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Posts Tagged ‘alzheimer’

Brain shrinks a decade before Alzheimer’s appears

In ALL ARTICLES on April 14, 2011 at 11:15 am
Brain shrinks a decade before Alzheimer’s appears

By Julie Steenhuysen – CHICAGO | Wed Apr 13, 2011 6:09pm EDT

(Reuters) – Brain scans of healthy people showed signs that the brain was shrinking in Alzheimer’s-affected areas nearly a decade before the disease was diagnosed, U.S. researchers said on Wednesday.

The finding, published in the journal Neurology, may offer a new way to detect the disease early, an advance that could help in the development of effective treatments for Alzheimer’s, a brain-wasting disease that affects up to 26 million people globally…

Read more…

THE WHOLE IS GREATER THAN THE SUM OF THE PARTS

In OFF THE BEATEN PATH on September 28, 2010 at 7:53 pm

Completely random, caffeine infused, unedited rant

(not really random, actually in response to this comment on facebook:

” Breaking news: Alzheimer’s is a whole body disease. Insulin, glucose, neurological system + nutrition all affect it. Breaking news? So…the entire body works holistically…diseases should be treated holistically? This is only breaking news in USA now, it was breaking news in Asia + India 3,000 years ago. Western med …always seems look through the wrong end of the binoculars + try to kill a fly with a shot gun.”

alexgrey33ri.gif alex grey image by breando

THE WHOLE IS GREATER THAN THE SUM OF THE PARTS

As I spend time with specialists I find more and more of them are either realizing or “able to empirically prove” that diabetes, Alzheimer’s, Parkinson’s, etc etc are a disease of the entire body. The evidence is all there.

SO the drugs that target a single chemical interaction, a single organ, a single anything…even if they work, will not fix the body, they will only fix that specific problem. So then 6-12 months later when that part is no longer screaming for fixing and the next part makes itself heard, you will then take a new drug in Act 2 of “my whole body is broken but I am going to treat it one problem at a time.”

Segue to car analogy: Go put 100,000 miles on your car. Don’t change the oil, don’t fill the tires, don’t put fuel line cleaner in the gas tank, don’t maintain it all. Wait until it is smoking, shaking, coughing and stalling. Wait until every turn produces squeals of protest from the tie rods, axle, wheels and steering column. Wait until every hill cause it to wheeze, belch smoke, shudder and shake. Then and only then, go out and buy your self a brand new carburetor or exhaust, or fuel injector. In fact, you can buy any one thing, brand new and replace it. Any one thing but just one thing. Then question why your car doesn’t drive like when it was new.

Now back to the movie analogy – Act 2 of “my whole body is broken and I am going to treat it one problem at a time.” ……… Now here’s the fun part. Act 2 assessment – problem 1 (antagonist #1) is fixed via drug #1 (savior #1), problem 2 (antagonist #2) enters the scene and drug #2 (savior #2) is introduced to quell problem #2…but as in all dramas, drug #1 (savior #1) is not so pure of heart. This hero is flawed and now there is a new problem (antagonist #3) generated by the introduction of savior #1. And so on and so on. COnfusing? Depressing? You’re damn right! Now here’s the b*tch of it…this tragic movie will go on for the rest of your life.

Here’s an interesting analogy: I envision the plot as a snake eating it’s own tail. The more he eats, the less hungry he is and the less body he has to sustain…but the more he eats, the more he is using up his own body…until when he has finally eaten himself all the way from tail to head, there is nothing left to sustain but there is also nothing left of his body. If this isn’t clear, feel free to go to the chemo or radiation ward. I think the analogy will absolutely be clear as day to you then.

And please understand that I truly mean no disrespect to these docs and scientists who are calling attention to the fact that diseases, once believed to be isolated events in the body; are actually system wide organisms within an organism and through circulation, electric-neurological exchange or associative influence actually interact with every other cell in your body. These docs and scientists who through empirical western analysis are trying to draw attention to a holistic approach of treatment are lone forces crying out for change in an industry of rigidity…they are often the sole open minded wise person in a forest full of old rooted dead trees…they are working in a centuries old system that is anti-free thought, anti- radical concept and anti “anything that challenges the status quo.”

