Archive for the ‘SCIENCE & STEM CELLS’ Category




In the next step of what may become the most monumental piece of medical legislature,


HB 810 will be effective on 9/1/17  

I express virtually no surprise what so ever that there has been no media coverage of this.*  The only piece of confirming data I can find is on the Texas Legislature site and in articles written by the tireless and noble Patient Warriors, around the world, who have been fighting for their lives and for this for years.


[original article below]
Around the world, stem cells have been used for therapeutic application for decades, treating incurable illnesses, recovering terminal patients and improving qualities of life of untold numbers.  In some form or another, Rafael Nadal got them…along with Peyton Manning, Jarvis Greene, Kobe Bryant and Dana White and hundreds or thousands of other athletes and weekend warriors but mostly outside the US because they weren’t available here.
Sadly, we in the US were…a little slow…to get the message. Foolishly allowing ourselves to get embroiled in the distracting political, financial and religious controversies; we have not been allowed to treat our sick and dying. Tragically, listening to the uninformed who said: “they are unproven!” despite thousands of studies and trials from around the world, the US stuck to our guns and enjoyed some of the worst medical care in the world.  I wrote this in 2010:
“We are in fact about 8 years behind most of the developed world in stem cell research. The WHO ranks our health system at 37th, our life expectancy is 30th in the world, infant mortality is 34th in the world and this is all with our Health Expenditures as a % of GDP being almost the highest in the world (we are ranked #2).”
Like many before and after him, Gov Perry made some in roads in 2012 but hit the wall of American “backward thinking.” https://repairstemcell.wordpress.com/2012/04/14/texas-oks-experimental-stem-cell-therapy-limits-questions/
Now, Texas, House Bill 810 amended the bill which was “relating to the provision of certain investigational stem cell treatments to patients with certain severe chronic diseases or terminal illnesses and regulating the possession, use, and transfer of adult stem cells; creating a criminal offense,” and passed the Senate, unanimously.
This is the bill now:

The bill is on its way to the Governor’s office for signature. This has been a LONG time coming.

A hearty congratulations goes out especially to the tireless patient advocates/patient warriors who said: “no more!” and threw off the yoke of servitude to a medical system which no longer served their self-interests. Their efforts and those of many, many others have inexorably, infinitesimally, pushed the needle over time against multiple immovable objects.

What happens next?  There will be chaos, turmoil and scrambling.  There will be resistance and bad mouthing and nay saying…and in the end, Texas industry will likely generate billions in revenue, treat the un-treatable, recover the unrecoverable, extend the lives of those told to get their affairs in order and become THE center of regenerative medical innovation in the US, if not, the world.



I now see that there was media coverage; we just apparently beat them all to the punch.  I am more than pleased that this advance is getting mass media coverage!

Stem Cell Therapy Becomes Law in Texas – Hawaii News Now … 2 hours ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

Health Care – FOX5 Vegas – KVVU  17 mins ago – House Bill (HB 810) on stem cell therapy has passed in the Texas state legislature and become law. Patients in Texas will now have access to this “Right to Try” …

Health Care – WDRB 41 Louisville News  36 mins ago – House Bill (HB 810) on stem cell therapy has passed in the Texas state legislature and become law. Patients in Texas will now have access to this “Right to Try” …

Stem Cell Therapy Becomes Law in Texas – WorldNews  3 hours ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

– TiGenix Launches Global Phase III Trial for Cx601 (EN – NL – ES …45 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

TiGenix announces final equity payment for cardiac platform …  41 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

Hope for Gabe Foundation Races Across America to Bring Awareness …   50 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …


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Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death. It is also called rebirth or transmigration, and is a part of the Saṃsāra doctrine of cyclic existence.”
“In Greek mythology, a phoenix is a long-lived bird that is cyclically regenerated or reborn. Associated with the Sun, a phoenix obtains new life by arising from the ashes of its predecessor.”
“The resurrection of Jesus is the Christian religious belief that, after being put to death, Jesus rose again from the dead. It is the central tenet of Christian theology and part of the Nicene Creed: “On the third day he rose again in accordance with the Scriptures”.

