DAVID GRANOVSKY

Posts Tagged ‘chemical’

PROOF THE ENVIRONMENT CONTRIBUTES TO DISEASE

In ALL ARTICLES, DISEASE INFO, HEALTH AND WELLNESS on November 26, 2014 at 4:33 pm

Science has poo-pooed the effect of environmental toxins for years citing that the miniscule concentrations of toxins couldn’t possibly cause harm to the human body. Everything from GMOs to toxins in vaccines were ignored based on this premise. New science reveals though that the environment can not only effect the human body but it can change DNA and contribute to diseases. Now that there’s proof, it’s time to get the crap out of our lives. -David Granovsky toxin-problem HOW ENVIRONMENT CONTRIBUTES TO SEVERAL HUMAN DISEASES National Institute of Environmental Health Sciences (NIEHS) Using a new imaging technique, researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures. These damaged molecules trigger cell death that produces some human diseases, according to the researchers. The work provides a possible explanation for how one type of DNA damage may lead to cancer, diabetes, hypertension, cardiovascular and lung disease, and Alzheimer’s disease… Samuel Wilson, M.D., senior NIEHS researcher on the team, explained that the damage is caused by oxidative stress, or the generation of free oxygen molecules, in response to environmental factors, such as ultraviolet exposure, diet, and chemical compounds in paints, plastics, and other consumer products… “When one of these oxidized nucleotides is placed into the DNA strand, it can’t pair with the opposing nucleotide as usual, which leaves a gap in the DNA,” Wilson said. “Until this paper, no one had actually seen how the polymerase did it or understood the downstream implications.” http://www.niehs.nih.gov/news/newsroom/releases/2014/november25/index.cfm http://www.sciencedaily.com/releases/2014/11/141125101703.htm

Reuters Health Update

In ALL ARTICLES on April 25, 2011 at 11:13 am
Pediatricians call for stricter laws for chemicals
NEW YORK (Reuters Health) – The U.S. is not doing enough to protect kids from exposure to potentially dangerous chemicals, pediatricians said in a new statement released today. | Full Article
China considers financial incentives to promote organ donation
April 25, 2011 04:59 AM ET
BEIJING (Reuters) – The Chinese government is considering offering financial incentives to people to voluntarily donate organs, state media said on Monday, as the country tries to tackle the problem of demand for transplants outstripping supply. | Full Article
Bullying sends kids to nurse for more than injury
April 25, 2011 01:28 AM ET
NEW YORK (Reuters Health) – Both bullies and their victims take more trips to the nurse’s office than other students – but not just for the obvious reasons. | Full Article
US FDA sees safety issue with Merck hepatitis drug
April 25, 2011 08:57 AM ET
WASHINGTON (Reuters) – U.S. drug reviewers have raised questions about safety issues with an experimental Merck & Co hepatitis drug, including anemia and reports of psychiatric problems, documents released on Monday said. | Full Article
Diabetic completes first-ever polar flight of its kind
April 23, 2011 08:09 PM ET
ANCHORAGE, Alaska (Reuters) – Former British Royal Air Force pilot Douglas Cairns succeeded in flying his light plane to the North Pole and landing it there this week, overcoming strong headwinds, the failure of his satellite-based navigation system and his diabetes to earn a place in aviation record books. | Full Article

CHEMICALLY BURNED EYES REPAIRED WITH STEM CELLS

In VICTORIES & SUCCESS STORIES on June 24, 2010 at 12:47 pm

BRIEF SUMMARY OF METHODS

  1. used autologous limbal stem cells cultivated on fibrin
  2. treated 112 patients with corneal damage
  3. most had burn-dependent limbal stem-cell deficiency

BRIEF SUMMARY OF RESULTS

  1. Permanent restoration of a transparent, renewing corneal epithelium was attained in 76.6% of eyes.
  2. Restored eyes remained stable over time, with up to 10 years of follow-up (mean, 2.91±1.99; median, 1.93).
  3. Cultures in which p63-bright cells constituted more than 3% of the total number of clonogenic cells were associated with successful transplantation in 78% of patients.

