DAVID GRANOVSKY

Posts Tagged ‘adult stem cells’

ANIMALS BENEFIT FROM STEM CELL TREATMENTS

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on January 16, 2013 at 9:00 am
Mikey along with owner Stephan Nadzam.

Mikey along with owner Stephan Nadzam.

Pineville vet using stem cell therapy

This past November, Mikey, a German Shepard, was dealing with “the most progressive hip dysplasia I’ve seen in 13 years,” said Dr. Michael Herman, a veterinarian who owns South Charlotte Animal Hospital in Pineville. “His X-rays were just horrific, showing bone against bone.”

Dr. Michael Herman, one of the first veterinarians in Charlotte to offer stem cell therapy for animals, used an innovative stem cell procedure to regenerate growth in Mikey’s hips and leg joints.  First, Dr. Herman extracted fat tissue from behind the shoulder area of Mikey.  Then his technician at the hospital then adds enzymes to “photo activate” the cells, which in turn accelerates the regeneration of cells. Dr. Herman then injected the regenerated cells directly into the joint areas while intravenously administering any leftover cells.

“I normally take about two tablespoons of fat from either the shoulder area of the animal or the abdomen and within that fat is five to 50 times the amount of stem cells than what we can get from bone marrow.”  Stem cells are the body’s repair cells, and they have the ability to divide and differentiate into many different types of cells based on where they are needed throughout the body.  The cells can divide and turn into tissues such as skin, fat, muscle bone, cartilage and nerve, said Dr. Herman.

“Cells at the embryonic level can differentiate cells on a much higher level, even replicating human organs.  Contrary to embryonic cells, Dr. Herman said, “There are no moral or ethical concerns in harvesting these adult cells, activating them and reintroducing them back to the animal patients in areas where healing and regeneration is needed.”

 “Regenerative medicine is really the wave of the futures for veterinarians…It’s less invasive and will be a huge part of treating patients.”

“Mikey’s owners, Stephan Nadzam, 37 and his wife, Rosa DiSimone, 44, who live near Lake Wylie, know how stem cell therapy has affected their beloved dog.  The pair rescued Mikey from a family that kept him crated nearly all day and night for four years, leaving Mikey’s legs in bad shape. He underwent stem cell therapy in 2009 performed by a New Jersey veterinarian. It provided relief for nearly four years until they noticed the dog was having trouble with stairs.”

Dr. Herman performed the procedure on Mikey in the end of November and within the first 24 hrs he was up and mobile.  Mikey’s owners noticed continued Improvement over the following days and noted that since the treatment, they have not fed Mikey any pain medication.

Saddie with owner Katie Miller

Saddie with owner Katie Miller

“Katie Miller of Cotswold is just as equally proud of her 13-year-old Labrador mix, Sadie, who suffers from osteoarthritis.  In addition to having Herman perform therapy on the dog, Sadie also received a dose of platelet-rich plasma.  Miller shared a video of Sadie walking across her kitchen the night before the treatment. The dog hobbled and limped, breathing heavily. She then shared a video of Sadie trotting outside happily after 12 days.  I truly think it’s been a miracle for her. It’s allowed cells to regenerate and cartilage to rebuild. She and our younger dog play now, and Leila can sense how much better Sadie feels. Even her eyes look happier.”

Dr Herman said, “He has had a 95 percent success rate and sees “amazing” differences in his patients on average about 45 days after procedures.

TEXAS OKs EXPERIMENTAL STEM CELL THERAPY LIMITS – questions

In STEM CELLS IN THE NEWS on April 14, 2012 at 5:08 am

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Texas OKs experimental stem cell therapy limits

Friday, April 14, 2012

Will this move by Texas lead to a faster process of FDA approval and insurance coverage? - Boonie

 

My gut says: baby steps. They need to define the IRB process and make sure all the pieces of the machine work well. There are many factors which will unfold now.

Will other states fall after Texas like for medical marijuana?

Will Texas stand alone and all US stem cell companies open clinics there?

Will patients go to a clinic in Texas regulated by an IRB with zero experience over a treatment center outside the US with thousands of successes?

Can the FDA approval process be changed from clinical trial to produce drugs INTO a process oriented hybrid?

Will insurance cover it…ie will the American people, many whom think all stem cells are embryonic still so all stem cells = murder, many whom don’t know about the thousands of trials and tens of thousands patients treated, want to ‘foot the bill’ for these Texas treatments?

Many many questions.

Rome. Built. Not one day.

Baby steps…but a step in the right direction.

