DAVID GRANOVSKY

Posts Tagged ‘artery’

Heart Muscle Health Aspects | VesCell adult stem cell therapy

In VICTORIES & SUCCESS STORIES on February 2, 2010 at 4:23 pm

Heart Muscle Health Aspects You Should Consider

Stunned or Dying Tissue can be Rejuvenated by Adult Stem Cells Injected in the Patient’s Heart

Heart muscle health aspect from James Eilert story

Click here to see if your heart disease is treatable with Adult/Repair Stem Cells now

James Eilert, a young man, who was a victim of the heart disease epidemic that is increasingly taking hold around the world, has been given a second chance at a healthy life thanks to VesCell adult stem cell therapy.

In 2006, at the relatively young age of 34, James experienced a major heart attack. His left anterior descending artery (or what the doctors call the ‘widowmaker’) was 100% blocked. The heart attack left him with severe damage to his heart. A normal ejection fraction is generally considered to be 55-75%. At the tender age of 34, James’ ejection fraction had sunk to 20-25%. The doctors diagnosed him as being in Class III NYHA Heart Failure.

He didn’t want to die, but figured dying would be a better option than living as he was. That was when James stumbled upon VesCell on the internet. Already a patient at the world renowned Henry Ford Heart and Vascular Institute in Detroit, James was shocked to find out that Dr. Barbara Czerska, the Medical Director of the Heart Failure Transplant Program at Henry Ford was featured prominently on the VesCell website. That, along with reading that recent medical research indicates that dead heart tissue can be ‘awakened’ by the implantation of adult stem cells gave James new hope.

He contacted VesCell and Dr. Czerska and prepared for his trip to Bangkok, Thailand to receive a new shot of hope using his own adult stem cells.

After arrival in Bangkok, James along with his father, were well taken care of by the TheraVitae team and the doctors and nurses at Phyathai 2 Hospital. James was treated by Dr. Damras Tresukosol, the director of the Phyathai-Harvard Heart Center and also the lead investigator of TheraVitae’s clinical trial using adult stem cells which was presented at the American Heart Association annual meeting in 2006.

Treated on November 14, 2007, James received 41 million of his own adult stem cells via catheter to heal his damaged heart muscle.

Told by doctors that the stem cells would take approximately 6-8 weeks to take affect, James was pleasantly surprised that the doctors were mistaken – just 1½ weeks after his stem cell treatment,

James had an echocardiogram done and found out his previously dead part of his heart had life again….

Click [HERE] to see if your heart disease is treatable with Adult/Repair Stem Cells now

via Heart Muscle Health Aspects | VesCell adult stem cell therapy.

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CATCH UP! – 12 Articles about revolutionary cardiac advances that are 4-6 years late

In ALL ARTICLES, VICTORIES & SUCCESS STORIES on May 29, 2009 at 10:51 am

HEART0008

Here are 12 articles about revolutionary cardiac advances that are 4-6  years late:

https://repairstemcell.wordpress.com/2009/02/10/trials-for-revolutionary-stem-cell-surgery-in-uk-within-a-year/

https://repairstemcell.wordpress.com/2009/02/10/cardiac-stem-cell-trials-usa-is-5-10-years-late/

https://repairstemcell.wordpress.com/2009/02/11/stem-cell-trial-seeks-pcardiac-stem-cell-trials-the-us-plays-catch-up-part-2/

https://repairstemcell.wordpress.com/2009/02/12/cardiac-stem-trials-the-us-plays-catch-up/

https://repairstemcell.wordpress.com/2009/02/12/cardiac-stem-cell-trials-the-us-plays-%e2%80%9ccatch-up%e2%80%9d-part-3/

https://repairstemcell.wordpress.com/2009/03/06/catch-up-stem-cell-company-makes-strides-in-cardiac-treatment/

https://repairstemcell.wordpress.com/2009/03/30/catch-up-stem-cell-research-effective-in-heart-disease-patients-at-northwestern-culture11/

https://repairstemcell.wordpress.com/2009/04/04/medical-news-acc-stem-cell-treatment-may-help-repair-mi-damage-in-meeting-coverage-acc-from-medpage-today/

https://repairstemcell.wordpress.com/2009/04/04/groundbreaking-stem-cell-therapy-phase-ii-trial-on-damage-heart-tissue-treatment/

https://repairstemcell.wordpress.com/2009/04/13/t%ce%b24-identified-as-key-molecule-capable-of-triggering-stem-cells-to-repair-damaged-adult-heart/

https://repairstemcell.wordpress.com/2009/05/20/catch-up-stem-cells-may-offer-new-way-to-treat-blocked-arteries-forbes-com/

https://repairstemcell.wordpress.com/2009/04/13/i-dont-have-the-heart-to-tell-you-this-but/

CATCH UP!! – Stem Cells MAY?? Offer New Way to Treat Blocked Arteries – Forbes.com

In ALL ARTICLES, STEM CELLS IN THE NEWS on May 20, 2009 at 6:21 pm

Once again, US research and especially the US media (Forbes) is years behind the rest of the world on stem cell progress!