“Frankenstein; or, The Modern Prometheus is a novel written by English author Mary Shelley that tells the story of Victor Frankenstein, a young scientist who creates a grotesque but sapient creature in an unorthodox scientific experiment.”Frankenstein's_monster_(Boris_Karloff).jpg

Humanity has always been fascinated by resurrection – bringing the dead back to life.  The references are plentiful and many will cry out that science should not mess with the great barrier of death for it is absolute and divine and we should not mess with nature.  But, are life and death truly black and white?

Perhaps not.  The “Lazarus syndrome, also known as autoresuscitation after failed cardiopulmonary resuscitation, is the spontaneous return of circulation after failed attempts at resuscitation. Its occurrence has been noted in medical literature at least 38 times since 1982.”

Are there shades of gray between the absolute states of life and death?
Miracle Max: It just so happens that your friend here is only MOSTLY dead. There’s a big difference between mostly dead and all dead. Mostly dead is slightly alive. With all dead, well, with all dead there’s usually only one thing you can do.
Inigo Montoya: What’s that?
Miracle Max: Go through his clothes and look for loose change.
Perhaps Benjamin Franklin was only half right: “…in this world nothing can be said to be certain, except death and taxes

Death, it seems is not as final as we once thought.  But, can it be done?  Scientists have been given the green light to try:
“By implanting stem cells in the patient’s brain…they hope to reboot the brain and jump-start neural activity. The result could be people coming back to life.”

On a serious note 

The above pics and quips aside…
this work is monumental and can have huge ramifications to the treatments of chronic and terminal disease, brain disorders and more.  Many people would like to classify AGING as a disease which we need to study, treat and conquer and scientists around the world are making great strides in their efforts.  Maybe one day soon we will also classify DEATH as a disease which we need to study, treat and conquer.  Let’s keep an open mind and support the discovery of new methods for treating disease. 



In ALL ARTICLES, genetic, HEALTH AND WELLNESS, SCIENCE & STEM CELLS on March 5, 2017 at 1:40 pm
“The folding mechanism of DNA is believed to play a large role in how genes are read by the rest of the cell…The results confirm that this second layer of information exists. This led them to conclude that genetic mutations are not just caused by a change in the sequence of codes but also by a change in the way the strands are folded


EVERY time I have a conversation with someone who is 100% sure, I laugh inside and remember that everything we know for sure will be disproved within our lifetimes.

Medical science was 100% sure:
the heart doesn’t regenerate…wrong
the brain and central nervous system doesn’t regenerate…wrong
all of the ligaments have been found…wrong
butter is healthier, margarine is healthier, butter, margarine…wrong
stem cells don’t work…wrong
cholesterol is bad…wrong
our DNA doesn’t change and is absolute…wrong
and now…
Physicists Confirm There’s a Second Layer of Information Hidden in Our DNA
IN BRIEF: Theoretical physicists have confirmed that it’s not just the information coded in our DNA that shapes who we are—it’s also the way DNA folds itself that controls which genes are expressed inside our bodies.
 This changes everything.

We all learned in high school how Watson and Crick pieced together the findings of many scientists to come up with a model of deoxyribonucleic acid (DNA). Information in DNA is stored as code sequences made up of nitrogenous bases. Each cell has the same sequence of codes but executes a different function. Code sequences determine the type of protein to be produced in a certain cell, but it is hypothesized that the mechanical properties of the DNA acts as a second layer of information.

Each cell in our body contains around 2 meters of DNA. But since our cells are so tiny, DNA strands have to be tightly wrapped into bundles called nucleosomes in order to fit.

Learn more about DNA and nucleosomes in the video below:

The folding mechanism of DNA is believed to play a large role in how genes are read by the rest of the cell. Biologists have started to isolate mechanical cues that determine how DNA is folded. Now, theoretical physicists from Leiden University in the Netherlands confirmed through computer simulations that these cues are actually coded into our DNA.

Physicist Helmut Schiessel and his group simulated the folding of DNA strands with randomly assigned cues. The team used genomes of baker’s yeast and fission yeast to find correlations between the mechanics and the actual folding structure of DNA in the two organisms.