These docs and scientists who are challenging their industry thinking deserve our support. They need our help to get the word out and more importantly, we as patients have a responsibility to ourselves and our loved ones to question what else is out there, what else is involved in this problem, what other factors are contributing to my illness. So do it!

…and that’s my rant.

NEW STEM CELL FOUND IN THE BRAIN

In SCIENCE & STEM CELLS on May 26, 2010 at 3:08 am

Discovery of Stem Cell Illuminates Human Brain Evolution, Points to Therapies

ScienceDaily (May 24, 2010) — UCSF scientists have discovered a new stem cell in the developing human brain. The cell produces nerve cells that help form the neocortex — the site of higher cognitive function — and likely accounts for the dramatic expansion of the region in the lineages that lead to humans, the researchers say.

Future studies of these cells are expected to shed light on developmental diseases such as autism and schizophrenia and malformations of brain development, including microcephaly, lissencephaly and neuronal migration disorders, they say, as well as age-related illnesses, such as Alzheimer’s disease…

via Discovery of stem cell illuminates human brain evolution, points to therapies.

Power3 Medical’s Goldknopf to Give Plenary Address to the European Molecular Histopathology Symposium

In BUSINESS OF STEM CELLS on April 28, 2010 at 5:47 pm

Press Release Source: Power3 Medical Products, Inc. On Tuesday, April 27, 2010, 6:49 pm EDT

HOUSTON–(BUSINESS WIRE)–StemTroniX, Inc., a Texas corporation (“StemTroniX”), and Power3 Medical Products, Inc. (OTCBB:PWRM – News) announced today that a plenary address entitled “The Genesis of Prototype Biomarkers for Identification and Use of Stem Cells for Therapeutics of Alzheimer’s Disease” will be delivered by Ira L. Goldknopf, PhD, Power3’s President and Chief Scientific Officer, to the European Molecular Histopathology Symposium on The Impact of Personalized Medicine, April 29, 2010, in Chantilly, France, organized by Ventana Medical Systems, a member of the Roche Group.

The focus of the presentation is on the progress Power3 and StemTroniX have made towards enhanced effectiveness of Alzheimer’s disease therapy by combining StemTroniX’s patented and patent pending adult stem cell regenerative medicine technologies with Power3’s patent pending blood serum adult stem cell protein biomarkers and diagnostic technologies. StemTroniX’s technologies include a licensed patent and several patent disclosures for monitoring of stem cell therapy, technology to aid in the viability of adult stem cells, injection technology, and non-invasive imaging technology. These technologies complement Power3’s technologies for Alzheimer’s specific diagnosis, multiple forms of Alzheimer’s disease, response to Alzheimer’s drug therapy, predictive drug response, and discovery of more clinically relevant tissue, blood and adult stem cell biomarkers.

“Biomarkers for the support of autologous (a patient’s own) stem cell therapies of Alzheimer’s disease are needed to light the way to true recovery, i.e. to the restoration of the patient through repair and regeneration of the brain tissue ravaged by the disease. Nothing less is acceptable for true regenerative medicine,” said Goldknopf. “To achieve these ends, we believe it is necessary to set the bar high, so that we can find biomarkers related to the restoration of normality, not only with respect to symptoms, but also with respect to correcting the underlying and devastating pathophysiology of Alzheimer’s disease. We will demonstrate steps already taken towards this goal as well as illustrate essential requirements for the way forward.”

“In conjunction with the upcoming acquisition of StemTroniX by Power3, and recent patent filings, this presentation marks a significant step towards the joint goal of StemTroniX and Power3, to fulfill the promise of personalized medicine by providing desperately needed diagnosis and targeted therapy for Alzheimer’s disease,” said Helen R. Park, StemTroniX’s CEO.

