DAVID GRANOVSKY

Posts Tagged ‘biotechnology’

CHILD RECEIVES NEW STEM CELL TRACHEA

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on April 30, 2013 at 2:44 pm
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Two years ago, 11 year old Ciaran Finn-Lynch, became the world’s first child to receive new trachea.  Scientists/doctors used the child’s own stem cells to rebuild the airway in his body.  This is the really cool stuff because the public can wrap their heads around it and see a trachea in a dish, a nose growing on an arm, etc.  The next step in evolution of the public consciousness is to get them to understand…we can regrow and heal the organs which are already present in their own bodies, already damaged and in need of fixing…with stem cells from their own body.  I think this will be difficult as the home owner with the means will almost always go to the outside plumber or the super store and get a new piece of equipment to replace the old rather than pick up a wrench and fix what they have already.  Another byproduct of the disposable society we live in.  Homes, cars, washing machines and now organs are believed to have a limited life span.  When it breaks, just buy a new one.  – DG

Here’s the article from ScienceDaily:

Surgeons Transplant New Trachea Into Child Using His Own Stem Cells to Rebuild Airway

http://www.sciencedaily.com/releases/2010/03/100325114400.htm

Which was written based on materials from the University College of London release (what, you thought this was in the US?):

UCL surgeons perform revolutionary transplant operation

http://www.ucl.ac.uk/news/news-articles/1003/10031903

trachea

Here’s the 2 year follow-up:

Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study.

http://www.ncbi.nlm.nih.gov/pubmed/22841419

And the human interest story coverage of the same:

Stunning Recovery for First Child to Get Stem Cell Trachea

http://abcnews.go.com/Health/stunning-recovery-child-stem-cell-trachea/story?id=16858771

BLOOD, HEART AND BRAIN STEM CELLS

In STEM CELLS IN THE NEWS on April 11, 2013 at 10:40 am

stem cell science

Science daily is an excellent source for medical article and studies.  I’ve received their feed for quite a while now.  Here, are 3 stem cell articles from today.

  1. Blood stem cells, besides turning into hema type cells can also become white blood cells.
  2. Cardiac stem cells from bone marrow can heal the heart.  This we’ve known since the late 90’s but additional confirmation is always appreciated.
  3. Brain stem cells not only can turn into brain and nerve cells but they also clear out the garbage in the brain and keep the cells in a perpetual stem cell state.

These are 3 good stem cell articles but also of note…

This is the first time Science Daily has had three stem cell articles in their feed.  The world is turning to stem cells.  Are you?

———————————————-

Surprising ability of blood stem cells to respond to emergencies

http://www.sciencedaily.com/releases/2013/04/130410131227.htm 

Posted: 10 Apr 2013 10:12 AM PDT

Scientists have revealed an unexpected role for hematopoietic stem cells: They do not merely ensure the continuous renewal of our blood cells; in emergencies they are capable of producing white blood cells “on demand” that help the body deal with inflammation or infection. This property could be used to protect against infections in patients undergoing bone marrow transplants, while their immune system reconstitutes itself.

 

Cardiopoietic ‘smart’ stem cells show promise in heart failure patients

 http://www.sciencedaily.com/releases/2013/04/130410103349.htm

Posted: 10 Apr 2013 07:33 AM PDT

Therapy with cardiopoietic (cardiogenically-instructed) or “smart” stem cells can improve heart health for people suffering from heart failure. This is the first application in patients of lineage-guided stem cells for targeted regeneration of a failing organ, paving the way to development of next generation regenerative medicine solutions.

 

Spring cleaning in your brain’s stem cells?

http://www.sciencedaily.com/releases/2013/04/130410094120.htm

Posted: 10 Apr 2013 06:41 AM PDT

Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells when you need them. New research shows the vital role of a type of internal “spring cleaning” that both clears out garbage inside the cells, and keeps them in their perpetual stem-cell state.

WHAT PRICE HEALTH?

