DAVID GRANOVSKY

Posts Tagged ‘chemo’

ZEROING IN ON LEUKEMIA SMART BOMBS

In PHARMA AND DRUGS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 31, 2017 at 1:30 pm

A little over a week ago, I posted an article that described:
Of the 100 million BULK CANCER CELLS in a 1-cm cancer tumor, there are about 1,000 to 10,000 CANCER STEM CELLS and those cells are up to 15 times more active and may be the only cells responsible for cancer cell reproduction and metastasis.

Scientists have zeroed in even deeper and targeted a new ‘CD99’ molecule expressed on certain stem cells that drive human leukemia malignancies.  They’ve designed antibodies that can directly kill human acute myeloid leukemia (AML) stem cells.

cd99-2164277470_3687e795d0_z

protein-sugar molecule, CD99

Researchers design antibody that recognizes and destroys blood cancer stem cells

Published on January 25, 2017 at 9:44 PM ·

Building on this discovery, the study authors designed an antibody that recognizes and destroys CD99-covered leukemia cells while sparing normal blood stem cells, a finding confirmed by experiments in human cells and in mice with AML cells. Antibodies are immune system proteins that stick to a specific target, like a protein on the surface of invading bacterium. In recent years, researchers have become capable of engineering antibodies so that they target disease-related molecules.

“Our findings not only identify a new molecule expressed on stem cells that drive these human malignancies, but we show that antibodies against this target can directly kill human AML stem cells,” says corresponding study author, Christopher Y. Park, MD, PhD, associate professor in the Department of Pathology at NYU Langone and its Perlmutter Cancer Center.

“While we still have important details to work out, CD99 is likely to be an exploitable therapeutic target for most AML and MDS patients, and we are working urgently to finalize a therapy for human testing,” says Park.

Direct Cell Killing

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) arise from abnormal stem cells that build up in bone marrow until they interfere with normal blood cell production. Patients struggle with anemia, increased risk for infection, and bleeding.

The study results are based on the understanding that cancers, like normal tissues, contain stem cells that give rise to all the other cells. Such “cancer stem cells” are known to be major drivers of many cancer types. In AML, a small group of leukemic stem cells become incapable of maturing into red or white blood cells as intended. Most leukemias respond initially to standard treatment, but relapse is common as standard treatments fail to kill leukemia stem cells, which continue to multiply.

leukemia-741px-symptoms_of_leukemia

The research team became interested in CD99 when they observed that it occurs frequently on AML and MDS cells, and then noted in the literature that CD99 is elevated in a rare bone cancer called Ewing’s Sarcoma. This prompted them to see if CD99 was important in the development of these blood diseases.

When researchers examined stem cell populations from 79 AML and 24 MDS patients, they found that approximately 85 percent of stem cells in both groups expressed high levels of CD99. The levels were so high that diseased stem cells could be cleanly separated from related, normal stem cells in AML patients.

Upon confirming that CD99 was abundant on leukemia stem cells, the research team then made several CD99 antibodies, and chose to focus on the one that most effectively killed those cells. Researchers found that when the study antibody attaches itself to CD99 on the surface of a cancer stem cell, it sends a signal inside the cell that increases the activity of enzymes called SRC-family kinases.

While the team does not yet know why, the binding of their antibody to CD99, and the subsequent activation of these enzymes, causes leukemia stem cells to die. Most cells with genetic mistakes leading to cancer “sense” they are flawed and self-destruct, but CD99, so the theory goes, may be part of a mechanism that prevents this. As the antibody binds to CD99, it appears to undo this block on self-destruction.

“With the appropriate support, we believe we can rapidly determine the best antibodies for use in patients, produce them at the quality needed to verify our results, and apply for permission to begin clinical trials,” says Park.

While the most common acute leukemia affecting adults (22,000 new cases each year) and expected to become more prevalent as the population ages, AML it is still relatively rare, accounting for 1.2 percent of U.S. cancer deaths. About 15,000 mostly elderly patients are diagnosed with MDS each year as well.

 

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WITH CANCER, AIM ONLY FOR FURTHER GROWTH

In PHARMA AND DRUGS, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 22, 2017 at 10:16 am

Did we just figure out which cells actually cause the creation of more cancer cells?

  • A 1-cm cancer tumor has about 100 million BULK CANCER CELLS.
  • A 1-cm cancer tumor has about 1,000 to 10,000 CANCER STEM CELLS.
  • We know that cancer cells may pass through blood vessel walls to metastasize Moses-stem-cell-pathways-and-maybe-metastatic-cancers/
  • We know that long telomeres increase risk of cancer in cells.

