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Posts Tagged ‘breast’

PLURIPOTENT CELLS DISCOVERED IN ADULT BREAST TISSUE

In STEM CELLS IN THE NEWS on March 12, 2013 at 9:00 am

epscolony

The top middle panel shows endogenous pluripotent somatic (ePS) cells, which can give rise to many tissue derivatives, including pancreas, bone, intestine, breast and cartilage cells.

“More evidence that any part of the body associated with reproduction has powerful stem cells with significant regenerative abilities!” – DG

New Type of Pluripotent Cell Discovered In Adult Breast Tissue

UC San Francisco researchers have found that certain rare cells extracted from adult breast tissue can be instructed to become different types of cells – a discovery that could have important potential for regenerative medicine.  As with human embryonic stem cells, the newly found cells are pluripotent, or capable of turning into most cell types, the authors said. The scientists discovered that when the cells were put either in mice, or in cell culture, the cells could differentiate to produce multiple cell types, including those that proceed to make heart, intestine, brain, pancreas and even cartilage.  The finding is significant, the authors said, because scientists previously believed that pluripotent cells did not exist in the body after the embryonic stage of human development.

“The ability of cells from an adult body to make so many tissue derivatives was completely unexpected,” said senior author Thea D. Tlsty, PhD, a UCSF professor of pathology. “When we saw that they could make cartilage, bone, gut, brain, pancreas cells – and even beating heart tissue – we were excited and intrigued.”

Though the newly discovered cells share some characteristics of embryonic stem cells, they appear to be unique to themselves, said Tlsty. They are mortal and genetically stable – characteristics that are barriers to subsequent cancer formation, which is a factor that could prove valuable if the cells are to be used for regenerative medicine, she explained. By contrast, human embryonic stem cells as well as engineered induced pluripotent stem cells, also known as iPS cells, are immortal and genetically unstable.

Additionally, the cells can expand to an extensive yet finite number before they stop growing. One cell can grow for almost 60 population doublings, producing in excess of one billion daughter cells, conceptually providing enough cells to help in the recovery of damaged or diseased tissue.  The scientists are currently searching for the rare cells in other organs of the body. They hypothesize that these “universal patch kits” are scattered throughout the body of adult men and women.

The special cells were discovered and isolated in healthy breast tissue from women of various ages and ethnicities who were undergoing breast reductions. All tissues used in the study were devoid of visible disease or contamination.

From Breast Tissue to Beating Heart Cells

Even a single one of these endogenous pluripotent somatic (ePS) cells, when placed in the appropriate conditions, exhibited the same pluripotent power to self-renew and to generate multiple lineages – both in vitro and in vivo – as embryonic stem cells. The cells could develop into any of the three germ layers: endoderm (such as the pancreas and gastrointestinal tract), the mesoderm (bone, heart muscle, blood vessel), or ectoderm (breast tissues and nervous system).

For example, when properly instructed, some ePS cells made human breast tissue that produced milk in transplanted mice, while other cells generated cartilage structures. To the surprise of the researchers, when the cells were differentiated into heart muscle, they even demonstrated the spontaneous beating seen in cardiomyocytes, or “beating heart” cells.

“The cells we describe here exist in the body devoid of commitment,” the authors wrote. “Taken together, these studies provide morphological, molecular and functional evidence of lineage plasticity of these cells. They will make human milk, bone, fat – they will beat like a heart.”

Only a small fraction of certain mammary cells have “this complete and sustained” unique profile capable of morphing themselves, the researchers said.

“Future research will tell us if we lose access to these cells as we age, if they are found in all tissues, and if they can be used to rescue diseased tissues,” said Tlsty.

“The observation that rare cells within an adult human body have the capacity to differentiate into many tissue types under different physiological cues will facilitate a fascinating area of research into the physiology and therapeutic potential of these cells,” said lead author Somdutta Roy, PhD, Department of Pathology and the UCSF Helen Diller Family Comprehensive Cancer Center.