The results confirm that this second layer of information exists. This led them to conclude that genetic mutations are not just caused by a change in the sequence of codes but also by a change in the way the strands are folded. This simulation may be helpful in hiding unwanted sequences like those that cause diseases.


Someone wrote:
“I tried to find out how to get this [reversing MS with stem cells] done and all the companies I called require you to pay $15,000 for stem cells they already have and go to Mexico for the procedure. I wanted to use the baby’s cord tissue stem cells”
It’s not a scam. Here’s the deal…
Cord blood is not the only game in town. You also have 80 some odd stem cell derivation sources in your OWN body…
So, odds are one of them WILL work if something goes a bit wrong down the line…
And to the most jaded, cord blood stem cell storage IS a timing marketing coup, hitting parents for stem cell storage to insure their new baby’s health when they are most vulnerable emotionally…
Then again, cord blood stem cells (all stem cells associated with reproduction) ARE very powerful with no known rejection issues…
And, there are also, of course, SOME few conditions that damage your own stem cells or production which might make the use of your existing cells non-indicated, requiring use of stored cord blood cells…
And often, older children didn’t have the opportunity to store cells and these COULD be potentially used for them…
So. Is cord blood storage a grand slam home run of guaranteed use and value? No, it is a hedging of your bets, cellular-level insurance policy against when things go terribly wrong and…that’s why most people do it.
PRICE: $15,000 is a fairly common cost as these are “one off” procedures to assist in recovery from the disease, not a bottle of pills to (maybe) mitigate symptoms. Monthly costs of some drugs are $12k, factor in loss of income, loss of quality of life, etc it all adds up to $15k as a significant bargain over yealry costs of $60k, $80k and more.  Btw, here’s some other procedure costs – the average cost of gastric bypass surgery is $23,000…he average cost of heart bypass surgery is $70-200,000 and on.  And yes, stem cell procedures have a long history of safety and efficacy and should be covered by insurance.  Write your congressman and vote your medical needs.
STEM CELL SOURCE: They wanted to use “stem cells they already have”:
Nobody I know will use cells, basically a tiny handful of unrecognizable goo, taken from someone else, stored by someone else, shipped by someone else to treat someone else. It’s a recipe for disaster and too much can go wrong with accidents, bacteria, reduced bioavailability, etc. Their ONLY using the stem cells they have doesn’t scam you…it PROTECTS you.
LOCATION: “and go to Mexico for the procedure”:
Blame American Medical System resistance to stem cells for the past 15 years, followed by a focus on cyst and tumor causing embryonic stem cells, followed by political and pharma and money and so on. The world has been recovering many chronic and terminal diseases since 2000 which are still incurable in the US because our medical system has been ostensibly blind to the benefits of stem cells for over a decade.


In ALL ARTICLES, SCIENCE & STEM CELLS on February 17, 2017 at 9:06 am

Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells…like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants


Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells, with potential application in stem-cell transplants and cancer diagnosis.

The new nanoscale ultrasound technique uses shorter-than-optical wavelengths of sound and could even rival the optical super-resolution techniques which won the 2014 Nobel Prize for Chemistry.

This new kind of sub-optical phonon (sound) imaging provides invaluable information about the structure, mechanical properties and behaviour of individual living cells at a scale not achieved before.

Researchers from the Optics and Photonics group in the Faculty of Engineering, University of Nottingham, are behind the discovery, which is published in the paper ‘High resolution 3D imaging of living cells with sub-optical wavelength phonons’ in the journal, Scientific Reports.

“People are most familiar with ultrasound as a way of looking inside the body — in the simplest terms we’ve engineered it to the point where it can look inside an individual cell. Nottingham is currently the only place in the world with this capability,” said Professor Matt Clark, who contributed to the study.

In conventional optical microscopy, which uses light (photons), the size of the smallest object you can see (or the resolution) is limited by the wavelength.

