cell engraftment.

via News – New Technique Reduces Toxicity Associated With Stem Cell Transplants in Children.

Gathering of Children Helped by Stem Cell Research using Adult Stem Cells

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on March 25, 2009 at 7:10 pm
Gathering of Children Helped by Stem Cell Research using Adult Stem Cells
Posted 25 March, 2009 in Optic Nerve Hypoplasia |

Stem Cell Research Video

Children Treated With Umbilical Cord Blood Stem Cells

Punta Gorda, Florida- This past Sunday, March 22, 2009,  a good time was had by all at a event organized by the Medical Awareness Association. This fun time was a gathering of mostly children with Optic Nerve Hypoplasia and their parents who had been overseas for stem cell treatment in China using Cord Blood Stem Cells.

One of the highlights was a speech given by Macie Morse, the 16 year old girl who was blind because her optic nerve failed to develop.  Recently, Macie returned from China where she received Adult Stem Cells.   Today, Macie has her learner’s permit and is driving!!   Don’t believe me?  Have a look at this stem cell video

Before the stem cell treatment in China, there was no treatment, no cure for Optic Nerve Hypoplasia.   Patients with this condtion were destined to a life of blindness.   Now, the word is getting out-  and more children like Jazmin Palmer with this condition are going to China to get this treatment.

Why isn’t it available here in the United States?   The Medical Awareness Asscociation, started by Carol Petersen, the grandmother of Cameron Petersen who was treated and helped for his Optic Nerve Hypoplasia last year,  is trying to make this happen here.  The stem cells used are cord blood stem cells- there is no controversy surrounding them.  NO reason why this shouldn’t be available now.

Here is their mission statement of the Medical Awareness Association:

We are, each one of us, Americans with conditions our US doctors have told us were untreatable, merely manageable, degenerative, unheard of, regressive, terminal or orphaned. We have witnessed the opportunity presented by adult umbilical cord and cord blood stem cell therapies outside our borders.

Many of us have questioned these terms by which our doctors labelled our conditions. Many of us have received stem cell therapies beyond the acceptance of the US medical tradition. We have accepted the risks inherent in our choice. We have also accepted the possibility of seeing “regression” itself regress.

We call on US researchers to actively pursue stem cell therapies while not belittling our choice to actively pursue therapies for ourselves internationally. We call on US researchers to engage us. We call on medical providers to not limit our treatment in US medical facilities because of our choice to receive stem cell therapies beyond our borders. We call on the press to include our perspective in their portrayal of stem cell technologies.

Stem cell therapies, even while exploratory, are gaining ground quickly. We are ultimately, and immediately, the intended beneficiaries of these therapies. And we are being forced to travel thousands of miles to foreign lands for any hope of benefit. We believe these therapies are ethical, immediately available and present no undue risk-save the journey we are forced to make to receive them. Please join us in our cause to increase exposure of these therapies and rush research into Stateside acceptance of adult stem cell therapy today.

There are quite a few groups sprouting up like the Repair Stem Cell Institute and this Medical Awareness Association,  largely ignoring the debate of adult stem cell research vs. embryonic stem cell research because they realize that adult stem cells can be used now!  They just can’t be used in the United States because the FDA is treating Adult Stem Cells like a new drug.      That is the reason these children in the video had to go to China for a safe and effective treatment with little to no side effects. It isn’t Obama, it wasn’t Bush- it is the FDA!

The original article on the stem cell gathering here

Children’s, UC ready for stem cell boost – Business Courier of Cincinnati:

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 11, 2009 at 4:05 am

Broken record interjects: Adult stem cells, repair stem cells, induced pluripotent stem cells work.  Embryonic stem cells do not. – dg

ipsc-neural-stem-cells1

Children’s, UC ready for stem cell boost

Cincinnati Children’s Hospital Medical Center and the University of Cincinnati are preparing for an expansion of stem cell research programs.

The federal government is implementing budget increases for biomedical research and easing restrictions on funding for embryonic stem cell research. As part of the economic stimulus bill just signed into law by President Barack Obama, the National Institutes of Health is receiving a $10.4 billion increase in funding for biomedical research.

The Cincinnati Children’s Research Foundation has budgeted $10 million to expand stem cell research programs over the next five years, according to a news release. That amount could increase to as much as $30 million, depending on the status of federal and private funding proposals.

“Our research foundation is deeply committed to stem cell research because of its potential to relieve incredible suffering and save the lives of children around the world,” said Dr. Arnold Strauss, director of the foundation and chair of pediatrics at UC, in the release. “We want to be able to use stem cells to treat fatal or life-threatening genetic disorders like we use drugs to treat other diseases.”

via Children’s, UC ready for stem cell boost – Business Courier of Cincinnati:.

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