 

Related articles:

TEXAS OKs EXPERIMENTAL STEM CELL THERAPY LIMITS – explained

In STEM CELLS IN THE NEWS on April 14, 2012 at 3:44 am

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Texas OKs experimental stem cell therapy limits

Friday, April 14, 2012

What this means:

1. This is not blind distribution of medicine with no control. The legislature demands full transparency & disclosure (not available to patients in clinical trials). In trials, patients have no idea what they are getting if anything! There is no patient, only guinea pigs.

2. There is oversight control by an Institutional Review Board. There will not be rampant, unchecked treatments or “growth motivated by cash only.”

Standard FDA clinical trials regulate only how DRUGS are brought to market. Adult stem cell therapies are not drugs, they are a procedure, a process, a protocol & must be treated differently in the courts & in practice like PRPs (which are legal. 2x standard?). It was way past time to end the idea: ‘the result of all medical intervention is a prescription drug.’ “Give a small boy a hammer, & he will find that everything he encounters needs pounding,” Texas is unburdened from the yoke of those blinded by a faith in a system that demands the mandatory adherence to “one size fits all,” “one size fits drugs,” “drugs fit all.”

Adult stem cells have a proven record of safety & efficacy in studies & trials around the world – thousands of them. American medical professionals are so Ameri-centric, they throw away or ignore anything conducted outside the USA…when our health system is ranked 37th in the world. This arrogance is suspect. “We’re 7th in literacy, 27th in math, 22nd in science, 49th in life expectancy,178 in infant mortality…” and the US throws away other country’s clinical trials & studies?  Perhaps we should throw away our entire medical system & start from scratch or at least start taking pointers from some other countries on how to improve our health care/medical system…countries who apparently do a better job at it than we do like ranked 27th to 36th: United  Arab  Emirates, Israel, Morocco, Canada, Finland, Australia, Chile, Denmark, Dominica and Costa Rica.

With our CLINICAL TRIAL system, a human patient is used as a Guinea pig & sacrificed for the patient of tomorrow, blindly & randomly given medications or not, given placebos or not or given nothing.  They are Guinea pigs by definition. There is no patient, there is no empowerment, there are no rights, there is no agenda for healing. The health of one patient is sacrificed today for the health of patients of tomorrow whom apparently have more value. Categorization of any human patient as dispensable, even in order to generate data for a drug treatment to be sold to a different patient tomorrow, is reprehensible.  Clinical trials = no agenda for healing today.

With ADULT STEM CELL TREATMENTS, a human is given a therapy today intended to heal that person today. That person. Their health, their survival, that patient is of paramount importance. Their life has value, today. Adult stem cell treatments are simply, a treatment today, paid for today, for a human today to heal today, live today and into tomorrow.

I guess you can be a Guinea Pig for future patients tomorrow or you can be an empowered patient for yourself today.  All this legislature does, is give you the choice. In the end, our choices are all we ever have.

Related articles:

WHY IS THE USA SO DAMN BEHIND? HAVE A HEART

In STEM CELLS IN THE NEWS on April 12, 2012 at 1:31 pm

My buddy David S. is raising funds for stem cell treatment for his heart.  He is a gentleman, a poet, a musician and he always seems to get right to the meat of the subject.  David asks:

What was the method used to develop [adult stem cell] therapies all over the world in other countries? Clinical trials?

————————————————–

Excellent question!

Short answer: American medical professionals are so Ameri-centric, they throw away or ignore anything (studies, trials, etc) conducted outside the USA.

I remember a few years ago, an acquaintance of mine who was pre-med sneered at my mention of any trials conducted outside the US and then sneered at the very thought of adult stem cells doing anything.  Well, I guess I’m laughing last but I brought up the point then that his arrogance was somewhat confusing to me since the USA health system is ranked 37th in the world by the World Health Organization.  What the hell was he so proud of??

HERE’S WHAT HAPPENED…

in 2005 the first stem cell treatment facility was created in Thailand where the environment was favorable (the king’s cardio thoracic surgeon was a fan of stem cells for heart disease) and theIr methods were based on half a decade of human research preceded by years and years of animal research. I present a short list of the ‘ignored’ studies below.  Read through and you will realize:

a. by the time these studies were published, everyone in the scientifically community new the results for a year or years and

b. by the time the Bangkok facility was created, Prof Doris Taylor was already creating hearts with stem cells from scratch

c. these studies and trials, when conducted outside the US, have been all but ignored and then repeated in the US. The inevitable successful trial results 6-8 years later in the US are always accompanied by an incorrect, ignorant and infuriating news article crying: “first ever in the world!”

d.  in addition to the studies/trials below, there were also hundreds or thousands of other studies showing the safety and efficacy of adult stem cell treatments in animals and humans in other organs/parts of the body.

