Posts Tagged ‘ADULT’


In ALL ARTICLES on January 12, 2015 at 1:49 pm


Should stem cells be used only as a last resort? 

Two reasons why the answer is NO!

1.  Last week I saw someone with no education on stem cells stating that stem cells should be used only as a last resort.
The presentation of stem cell therapies as a last resort is tragic. Unfortunately, most people do come to me asking for information as a last resort.  They have been advised by their friends, family, medical professionals and media that they should try everything else and not try stem cells.  When all else fails and they finally approach me, “I’ve tried everything,” is a common explanation. Again, tragic. In many cases, the sooner stem cells are used, the faster patients can improve their quality of life, relieve their suffering and mediate their symptoms.
The CEO of a well known stem cell company made this analogy: “Most people renovate their homes just before selling them.  What a missed opportunity!  If they renovated them earlier they would derive years of pleasure from the renovation instead of fixing things up for the next owner.”  But what if you used stem cell therapies to improve your health and fix your body BEFORE you exhausted all other resources, money, energy, your immune system and your health?   What a concept.
2.  A new study is investigating the question: Is stem cell therapy less effective in older patients with chronic diseases?
Let’s over-simplify…
When was the last time a piece of equipment in your car failed and another one didn’t fail soon after.  This is because they are dependent upon each other for optimum efficiency.  The older the patient and the more advanced their disease, the odds are, the more there are other organs and systems being taxed beyond their capabilities.  And many people believe one pill will fix their disease but it’s far from true.  We must change the one pill for one one disease, one size fits all, magic cure belief which is rampant in the USA.  There is no evidence to support it.
Look at it another way.  Consider your body a battleground and the disease is the enemy.  The surest way to fight the enemy is to send wave after wave of soldiers (stem cells) into battle.  But many of the same issues in battle restrict maximizing the success of your therapy.  If you cut off the supply routes to the soldiers carrying food and ammunition (a weakened or restricted circulatory system), your soldiers’ ability to move to the battle will be ineffective.  If you wipe out their communications (cytokines/messenger cells), your soldiers won’t know where to go or what is needed to fight.
Time is always against us.  The longer we wait, the more our resources will be depleted and our other organs and systems will be taxed, both to support the failing areas and due to the natural deterioration associated with aging.  “Aging and chronic diseases including CVD and diabetes substantially affect stem/progenitor cells of adult organism. Such conditions could restrict the effectiveness of autologous cell therapy in aged patients with CAD, lower limb ischemia, T2DM and other chronic pathologies, although these patients are some of the most obvious candidates for cell therapy.”

Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells – http://online.liebertpub.com/doi/full/10.1089/biores.2014.0042

It is my hope that people do real research or talk to someone who has so they can make an educated decision about reclaiming their health. There is a great deal of misinformation out there and many people are trying to sabotage the real info and data getting to those whom need it most. Let’s work together to get rid of misinformation and not perpetuate the confusion which may lead to unnecessary suffering.  DON’T WAIT.





What do you get when you add 1,100 ADULT STEM CELL PATIENTS studied over 5 years,

plus another 1,873 ADULT STEM CELL PATIENTS studied over an average 12.5 years,

plus another ~7,000 ADULT STEM CELL PATIENTS in studies and FDA clinical trials data?



“A total of 1873 patients were treated from 1990 to 2006 with bone marrow-derived concentrated cells. Patients were monitored for cancer incidence from the date of the first operation (1990) until death, or until December 31, 2011. The mean follow-up time was 12.5 years (range, five to twenty-two years)…No tumor formation was found at the treatment sites on the 7306 magnetic resonance images and 52,430 radiographs among the 1873 patients…This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.

The upshot? This most recent study, as well as others, FDA clinical trials data, and the data we have published now amounts to about 10,000 patients who have been treated with adult stem cells and extensively tracked for this issue. There is no evidence that adult stem cells cause cancer. There is no rational reason for the fear, other than a completely different type of cell (ESC) that happens to have a similar name (stem cell) can cause teratomas – hence the confusion!”

Tumors, cancers and teratomas may result from Embryonic stem cell (ESC) treatments or Induced Pluripotent stem cell (iPSC) treatments






Georgia O'Keeffe

Georgia O’Keeffe

“Four women have had new vaginas grown in the laboratory and implanted by doctors in the US.

A tissue sample and a biodegradable scaffold were used to grow vaginas in the right size and shape for each woman as well as being a tissue match.

They all reported normal levels of “desire, arousal, lubrication, orgasm, satisfaction” and painless intercourse.

Experts said the study, published in the Lancet, was the latest example of the power of regenerative medicine.”

Stem Cell-based Baldness Cure One Step Closer | Beyond the Dish

In STEM CELLS IN THE NEWS on January 29, 2014 at 3:01 pm

Stem Cell-based Baldness Cure One Step Closer


January 28, 2014 – by mburatov

Scientists might be able to offer people with less that optimal amounts of hair new hope when it comes to reversing baldness. Researchers from the University of Pennsylvania say they’ve moved closer to using stem cells to treat thinning hair — at least in mice.