Power3 Medical Products

Power3 Medical Products, Inc. is a leader in bio-medical research and the commercialization of biomarkers, tests, and mechanisms of disease. Power3’s patent-pending technologies are being used to develop screening and diagnostic tests for the early detection and prognosis of disease, identify protein biomarkers, and drug targets, to fulfill critical unmet needs in areas including neurodegenerative disease (NuroPro®) and breast cancer (BC-SeraPro™). Power3 operates a state-of-the-art CLIA certified laboratory in The Woodlands (Houston), Texas and continues to evolve and enhance its IP portfolio, employing sensitive and specific combinations of biomarkers blood-based tests for ALS, Alzheimer’s, and Parkinson’s diseases, breast cancer, and drug resistance.

For more information, please visit http://www.power3medical.com

StemTroniX

StemTroniX, Inc. is a medical biotechnology company that is committed to improving the lives of individuals by using autologous adult stem cell technology to repair tissue damage in patients. Autologous adult stem cell therapy is the process of using an individual’s own stem cells for the purpose of repairing and regenerating damaged tissue. StemTroniX also provides a patented system to augment this process in a non-invasive method for in-body monitoring of the stem cells at the site of injury as they are being introduced into the patients.

via Power3 Medical’s Goldknopf to Give Plenary Address to the European Molecular Histopathology Symposium – Yahoo! Finance.

AMIE,DSCO,SPDE,SCII OTC Picks Sept 14 – Stocks to Watch

In BUSINESS OF STEM CELLS on September 14, 2009 at 6:28 pm

STEM CELL THERAPY INTERNATIONAL (OTCBB: SCII | Quote | Chart | News | PowerRating) “Up 69.81% on Friday”

Detailed Quote: http://www.otcpicks.com/quotes/SCII.php

Stem Cell Therapy International, Inc., through its wholly owned subsidiary, Stem Cell Therapy International Corp., engages in licensing of stem cell technology and the sale of stem cell products, as well as the provision of information, education, and referral services. It provides allo stem cell biological solutions that are used in the treatment of patients suffering from degenerative disorders of the human body, such as Alzheimer's Disease, Parkinson's Disease, ALS, leukemia, muscular dystrophy, multiple sclerosis, arthritis, spinal cord injuries, brain injury, stroke, heart disease, liver and retinal disease, and diabetes, as well as certain types of cancer. The company's stem cell biological solutions can be used to alleviate the side effects of chemotherapy

. Its principal stem cell products are solutions containing allo stem cell biological solutions, either adult stem cells, and stem cells that are extracted from umbilical cord blood. It intends to offer biological solutions containing stem cell products primarily in the United States to universities, institutes, and privately funded laboratory facilities for research purposes and clinical trials. The company was incorporated in 2004 and is headquartered in Tampa, Florida.

via AMIE,DSCO,SPDE,SCII OTCPicks.com: AMIE, DSCO, SCII, SPDE, September 14 Stocks to Watch from OTCPicks.com.

Stem cell successes go unreported

In STEM CELLS IN THE NEWS on September 7, 2009 at 7:30 pm

“ADULT” Stem cell successes go unreported

Charlie Butts and Marty Cooper – OneNewsNow – 9/5/2009 4:10:00 AM

Medical Research – The Culture and Media Institute believes the media is biased in favor of research on human embryos, but that there is scant coverage of successful work with adult stem cells.

CMI’s Colleen Raezler says the media is playing upon emotions in its promotion of embryonic stem-cell research. “Reporter after reporter keeps touting the line that scientists believe that by turning embryonic stem cells into cells damaged by injury or disease, they can treat or even cure everything from spine cord injuries to Alzheimer’s disease to diabetes,” she notes.

She contends the media fails to mention that such research has proven nothing and has been scientifically ineffective.

Colleen Raezler”And they’re also ignoring the fact that adult stem-cell research has provided 73 different breakthroughs to help people with spinal cord injuries, with Alzheimer’s disease, with Parkinson’s, and with diabetes,” Raezler adds.

The CMI spokeswoman points out that adult stem cells can be taken from hair, skin, and fat and do not involve killing a tiny human being. Those successes, she laments, are not being reported in the media and should be.

via Stem cell successes go unreported (OneNewsNow.com).