Scientists found that cancer stem cells which have the enzyme called Telomeras, were found to be up to 15 times more active and may be the only cells responsible for cancer cell reproduction and metastasis.
“We can now begin to think of cancer stem cells as being at the heart of tumour regrowth and turn our efforts away from ‘bulk cancer cells’, which don’t really drive tumour recurrence and metastasis.”

Now, we know how to aim at the cells responsible for tumor growth we can change how we fight cancer!

Puts a whole new spin on the Niki Lauda quote:

Stem cell ‘marking’ study offers alterative hypothesis of cancer metastasis

Date:January 18, 2017- Source: University of Salford – Summary: Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumour cells, according to observations by scholars at the Biomedical Research Centre at the University of Salford.

Cancerous stem cells are often left behind after chemotherapy with the potential to create new tumours — a process called recurrence and metastasis.

In research published in the journal Oncotarget, the Salford team conclude that stem cell characteristics and behaviour are instrumental in metastasis and believe the key to their reactivation is an enzyme called Telomerase, or hTERT.

Using lung, breast and ovarian cancer cells, the team set out to identify which cells are cancerous by their levels of Telomerase, an enzyme which endows cells with the ability to multiply.

To achieve this, they followed Telomerase activity with a fluorescent protein, GFP, more commonly found in jellyfish, effectively colouring each cells to mark it either ‘active’ or ‘inactive’.

Cells highlighted ‘fluorescent’ (hTERT-high) were found to be up to 15 times more active than others with an vastly increased capacity for migration and cell proliferation.

Michael Lisanti, Professor of Translational Medicine at the University of Salford said: “We reasoned that if we could spot the telomerase activity, we could identify which cells were cancerous.

“What we had not expected was to find the very rapid rate of proliferation of the cancer stem cells.

“Clearly, this contradicts the accepted view that stem cells do not proliferate quickly, and offers an alternative view of the process of metastasis, and moreover, a method of identifying, isolating and potentially killing tumour-forming cells.”

As part of the study, the team found that FDA-approved drugs, such as doxycycline and palbociclib, were effective at halting cancer stem cell propagation. Palbociclib blocks the activity of proteins known as cyclin-dependent kinases (CDK) and inhibits the division of cancer cells, but until now hadn’t been shown to effectively block cancer stem cell reproduction.

“The use of these FDA-approved drugs may provide a mechanism for treating metastatic disease on a larger scale and certainly opens the way for new Phase II clinical trials in multiple cancer types,” adds Professor Lisanti.

Dr Federica Sotgia, Reader of Translational Medicine at the University of Salford said: “We can now begin to think of cancer stem cells as being at the heart of tumour regrowth and turn our efforts away from ‘bulk cancer cells’, which don’t really drive tumour recurrence and metastasis.”


Story Source:

Materials provided by University of Salford. Note: Content may be edited for style and length.


Journal Reference:

  1. Gloria Bonuccelli, Maria Peiris-Pages, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti. Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity. Oncotarget, 2016; DOI: 10.18632/oncotarget.14196

Chicago Woman Cured of Sickle Cell Disease

In VICTORIES & SUCCESS STORIES on June 20, 2012 at 11:14 pm
Chicago Woman Cured of Sickle Cell Disease

Posted: June  18, 2012 by Sherri McGinnis Gonzalez

Chicagoan Ieshea Thomas is the first Midwest patient to receive a successful stem cell transplant to cure her sickle cell disease without chemotherapy in preparation for the transplant. University of Illinois Hospital & Health Sciences System physicians performed the procedure using medication to suppress her immune system and one small dose of total body radiation right before the transplant.The transplant technique is relatively uncommon and is a much more tolerable treatment for patients with aggressive sickle cell disease who often have underlying organ disease and other complications, says Dr. Damiano Rondelli, professor of medicine at UIC, who performed Thomas’s transplant.

The procedure initially allows a patient’s own bone marrow to coexist with that of the donor. Since the patient’s bone marrow is not completely destroyed by chemotherapy or radiation prior to transplant, part of the immune defense survives, lessening the risk of infection. The goal is for the transplanted stem cells to gradually take over the bone marrow’s role to produce red blood cells — normal, healthy ones…

Ethan Zohn undergoes stem-cell transplant

In VICTORIES & SUCCESS STORIES on March 5, 2012 at 4:04 am

Ethan Zohn undergoes stem-cell transplant, thanks ‘Survivor’ girlfriend Jenna Morasca

His fighting spirit, family & friends keep him positive

By Joyce Chen / NEW YORK DAILY NEWS
Thursday, March 1, 2012, 4:39 PM

 	Ethan Zohn had a stem-cell transplant to treat his Hodgkin’s lymphoma.