In STEM CELLS IN THE NEWS on April 2, 2013 at 4:02 pm

https://i0.wp.com/www.defendingfoodsafety.com/uploads/image/FDA%20-%20Grant%20Money.jpg

Greg said:

“Dave, word on the grapevine is a few stem cell professionals almost or did come to blows over the FDA nonsense. They couldn’t understand how the FDA has been stonewalling them when the FDA has okayed dangerous drugs with far less data and safety.”

I responded:

“This has been going on for some time. Simply put, there are a number of docs and treatment centers that are leading the charge, a full frontal assault on the FDA to obtain the right (which should not be something they need to petition for) to use autologous (from the patient’s own body) adult stem cells for treatment. There are a number of regulations that need to be met and federal, state and local law before one can treat in the USA. Almost nobody knows how to do this. Even those that do, can still come under fire and spend their entire war chest battling in the courts. Even if you win over and over, you still can waste valuable time, money and energy better spent treating patients and researching protocols and developing ideas.

There are also many patient groups who are actively lobbying for these rights and numerous petitions floating around. The call to arms I recently wrote which I am putting the finishing touches on, entitled “The Public Wants Stem Cell Treatments” addresses these issues directly. These are the front lines my friends and the docs and patients are on one side and the FDA and upstart regulatory bureaus trying to get a market share of stem cell regulation are on the other. Welcome to the wild west. The mortars and shrapnel are flying and anyone who sticks their head out of the fox hole will incur a mortal wound.

The number of hoops required to jump through are daunting and almost nobody knows how and fewer are willing to take the chance but the potential upside is thousands, tens of thousands, hundreds of thousands, millions of chronic and terminally ill patients with incurable disease recovering, going into remission, reclaiming their health and their lives.

What’s the value of that? What price can we put on our health? I’m reminded of the old credit card commercials…

Chronic disease = $30-150,000 per year
Loss of income from inability to work = $30-150,000 per year
Adult stem cell treatment = $8 – 10,000
Living without symptoms after treatment = Priceless
Living to see your daughter married = Priceless
Living to see your grandchild born = Priceless
Living without pain = Pricelesshttps://i1.wp.com/www.statusant.com/large/Today-be-thankful-and-think-how-rich-you-are.-Your-family-is-priceless%7C2C-your-time-is-gold-and-your-health-is-wealth.-status.jpgRelated articles

STEM CELLS USED TO RESTORE WOMEN’S FERTILITY

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 14, 2013 at 9:00 am

fertility-self

Egg-producing stem cells found in human ovaries

Scientists say they have found a way to use ovarian stem cells to perhaps one day help infertile women get pregnant — or add years to a woman’s reproductive cycle.

In a study published in Nature Medicine, researchers report finding egg-producing stem cells in human ovaries. They also report being able to make some of those ovarian stem cells grow into immature eggs that may someday be useful for reproduction.  At this point, such “seed” eggs can’t be fertilized by sperm. But if scientists are able to entice them to mature and can prove they can be fertilized and grow into embryos — a feat that has been reported in mice — it would overturn a long-held scientific belief that women can’t make new eggs as they get older.

“What it does is really open a door into human reproduction that 10 years ago didn’t even exist,” says researcher Jonathan L. Tilly, PhD, director of the Vincent Center for Reproductive Biology at Massachusetts General Hospital, in Boston.

Outside experts agree. They say the findings could have profound importance for reproductive medicine and aging, allowing doctors not only to restore a woman’s fertility but also to potentially delay menopause.  “I think the significance of this work is like reporting that we found microorganisms on Mars,” says Kutluk Oktay, MD, who directs the Division of Reproductive Medicine and the Institute for Fertility Preservation at New York Medical College in Valhalla, N.Y.

“It’s a proof of principle that they could do it,” says David F. Albertini, PhD, director of the Center for Reproductive Sciences at the University of Kansas Medical Center in Kansas City, Kan.

The egg-generating stem cells the researchers were able to extract from ovaries were very rare. The researchers only came across one for every 10,000 or so ovarian cells that they counted.  But when they took those cells and implanted them back into human ovarian tissue, they divided and essentially made young eggs.