To read entire article – http://www.ucsf.edu

BREAST STEM CELLS

In STEM CELLS IN THE NEWS on April 5, 2012 at 4:46 am

This article which can be found at http://www.scribd.com/doc/79116123/New-Scientist-November-19th-2011 (page 14) references embryonic like stem cells in breast milk as the first ever found in adults. This is incorrect. Embryonic like stem cells or stem cells with totipotency has been found in a number of other adult stem cells previously. I am referring to naturally occurring adult stem cells as opposed to ipsc.

That said, a concept of FDA regulation of breast feeding is not that far from the truth unfortunately. See my article here: https://repairstemcell.wordpress.com/2012/03/21/fdas-new-claim-your-body-is-a-drug-and-we-have-the-authority-to-regulate-it-the-alliance-for-natural-health-usa/

 

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REUTERS UPDATE

In ALL ARTICLES on January 4, 2012 at 12:09 pm
UK wants results of breast implant review this week
LONDON (Reuters) – Britain expects the results of a review of breast implant safety to come this week following a global health scare focused on products from a now defunct French company, Health Secretary Andrew Lansley said on Wednesday. | Full Article
Want your kids to do better in school? Try exercise
January 04, 2012 08:17 AM ET
(Reuters) – Children who get more exercise also tend to do better in school, whether the exercise comes as recess, physical education classes or getting exercise on the way to school, according to an international study. | Full Article
Daycare providers say kids are too inactive
January 04, 2012 09:22 AM ET
NEW YORK (Reuters Health) – Potential playground hazards, a focus on classroom learning and boring play equipment have children spending too little time being physically active at daycare, according to a survey of staff members at child care centers in Ohio. | Full Article

Heart drug linked to higher breast cancer risk | Reuters

In PHARMA AND DRUGS on March 23, 2011 at 1:44 pm

Heart drug linked to higher breast cancer risk

Women taking the heart drug digoxin have an increased risk of breast cancer, according to a study of more than 2 million Danes.

By Genevra Pittman – NEW YORK | Tue Mar 22, 2011 5:27pm EDT

(Reuters Health) –

Digoxin, marketed as Lanoxin and Digitek, is used by people with heart failure or with abnormal heart beats. But it can also act like the female hormone estrogen in the body…

those currently on it were about 40 percent more likely to get breast cancer.

https://i1.wp.com/breast-cancer-treatments.net/wp-content/uploads/2010/01/breast-cancer.jpg

Heart drug linked to higher breast cancer risk | Reuters.

1ST STEM CELL BREAST AUGMENTATION??

In VICTORIES & SUCCESS STORIES on January 20, 2010 at 3:59 pm

This is not the first, not by a long shot…but I’m glad to see the US is starting to catch on that adult/repair stem cells have amazing therapuetic capabilities…even if they are only going to use them for cosmetic surgery and ignore the millions dying each year around the world of what the world and studies and trials have determined can be safely and effectively treated with stem cells….designating hundreds of diseases classified as no-option or incurable or untreatable as “stem cell TREATABLE diseases” …

…the same diseases that are also classified as stem cell UNTREATABLE in the US. 

SIgh….it’s a start, it’s a start, it’s a start…. dg

First Regenerative Cell Breast Augmentation Surgery Performed Through Stem Cell Assurance Physician Network
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Press Release Source: Stem Cell Assurance, Inc. On Wednesday January 20, 2010, 9:30 am EST

BOCA RATON, Fla., Jan. 20 /PRNewswire-FirstCall/ — Stem Cell Assurance, Inc. (Pink Sheets: SCLZ) announced today that an MD., F.A.C.S. has performed the first regenerative cell breast augmentation through its nationwide physician network.  The procedure was performed in the practice’s onsite accredited ambulatory surgical facility.  

The patient treated underwent regenerative cell breast augmentation on Monday with the goal of an approximate one cup size increase in each breast.  Fat was taken from her hips and thighs by tumescent liposuction and processed to extract naturally-occurring regenerative cells.  Commenting after the surgery, the doctor stated, “Today is a defining moment in breast augmentation surgery.  The offering of this pioneering procedure through a collaborative national physician network is an important milestone that marks major improvement on current technology and the way in which it is delivered to the patient.”