This group said that the use of stem cells to regenerate missing or dying hair follicles is considered a potential way to reverse hair loss. However, the technology did not exist to generate adequate numbers of hair-follicle-generating stem cells.

But new findings indicate that this may now be achievable. “This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles,” Dr. Xiaowei Xu, an associate professor of dermatology at Penn’s Perelman School of Medicine, said in a university news release.

According to Xu, those cells have many potential applications that extend to wound healing, cosmetics and hair regeneration.In their new study, Xu’s team converted induced pluripotent stem cells iPSCs – reprogrammed adult stem cells with many of the characteristics of embryonic stem cells – into epithelial stem cells. This is the first time this has been done in either mice or people.

The epithelial stem cells were mixed with certain other cells and implanted into mice. They produced the outermost layers of the skin and hair follicles that are similar to human hair follicles.

This study was published in the Jan. 28 edition of the journal Nature Communications.This suggests that these cells might eventually help regenerate hair in people.

Xu said this achievement with iPSC-derived epithelial stem cells does not mean that a treatment for baldness is around the corner. Hair follicles contain both epithelial cells and a second type of adult cells called dermal papillae.

“When a person loses hair, they lose both types of cells,” Xu said. “We have solved one major problem — the epithelial component of the hair follicle. We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet.”

Experts also note that studies conducted in animals often fail when tested in humans.

via Stem Cell-based Baldness Cure One Step Closer | Beyond the Dish.

Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report

In STEM CELLS IN THE NEWS on January 24, 2014 at 8:05 am

November 8, 2012

Vitamin C boosts the reprogramming of adult cells into stem cells 1


Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.

Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.

“The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated,” explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.

Dr. Pei and colleagues measured the production of reactive oxygen species or ROS during reprogramming and discovered a potential link between high ROS and low reprogramming efficiency. They became particularly interested in antioxidants, hypothesizing that they might suppress ROS and cell senescence, which seems to be a major roadblock for the generation of iPSCs.

The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.

“Our results highlight a simple way to improve iPSC generation and provide additional insight into the mechanistic basis of reprogramming,” concludes Dr. Pei. “It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level. It is likely that our work may stimulate further research in this area as well.”

via Vitamin C boosts the reprogramming of adult cells into stem cells « Health Research Report.

Stem Cell Transplantation in Traumatic Spinal Cord Injury

In STEM CELLS IN THE NEWS on January 23, 2014 at 5:59 pm

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies


From http://www.plosbiology.org – January 6, 7:09 AM

Spinal cord injury is an important cause of disability in young adults, and stem cells have been proposed as a possible treatment. Here we systematically assess the evidence in the scientific literature for the effectiveness of stem-cell–based therapies in animal models of spinal cord injury.

Ella Buzhor\’s insight:

The comparison between multiple allogeneic stem cell treatments revealed improved both motor and sensory function in SCI animal models. Differentiation prior to implantation and IV route of cell administration yielded better outcomes.

via Cell Therapy & Regenerative Medicine | Scoop.it.

Pluristem stem cell trial to treat muscle injury meets main goal | Reuters

In STEM CELLS IN THE NEWS on January 22, 2014 at 5:32 pm
  • cells were safe and well tolerated
  • one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group.
  • Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.
  • An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated…versus the placebo group.

Pluristem stem cell trial to treat muscle injury meets main goal

TEL AVIV Tue Jan 21, 2014 3:07am EST

(Reuters) – Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided evidence the cells might be effective in treating orthopedic injuries.

\”Patients treated with PLX-PAD had a greater improved change of maximal voluntary muscle contraction force than the placebo group,\” Israel-based Pluristem said in a statement on Tuesday.

The trial was conducted at the Orthopedic Clinic of the Charite University Medical School under the auspices of the Paul-Ehrlich-Institute, Germany\’s health authority.

\”This was a very important study not only for Pluristem but for the cell therapy industry in general,\” Pluristem chief executive Zami Aberman said. \”Based on these results, we intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma.\”

The injured muscle studied was the gluteus medius muscle in the buttock. Total hip replacement surgery via the standard transgluteal approach necessitates injury of the gluteus medius muscle, and post-operative healing is crucial for joint stability and function.

\”The study showed that PLX-PAD cells were safe and well tolerated,\” the statement said.

The primary efficacy endpoint of the study was the change in maximal voluntary isometric contraction force of the gluteal muscle six months after surgery.

Efficacy was shown in two groups treated with the cells, with one group receiving a 150 million cell dose displaying a 500 percent improvement over the placebo group. Patients treated with a 300 million cell dose showed a 300 percent improvement over the placebo.

An analysis of the gluteal muscle indicated an increase in muscle volume in those patients treated with PLX-PAD cells versus the placebo group.

via Pluristem stem cell trial to treat muscle injury meets main goal | Reuters.

MS patient to take part in pioneering experiment – CBS News

In STEM CELLS IN THE NEWS on January 21, 2014 at 1:42 pm

No mention of the words “stem cell” in the headline.  No mention of stem cells until the 6th paragraph.  Why make it so difficult for patients to find these articles? In any case, we eagerly await the results! -dg

“Stem cells can be morphed into any cell in the body. Patients like Quinn have bone marrow removed and the stem cells inside are then changed in the kind of stem cells found in the brain and spinal cord.