Tilly says his team stopped short of trying to make one of the eggs functional because “for a lot of reasons, as it should be,” it is illegal in the U.S. to experimentally fertilize human eggs.

“We think the evidence provided clearly indicates that this very unique, newly discovered pool of cells does exist in women,” he says.

“It’s a really exciting result,” says Evelyn Telfer, PhD, a cell biology expert at the University of Edinburgh in Scotland.  “What we’ve previously believed is that you don’t get new eggs formed during your adult life. This discovery shows that there’s the potential for them to be formed, no question about that,” Telfer says, “but it doesn’t actually show that they’re being formed under normal conditions.”

Indeed, she notes, experience would suggest otherwise. Women, after all, do lose their fertility as they age.  “There are cells there that under certain conditions have the potential to form [eggs]. That’s the really exciting part of this work. And of course they can be used. There’s a practical application,” she says.

Telfer has pioneered a technique that allows her to take immature human eggs and turn them into mature, fertilizable eggs outside the body. She has already partnered with Tilly to try to take his “seed” eggs to the next stage of development. With special government permission, she says, they may even be able to try to experimentally fertilize the eggs.

“It’s actually opening up a whole new field of research, to define these cells, to characterize these cells, and to use them in a practical way,” she says.

Tilly says that by using egg-generating stem cells to make large numbers of viable eggs, doctors might one day be able to cut the expense of in vitro fertilization (IVF), since women would no longer have to go through multiple cycles of treatment to harvest enough eggs to generate a pregnancy.

WebMD Health News

A DOG’S LIFE SAVED THROUGH STEM CELL TREATMENT

In STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on March 6, 2013 at 9:00 am

This is Thelma. She is an adorable, friendly, 7 year old Boxer. Thelma was to be put down because she was suffering from Intervertebral Disc Disease (IVDD) in her neck. It was ultimately decided however to try stem cell therapy, performed by Pet Central Animal Hospital in Minneapolis, MN. This is a video of her BEFORE MediVet America’s stem cell procedure…..
AFTER: This is the after video of Thelma’s AMAZING progress after just 9 weeks from being treated with stem cell therapy!

WHY TRAVEL ABROAD FOR STEM CELL TREATMENTS???

In ALL ARTICLES, CELEBRITIES & STEM CELLS, VICTORIES & SUCCESS STORIES on February 12, 2013 at 9:00 am
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“Woke up this morning and am “aware” of my surroundings. I guess in other words I’m not a zombie. Haven’t been this clear in years. And the headache i’ve had all week is GONE!”

A women who has been battling Multiple Sclerosis, wheel chair bound for two years, unable to grasp objects due to severe shaking, and dealing with daily Brainfog, was treated with stem cells here in the United States two weeks ago.   For the first time in two years she was walking with the assistance of a cane and able to grasp her morning coffee cup and this was ONLY AFTER TEN DAYS!!!

Jack Osbourne

It’s a shame that Son of rocker Ozzy Osbourne, Jack Osbourne has had to travel to Germany to ­undergo stem cell replacement therapy to treat his Multiple Sclerosis, when he could have been treated here in the United States..  Jack, who went public about his health crisis last summer, said he is currently feeling well and getting plenty of rest – despite being a new dad to nine-month-old daughter Pearl.

“There are odd restrictions here in America because everybody still thinks it’s, like, what it isn’t. So I’m going to Germany. They pull stem cells from your own blood then inject them back into you.  Hopefully it will repair any damaged cells and nerves and things like that.” said Jack.

For more articles related to Stem Cell treatments for Multiple Sclerosis click HERE.

 

SPINAL CORD REPAIRED THROUGH STEM CELLS

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 23, 2013 at 9:00 am

spinal-cord

Stem cells breathe new life into paralyzed gymnast

At the Dasara Games in September of 2010, a meticulous gymnast with the ambition to achieve the same stardom as his hero Ashish Kumar, met an untimely misfortune when mistiming a somersault during a practice routine.