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MORE DETAILED INFORMATION:

https://i0.wp.com/content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f3.jpeg

Figure 3. Regeneration of a Functional Corneal Epithelium and Restoration of Visual Acuity.

[Brief: “All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left).  In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium.“]

Panel A shows the left eye of Patient 93 (see Table 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org), who had total limbal stem-cell deficiency due to an acid burn (image at left). His visual acuity was reduced to counting fingers. A graft of autologous limbal cultures was sufficient to regenerate functional corneal epithelium (image at right) and to restore normal vision (visual acuity, 0.7), since the eye had no stromal scarring. Panel B shows the eyes of Patients 22, 26, and 46 (see Table 1 in the Supplementary Appendix), which were damaged by alkali burns and were treated with unsuccessful surgery 13, 30, and 3 years before admission, respectively. All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left). Vision was reduced to counting fingers (in Patient 22) or perceiving hand movements (in Patients 26 and 46). In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium. To improve their visual acuity after grafting, the patients underwent penetrating keratoplasty. In all three eyes, the engrafted limbal stem cells resurfaced the donor stroma. At the last follow-up visits (at 6, 6.5, and 4 years, respectively), all eyes were covered by stable corneal epithelium (images at right). The keratoplasty resulted in complete restoration of visual acuity in Patients 22 and 46 (0.9 and 0.8, respectively). The visual acuity of Patient 26 increased to only 0.3 because of a concomitant amblyopia (the alkali burn had occurred 30 years before admission). In Patient 46, the follow-up image shows that the conjunctival vessels stop at the conjunctival–corneal boundary (arrowheads); they do not invade the restored corneal surface.

https://i2.wp.com/content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f1.jpeg

Figure 1. Kaplan–Meier Estimates of Grafted Limbal Stem-Cell Survival.

[Brief: “the final clinical outcome was deemed a success in 76.6% of the eyes treated“]

Panel A shows the survival estimates for the cultures after one graft was placed, with partial or total success attained in 68.2% of the eyes treated. Panel B shows survival estimates after a second graft was placed in 11 eyes (a total of 12 additional grafts, since 1 eye was regrafted twice), indicating either partial success or failure. After regrafting, 9 of these eyes regenerated normal epithelium. Thus, the final clinical outcome was deemed a success in 76.6% of the eyes treated. All failures occurred within the first year after grafting, whereas successful cultures remained stable for up to 10 years of follow-up.

THIS POST IS AN ADDENDUM TO EARLIER STORY:  Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg – VIA

THE IMAGES AND TEXT ARE VIA: http://content.nejm.org/cgi/content/full/NEJMoa0905955v1#F3

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg

In VICTORIES & SUCCESS STORIES on June 22, 2010 at 3:00 am

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows

Patients blinded in one or both eyes by chemical burns regained their vision after healthy stem cells were extracted from their eyes and reimplanted, according to a report by Italian researchers at a scientific meeting.

Patient's Own Stem Cells Fix Damaged Eyes

The tissue was drawn from the limbus, an area at the junction of the cornea and white part of the eye. It was grown on a fibrous tissue, then layered onto the damaged eyes. The cells grew into healthy corneal tissue, transforming disfigured, opaque eyes into functioning ones with normal appearance and color, said researchers led by Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine.

The stem-cell treatment restored sight to more than three- quarters of the 112 patients treated, Pellegrini said yesterday in a presentation at the International Society for Stem Cell Research meeting. She estimated the work may benefit 1,000 to 2,000 patients in Europe whose eyes have been damaged by chemical burns and many more in developing countries where the use of chemicals is less regulated. Her patients were followed for an average of three years and some for as long as a decade…..

via Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg.

New Alarm Bells About Chemicals and Cancer – NYTimes.com

In ALL ARTICLES on May 12, 2010 at 12:07 am

New Alarm Bells About Chemicals and Cancer

By NICHOLAS D. KRISTOF

Published: May 5, 2010

The President’s Cancer Panel is the Mount Everest of the medical mainstream, so it is astonishing to learn that it is poised to join ranks with the organic food movement and declare: chemicals threaten our bodies.