[While, 'it worked there, so it will work here' is not an accepted scientific method, at some point there is an increase in confidence when you realize: adult stem cells are in the body to repair, that's what they do, they are safe, they fix stuff, now let's figure out how to maximize there effects.]

For more information: https://repairstemcell.wordpress.com/heart-disease-treatment/

HEART DISEASE CLINICAL STUDIES – A BRIEF HISTORY

2002

A clinical trial led by Dr. Hans Dohmann plus six colleagues in Brazil took 21 transplant candidates and gave 14 of them bone marrow cells. The results were so spectacular that the American Heart Association accepted the paper and it was presented in 2003. Five of the seven in the control group opted in to make a total of 19 stem cell transplants. The mortality rate for transplant candidates is about 35% per year. At that rate there would be, of those 19, only 2.2 patients still alive without a transplant after five years. There were, in fact, 12 alive as of Dec. 31, 2007; more than five years down the road.

If you did not want or could not get a heart transplant (as is true of 90%+ of dying heart patients in North America) then you had to make a choice between stem cell treatment or standard Western Cardiology methodology.

Western Cardiology methodology kept 12% of patients (waiting for heart transplants) alive for five years.

Adult/repair Stem cell treatments kept 63% of patients (waiting for heart transplants) alive for five years. More than 5 times more heart transplant candidates lived for 5 years with stem cell treatments than the typical heart transplant recipient! Btw, stem cell science has made huge advancements in treating heart disease over the past seven years.

2003

Dr. Andreas Zeiher of the Goethe Institute in Frankfurt began much larger trials. As of 2007, he has overseen more ASC implants into hearts than anyone, both in and out of clinical trials and he was the first to prove that timely implant of RSC in new heart attack victims improves future mortality and morbidity – http://circ.ahajournals.org/cgi/search?journalcode=circulationaha&fulltext=zeiher

2004

Dr. Amit Patel of Pittsburgh completed two of the most successful trials ever. In Uruguay, he proved, on a group of ischemic heart failure patients, that a bypass plus cells was infinitely better than a bypass only. That same year, TheraVitae, in Israel, developed a new, powerful blood-derived stem cell and dared to treat the sickest patients no clinical trial (except Brazil) would consider.

One of the Brazilians, Dr. Perin, came to Texas, used the Brazil results to get the first ASC heart clinical trial approved by the FDA. Over a dozen such approvals were granted in the next 12-18 months.

The first-ever commercial stem cell treatment center in the world starts adult stem cell treatment of hundreds of human patients. Results are amazing and include the regrowing of cardiac muscle tissue in patients, significant increases and sometimes a doubling of ejection fractions (the % volume of blood the heart can pump out per beat), etc! Stem cells are also recognized as “smart,” going to where they were needed most, creating micro-vessel bypasses around existing blockages areas, areas that previously were blocked and in areas where stents were implanted.

2005

Dr Taylor removed all cells from rat hearts except for a thin skeleton of tissue translucent as wax paper. She then injected the scaffold with fresh Cardiac Repair Stem Cells from newborn rats. Four days later, “We could see these little areas that were beginning to beat. By eight days, we could see the whole heart beating.” The experiment, reported in the journal Nature Medicine, marked the first time scientists created a functioning heart in the lab from biological tissue.

ADULT STEM CELLS vs. HEART DISEASE – UNDENIABLE SCIENTIFIC EVIDENCE

HEART DISEASE TRIAL – 2004 to 2006 –

Clinical trial illustrates the safety and efficacy of VesCell Adult Stem Cell treatment. Accepted by the American Heart Assn in 2005-6. This trial was a key element in attaining regulatory approval for the treatment protocol that improved the lives of 300 mostly “no-option” heart patients.

BRITISH JOURNAL OF HAEMOTOLOGY – 2006

Research paper shows that peripheral blood derived stem cells can differentiate into a variety of other stem cells (angiogenic, myocardial and neural lineages) and do so in sufficient quantities to use as autologous treatment for a variety of diseases.

ANGIOGENIC CELL CLINICAL STUDY – 106 CASES – 2005 to 2008

Clinical study at Chao Phya Hospital Heart Center and Siriraj Hospital H.M. Cardiac Center clinical study shows that transcoronary injection of angiogenic cells precursors improved cardiac/left ventricular ejection fraction (LVEF), exercise capacity and quality of life with high safety profile for 70% of ischemic cardiomyopathy patients with no-option revascularization.