“Ananth Rao’s head crashed on to the mat and he heard a cracking sound. His spine was shattered at the cervical region (C-6, C-7), paralyzing him for life. “I’ve always been told that one must learn from mistakes,” Ananth said. “One small mistake I made has cost me so much. I lost hope completely, I thought my life was over,” said the youngster, who was operated upon after his accident at the JSS Hospital in his hometown.  Although the doctors stabilized his neck, Ananth became a bedridden quadriplegic (all four limbs paralyzed) with no control over his bowel movements and was susceptible to a number of ailments.” He was forced to drop out of Mysore Maharaja College to focus on receiving vigorous physiotherapy and standard forms of treatment. But there was little improvement in his condition.  Just over a year after his accident, doctors heard about Ananth’s condition and decided to take up his case in a bid to improve his quality of life.  With the backing of the HCG Foundation, Ananth was exposed to advanced treatment in the form of mesenchymal stem cells – connective tissue cells that can differentiate into a variety of cell types – in a bid to try to regenerate nerve cells in his spinal cord.

After two stem cell injections and 11 months of focused rehabilitation, Ananth has shown remarkable signs of improvement.

“Today, I can dream new dreams of a future where I am not dependant on anyone and I can see myself living with dignity,” said Ananth, who showed no signs of difficulty lifting his arms, holding a pen or a cup of coffee. “He had been undergoing regular treatment for a year,” said HCG chairman and CEO Dr Ajaikumar, who along with orthopaedician Dr Pramod S Chinder, took a personal interest in Ananth’s case. “He was someone who led an active life as a gymnast and I felt we should take up this challenging case to show how regeneration can happen through stem cell treatment. We are glad our efforts have finally paid off,” he said, without ruling out further improvement.” “Ananth’s case was studied in detail. Stem cells of the patient were cultured and two injections were given to him,” said Dr Chinder, who was quick to add recovery chances were case specific. “Post treatment, the patient progressed significantly, with the movements of hands and there is sensation in his legs. There is increasing evidence in the benefits of stem cell therapies and spinal cord injuries are one of the most researched. In patients, who do not have any other option of recovering from spinal cord injuries, stem cell treatment is the way to go forward,” Dr. Chinder added.

http://timesofindia.indiatimes.com

DENTAL STEM CELLS CARRY GREAT POTENTIAL

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 21, 2013 at 9:00 am

ed_helms

Dental pulp stem cells: a promising tool for bone regeneration.

Human tissues are different in term of regenerative properties. Stem cells are a promising tool for tissue regeneration, thanks to their particular characteristics of proliferation, differentiation and plasticity. Several “loci” or “niches” within the adult human body are colonized by a significant number of stem cells. However, access to these potential collection sites often is a limiting point. The interaction with biomaterials is a further point that needs to be considered for the therapeutic use of stem cells. Dental pulp stem cells (DPSCs) have been demonstrated to answer all of these issues: access to the collection site of these cells is easy and produces very low morbidity; extraction of stem cells from pulp tissue is highly efficiency; they have an extensive differentiation ability; and the demonstrated interactivity with biomaterials makes them ideal for tissue reconstruction. SBP-DPSCs are a multipotent stem cell subpopulation of DPSCs which are able to differentiate into osteoblasts, synthesizing 3D woven bone tissue chips in vitro and that are capable to synergically differentiate into osteoblasts and endotheliocytes.  Several studies have been performed on DPSCs and they mainly found that these cells are multipotent stromal cells that can be safety cryopreserved, used with several scaffolds, that can extensively proliferate, have a long lifespan and build in vivo an adult bone with Havers channels and an appropriate vascularization.

http://www.ncbi.nlm.nih.gov/pubmed/18300003

Dental stem cell banking facility launched by Stemade Biotech this week in Punjab, India with the intent to expand across the county.    “This will help the people to secure their healthy future. Like timely monetary investments help plan future financial security, dental stem cell banking can help plan for a disease- free body.” said Dr Vikas Jindal.