Women with breast cancer may benefit from autologous stem cell transplantation

In ALL ARTICLES on January 12, 2010 at 9:37 pm

Women With Breast Cancer May Benefit from Autologous Stem Cell Transplantation

ScienceDaily (Jan. 12, 2010) — Compared to conventional chemotherapy, autologous stem cell transplantation can extend “event-free survival” for breast cancer patients. Clinical trials provide proof of this for breast cancer with and without distant metastases. However, there are indications that this type of stem cell transplantation can more frequently give rise to severe complications affecting almost all organ systems. This is the conclusion of the final report of the Institute for Quality and Efficiency in Health Care (IQWiG) published on 16 December 2009.

See Also:

Health & Medicine

* Breast Cancer

* Lung Cancer

* Prostate Cancer

* Cancer

* Colon Cancer

* Stem Cells

Reference

* Metastasis

* Bone marrow transplant

* Breast cancer

* Skin grafting

In autologous stem cell transplantation (autologous SCT), the patient’s own (autologous) haematopoietic stem cells are removed at a suitable time during treatment and re-implanted after high-dose chemotherapy. Initially, this treatment was hailed with great excitement and widely used in the 1980s, but its benefit for patients with advanced breast cancer has been hotly debated by scientists for some years. The Federal Joint Committee (G-BA) therefore commissioned IQWiG to examine the available literature to find out whether autologous SCT could have advantages for breast cancer patients compared to conventional chemotherapy.

via Women with breast cancer may benefit from autologous stem cell transplantation.

STEM CELLS RESHAPE BREASTS AFTER CANCER

In VICTORIES & SUCCESS STORIES on December 5, 2009 at 2:04 pm

Stem Cells Reshape Breasts After Cancer

Four-Fifths of Women Satisfied With Cosmetic Results Following Breast Cancer Surgery,By Charlene Laino
WebMD Health News,Reviewed by Louise Chang, MD

Dec. 17, 2007 (San Antonio) — In a medical first, researchers have used stem cells to help reshape the breasts of women who have undergone a lumpectomy to remove a breast tumor.

In a small study, nearly four-fifths of women who got injections of stem cells derived from their own fat tissue were satisfied with the cosmetic results.

During a lumpectomy, surgeons take out only the tumor and surrounding tissue, sparing the remainder of the breast. Radiation is typically given afterward to kill any missed cancer cells.

While the goal is to preserve as much of the breast as possible, the procedures can leave a woman with a scarred, misshapen, and cratered breast.

Currently, there’s not much doctors can offer these women, says Eric Daniels, MD, a surgeon at Cytori Therapeutics. Cytori developed the device used in the stem cell treatment but was not involved in the new study.

“The defect is too small to make her a candidate for the breast implants [offered to women who have a breast removed during a mastectomy],” he says.

Doctors can try rearranging the breast tissue that is left or modifying the other breast to match the flawed one, says Sameer Patel, MD, a reconstructive surgeon at Fox Chase Cancer Center in Philadelphia that was not involved with the work.

But this involves surgery and can leave additional scars. “It’s far from ideal,” he tells WebMD.

Stem Cells Overcome Problems With Fat Implants

Patel says that injections of fat tissue have been tried, but the fat is often reabsorbed or dies.

That happens, he says, primarily because of a poor blood supply between the implanted fat cells and the breast cells.

That’s where stem cells — those miraculous master cells that have the potential to form many other types of cells — come in.

While the research is still early, it is thought that the stem cells develop into the cells needed to form new blood vessels.

“The stem cells likely stimulate the breast tissue to make new blood vessels,” Daniels says. The new blood vessels supply oxygen and nourishment to the implanted cells, keeping the graft alive.

It’s possible, but unlikely, that the procedure actually builds new fat tissue, he says.

Stem Cell Injections Increase Breast Thickness

The new study involved 21 women who had undergone a lumpectomy. Using liposuction, fat was removed from their abdomens, hips, thighs, or lower backs. Half was set aside as the main implant material.  The rest of the fat was processed so that only stem cells and other types of tissue capable of regeneration were left behind.

The stem cell juice was then combined with the reserved fat and injected into the area of the breast defect. The procedure takes about three hours.  Six months after treatment, 79% of 19 women surveyed were satisfied with the results, says researcher Keizo Sugimachi, MD, president of Kyushu Central Hospital in Fukuoka, Japan. He presented the findings here at the San Antonio Breast Cancer Symposium.