Rob Loud/Getty Images

Ethan Zohn had a stem-cell transplant to treat his Hodgkin’s lymphoma.

Ethan Zohn is by all measures the definition of a true survivor.

The former “Survivor” winner underwent a stem-cell transplant Wednesday to treat his recurring case of Hodgkin’s lymphoma, and even under the serious circumstances, Zohn still had competition on his mind.

“Ethan asked the doctor what was the record time for getting out of here, so he wants to beat that,” Zohn’s longtime girlfriend Jenna Morasca told People.

“His doctor said there was no prize, and Ethan said, ‘Yes, there is. You’re going to tell the other patients that I made it out in three weeks.’”…

Read more: Ethan Zohn undergoes stem-cell transplant, thanks ‘Survivor’ girlfriend Jenna Morasca – NY Daily News.

Sperm Grown in a Dish – Technology Review

In VICTORIES & SUCCESS STORIES on March 24, 2011 at 9:46 am

Stem cells now capable of making sperm. – dg


Sperm Grown in a Dish

Researchers make sperm that successfully produces offspring in mice—a development that could one day help infertile men.

Savior sperm: Scientists in Japan have grown functional mouse sperm (shown here in green) in a dish by mimicking the chemical environment of the testes. The sperm is capable of producing fertile offspring.  – Credit: Takehiko Ogawa, Yokohama City University

In a significant step toward combating male infertility, researchers at Yokohama City University have grown mouse sperm in a dish and used the sperm to produce pups that were themselves fertile in adulthood.

Researchers started with small fragments of tissue containing sperm stem cells, called spermagonia, collected from the testes of baby mice. They then grew those cells into functional sperm, using various chemicals to simulate the natural environment of the testes. The results of the study, published in this week’s issue of Nature, may eventually benefit infertile men and boys undergoing chemotherapy.

http://inplacenews.files.wordpress.com/2008/04/sperm.jpg

Sperm Grown in a Dish – Technology Review.

Autologous Blood Stem Cell Transplant Improves Survival for Children with Advanced Neuroblastoma : Cancer News

In VICTORIES & SUCCESS STORIES on May 24, 2010 at 8:09 pm

The stem cells that worked in these children are autologus stem cells (autologus means: from the patient’s own body).  They are ADULT or REPAIR stem cells, not embryonic and not induced pluripotent.  Why? Because:

1.  ADULT STEM CELLS HAVE NO ETHICAL OR MORAL ISSUES
2.  ADULT STEM CELLS WORK BETTER THAN EMBRYONIC
3.  ADULT STEM CELLS DO NOT CAUSE TUMORS OR CYSTS
4.  ADULT STEM CELLS HAVE LOWER RISK OF REJECTION…
ETC., ETC.
-dg

Autologous Blood Stem Cell Transplant Improves Survival for Children with Advanced Neuroblastoma

Two sequential doses of high-dose chemotherapy each supported by autologous peripheral blood stem cell transplantation was shown to be very effective in the treatment of advanced neuroblastoma in children, according to a study performed by researchers at the University of Pennsylvania and several other medical centers…

via Autologous Blood Stem Cell Transplant Improves Survival for Children with Advanced Neuroblastoma : Cancer News.

New Alarm Bells About Chemicals and Cancer – NYTimes.com

In ALL ARTICLES on May 12, 2010 at 12:07 am

New Alarm Bells About Chemicals and Cancer

By NICHOLAS D. KRISTOF

Published: May 5, 2010

The President’s Cancer Panel is the Mount Everest of the medical mainstream, so it is astonishing to learn that it is poised to join ranks with the organic food movement and declare: chemicals threaten our bodies.

The cancer panel is releasing a landmark 200-page report on Thursday, warning that our lackadaisical approach to regulation may have far-reaching consequences for our health.

I’ve read an advance copy of the report, and it’s an extraordinary document. It calls on America to rethink the way we confront cancer, including much more rigorous regulation of chemicals.

