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Posts Tagged ‘autologous’

INDIA TO START STEM CELL THERAPY TRIALS FOR SPINAL CORD INJURIES

In STEM CELLS IN THE NEWS on November 29, 2012 at 9:00 am

 A bone marrow harvest.

Ahead of a planned five-centre nationwide trial, the Indian Council of Medical Research (ICMR) has approved a special project at the AIIMS Trauma Centre in New Delhi where stem cell therapy will be conducted on complete paraplegics and quadriplegics to try and revive limb function.

A similar trial will be conducted at the Indian Spinal Injuries Centre (ISIC) in Vasant Kunj, south-west Delhi where 21 patients have already been registered. This project too has been approved by the ICMR. Senior ICMR scientists from the apex committee to monitor stem cell research said the five-centre trial will be coordinated from ISIC and is in the final stages of approval.  “This will be the first national ICMR trial of autologous bone marrow stem cell transplant on complete quadriplegics and paraplegics. We are finalizing the number of patients. The ISIC will be the coordinating centre. The next meeting has been scheduled for December 4,” a senior scientist said.

An autologous stem cell transplantation is a procedure in which stem cells are removed, stored and returned to the same person.  For its project, the AIIMS Trauma Centre has registered eight patients. They will be injected with stem cells from their own bone marrow to see if the damaged neurological function can be regenerated. Doctors have cautioned that earlier trials on incomplete quadriplegics and paraplegics have not suggested significant clinical improvement.

Dr. Deepak Aggarwal, associate professor of neurosurgery at the AIIMS Trauma Centre who is coordinating the study, said: “We have necessary clearances from our internal ethics committee and the national apex committee for stem cell research and therapy which has members from the ICMR and Department of Biotechnology.”

“We are trying to see if injecting patients of irreversible spinal cord injuries with stem cells from their own bone marrow, under autologous stem cell transplantation, can help regenerate neurological function,” he said.   According to Dr. Aggarwal, clinical evidence in previous international trials have not given “satisfactory results”. This is the first time that AIIMS is undertaking such a project.

At the ISIC, doctors have selected 21 complete paraplegics who are being injected with stem cells retrieved from their own bone marrow within 10-14 days of injury.  “We had done one project in 2009 to see the use of stem cell transplant in restoring limb function on spinal cord injuries, but we had only selected chronic patients where the time lapse after the injury was far more. We could not demonstrate any clinical improvement. One criticism was that the spinal cord loses its plasticity and ability to regenerate after such a long time,” Dr. H S Chhabra, medical director at ISIC, said.

In the 2009 study, where five patients were selected, the site of stem cells was the olfactory mucosa or the upper region of the nasal cavity. For the new trial at ISIC, stem cells are being retrieved from the bone marrow of patients.  At AIIMS, patients will be monitored for six months after one procedure. If there is no significant change, another procedure of extraction of stem cells and autologous transplantation will be repeated. There will be follow-ups for two years.

Of the eight patients shortlisted for the project at AIIMS, three are quadriplegics and have lost function in all four limbs. Patients were evaluated to ensure only those with “complete” loss of limb function were included, and all within six months of injury.

At ISIC, the 21 patients have been divided into three arms. The first group will be injected stem cells directly into the spinal cord, at the site of injury. For the second group, stem cells will be injected into the cerebrospinal fluid that surrounds the spinal cord.

The third arm, which will be the control arm, will not be injected with stem cells, but given other rehabilitative therapies. The functional outcome of all three groups will be compared at the end of two years.

http://www.indianexpress.com/news/two-delhi-centres-ready-to-try-stem-cell-therapy-on-paraplegics/1036299/

Stem cell transplants help kidney damage

In ALL ARTICLES on February 18, 2011 at 10:13 am

“Transplanting autologous renal progenitor cells (RPCs), (kidney stem cells derived from self-donors), into rat models with kidney damage from pyelonephritis – a type of urinary infection that has reached the kidney – has been found to improve kidney structure and function.”

Stem cell transplants help kidney damage

https://i0.wp.com/galileo.phys.virginia.edu/classes/304/kidney.gif

Tampa, Fla. (Feb. 14, 2011) – Transplanting autologous renal progenitor cells (RPCs), (kidney stem cells derived from self-donors), into rat models with kidney damage from pyelonephritis – a type of urinary infection that has reached the kidney – has been found to improve kidney structure and function.

The study, authored by a research team from the Tehran University of Medical Sciences, is published in the current issue of Cell Medicine [1(3)] and is freely available on-line at: http://www.ingentaconnect.com/content/cog/cm .

“Advancements in stem cell therapies and tissue engineering hold great promise for regenerative nephrology,” said Dr. Abdol-Mohammad Kajbafzadeh, corresponding author. “Our RPC transplant study demonstrated benefits for pyelonephritis, a disease characterized by severe inflammation, renal function impairment and eventual scarring, and which remains a major cause of end-stage-renal disease worldwide.”