The cancer panel is releasing a landmark 200-page report on Thursday, warning that our lackadaisical approach to regulation may have far-reaching consequences for our health.

I’ve read an advance copy of the report, and it’s an extraordinary document. It calls on America to rethink the way we confront cancer, including much more rigorous regulation of chemicals.

Traditionally, we reduce cancer risks through regular doctor visits, self-examinations and screenings such as mammograms. The President’s Cancer Panel suggests other eye-opening steps as well, such as giving preference to organic food, checking radon levels in the home and microwaving food in glass containers rather than plastic.

In particular, the report warns about exposures to chemicals during pregnancy, when risk of damage seems to be greatest. Noting that 300 contaminants have been detected in umbilical cord blood of newborn babies, the study warns that: “to a disturbing extent, babies are born ‘pre-polluted.’ ”

It’s striking that this report emerges not from the fringe but from the mission control of mainstream scientific and medical thinking, the President’s Cancer Panel. Established in 1971, this is a group of three distinguished experts who review America’s cancer program and report directly to the president.

One of the seats is now vacant, but the panel members who joined in this report are Dr. LaSalle Leffall Jr., an oncologist and professor of surgery at Howard University, and Dr. Margaret Kripke, an immunologist at the M.D. Anderson Cancer Center in Houston. Both were originally appointed to the panel by former President George W. Bush.

“We wanted to let people know that we’re concerned, and that they should be concerned,” Professor Leffall told me.

The report blames weak laws, lax enforcement and fragmented authority, as well as the existing regulatory presumption that chemicals are safe unless strong evidence emerges to the contrary.

“Only a few hundred of the more than 80,000 chemicals in use in the United States have been tested for safety,” the report says. It adds: “Many known or suspected carcinogens are completely unregulated.”

Industry may howl. The food industry has already been fighting legislation in the Senate backed by Dianne Feinstein of California that would ban bisphenol-A, commonly found in plastics and better known as BPA, from food and beverage containers.

Studies of BPA have raised alarm bells for decades, and the evidence is still complex and open to debate. That’s life: In the real world, regulatory decisions usually must be made with ambiguous and conflicting data. The panel’s point is that we should be prudent in such situations, rather than recklessly approving chemicals of uncertain effect.

The President’s Cancer Panel report will give a boost to Senator Feinstein’s efforts. It may also help the prospects of the Safe Chemicals Act, backed by Senator Frank Lautenberg and several colleagues, to improve the safety of chemicals on the market.

Some 41 percent of Americans will be diagnosed with cancer at some point in their lives, and they include Democrats and Republicans alike. Protecting ourselves and our children from toxins should be an effort that both parties can get behind — if enough members of Congress are willing to put the public interest ahead of corporate interests.

One reason for concern is that some cancers are becoming more common, particularly in children. We don’t know why that is, but the proliferation of chemicals in water, foods, air and household products is widely suspected as a factor. I’m hoping the President’s Cancer Panel report will shine a stronger spotlight on environmental causes of health problems — not only cancer, but perhaps also diabetes, obesity and autism.

This is not to say that chemicals are evil, and in many cases the evidence against a particular substance is balanced by other studies that are exonerating. To help people manage the uncertainty prudently, the report has a section of recommendations for individuals:

¶Particularly when pregnant and when children are small, choose foods, toys and garden products with fewer endocrine disruptors or other toxins. (Information about products is at www.cosmeticsdatabase.com or www.healthystuff.org.)

¶For those whose jobs may expose them to chemicals, remove shoes when entering the house and wash work clothes separately from the rest of the laundry.

¶Filter drinking water.

¶Store water in glass or stainless steel containers, or in plastics that don’t contain BPA or phthalates (chemicals used to soften plastics). Microwave food in ceramic or glass containers.

¶Give preference to food grown without pesticides, chemical fertilizers and growth hormones. Avoid meats that are cooked well-done.

¶Check radon levels in your home. Radon is a natural source of radiation linked to cancer.

via Op-Ed Columnist – New Alarm Bells About Chemicals and Cancer – NYTimes.com.

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