DAVID GRANOVSKY

FRIEDREICH’S ATAXIA

STEM CELLS FOR FRIEDREICH’S ATAXIA:

PROOF OF CONCEPT

 
Human Adipose Stem Cell–Conditioned Medium Increases Survival of Friedreich’s Ataxia Cells Submitted to Oxidative Stress

http://online.liebertpub.com/doi/abs/10.1089/scd.2012.0029

 

Stem Cells from Wildtype and Friedreich’s Ataxia Mice Present Similar Neuroprotective Properties in Dorsal Root Ganglia Cells

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062807

Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia

http://www.sciencedirect.com/science/article/pii/S0969996110002251

Stem cell Research in Friedreich Ataxia

http://www.ataxia.org/events/2012-Presentations/Saturday/Puccio_2012.pdf

 

 

 

Additional references:
Caplan AI and JE Dennis. (2006). Mesenchymal stem cells as

trophic mediators. J Cell Biochem 98:1076–1084.

 

11. Rodrigues-Hell RC, MM Silva-Costa, A Miranda-Goes and

ALR Oliveira. (2009). Local injection of BDNF producing

mesenchymal stem cells increases neuronal survival and

synaptic stability following ventral root avulsion. Neurobiol

Dis 33:290–300.

 

12. Constantin G, S Marconi, B Rossi, S Angiari, L Calderan, E

Anghileri, B Gini, SD Bach, M Martinello, et al. (2009).

Adipose-derived mesenchymal stem cells ameliorate chronic

experimental autoimmune encephalomyelitis. Stem Cells

27:2624–2635.

 

13. Brazelton TR, FM Rossi, GI Keshet and HM Blau. (2000).

From marrow to brain: expression of neuronal phenotypes

in adult mice. Science 290:1775–1779.

 

14. Bonilla S, A Silva, L Valdes, E Geijo, JM Garcıa-Verdugo and

S Martınez. (2005). Functional neural stem cells derived from

adult bone marrow. Neuroscience 133:85–95.

 

15. Rivera FJ, S Couillard-Despres, X Pedre, S Ploetz, M Caioni,

C Lois, U Bogdahn and L Aigner. (2006). Mesenchymal stem

cell instruct oligodendrogenic fate decision on adult neural

stem cells. Stem Cells 24:2209–2219.

 

16. Wang Y, W Tu, Y Lou, A Xie, X Lai, F Guo and Z Deng.

(2009). Mesenchymal stem cells regulate the proliferation

and differentiation of neural stem cells through Notch sig-

naling. Cell Biol Int 33:1173–1179.

 

17. Cabanes C, S Bonilla, L Tabares and S Martınez. (2007).

Neuroprotective effect of adult hematopoietic stem cells in a

mouse model of motoneuron degeneration. Neurobiol Dis

26:408–418.

 

18. Pastor D, MC Viso-Leon, J Jones, J Jaramillo-Merchan, JJ

Toledo-Aral, JM Moraleda and S Martinez. (2011). Com-

parative effects between bone marrow and mesenchymal

stem cell transplantation in gdnf expression and motor

function recovery in a motorneuron degenerative mouse

model. Stem Cell Rev 8:445–458.

 

19. Jones J, J Jaramillo-Merchan, C Bueno, D Pastor, MC Viso-

Leon and S Martınez. (2010). Mesenchymal stem cells rescue

Purkinje cells and improve motor functions in a mouse

model of cerebellar ataxia. Neurobiol Dis 40:415–423.

 

20. Kern S, H Eichler, J Stoeve, H Kluter and K Bieback. (2006).

Comparative analysis of mesenchymal stem cells from bone

marrow, umbilical cord blood, or adipose tissue. Stem Cells

24:1294–1301.

 

21. Palomo GM, T Cerrato, R Gargini and J Diaz-Nido. (2011).

Silencing of frataxin gene expression triggers p53-dependent

apoptosis in human neuron-like cells. Hum Mol Genet

20:2807–2822.

 

22. Huang CY, D Pelaez, J Dominguez-Bendala, F Garcia-Godoy

and HS Cheung. (2009). Plasticity of stem cells derived from

adult periodontal ligament. Regen Med 4:809–821.

 

27. Coura GS, RC Garcez, CB de Aguiar, M Alvarez-Silva, RS

Magini and AG Trentin. (2008). Human periodontal ligament:

a niche of neural crest stem cells. J Periodontal Res 43:531–536.

 

29. Kemp K, E Mallam, K Hares, J Witherick, N Scolding and A

Wilkins. (2011). Mesenchymal stem cells restore frataxin

expression and increase hydrogen peroxide scavenging en-

zymes in Friedreich ataxia fibroblasts. PLOS One 6:e26098.

 

30. Lopatina T, N Kalinina, M Karagyaur, D Stambolsky, K

Rubina, A Revishin, G Pavlova, Y Parfyonova and V Tka-

chuk. (2011). Adipose-derived stem cells stimulate regener-

ation of peripheral nerves: BDNF secreted by these cells

promotes nerve healing and axon growth de novo. PLOS One

6:e17899.

 

31. Tan B, Z Luan, X Wei, Y He, G Wei, BH Johnstone, M Farlow

and Y Du. (2011). AMP-activated kinase mediates adipose

stem cell-stimulated neuritogenesis of PC12 cells. Neu-

roscience 181:40–47

 

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