The headline in Forbes reads, “Stem Cells May Offer New Way to Treat Blocked Arteries.”  Here is where the rest of the world stands on cardiac and arterial treatment with stem cells.

1998 – Dr Doris Taylor takes stem cells from the thigh of a rabbit, injects them into scar tissue in the animal’s heart and repairs the damaged muscle.  The research was published in Nature Medicine.

1998-1999 – French researchers transplanted muscle cells into a human heart.

2000 – Human studies and trials using adult stem cells to regrow muscle tissue, including cardiac muscle tissue, are performed in many countries around the world.

2002 – Dr Taylor herself witnessed in Rotterdam the first patient in the world to get stem cells injected through a catheter into the wall of the heart. Encouraging results began to come in—improved ejection fractions, reduced diameters, thicker muscle tissue.

2004 – The first-ever commercial stem cell treatment center in the world was regrowing human cardiac muscle tissue in hundreds of patients in Thailand!  Stem cells are recognized as “smart,” going to where they were needed most, creating micro-vessel bypasses around blockages that were existing, those that were removed previously and in areas where stents were implanted.

2005 – Dr Taylor  rinsed rat hearts with detergent until the cells washed away and all that remained was a skeleton of tissue translucent as wax paper. She then injected the scaffold with fresh heart (stem) cells from newborn rats.  Four days later, “We could see these little areas that were beginning to beat.  By eight days, we could see the whole heart beating.”  The experiment, reported in the journal Nature Medicine, marked the first time scientists had created a functioning heart in the lab from biological tissue.

2009 – Present day.  There are currently dozens of stem cell treatment centers around the world who are using adult stem cells to treat cardiac disease in human patients and regrow both cardiac and skeletal muscle tissue and more.

CATCH UPCATCH UP!!

Stem Cells May Offer New Way to Treat Blocked Arteries – 05.19.09, 04:00 PM EDT

Injections into heart restore blood flow in small study

TUESDAY, May 19 (HealthDay News) — Injecting bone marrow cells into the heart’s muscular wall restored blood flow to hearts with blocked arteries for which conventional treatments had proven ineffective, Dutch physicians have reported.

“I think this is very good news for patients who are at the end of the line and have no options left,” said Dr. Douwe E. Atsma, an interventional cardiologist at Leiden University Medical Center and an author of the study, which appears in the May 20 issue of the Journal of the American Medical Association.

The 50 people in the study, 43 of them men, were experiencing angina, or severe chest pain, because of blockages in their heart arteries. All had undergone several artery-opening procedures, such as angioplasty or bypass surgery, to restore blood flow, but such measures would no longer help them, Atsma said.

Half of the participants received injections of cells taken from their own bone marrow, and the others received inactive cell injections. After three months, the responses were varied, with some participants reporting complete relief and others with partial benefits.

“The most important thing is that the amount of ischemia [artery blockage] was halved” in those given the marrow cells, Atsma said. “The amount of tissue with ischemia was reduced, heart function improved significantly in a small way and their grades of quality of life were higher.”

Two earlier and smaller trials of bone marrow cell therapy for heart disease had produced conflicting results, Atsma said. “We are the largest trial to date and the first to demonstrate a decrease in ischemia,” he said.

The results were so good, Atsma said, that the participants who had gotten the dummy injections have since been given bone marrow cell therapy, and “we now consider it an option for patients in the same condition,” he said.

The study excluded people with heart failure, which occurs when the heart muscle has become too weak to pump blood properly. But Atsma said that a trial of bone marrow cell therapy for people who have blocked arteries as well as heart failure is planned.

The bone marrow cell injections help restore blood flow by promoting the creation of new blood vessels, Atsma said, but it’s not clear how this happens. “It could be that the cells that are injected become part of the vasculature, the blood vessels,” he said. “Even better, the injected cells may secrete proteins that stimulate angiogenesis, formation of blood vessels. Or it might be a combination of those two things.”

Whatever the reason for the benefit of bone marrow cell therapy, “we are fairly enthusiastic, considering that these patients had no alternative,” Atsma said. “They had all the surgery and angioplasty they could have.”

Dr. Amit Patel, director of cardiovascular regenerative medicine at the University of Utah, described the finding as “definitely a step forward in the treatment of chronic angina.” But he had some cautionary comments.

It was a small study, with just 50 participants, he said, adding that “to make it a more reproducible therapy, you would have to do at least a couple of hundred patients.”

Also, the follow-up period was relatively short, at three months, he noted. “Something positive happened, but you would have to follow these patients further to see how long it would last,” Patel said. Future studies to determine whether there would be an overall improvement in heart function would also be welcome, he said.

Doris Taylor, director of the University of Minnesota Center for Cardiovascular Repair, also had qualified praise for the results.

