DAVID GRANOVSKY

Posts Tagged ‘Adipose tissue’

Stem Cells from Human Adipose Tissue Used to Chase Migrating Cancer Cells

In ALL ARTICLES, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on March 15, 2013 at 11:21 am
Stemness of primary AMSC lines demonstrated with differentiation along three mesenchymal lineages, Adipocyte (a, d [48], g), Osteocyte (b [48], e, h), and Chondrocyte (c [48], f, i), documented via lineage specific staining with Oil Red O, Alizarin Red, and Collagen II, respectively. (Credit: Pendleton et al. Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas. PLoS ONE, 2013; 8 (3): e58198 DOI: 10.1371/journal.pone.0058198)
Using Fat to Fight Brain Cancer: Stem Cells from Human Adipose Tissue Used to Chase Migrating Cancer Cells

Mar. 12, 2013 — In laboratory studies, Johns Hopkins researchers say they have found that stem cells from a patient’s own fat may have the potential to deliver new treatments directly into the brain after the surgical removal of a glioblastoma, the most common and aggressive form of brain tumor.


The investigators say so-called mesenchymal stem cells (MSCs) have an unexplained ability to seek out damaged cells, such as those involved in cancer, and may provide clinicians a new tool for accessing difficult-to-reach parts of the brain where cancer cells can hide and proliferate anew. The researchers say harvesting MSCs from fat is less invasive and less expensive than getting them from bone marrow, a more commonly studied method.

Advertisements

ADULT STEM CELL POTENTIAL IN REGENERATIVE MEDICINE

In STEM CELLS IN THE NEWS on November 14, 2012 at 7:57 pm

Adipose tissue embolus  Case 104

 

By expanding the use of adipose tissue and its stem cell components, scientist and surgeons have made significant strides in aesthetic and reconstructive surgery. “The opportunities for regenerative medicine interventions based on adult stem cells are tremendous…” – Ivona Percec, MD, PhD

 

As researchers work on reconfiguring cells to take on new regenerative properties, a new review from Penn Medicine plastic surgeons sheds additional light on the potential power of adipose-derived stem cells – or adult stem cells harvested from fatty tissue – in reconstructive and regenerative medicine.

Fat-derived stem cells hold potential for regenerative medicine November 9, 2012 in Surgery (Medical Xpress)—As researchers work on reconfiguring cells to take on new regenerative properties, a new review from Penn Medicine plastic surgeons sheds additional light on the potential power of adipose-derived stem cells – or adult stem cells harvested from fatty tissue – in reconstructive and regenerative medicine.

 

Reconstructive plastic surgeons have clinically integrated “fat grafting” into different surgeries for years, for breast, facial, and other reconstructive and restorative surgeries, with good success. Now, researchers are beginning to understand the power that fatty tissue holds. This new paper, published in the Aesthetic Surgery Journal, enforces that adipose-derived stem cells can be routinely isolated from patients, and once molecular methods are worked out, may be useful for a multitude of regenerative medicine applications. “The opportunities for regenerative medicine interventions based on adult stem cells are tremendous. It is critically important for us to better understand the biology of these cells so that we can develop novel, safe and effective treatments for our patients using their own cells.” said the paper’s senior author, Ivona Percec, MD, PhD, assistant professor in the division of Plastic Surgery in the Perelman School of Medicine at the University of Pennsylvania.

 

Many groups are looking into different modes of isolating and modifying these cells for their regenerative properties, including experts at Penn’s Institute for Regenerative Medicine and around Penn Medicine. For example, Dr. Percec’s team is conducting translational research into the mechanisms controlling adipose-derived stem cells, and how they contribute to the normal human aging process. Stem cells can undergo multiple divisions without differentiation, making them useful tools for cell-replacement therapy. Embryonic stem cells can convert to any cell type, whereas adult stem cells, like the stem cells derived from fat, can differentiate into many, but not all, cell types. A person’s own fat tissue could then potentially be converted into cells specially designed to repair damage to the heart, cartilage, blood vessels, brain, muscle, or bone. As regenerative medicine techniques are refined, experts will continue to explore the utility and benefits of stem cells derived from adipose tissue.

 

Fat Grafting’s Past, Present and Future:  Why Adipose Tissue Is Emerging as a Critical Link to the Advancement of Regenerative Medicine  –  Ivona Percec, MD, PhD

medicalexpress.com

%d bloggers like this: