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Posts Tagged ‘burn’

BBC News – Chemical found which ‘makes bone marrow repair skin’

In ALL ARTICLES on April 6, 2011 at 2:06 pm

‘Chemical found which ‘makes bone marrow repair skin’

Healing skin graft
Skin grafts trigger repair by bone marrow cells

The chemical which summons stem cells from bone marrow to the site of a wound has been discovered by scientists in the UK and Japan.

The study, published in Proceedings of the National Academy of Sciences, identified the distress signal – HMGB1.

The authors believe it can be used to put “a megaphone in the system” to improve the treatment of injuries such as burns and leg ulcers.

Another UK expert said the research had potential.

Bone marrow was thought to play a role in repairing damaged skin, but the exact process was unknown.

https://i0.wp.com/www.ncbi.nlm.nih.gov/projects/genome/guide/img/GreenMouseAdult.gif

Scientists at Osaka University and King’s College London gave mice bone marrow cells that glow green – which can be tracked while moving round the body…

BBC News – Chemical found which ‘makes bone marrow repair skin’.

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New approach of screening drugs that encourage stem cells to repair damaged tissue

In STEM CELLS IN THE NEWS on July 19, 2010 at 2:42 pm

New approach of screening drugs that encourage stem cells to repair damaged tissue

12. July 2010 06:13

Professor Fiona Watt will today (12 July) give the Anne McLaren Memorial Lecture at the UK National Stem Cell Network annual science meeting and will detail a new approach to screening for drugs that target stem cells. To begin with, this is being developed for adult skin stem cells, giving hope for new drugs to promote wound healing and aid the use of stem cells to, for example, treat severe burns. This technique can also be applied to a wide range of stem cells, opening up the possibilities for harnessing stem cells in regenerative medicine.

Professor Watt said “We are very interested in developing regenerative medicine as a way to heal our bodies when they can’t heal themselves – when the damage from an injury or disease is too severe, for example. For this type of approach to be successful it is important to have powerful ways of identifying the processes that stimulate stem cells to renew themselves or mature into the cells that are needed for healing. When we know what these processes are, we can use that knowledge to develop new treatments…

via New approach of screening drugs that encourage stem cells to repair damaged tissue.

CHEMICALLY BURNED EYES REPAIRED WITH STEM CELLS

In VICTORIES & SUCCESS STORIES on June 24, 2010 at 12:47 pm

BRIEF SUMMARY OF METHODS

  1. used autologous limbal stem cells cultivated on fibrin
  2. treated 112 patients with corneal damage
  3. most had burn-dependent limbal stem-cell deficiency

BRIEF SUMMARY OF RESULTS

  1. Permanent restoration of a transparent, renewing corneal epithelium was attained in 76.6% of eyes.
  2. Restored eyes remained stable over time, with up to 10 years of follow-up (mean, 2.91±1.99; median, 1.93).
  3. Cultures in which p63-bright cells constituted more than 3% of the total number of clonogenic cells were associated with successful transplantation in 78% of patients.

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MORE DETAILED INFORMATION:

https://i1.wp.com/content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f3.jpeg

Figure 3. Regeneration of a Functional Corneal Epithelium and Restoration of Visual Acuity.

[Brief: “All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left).  In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium.“]

Panel A shows the left eye of Patient 93 (see Table 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org), who had total limbal stem-cell deficiency due to an acid burn (image at left). His visual acuity was reduced to counting fingers. A graft of autologous limbal cultures was sufficient to regenerate functional corneal epithelium (image at right) and to restore normal vision (visual acuity, 0.7), since the eye had no stromal scarring. Panel B shows the eyes of Patients 22, 26, and 46 (see Table 1 in the Supplementary Appendix), which were damaged by alkali burns and were treated with unsuccessful surgery 13, 30, and 3 years before admission, respectively. All three eyes had total limbal stem-cell deficiency, complete corneal opacification, and stromal scarring (images at left). Vision was reduced to counting fingers (in Patient 22) or perceiving hand movements (in Patients 26 and 46). In all three patients, autologous limbal stem-cell cultures successfully regenerated functional corneal epithelium. To improve their visual acuity after grafting, the patients underwent penetrating keratoplasty. In all three eyes, the engrafted limbal stem cells resurfaced the donor stroma. At the last follow-up visits (at 6, 6.5, and 4 years, respectively), all eyes were covered by stable corneal epithelium (images at right). The keratoplasty resulted in complete restoration of visual acuity in Patients 22 and 46 (0.9 and 0.8, respectively). The visual acuity of Patient 26 increased to only 0.3 because of a concomitant amblyopia (the alkali burn had occurred 30 years before admission). In Patient 46, the follow-up image shows that the conjunctival vessels stop at the conjunctival–corneal boundary (arrowheads); they do not invade the restored corneal surface.

https://i1.wp.com/content.nejm.org/content/vol0/issue2010/images/large/NEJMoa0905955f1.jpeg

Figure 1. Kaplan–Meier Estimates of Grafted Limbal Stem-Cell Survival.