Do Stem Cells Repair Damaged Brain Cells

In VICTORIES & SUCCESS STORIES on August 25, 2009 at 9:15 am

Someone should tell Michael J. Fox:

There is no known cure for neurodegenerative diseases such as Huntington’s, Alzheimer’s and Parkinson’s. But new hope, in the form of stem cells created from the patient’s own bone marrow, can be found ― and literally seen ― in laboratories at Tel Aviv University.

Dr. Yoram Cohen of TAU’s School of Chemistry has recently proven the viability of these innovative stem cells, called mesenchymal stem cells, using in-vivo MRI. Dr. Cohen has been able to track their progress within the brain, and initial studies indicate they can identify unhealthy or damaged tissues, migrate to them, and potentially repair or halt cell degeneration. His findings have been reported in the journal Stem Cells.

“By monitoring the motion of these cells, you get information about how viable they are, and how they can benefit the tissue,” he explains. “We have been able to prove that these stem cells travel within the brain, and only travel where they are needed. They read the chemical signalling of the tissue, which indicate areas of stress. And then they go and try to repair the situation.”…

Dr. Cohen and his team of researchers took magnetic iron oxide nanoparticles and used them to label the stem cells they tested. When injected into the brain, they could then be identified as clear black dots on an MRI picture. The stem cells were then injected into the brain of an animal that had an experimental model of Huntington’s disease. These animals suffer from a similar neuropathology as the one seen in human Huntington’s patients, and therefore serve as research tool for the disease.

On MRI, it was possible to watch the stem cells migrating towards the diseased area of the brain. “Cells that go toward a certain position that needs to be rescued are the best indirect proof that they are live and viable,” explains Dr. Cohen. “If they can migrate towards the target, they are alive and can read chemical signalling.”…

Although there is a drawback to using this particular type of stem cell ― the higher degree of difficulty involved in rendering them “neuron-like” ― the benefits are numerous. “Bone marrow-derived MSCs bypass ethical and production complications,” says Dr. Cohen, “and in the long run, the cells are less likely to be rejected because they come from the patients themselves. This means you don’t need immunosuppressant therapy.”

via http://adultstemcellawareness.wordpress.com/2009/08/24/mesenchymal-stem-cells-may-repair-damaged-brain-cells/

and http://www.news-medical.net/news/20090820/Mesenchymal-stem-cells-repair-human-brain.aspx

FREE DISEASE TREATMENT ASSESSMENT

In ALL ARTICLES, STEM CELLS IN THE NEWS on March 13, 2009 at 12:18 pm

FREE DISEASE TREATMENT ASSESSMENT

huh-red-grn-stem-cellsFor a limited time, if you comment on any of the articles on this blog, I will research the disease of your choice and show you how to find out where in the world it is being treated by stem cells!

Where are they treating…

Autism?

MS?

Heart disease?

CP?

MD?

Alzheimer’s?

Parkinson’s?

All of your questions will be answered!

Family hopes stem cell treatment in Thailand will improve daughter’s health

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on February 25, 2009 at 12:52 am
doctor-default-imageBenefit may help girl regain vision – By Hillary Gavan
Published: Monday, February 23, 2009 11:47 AM CST

Family hopes stem cell treatment in Thailand will improve daughter’s health

One Beloit mom and daughter are gearing up for the trip of a lifetime. Pamela Hottenstein is taking daughter, Cassondra Boyda, 17, to Thailand for what she hopes will be a life-changing stem cell treatment.

To help pay for the trip, friends and family are hosting a benefit starting at 2 p.m. March 14 at the Odd Fellow Lodge, 22 N. Main St., Janesville. There will be food, raffles and live music, according to organizer Barb Hansen.

Cassondra is the daughter of Pamela and James Hottenstein, a roofing supervisor at Corporate Contractors Inc. The couple has two other children – Hannah, 9, and Gracie, 2.

Cassondra was born with the underdevelopment of optic nerves and a pituitary gland as well as midline abnormalities of the brain. Her mother said doctors noticed something was different about Cassondra when she was 2 weeks old and her eyes started jerking. As she grew older, Cassondra looked young for her age and had developmental delays.

Cassondra’s condition has rendered her completely blind, hormonally insufficient and with significant cognitive and speech delays. Although Cassondra takes growth hormones and an array of other medications, there hasn’t been much doctors can do for her.