CARDIOMYOPATHY TRIAL – 55 CASES – 2005 to 2006

Bangkok Heart Hospital and U of Pittsburgh Medical Center/McGowan Institute for Regenerative Medicine clinical trial shows that expanded autologous blood derived stem cells utilized in intramyocardial transplantation is feasible and safe in severely ill patients with intractable heart failure in all cases of dilated cardiomyopathy (DCM) and in both first-time and “redo” ischemic cardiomyopathy (ICM) patients.

PERIPHERAL ARTERY DISEASE – SCIENTIFIC PAPER – 6 CASES

Shows the safety, and feasibility and enhancement of limb salvage from implantation of non-mobilized peripheral blood angiogenic cell precursors (NMPB-ACPs) in 80% of patients with critical limb ischemia (CLI) who were poor candidates for standard revascularization treatment options.

BIOPROCESSING JOURNAL – 2007

Bioprocessing Journal scientific paper shows the consistent and reliable manufacturing procedure utilized for transforming bone marrow and blood-derived stem cells into angiogenic cell precursors (ACPs) and hematopoietic stem cell (HSC) cellular products for the treatment of severe heart diseases. End product was found to be a) safe and effective; b) prepared from non-mobilized peripheral blood; c) stable, with a relatively long shelf-life; and d) ready-to-use and easily utilized by the physician.

Spinal Cord Injury and Adult Stem Cell Treatments

In VICTORIES & SUCCESS STORIES on February 7, 2011 at 11:42 pm

Recently, two New Zealand “experts” in the field of spinal cord injuries weighed in on stem cell treatments.  One of them,  Dr Richard Acland, Christchurch’s Burwood Hospital director of the spinal injuries unit, told TV ONE’s Breakfast today that he has concerns about stem cell treatments and their ability to help SCI patents recover.  The other, “Spinal Cord Society president Noela Vallis said the procedure has been carried out overseas on well over 100 people with few negative side-effects and varying degrees of improvement for each patient.”  via

Well done Noela!  It is obvious to me that you are familiar with and have based your optimism on these articles…and it is further obvious that Dr Acland has never seen any of them:

SPINAL CORD INJURY vs ASC HISTORY OF TREATMENT – http://bit.ly/SCI-STEMCELLS

REGENERATING THE CENTRAL NERVOUS SYSTEM  https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6…-C7 injury
https://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

Paraplegic – Adult Stem Cell Success Stories – Laura Dominguez
https://repairstemcell.wordpress.com/2010/05/05/paraplegic-adult-stem-cell-success-stories-laura-dominguez/

PARALYZED COUSINS PLEASED WITH STEM CELL TREATMENT
https://repairstemcell.wordpress.com/2010/02/15/paralyzed-cousins-pleased-with-stem-cell-treatment/

Successful Stem Cell Treatment of Spinal Cord Injury in Dogs
https://repairstemcell.wordpress.com/2010/02/08/successful-stem-cell-treatment-of-spinal-cord-injury-in-dogs/

Spinal Cord Injury Patient Wins…and Loses
https://repairstemcell.wordpress.com/2010/02/08/spinal-cord-injury-patient-wins-and-loses/

STEM CELLS FOR SPINAL CORD INJURY
https://repairstemcell.wordpress.com/2009/12/31/stem-cells-for-spinal-cord-injury/

Adult Stem Cell Grafts Help Paralyzed Heal
https://repairstemcell.wordpress.com/2009/10/21/adult-stem-cell-grafts-help-paralyzed-heal/

Medical hope as paralysed dog cured by stem cell therapy – mirror.co.ukhttps://repairstemcell.wordpress.com/2009/10/08/medical-hope-as-paralysed-dog-cured-by-stem-cell-therapy-mirror-co-uk/

Major the Roseville police dog gets stem cell treatment - http://blogs.citypages.com/blotter/2011/01/major_police_dog_stem_cell.php

Or email me at dsgrano@gmail.com

Vatican to finance adult stem cell research

In STEM CELLS IN THE NEWS on April 26, 2010 at 1:31 pm

Cardinal Renato Martino gestures during a meeting at Rome’s National Institute of Health, Friday, April 23, 2010. The Vatican is pushing for research of adult stem cells as an alternative to the use of embryonic stem cells, which the Catholic Church opposes because it maintains that the destruction of the embryo amounts to the killing of human life. (AP Photo/Pier Paolo Cito)

By ALESSANDRA RIZZO | Posted: Friday, April 23, 2010 4:43 pm | buy this photo

The Vatican is pushing for research of adult stem cells as an alternative to the use of embryonic stem cells, which the Catholic Church opposes because it maintains that the destruction of the embryo amounts to the killing of human life.