In addition, the improvement in breast tissue thickness that was observed at one month persisted at six months.  That’s how the researchers know it is working, Daniels says. If the fat tissue hadn’t been supercharged, a portion probably would have died off during the six-month period, he tells WebMD.

“The work is in its infancy but shows a lot of promise,” Patel says.  Cytori Therapeutics plans to undertake two additional studies of the technique in Europe and Japan next year.

via Stem Cells Reshape Breasts After Cancer.

Stem cells in breast milk could fulfil baby’s ‘genetic destiny’

In VICTORIES & SUCCESS STORIES on November 23, 2009 at 3:01 am

Stem cells in breast milk are adult or repair stem cells.  Is it any wonder repair stem cells are so good for you? – dg

https://i0.wp.com/www.impactlab.com/wp-content/uploads/2008/05/breastfeeding-243.jpgStem cells in breast milk could fulfil baby’s ‘genetic destiny’

by ANI on November 22, 2009

London, Nov 22 (ANI): A new research has found three different types of stem cells in breast milk which may be the reason why mother’s milk is deemed best for babies.

Dr Mark Cregan, medical director at the Swiss healthcare and baby equipment company Medela, has discovered adult stem cells of epithelial (mammary) and immune origin and found “very preliminary evidence” that stem cells in breast milk boost the growth of muscle and bone tissue.

According to him, mother’s milk could enable a child to “fulfil its genetic destiny”.

“Breast milk is the only adult tissue where more than one type of stem cell has been discovered. That is very unique and implies a lot about the impressive bioactivity of breast milk and the consequential benefits to the breastfed infant,” the Independent quoted Dr Cregan, as saying.

via Stem cells in breast milk could fulfil baby’s ‘genetic destiny’ adult stem cells, consequential benefits, different types of stem cells, types of stem cells.

Exercise Associated With Reduced Breast Cancer Risk

In ALL ARTICLES on October 8, 2009 at 2:33 pm

Recent, Vigorous Exercise Is Associated With Reduced Breast Cancer Risk

ScienceDaily (Oct. 1, 2009) — Post-menopausal women who engage in moderate to vigorous exercise have a reduced risk of breast cancer. This comes from researchers writing the open access journal BMC Cancer who investigated the link between breast cancer and exercise.

“With an estimated 182,460 new cases diagnosed in the United States in 2008, breast cancer is recognized as the most common cancer affecting U.S. women,” says Dr. Tricia M Peters from the U.S. National Cancer Institute, Bethesda, Maryland, who headed up an international team of researchers. Vigorous exercise has been hypothesized to reduce cancer risk for some time. However, this new study is one of the first prospective investigations to look at the importance of various intensities of exercise at different stages in an individual’s life.

Over 110,000 post menopausal women were asked to rate their level of physical activity at ages 15-18, 19-29, 35-39, and in the past 10 years. It was found, over 6.6 years of follow up, that women who engaged in more than 7 hours per week of moderate-to-vigorous exercise for the last ten years were 16% less likely to develop breast cancer than those who were inactive. However, no link was observed between breast cancer risk and physical activity in women who were active at a younger age.

via Recent, Vigorous Exercise Is Associated With Reduced Breast Cancer Risk.

STEM CELL BREAST RECONSTRUCTION

In ALL ARTICLES on October 5, 2009 at 2:02 pm

breast reconstruction

Cytori Therapeutics, Tissue Genesis, Thermogenesis, Stem Cell Therapies, Branding, And Joining Forces

Stem cell therapy is quietly entering areas where it provides improved or alternative therapeutic results. Cytori is showing continually improved study and anecdotal results in breast reconstruction with adipose stem cells, a result which implicitly includes the creation of new blood vessels. If positive results continue, breast reconstruction is going to be an excellent market for Cytori, one already generating the lion’s share of its current revenues, and one in which it is clearly establishing a leadership position.

via Stem Cell Research: Cytori Therapeutics, Tissue Genesis, Thermogenesis, Stem Cell Therapies, Branding, And Joining Forces.

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