Those cells will then be injected directly into the spinal cord. The hope is that they will repair the insulation and perhaps even the wires underneath.”

via MS patient to take part in pioneering experiment – CBS News.



  • FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

“To my knowledge, this is the first FDA-approved stem cell trial in the United States to investigate direct injection of stem cells into the cerebrospinal fluid of MS patients, and represents an exciting advance in MS research and treatment,” said Dr. Saud A. Sadiq, Senior Research Scientist at Tisch MS Research Center of New York and the study’s principal investigator.

The groundbreaking study will investigate a regenerative strategy using stem cells harvested from the patient’s own bone marrow.  These stem cells will be injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial.  This will be an open label safety and tolerability study.  All study activities will be conducted at the Tisch MS Research Center and affiliated International Multiple Sclerosis Management Practice (IMSMP).”  via http://www.prnewswire.com/news-releases/fda-approves-stem-cell-clinical-trial-for-multiple-sclerosis-219553021.html

  • Meredith Vieira’s Family Health Battle

12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?


In VICTORIES & SUCCESS STORIES on November 17, 2013 at 9:18 am


 “i have been doing manual labor with my dads company the heart is doing well im getting in better shape every week.

im to the piont now i can carry 5 gallon buckets of concrete up hills lol, pretty cool still
in a few days it will be my 6 year anniversary and still no reversion!!”


Case Study: James Eilert, 34 years old, presents with a “widowmaker” [100 % blockage of the left ascending coronary artery]. His ejection fraction (EF – volume of blood his heart pumps out) was between 20 and 25 percent (55 is normal). His cardiologist told him he has about 5 years left to live.  James left the country in order to receive Adult Stem Cell treatment.

1 1/2 weeks after treatment – Echocardiogram revealed that his completely dead apex was beating again.

6 months after treatment – Sidewalls of heart beat normally.  Septum went from 100% damage to 30% damage. Cardiologist confirms James’ heart is 50 percent more elastic than the year before Repair Stem Cell therapy.

6 – 9 months after treatment – James’ total dead heart tissue is down to about 10%.  EF is up to 50%!

4 years later – James’ heart and health continue to improve. He continues to push himself and his limits.  He runs regularly, works 7 days a week and can bike 20 miles .


James went from Class III congestive heart failure to Class I with an ejection fraction (EF) increase from ~20-25% to his current EF of 50%.  His doctors have lifted all restrictions and limitations on his physical activities.

James is only one of many adult stem cell treatment success stories…

November 17, 2011 Update:

A letter from James.  How is he doing today?

“its amazing how fast reality can change, the differences that you see in others that they dont notice themselves. the changes in attitudes and perceptions that the “new” was never in doubt and is accepted as if it were always true. the new studies showing the truth about adult stem cell heart treatments the last few months have proven that we the few pioneers that have made huge financial sacrifices to try and save our lives were not crazy, stupid or otherwise deluded!

it was a risk and for the last four years despite proving over and over by running uphill on so many treadmills my improvments were basically ignored by cardiologists, general practitioners, and even my own wife and stepdaughters.

that i am happy to say has changed!!!!

i went to see my doctor yesterday, he told me to start heavy weight training and interval running, to help me lose weight better. what was differnet? nobody has told me to do that since my heart attack, there was no mention of taking it easy, in fact before i was told to only do light weights and take it easy, watch my heart rate, dont push past 150bpm ever.

it was like i never even had a heart attack.

i asked in disbelief if i should watch my heart rate, keep it a safe zone. the answer “no, stick to 85 to 90 percent and youll be fine, your exercise scores and echos show you can handle it”

vindication, no longer an unexplained anamoly, just a patient that responded better than average to a new treatment – like it was always true in thier minds, never a doubt.

what a feeling!! it has taken ten years to go from the “fringe” to the mainstream – i look forward to getting treatments here in america, and i’m so happy i took the risk that now ensures i will be alive to reap the benifits when it becomes available here!

have a good day david – it nice to be right once in a while!
jim eilert

Congratulations as always Jim!  On your heart recovery success and on having the courage to be a pioneer with an adult stem cell treatment that was cutting edge around the world 5 years ago and is still barely know today in the USA! – David

Stem cell scarring aids recovery from spinal cord injury

In VICTORIES & SUCCESS STORIES on November 5, 2013 at 2:45 pm

Scarring created by stem cells at the site of spinal cord injury actually assists in healing, instead of impeding it as previously thought! -dg

Stem Cell Scarring Aids Recovery from Spinal Cord Injury

Oct. 31, 2013 — In a new study, researchers at Karolinska Institutet in Sweden show that the scar tissue formed by stem cells after a spinal cord injury does not impair recovery; in fact, stem cell scarring confines the damage. The findings, which are published in the scientific journal Science, indicate that scar tissue prevents the lesion from expanding and helps injured nerve cells survive…

Stem cell scarring aids recovery from spinal cord injury.


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