For biological specimens, the wavelength cannot go smaller than that of blue light because the energy carried on photons of light in the ultraviolet (and shorter wavelengths) is so high it can destroy the bonds that hold biological molecules together damaging the cells.

Optical super-resolution imaging also has distinct limitations in biological studies. This is because the fluorescent dyes it uses are often toxic and it requires huge amounts of light and time to observe and reconstruct an image which is damaging to cells.

Unlike light, sound does not have a high-energy payload. This has enabled the Nottingham researchers to use smaller wavelengths and see smaller things and get to higher resolutions without damaging the cell biology.

“A great thing is that, like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants,” adds Professor Clark.


More information is available from Professor Matt Clark in the Faculty of Engineering, University of Nottingham on +44 (0)115 951 5536, matt.clark@nottingham.ac.uk; or Emma Lowry, Media Relations Manager, on +44 (0)115 846 7156, emma.lowry@nottingham.ac.uk

Our academics can now be interviewed for broadcast via our Media Hub, which offers a Globelynx fixed camera and ISDN line facilities at University Park campus. For further information please contact a member of the Communications team on +44 (0)115 951 5798, email mediahub@nottingham.ac.uk or see the Globelynx website for how to register for this service.

About The University of Nottingham: The University of Nottingham has 43,000 students and is ‘the nearest Britain has to a truly global university, with a “distinct” approach to internationalisation, which rests on those full-scale campuses in China and Malaysia, as well as a large presence in its home city.’ (Times Good University Guide 2016). It is also one of the most popular universities in the UK among graduate employers and winner of both ‘University of the Year for Graduate Employment’, according to the 2017 The Times and The Sunday Times Good University Guide and ‘Outstanding Support for Early Career Researchers’ at the Times Higher Education Awards 2015. It is ranked in the world’s top 75 by the QS World University Rankings 2015/16. More than 97 per cent of research at The University of Nottingham is recognised internationally and it is 8th in the UK by research power according to the Research Excellence Framework 2014. It has been voted the world’s greenest campus for four years running, according to Greenmetrics Ranking of World Universities.


In Daily Dose of Stem Cells, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on February 16, 2017 at 12:36 pm

While high-dose immunosuppressive therapy is not without complications, we must remember that research is rarely linear and every step closer is a step closer – we learn a bit more and refine the process with each step as our understanding of all of the elements which make up our health, recover and illness are slowly puzzled together like a patch-work quilt…


Stem cell transplants may induce long-term remission of multiple sclerosis

Encouraging results help set stage for larger studies.

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person’s own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

Five years after receiving the treatment, called high-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT), 69 percent of trial participants had survived without experiencing progression of disability, relapse of MS symptoms or new brain lesions. Notably, participants did not take any MS medications after receiving HDIT/HCT. Other studies have indicated that currently available MS drugs have lower success rates.

The trial, called HALT-MS, was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and conducted by the NIAID-funded Immune Tolerance Network (ITN). The researchers published three-year results from the study in December 2014, and the final five-year results appear online Feb. 1 in Neurology, the medical journal of the American Academy of Neurology.


12/12/2013 – Dr Oz and Dr Tisch discuss MS and stem cells http://www.doctoroz.com/episode/meredith-vieiras-family-health-battle?



Color Rat Laboratory Cage Mammal Rat Rodent Pet

Let’s take a page out of what was not too long ago science fiction; which is now science-fact.

  • A pancreas was grown in a rat,
  • the organ was transplanted into a mouse,
  • the mouse was given immunosuppressive therapy to prevent rejection,
  • the diabetic mice were able to normalize their blood glucose levels for over a year.

This illustrates the long proven regenerative capacity of stem cells and the recent advancements scientists have made with anti-rejection protocols…And of course, the cool inter-species transplant of rat to mouse.

Rat-grown mouse pancreases help reverse diabetes in mice

Growing organs from one species in the body of another may one day relieve transplant shortages. Now researchers show that islets from rat-grown mouse pancreases can reverse disease when transplanted into diabetic mice.