“The good news is that it is more mechanistic in that it gives some insights into perfusion,” she said. “It reinforces the evidence that bone marrow cells are safe and effective. It also reinforces the prevailing wisdom that it is not a home run. The results are positive, but it is not the panacea we hoped it would be.”

To further the baseball analogy, Taylor said that “for the people who feel better, I would consider it a double.”

More studies are needed to learn about the value of cell therapy “across the complete spectrum of cardiovascular disease,” she said. “We need to understand what we need to do differently. I hope these data provoke that conversation.”

via Stem Cells May Offer New Way to Treat Blocked Arteries – Forbes.com.

CATCH UP! – Stem Cell Research Effective in Heart Disease Patients at Northwestern | Culture11

In ALL ARTICLES on March 30, 2009 at 9:51 am

With hundreds if not thousands of successful adult stem cell treatments around the world for cardiovascular patients, the US is s..l..o..w..l..y.. realizing the benefits of adult stem cells and posting headlines like

“Stem Cell Research Effective in Heart Disease Patients”

Great news! and you are only a full five years late.  CATCH UP! – dg

heart-stem-cell-treatment-cardiac-cure

Stem Cell Research Effective in Heart Disease Patients at Northwestern

by Don Margolis, March 29, 2009

Stem Cell Research for Coronary Artery Disease a Success

Dr. Douglas Losordo, the director of Northwestern University’s Cardiovascular Institute is reporting that his stem cell research Phase II study of 170 heart disease (severe coronary artery disease) patients treated with using Adult Stem Cells was a success.

Adult Stem Cells Give Impressive Results

Patients receiving their own Adult Stem Cells had improved tolerance to exercise and less discomfort after their follow up at 6 months.

From the stem cell treatment article:
Dr. Losordo says “The six-month, phase II data provide the first evidence that a patient’s own stem cells could actually be used as a treatment for their heart disease.”

How Adult Stem Cells Work for Heart Disease

It is believed the stem cells help rebuild damaged heart tissue as well as create new blood vessels helping more blood flow through out the body.

5 more years until Stem Cell Therapy Available for Heart Patients?

The results were so promising that Dr. Losordo and Baxter, the stem cell research company that sponsored the study will move forward with a Phase III trial.

After the Phase III trial is completed, Baxter would be able to submit the results to the US FDA for approval. However, before heart disease patients start celebrating, keep in mind that this will take at least 5 more years.

And Stem Cell Research for Other Diseases?

5 more years for Adult Stem Cell treatment to be available to heart patients in the United States- and stem cell therapy for the heart is the most advanced as far as clinical trials using Adult Stem Cells go. So for Diabetes, Emphysema, Peripheral Artery Disease and others…we are probably looking at 10+ years before Adult Stem Cell research will be put to use.

Better Late Than Never for Adult Stem Cells? Is this the best we can hope for?  Wait for these endless clinical trials to be completed for each particular disease? Wait for the use of our own cells, something already proven safe? Or is there something we can do to speed things up? A group of US doctors for Adult Stem Cell Therapy are trying to change things. What do you think we can do?

CATCH UP!…with a twist! (Part 1) – Stem cells implanted into pancreas of diabetic patient through an artery

In ALL ARTICLES, CATCH UP!, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 20, 2009 at 3:02 am

I have a category entitled CATCH UP!  This article is what I am talking about.  You may be confused when you read it because while Dr Vina is implanting stem cells into the pancreas of diabetic patient and even developed the procedure…it is “fairly” common today.  Point is, check the date for when he was doing it.  Feb 2005!!  SO when I say “CATCH UP!” I mean that everyone else in the world should CATCH UP with guys like Dr Vina.  Well done Dr V!  –  DG

CATCH UP!

CATCH UP!

Stem cells implanted into pancreas of diabetic patient through an artery, Argentina – Feb 2005

Main Category: Diabetes -Article Date: 09 Feb 2005 – 10:00 PST

On January 5th, stem cells were implanted in the pancreas of a diabetic patient through a small artery that irrigates this organ – this is the first time this has ever happened anywhere in the world.

The procedure was carried out by a Team of Interventional Cardiologists from the Clinica San Nicol�s, Buenos Aires, Argentina and the Don Roberto Fern�ndez Vina Foundation. Team leaders were Drs Roberto Fern�ndez Vina, Oberdan Andrin and Francisco Vrsalovic.

The procedure was designed by Dr. Roberto Fernandez Vina.

The objective was to implant selectively some stem cells (obtained from the patient’s bone marrow) in the Pancreas, where the Beta Cells are located – hoping to regenerate the insulin producing capacity of the pancreas.

The patient was awake throughout the whole operation. The stem cells were fed through the femoral artery. Within 24 hours the patient was discharged (allowed to go home).

This is a press release from the Fundaci�n Don Roberto Fern�ndez Vi�a, Argentina

via Stem cells implanted into pancreas of diabetic patient through an artery, Argentina.

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