Traditionally, we reduce cancer risks through regular doctor visits, self-examinations and screenings such as mammograms. The President’s Cancer Panel suggests other eye-opening steps as well, such as giving preference to organic food, checking radon levels in the home and microwaving food in glass containers rather than plastic.

In particular, the report warns about exposures to chemicals during pregnancy, when risk of damage seems to be greatest. Noting that 300 contaminants have been detected in umbilical cord blood of newborn babies, the study warns that: “to a disturbing extent, babies are born ‘pre-polluted.’ ”

It’s striking that this report emerges not from the fringe but from the mission control of mainstream scientific and medical thinking, the President’s Cancer Panel. Established in 1971, this is a group of three distinguished experts who review America’s cancer program and report directly to the president.

One of the seats is now vacant, but the panel members who joined in this report are Dr. LaSalle Leffall Jr., an oncologist and professor of surgery at Howard University, and Dr. Margaret Kripke, an immunologist at the M.D. Anderson Cancer Center in Houston. Both were originally appointed to the panel by former President George W. Bush.

“We wanted to let people know that we’re concerned, and that they should be concerned,” Professor Leffall told me.

The report blames weak laws, lax enforcement and fragmented authority, as well as the existing regulatory presumption that chemicals are safe unless strong evidence emerges to the contrary.

“Only a few hundred of the more than 80,000 chemicals in use in the United States have been tested for safety,” the report says. It adds: “Many known or suspected carcinogens are completely unregulated.”

Industry may howl. The food industry has already been fighting legislation in the Senate backed by Dianne Feinstein of California that would ban bisphenol-A, commonly found in plastics and better known as BPA, from food and beverage containers.

Studies of BPA have raised alarm bells for decades, and the evidence is still complex and open to debate. That’s life: In the real world, regulatory decisions usually must be made with ambiguous and conflicting data. The panel’s point is that we should be prudent in such situations, rather than recklessly approving chemicals of uncertain effect.

The President’s Cancer Panel report will give a boost to Senator Feinstein’s efforts. It may also help the prospects of the Safe Chemicals Act, backed by Senator Frank Lautenberg and several colleagues, to improve the safety of chemicals on the market.

Some 41 percent of Americans will be diagnosed with cancer at some point in their lives, and they include Democrats and Republicans alike. Protecting ourselves and our children from toxins should be an effort that both parties can get behind — if enough members of Congress are willing to put the public interest ahead of corporate interests.

One reason for concern is that some cancers are becoming more common, particularly in children. We don’t know why that is, but the proliferation of chemicals in water, foods, air and household products is widely suspected as a factor. I’m hoping the President’s Cancer Panel report will shine a stronger spotlight on environmental causes of health problems — not only cancer, but perhaps also diabetes, obesity and autism.

This is not to say that chemicals are evil, and in many cases the evidence against a particular substance is balanced by other studies that are exonerating. To help people manage the uncertainty prudently, the report has a section of recommendations for individuals:

¶Particularly when pregnant and when children are small, choose foods, toys and garden products with fewer endocrine disruptors or other toxins. (Information about products is at www.cosmeticsdatabase.com or www.healthystuff.org.)

¶For those whose jobs may expose them to chemicals, remove shoes when entering the house and wash work clothes separately from the rest of the laundry.

¶Filter drinking water.

¶Store water in glass or stainless steel containers, or in plastics that don’t contain BPA or phthalates (chemicals used to soften plastics). Microwave food in ceramic or glass containers.

¶Give preference to food grown without pesticides, chemical fertilizers and growth hormones. Avoid meats that are cooked well-done.

¶Check radon levels in your home. Radon is a natural source of radiation linked to cancer.

via Op-Ed Columnist – New Alarm Bells About Chemicals and Cancer – NYTimes.com.

See also:

STEM CELLS KICK HODGKINS LYMPHOMA’S BUTT!

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on December 9, 2009 at 10:15 pm
Hodgkin's lymphoma cells. This form of cancer begins in a lymph node—often in the neck—then progresses to other nodes. (Photograph by Andrejs Liepins. Reproduced by permission of Photo Researchers, Inc.)

Hodgkin's lymphoma cancer cells begin in a lymph node—often in the neck—then progress to other nodes.

SURGERY VS. HODGKINS LYMPHOMA… HL IS THE VICTOR!

CHEMOTHERAPY VS. HODGKINS LYMPHOMA… HL IS THE VICTOR!

RADIATION VS. HODGKINS LYMPHOMA… HL IS THE VICTOR!