Today, Cassondra attends the Wisconsin Center for the Blind and Visually Impaired in Janesville.

She still has many challenges. Because of her hormone imbalance she often has behavior problems and can be moody. Although she can understand her family, she only has a few words she can clearly speak.

“She kind of has a language of her own,” Pamela Hottenstein said.

Pamela Hottenstein was thrilled, however, when she found out that there might be some hope for her daughter’s condition. She learned about a company which has been successful in treating children like Cassondra with umbilical cord stem calls.

The stem cells – taken from the umbilical cord of infants – are delivered through intravenous injections into the spinal cord fluid or surgical injections. Except for the surgical injections of the stem cells, the treatments are done as outpatient procedures.

Stem cells can replenish dying cells and regenerate damaged tissues. Due to the use of stem cells, some blind children have been able to have a degree of restored vision, and others with speech problems have shown verbal improvements.

Cassondra has already been accepted for treatment and will need at least six sessions. The cost of the treatments is $33,000, not including airfare or living expenses for the six- to seven-day stay in Bangkok. The family’s goal is to raise $45,000 for the trip. So far they’ve only raised about $5,000.

Because of all the strict FDA regulations, Cassondra’s mother said she won’t be able to undergo a surgery in the United States for 10 years. Even if the procedure’s approved, it may be far more costly for the treatments than in China or Thailand.

Pamela Hottenstein said her doctors at home support her decision. The mother feels that something positive will come from the treatments.

“I know and believe she will get good results,” Pamela Hottenstein said.

The benefit will be entertaining, and Pamela Hottenstein hopes it will raise money for the trip. Music will consist of a jam session, or eight hours of different musicians performing. Because Cassondra likes macaroni and cheese, there will be plenty on hand as well as barbecue. Some of the 100 raffle items include a $250 gift certificate to a furniture store, stays at various hotels and much more.

Donations can be made at any First American Credit Union, 746 Fourth St., Beloit, in care of Cassondra Boyda.

The brain´s reserve cells can be activated

In ALL ARTICLES, STEM CELLS IN THE NEWS on February 23, 2009 at 10:29 am
Calling the Cavalry

Calling the Cavalry

The brain´s reserve cells can be activated

Published on 22 February 2009, 23:38 Last Update: 8 hour(s) ago by Insciences

Tags: Biology Neuroscience Stem cells

Scientists at Karolinska Institutet have found a way of activating the neuronal reserves in the brains of mice by switching off the signal that inhibits the formation of  new nerve cells. The study is presented in the online edition of the scientific journal Nature Neuroscience.

Jonas Frisén Photo: Stefan Zimmerman

“So far, this is just basic research of no immediate practical significance, but the results are very exciting nonetheless,” says Professor Jonas Frisén at the Department of Cell and Molecular Biology, who led the study.

New nerve cells are formed from stem cells in specific areas of the human brain. This process increases after a stroke, something that might explain the recovery that is often observed in patients, particularly in the first year following the onset of illness. In the present study, the scientists have demonstrated how a type of cell that does not give rise to new cells in the healthy brain is activated after a stroke in laboratory animals.

In addition to the stem cells that are normally active, there is therefore also a kind of reserve stock of cells the can be activated when demand increases. The team have identified the molecular mechanisms that control the activation of these cells, and shown that it is possible to increase the formation of new nerve cells in healthy mice by switching off the so-called Notch signalling pathway, which inhibits the creation of new nerve cells.

journal Nature Neuroscience.

Publication

Marie Carlén, Konstantinos Meletis, Christian Göritz, Vladimer Darsalia, Emma Evergren, Kenji Tanigaki, Mario Amendola, Fanie Barnabé-Heider, Maggie S Y Yeung, Luigi Naldini, Tasuku Honjo, Zaal Kokaia, Oleg Shupliakov, Robert M Cassidy, Olle Lindvall & Jonas Frisén

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

Nature Neuroscience AOP, 22 February 2009, doi 10.1038/nn.2268

via insciences.org – The brain´s reserve cells can be activated.

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