[Brief: “the final clinical outcome was deemed a success in 76.6% of the eyes treated“]

Panel A shows the survival estimates for the cultures after one graft was placed, with partial or total success attained in 68.2% of the eyes treated. Panel B shows survival estimates after a second graft was placed in 11 eyes (a total of 12 additional grafts, since 1 eye was regrafted twice), indicating either partial success or failure. After regrafting, 9 of these eyes regenerated normal epithelium. Thus, the final clinical outcome was deemed a success in 76.6% of the eyes treated. All failures occurred within the first year after grafting, whereas successful cultures remained stable for up to 10 years of follow-up.

THIS POST IS AN ADDENDUM TO EARLIER STORY:  Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg – VIA

THE IMAGES AND TEXT ARE VIA: http://content.nejm.org/cgi/content/full/NEJMoa0905955v1#F3

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg

In VICTORIES & SUCCESS STORIES on June 22, 2010 at 3:00 am

Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows

Patients blinded in one or both eyes by chemical burns regained their vision after healthy stem cells were extracted from their eyes and reimplanted, according to a report by Italian researchers at a scientific meeting.

Patient's Own Stem Cells Fix Damaged Eyes

The tissue was drawn from the limbus, an area at the junction of the cornea and white part of the eye. It was grown on a fibrous tissue, then layered onto the damaged eyes. The cells grew into healthy corneal tissue, transforming disfigured, opaque eyes into functioning ones with normal appearance and color, said researchers led by Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine.

The stem-cell treatment restored sight to more than three- quarters of the 112 patients treated, Pellegrini said yesterday in a presentation at the International Society for Stem Cell Research meeting. She estimated the work may benefit 1,000 to 2,000 patients in Europe whose eyes have been damaged by chemical burns and many more in developing countries where the use of chemicals is less regulated. Her patients were followed for an average of three years and some for as long as a decade…..

via Stem Cells From Own Eyes Restore Vision to Blinded Patients, Study Shows – Bloomberg.

Haitian Farmers Commit to Burning Monsanto Hybrid Seeds

In HOPE AND INSPIRATION on May 21, 2010 at 1:47 pm

Haitian Farmers Commit to Burning Monsanto Hybrid Seeds

Tuesday 18 May 2010 – by: Beverly Bell, t r u t h o u t | Report

Jonas Deronzil from Verrettes has been farming since 1974. Like small producers throughout Haiti, his meager income from corn, rice and beans is threatened by new competition from Monsanto. (Photo: Beverly Bell)

“A new earthquake” is what peasant farmer leader Chavannes Jean-Baptiste of the Peasant Movement of Papay (MPP) called the news that Monsanto will be donating 60,000 seed sacks (475 tons) of hybrid corn seeds and vegetable seeds, some of them treated with highly toxic pesticides. The MPP has committed to burning Monsanto’s seeds, and has called for a march to protest the corporation’s presence in Haiti on June 4, for World Environment Day…

via t r u t h o u t | Haitian Farmers Commit to Burning Monsanto Hybrid Seeds.

Stemedica Selected by World Stem Cell Summit…

In BUSINESS OF STEM CELLS on August 27, 2009 at 8:52 am

Stemedica Selected by World Stem Cell Summit to Present Scientific Discoveries

SAN DIEGO, Aug. 27 /PRNewswire/ — Stemedica Cell Technologies , Inc., (“Stemedica”), a world leader in stem cell research and manufacturing (a licensed manufacturer of clinical grade biological products as licensed by the State of California Food and Drug Branch) continues to advance the stem cell industry with the presentation of two of its latest scientific discoveries at the 2009 World Stem Cell Summit.
Neural Stem Cell Potency Evaluation Model (Chickens)

The first discovery…submitted by Chih-Min Lin, PhD is entitled, “Chicken Embryonic Brain: A Model for Testing Neural Stem Cell Potency.” This Neural Stem Cell Evaluation Model determines the potency of neural stem cells and quickly assesses their ability to migrate and engraft inside the developing brain. Stemedica’s technology allows neural precursors to be distinguished at various stages of their maturation, providing timely and cost effective verification of neural stem cell potency in vivo.

Wound Healing Associated Protein Analysis

The second finding…Ludmila Kharazi, MD, PhD…“Up-Regulation of Wound Healing Associated Proteins in Long-Term Culture of Human Keratinocyte Precursor Cells.” Dr. Kharazi’s work demonstrates that long term cultivation of human keratinocytes in serum free, low-Ca++ media (SFM) leads to the increased expression of genes for wound healing-associated proteins such as fibronectin, metalloproteinase (MMP9, MMP10), and tissue-type plasminogen activator (TPA). The purpose of Dr. Kharazi’s work was to determine how the propagation of human skin keratinocyte precursor cells (KPC) in SFM to clinically significant numbers will affect their ability to produce fibronectin and other wound healing associated proteins.

The 2009 World Stem Cell Summit is being held in Baltimore, Maryland from September 21st – 23rd. Presented by the Genetics Policy Institute, the 2009 Summit is hosted by Johns Hopkins University and other leadership organizations from within the stem cell industry, bringing together more than 1,200 researchers, clinicians, business leaders, key policy makers, regulators, advocates, and experts in law & ethics from around the world.

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