White rat with black patches

A rat in which researchers were able to grow a mouse pancreas. Islets from the pancreases were transplanted into mice with diabetes. The transplants helped control the mice’s blood sugar levels.
Courtesy of the Nakauchi lab

 Mouse pancreases grown in rats generate functional, insulin-producing cells that can reverse diabetes when transplanted into mice with the disease, according to researchers at the Stanford University School of Medicine and the Institute of Medical Science at the University of Tokyo.

The recipient animals required only days of immunosuppressive therapy to prevent rejection of the genetically matched organ rather than lifelong treatment.

The success of the interspecies transplantation suggests that a similar technique could one day be used to generate matched, transplantable human organs in large animals like pigs and sheep.

To conduct the work, the researchers implanted mouse pluripotent stem cells, which can become any cell in the body, into early rat embryos. The rats had been genetically engineered to be unable to develop their own pancreas and were thus forced to rely on the mouse cells for the development of the organ.

Once the rats were born and grown, the researchers transplanted the insulin-producing cells, which cluster together in groups called islets, from the rat-grown pancreases into mice genetically matched to the stem cells that formed the pancreas. These mice had been given a drug to cause them to develop diabetes.

“We found that the diabetic mice were able to normalize their blood glucose levels for over a year after the transplantation of as few as 100 of these islets,” said Hiromitsu Nakauchi, MD, PhD, a professor of genetics at Stanford. “Furthermore, the recipient animals only needed treatment with immunosuppressive drugs for five days after transplantation, rather than the ongoing immunosuppression that would be needed for unmatched organs.”

Nakauchi, who is a member of Stanford’s Institute for Stem Cell Biology and Regenerative Medicine, is the senior author of a paper describing the findings, which was published online Jan. 25 in Nature. Tomoyuki Yamaguchi, PhD, an associate professor of stem cell therapy, and researcher Hideyuki Sato, both from the University of Tokyo, share lead authorship of the paper.

Hiro Nakauchi

Although much research remains to be done, scientist Hiromitsu Nakauchi and his colleagues believe their work with rodents shows that a similar technique could one day be used to generate matched, transplantable human organs in large animals like pigs and sheep.
Wing Hon Films

Organs in short supply

About 76,000 people in the United States are currently waiting for an organ transplant, but organs are in short supply. Generating genetically matched human organs in large animals could relieve the shortage and release transplant recipients from the need for lifelong immunosuppression, the researchers say.

People suffering from diabetes could also benefit from this approach. Diabetes is a life-threating metabolic disease in which a person or animal is unable to either make or respond appropriately to insulin, which is a hormone that allows the body to regulate its blood sugar levels in response to meals or fasting. The disease affects hundreds of millions of people worldwide and is increasing in prevalence. The transplantation of functional islets from healthy pancreases has been shown to be a potentially viable option to treat diabetes in humans, as long as rejection can be avoided.

The researchers’ current findings come on the heels of a previous study in which they grew rat pancreases in mice. Although the organs appeared functional, they were the size of a normal mouse pancreas rather than a larger rat pancreas. As a result, there were not enough functional islets in the smaller organs to successfully reverse diabetes in rats.

Mouse pancreases grown in rats

In the current study, the researchers swapped the animals’ roles, growing mouse pancreases in rats engineered to lack the organ. The pancreases were able to successfully regulate the rats’ blood sugar levels, indicating they were functioning normally. Rejection of the mouse pancreases by the rats’ immune systems was uncommon because the mouse cells were injected into the rat embryo prior to the development of immune tolerance, which is a period during development when the immune system is trained to recognize its own tissues as “self.” Most of these mouse-derived organs grew to the size expected for a rat pancreas, rendering enough individual islets for transplantation

Next, the researchers transplanted 100 islets from the rat-grown pancreases back into mice with diabetes. Subsequently, these mice were able to successfully control their blood sugar levels for over 370 days, the researchers found.

Because the transplanted islets contained some contaminating rat cells, the researchers treated each recipient mouse with immunosuppressive drugs for five days after transplant. After this time, however, the immunosuppression was stopped.

After about 10 months, the researchers removed the islets from a subset of the mice for inspection.