“Stem cells have a defining property to self- regenerate, which can be used to treat serious ailments. Unlike bone marrow stem cells, extracting dental cells is a noninvasive procedure. Dental pulp contains stem cells, known as dental pulp stem cells. The finest dental pulp stem cells are found in baby teeth or milk teeth. Dental stem cells can generate solid structures such as bone, new dental tissue, cartilage and muscle. Dental pulp stem cell banking can be done on milk teeth of children in the age group of five to 12. Teens that are undergoing orthodontic procedures, such as getting braces, have the opportunity to bank their premolars that are often extracted during the procedure. Adults on the other hand have the opportunity to bank on their dental pulp stem cells through wisdom teeth.”

dental-pulp-stem-cell

“Dental Stem cells are Mesenchymal (tissue-related) stem cells whilst umbilical cord blood provides hematopoietic (blood-related) stem cells. Hematopoietic stem cells have the potential to treat only blood-related disorders such as leukemia etc whereas, mesenchymal stem cells have potential applications in all other tissues of our body such as brain for treatment of Alzheimer’s, Parkinson’s, eye for corneal reconstruction and liver for cirrhosis, said Shailesh Gadre Managing Director, Stemade Biotech.”

STEM CELL TREATMENT FOR DEMENTIA SHOWS IMPROVEMENT

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 17, 2013 at 9:00 am

demencia-senil1

Stem Cells Shown to Reverse Dementia

Mary Holler, age 80, of Marco Island, Florida is smiling again.  Mary was suffering from dementia and felt her ability to function on a daily basis was slipping away.  Now, after undergoing a successful stem cell treatment in early December 2012, Mary is more like her old self again. She no longer suffers the frustration and agitation of being told she had already asked that question several times. Peter Holler , age 82, had become very concerned that his wife of 60 years was slowly losing her memory. She had been on medications for memory loss for several years but the deterioration in her recall accelerated in the last six months.  It was not unusual for him to answer the same question 4 to 5 times over the course of a day.  He felt he was losing his wife right in front of his eyes.  Mary’s poor performance on an in-depth memory test revealed that she should be in an assisted living facility.  This frightened both the Hollers and their children.

Peter Holler sought out stem cell therapy. He felt it was his wife’s only option. Peter, no stranger to stem cells, had undergone a stem cell treatment for his failing heart in 2008. He had experienced great success. “Even my lung function improved dramatically,” he recalls.  So using the same group that he had trusted with his heart, he made arrangements to get the love of his life treated.

A track record of several successfully treated patients with dementia already existed.  So the doctors knew exactly what to do.  Heading the team is Dr. Hector Rosario , an interventional cardiologist and head of the stem cell program in the Dominican Republic.  Dr. Zannos Grekos, Chief Science Officer for Intercellular, was present as well. “It’s very exciting to be able to have such a positive impact on a disease process that otherwise has such a grim prognosis,” Grekos explained.

After an activation and concentration process, stem cells collected from Mary’s bone marrow were injected into her cerebral circulation. “Look at the difference,” Dr. Rosario exclaimed while pointing to the before and after pictures of the brain circulation. The increase in blood vessel flow was astonishing. Since only adult stem cells from the patient are used, the political, ethical and medical issues are avoided and there is no risk of rejection.

“We’re able to normalize a patient’s brain function testing in 6 months after the treatment,” said Grekos, commenting on the success rate of patients receiving adult stem cell therapy to reverse the effects of dementia.

Dementia is a loss of brain function that occurs with age and certain diseases. Some types of dementia are non-reversible (degenerative) but others have a vascular component, even Alzheimer’s.  These respond especially well to stem cell treatment.

Press Release: Intercellular Sciences, LLC – Mon, Jan 7, 2013 6:01 PM EST

WAKE UP!!!

In ALL ARTICLES, STEM CELLS IN THE NEWS on January 10, 2013 at 12:42 pm

WAKE UP!!!

ABOUT
STEM
CELLS!

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