The researchers divided 27 rats into three groups, two of which were modeled with an induced pyelonephritis in their right kidneys, while the third group did not have induced disease. RPCs were obtained from the diseased animals’ left kidneys and injected into the right kidney six weeks later. Two weeks after injection, tubular atrophy was reduced. After four weeks, fibrosis was reduced and after sixty days, right renal tissue integrity was “significantly improved.”

“We propose that kidney augmentation was mainly due to functional tissue regeneration following cellular transplantation,” said Dr. Kajbafzadeh. “Kidney-specific stem/progenitor cells might be the most appropriate candidates for transplantation because of their inherent organ-specific differentiation and their capacity to modulate tissue remodeling in chronic nephropathies.”

The researchers concluded that because renal fibrosis is a common and ultimate pathway leading to end-stage renal disease, amelioration of fibrosis might be of major clinical relevance.

“Transplanting RPCs showed the potential for partial augmentation of kidney structure and function in pyelonephritis,” said Dr. Kajbafzadeh. “This is one of the first studies to demonstrate improved renal function after cell transplantation. The translation of this study into larger clinical models will be very relevant to validate the success of this small animal study.” said Dr. Amit Patel, Section Editor Cell Medicine, Associate Professor of Surgery, University of Utah.

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Citation. Kajbafzadeh, A-M.; Elmi, A.; Talab, S. S.; Sadeghi, Z.; Emami, H.; Sotoudeh, M. Autografting of Renal Progenitor Cells Ameliorates Kidney Damage in Experimental Model of Pyelonephritis. Cell Med. 1(3): 115-122; 2010.

Stem cell transplants help kidney damage

Adult Stem Cells Help Stroke Victims

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on April 20, 2009 at 10:48 pm

brain-stroke-21

Stem Cell Research Shows Adult Stem Cells Help Stroke Victims

Posted 20 April, 2009 in Stroke |

Stem Cell Research Study Reveals Stroke Patients Helped by Own Stem Cells

A new stem cell research study/trial recently completed shows that implanting a person’s own Adult Stem Cells helps stroke patients overcome partial paralysis. Dr. Kameshwar Prasad of the All India Institute of Medical Sciences (AIIMS) will present his stem cell study at the European Stroke Research Conference in May, 2009.

Stroke Victims Own Adult Stem Cells Used

In the stem cell study that took place in New Delhi, India, 12 stroke victims had their own stem cells implanted within 1 month after a stroke. Also, 3 stroke patients were used as a control group and were not given any stem cells.

Process of Stem Cells for Stroke

  1. Adult Stem Cells extracted from patient’s bone marrow
  2. Stem Cells are then purified
  3. Patient’s own stem cells are then reintroduced intravenously into the antecubital vein (in the forearms, near the elbow)
  4. Stem Cells migrate to area of injury (in this case- the brain)
  5. Adult Stem Cells enhance repair process and reduce brain damage

The Stem Cell Treatment Results

At the beginning of the stem cell study, none of the 12 stroke patients were able to carry out daily activities, use the toilet, take a bath, dress and eat independently.

However, within 1 year, 70% (I assume 7 or 8 of the patients) were able to overcome their handicaps and successfully return to previous activities like playing golf, working in the office and cooking.

Only 1 out of the 3 stroke patients in the control group were able to go back to their normal routine.

No Side Effects From Your Own Stem Cells

From the stem cell article:
“The stem cells had excellent safety profile. After carrying out Pet scans and MRIs thrice in a year on patients who received stem cells, we found no side-effects. This study shows that stem cells are a safe and feasible therapy in acute stroke. This holds promise and needs to be confirmed in a bigger study,” Dr Prasad said.

Of course there were no side effects, the trial used the patient’s own cells. Rejection isn’t an issue.  As I say time and time again, the patient has everything to gain and nothing to lose.  There is no downside to this treatment.  It is a shame this isn’t being put to use in the United States and made available to everyone who may need it.

These same doctors will follow up this stem cell clinical trial for stroke with a 120 patient trial in the next 3 years.  Hopefully, this will speed things up for Adult Stem Cells to be accepted sooner rather than later.

Related Stem Cells for Stroke Success Stories

The results of this study comes just after I covered this stem cell trial for stroke in Texas.  Also, earlier this year, I covered the stem cell tea bag which helped a German stroke victim as well.

see also:

Brain Reconstruction: Stem-Cell Scaffolding Can Repair Stroke Damage

Stem Cells Revive Woman in Coma From Stroke

STEM CELLS & STROKE

via Stem Cell Research Shows Adult Stem Cells Help Stroke Victims | Adult Stem Cell Research.

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