“We examined them closely for the presence of any rat cells, but we found that the mouse’s immune system had eliminated them,” said Nakauchi. “This is very promising for our hope to transplant human organs grown in animals because it suggests that any contaminating animal cells could be eliminated by the patient’s immune system after transplant.”

Importantly, the researchers also did not see any signs of tumor formation or other abnormalities caused by the pluripotent mouse stem cells that formed the islets. Tumor formation is often a concern when pluripotent stem cells are used in an animal due to the cells’ remarkable developmental plasticity. The researchers believe the lack of any signs of cancer is likely due to the fact that the mouse pluripotent stem cells were guided to generate a pancreas within the developing rat embryo, rather than coaxed to develop into islet cells in the laboratory. The researchers are working on similar animal-to-animal experiments to generate kidneys, livers and lungs.

Although the findings provide proof-of-principle for future work, much research remains to be done. Ethical considerations are also important when human stem cells are transplanted into animal embryos, the researchers acknowledge.

The research was funded by the Japan Science and Technology Agency, the Japan Agency for Medical Research and Development, the Japan Society for the Promotion of Science, a KAKENHI grant, the Japan Insulin Dependent Diabetes Mellitus Network and the California Institute for Regenerative Medicine.

Stanford’s Department of Genetics also supported the work.



There’s a lot going on in this article.  14 patients with Down Syndrome were treated with stem cells.  Down Syndrome is a common chromosomal disorder caused by trisomy of chromosome 21 (HSA21q). I’m not going to introduce a critical analysis of this.  This article does that with great skepticism.  Let’s take a different tact.  Let’s approach this with the idea that it could happen but we don’t yet know how.  How about I raise some questions of my own with the intention to not tear down but rather to perhaps, inspire someone else to discover a new path to some answers.  Let’s throw away conventional thought and limitations and try to grasp a kernel of truth from a bag of confusion.  I’m going to blue sky here…
Blue Sky: adjective – using the imagination to think of ideas that do not yet have practical uses or make money.


How can stem cells possibly modify a genetic disorder?   Maybe they can’t, but maybe they can.  Epigenetics tells us that our gene expressions are constantly changing and our concept of what can and can’t change in the human body is constantly evolving.  Are the stem cells modifying the chromosome?  Conventional science would indicate that this is impossible.  But maybe we are seeing the results from a change in phenotype without a change in genotype.  15 years ago, conventional science was positive that heart cells couldn’t regenerate either.  We still have an enormous amount to learn.  Perhaps our genetics are even less stable than we thought?

Non-scientist gene therapy? Gene therapy is a technique that uses genes to treat or prevent disease.  Three techniques of gene therapy are:

  • Replacing a mutated gene that causes disease with a healthy copy of the gene.
  • Inactivating, or “knocking out,” a mutated gene that is functioning improperly.
  • Introducing a new gene into the body to help fight a disease.

Is it so far fetched to imagine that the stem cells can do already what scientists do?  We know stem cells can heal and regenerate.  Why not also perform gene therapy?  We’ve seen modified allogeneic stem cells recover fetuses (in the womb) from the genetic disorder of severe osteogenesis imperfecta before 2005.  1, 2  We know stem cells can regrow finger tips in kids under 8, become skin cells and then if not needed, reverting back to a nascent state and becoming nail cells and then reverting back, etc.  So maybe they can modify at the genetic level too, but how?


What’s mine is…yours?  (The Good, The Bad and the Ugly)  What needs to happen to modify genetics?  Not the science, but the logic.  The stem cells would need to recognize that the chromosomal disorder is atypical – an aberrant construct needing modification – and then change it towards a different paradigm.  Maybe they can do that because the cells used are from someone else (allogenic) – so perhaps the stem cells carry the blue prints and adhere to the donor’s physiology?  
The donor’s physiology then, becomes the road map, the standard which the stem cells are healing the patient towards.  The “normal standard,” so to speak.  It makes some sense as, often, in allogenic stem cell treatment scenarios (Embryonic and induced Pluripotent for example), the genetic anomalies of the donor influence the recipient.  So if the negative elements within the donor can influence the patient, why not the positive?  Why wouldn’t the relative genetic normalcies of the donor influence the physiology of the recipient?