STEM CELLS VS. HODGKINS LYMPHOMA…

…STEM CELLS KICK HODGKINS LYMPHOMA’S BUTT!


In 2003, 13 year-old Kirk Lee was diagnosed with Hodgkins Lymphoma, a disease that affects the body’s lymph nodes.

Kirk Lee first noticed something was wrong when he detected a knot on his neck. His grandmother Carolyn Lee said he was taken to the hospital and consequently diagnosed with Hodgkins Lymphoma. He was immediately transported to Jackson for surgery to remove tissue from his lungs and undergo chemotherapy.

After receiving radiation, chemotherapy and some experimental treatment in Jackson, Lee still had third-stage lymphoma, meaning the disease was in his abdomen and his neck. (1)

When neither of those treatments was successful, he was taken for stem cell transplant therapy.

That stem cell treatment put his illness into remission.

*     * *     *     *

To see if you are a candidate for stem cell treatment for Hodgkin’s Lymphoma, click here [ REQUEST INFO ]

Hodgkin's Disease (After Chemotherapy)

via story

JOHN STEWART HAS STEM CELL TREATMENT…

In CELEBRITIES & STEM CELLS, VICTORIES & SUCCESS STORIES on November 25, 2009 at 3:28 pm

https://i0.wp.com/static.crooksandliars.com/files/uploads/2006/07/TDS-StemCells1.jpg

John Stewart has repair stem cell treatment patient and musician Jack Mennequin on the Daily Show.  Jack Mennequin documented the process of receiving a stem cell transplant from his sister and the repair stem cell treatment for his leukemia.  He made a DVD about the process. He was on the Daily show and they talked about it and he performed his song Swim.

STEM CELLS ARE NOW!!!!

Vodpod videos no longer available. Vodpod videos no longer available.

 

https://i0.wp.com/a323.yahoofs.com/ymg/bestofthefests__4/bestofthefests-200657525-1257905510.jpg

http://new.music.yahoo.com/blogs/live/3453/documenting-jacks-mannequin/

http://www.thedailyshow.com/watch/thu-november-19-2009/jack-s-mannequin—swim

https://i1.wp.com/a323.yahoofs.com/ymg/bestofthefests__4/bestofthefests-739686612-1257905849.jpg

Lisa Ray to undergo stem cell transplant for cancer

In CELEBRITIES & STEM CELLS on November 18, 2009 at 10:02 am

Lisa Ray to undergo stem cell transplant for cancer
Knoxville Times – Wednesday 18th November, 2009   – (IANS)
Indo-Canadian actress Lisa Ray will undergo a stem cell transplant to treat her multiple myeloma, an incurable form of blood cancer.  The 37-year-old star was diagnosed with the cancer of the bone marrow in June and has been undergoing chemotherapy since July.

Toronto-born Lisa made this announcement Tuesday while visiting the Marshall McLuhan Catholic Secondary School where her film ‘Water’, directed by Deepa Mehta, was screened. 

Ray, who was born to a Polish mother and Bengali father, said the process for a stem cell transplant would begin next week in a city hospital.  The procedure would begin by releasing her own stem cells into her blood, then collecting them and later freezing them, she said.  Calling it a ‘reboot’ of her system, she said the process would take up to two weeks to complete.  After this, she would put on a waiting list for a stem cell transplant.

Discovered, at the age of sixteen, by Maureen Wadia, through her Glad Rags magazine, nearly ten years ago, Lisa ray flew to India from Canada,where she had been raised,little did she know what future had in store for her. Her visit to India—to meet her near and dear ones—proved to be a turning point in her life and career. Lisa’s chiseled face and sylph-like figure caught the attention of the modeling world and soon she got the offer for an ad for a well-known fabrics company. Since then there has been no looking back for Lisa as she went on to become one of the most sought after models who could steal the entire show with her shimmering presence.

But soon she got over the appreciation from the fashion fraternity and forayed into the world of films with the music video ‘Afreen’ (for Nusrat Fateh Ali Khan). She is also the beautiful host of the movie show ‘Star Buzz’ (with Kelly Dorjee) on Star Movies. Now Lisa has jumped aboard the Bollywood bandwagon with Vikram Bhatt’ production in which she has acted quite well, considering it is her maiden attempt in films. For future Lisa is not much enthusiastic about pursuing an acting career in Bollywood, although there are chances of her doing more films. Indian origin actress Lisa Ray has been featured in the Canadian edition of Hello magazine as one of the ‘50 Most Beautiful People’ of the country.
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