On Friday, the Catholic Church threw its support and resources behind the study of intestinal adult stem cells by a group of experts led by the University of Maryland School of Medicine. The group wants to explore the potential use of those cells in the treatment of intestinal and possibly other diseases, and is seeking an initial euro2 million ($2.7 million) to get the project going, officials said.

“This research protects life,” Cardinal Renato Martino said during a meeting with Italian and American scientists and health officials to outline the project. “I want to stress that it doesn’t involve embryonic stem cells, where one helps oneself and then throws the embryo away and kills a human life.”

The church is opposed to embryonic stem cell research because it involves the destruction of embryos, but it supports the use of adult stem cells, which are found in the bodies of all humans…

Still, adult stem cells could be easier to use if they are taken from patients themselves, because the replacement tissue would have less chance of being rejected.

Martino, a powerful cardinal and retired head of the Pontifical Council for Justice and Peace, told The Associated Press after the meeting that he had “no doubt” that the Vatican would help finance the project through its Rome hospital, Bambin Gesu, and other funding. The exact amount and modalities will be worked out in future meetings with the University of Maryland and other scientists involved in the project.

http://mrhiggins.net/algebra2/wp-content/uploads/2008/04/vatican.jpg

In 2007, Pope Benedict XVI said the Catholic Church can encourage somatic stem cell research _ also known as adult stem cell research _ “because of the favorable results obtained through these alternative methods,” and more importantly because it respects “the life of the human being at every stage of his or her existence.”

During a meeting with President Barack Obama last year at the Vatican, Benedict underscored his beliefs about stem cells by giving the U.S. leader a copy of a Vatican document on bioethics that hardened the church’s opposition to using embryos for stem cell research, cloning and in-vitro fertilization.

Obama has lifted restrictions, imposed by his predecessor President George W. Bush, on federal funding of research using human embryonic stem cells.

The Vatican has drawn criticism for its opposition to embryonic stem cell research. But it insists there are scientifically viable alternatives and that the efforts of the scientific community should go in that direction.

Supporting this university project is part of those efforts.

“Ethically, the rules the Catholic Church promotes are really very simple: That all research be respectful of human life,” said Father Bob Gahl, an American professor of Moral Philosophy at the Pontifical University of the Holy Cross. “Nobody should be killed in the process of doing medical research. So this new project falls exactly within the Catholic Church’s ethical guidelines.”

Dr. George Daley, a stem cell expert at Children’s Hospital in Boston and past president of the International Society for Stem Cell Research, said both adult and embryonic stem cells may prove useful for treating different diseases.

“I applaud the Vatican for being interested in supporting biomedical research,” Daley said Friday, “but I can’t help but think there’s an agenda.”

He called intestinal stem cells “a very exciting area of basic research” but said therapeutic uses are only speculative at this point.

Researchers involved in the Vatican-backed project are convinced that intestinal stem cells _ a relatively new field _hold promise and want to assess their potential for therapeutic use.http://aftermathnews.files.wordpress.com/2009/07/pope_obama_jul_10_09_1.jpg

“We want to harvest them, we want to isolate them, we want to make them grow outside our body,” and transform them into cells of any kind, said Alessio Fasano, the scientist leading the project and the director of the University of Maryland’s Center for Celiac Research.

“If we reach that phase, if we are able to achieve that goal, then our next step is to eventually move to clinical application,” Fasano told the AP before Friday’s announcement.

Intestinal stem cells have certain features that make them appealing for this kind of research, Fasano said.

They are very active cells _ the intestine replenishes all its cells every few days _ and they are intrinsically flexible _ already programmed to generate all the various kinds of cells such as mucus cells or epithelial cells present in the highly complex organ. Furthermore, harvesting them can be done through a routine medical procedure, Fasano noted.

Fasano said his team hopes to decide about the feasibility of the project within the next two to three years. He said the network of experts, expected to be around 40 people, would work at their respective facilities, sharing information and the workload to speed up the process.

___

AP Medical Writer Maria Cheng in London and AP Science Writer Malcolm Ritter in New York contributed to this report.

Eds: CORRECTS to say meeting between pope and Obama took place at the Vatican in graf 10.

via Vatican to finance adult stem cell research.

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