An improvement by any other name would smell just as sweet?  ‘“He started babbling and crawling, and his facial features underwent a change.” The boy, who lives in Singapore, is now 3 years old. “He continues to develop age-appropriate skills,” says Titus.’  

If the indicators and symptoms of  Down Syndrome reduced or went away  and they ARE tied to the genetics, how did that happen? If the indicators and symptoms of  Down Syndrome reduced or went away and they are NOT tied to the genetics, maybe the connections between the cause and the result is not as rigid as we thought.  Can someone have the chromosomal variant of Down Syndrome but have no indicators and no symptoms?   Something very worthwhile to work towards.  Perhaps we have to expand our view of what it means to recover from an illness beyond just reversing the criteria we currently use to define the disease.  

What if  everything else in the body works better due to the stem cells?  The circulatory system, the GI, the neurological, the lymph and all of ancillary parts and pieces work better resulting in a greater capacity for learning, growth, development, etc.  We know the central nervous system does regenerate as well as the brain, though very slowly; so if you can improve the workings of every part of the body, even without addressing the additional chromosome issue of Down Syndrome, wouldn’t that potentially result in the smartest, strongest, healthiest person with Down Syndrome?  Isn’t that significant improvement?

If you were diagnosed with cancer but there was a simple treatment which would allow you to have no symptoms and you could live a full and complete life; curing cancer wouldn’t really matter to you, would it?  That goal would cease to be our priority.  Now we are shifting from disease mitigation to quantifiable improvements in the measurable criteria by which the Down Syndrome patient is defined.  Maybe negating the symptoms and the ramifications of a disease is equal in importance to curing it.  Maybe it is even easier to do and the patient won’t be able to tell the difference between the two.   The patient; healthier, better, with fewer or no symptoms.  Isn’t that what we are all working towards anyway?

IS that what we are all working towards?  Survey says…
The Purist says: “Scam!  You can’t fix genetic conditions.  You didn’t fix the Down Syndrome!”
The Parent says: “My child’s ability to xyz has improved!  They are at age level in school and on height and weight and on and on…”
The Prognosis says: “Patient presents with fewer or none of the indicators and symptoms commonly associated with Down Syndrome and what is exhibited is more mild in nature.”
The Pragmatist says:  “This advancement in therapies for Down Syndrome allows the patient to live a normal life, unburdened by the symptoms and long term ramifications of the disease.”
The Future says: “We have seen a lower incidence of the common conditions associated with this Down Syndrome – various congenital and progressive medical conditions such as mental retardation, congenital heart disease, gastrointestinal anomalies, skeletal anomalies, leukemia and Alzheimer’s disease.”

Adverse side affects?  The cells used were Human Embryonic stem cells.  Now, they are very powerful as they have the capacity to differentiate into the hundreds of cells in the human body…but they also have a history of rejection and cysts and tumors which can become cancerous.  This is an area of great concern and I am very curious as to how the doctors addressed these issues or felt they were insignificant.  This issue needs more research…

Taoist philosophy says: ‘“Water always seeks the easiest path, the common level of life. When it reaches a spot where there is a blockage, water finds the easiest path around the blockage. Or, if it can’t find a way around the blockage, it continues to assemble. The water gets deeper and deeper until finally the level increases and it flows over the blockage. It uses itself to go beyond whatever it needs to go beyond.” Eventually, water wears down even the hardest rock. Proof of this is seen in the Grand Canyon. The power of water may not be evident right away; over time, though, the massive mountain is worn away while the stream remains.’  Go around.  Go over.  Go through.  Each has it’s merits and disadvantages. Let’s pursue all as viable paths for the healing of the patient.

Most would argue that stem cells encompass the most significant change to disease treatment and medicine in all history.  Stem cells are a game changer.  THE game changer.

If stem cells are the game changer…

maybe it’s past time we changed HOW WE KEEP SCORE.


Clinic claims it has used stem cells to treat Down’s syndrome

A clinic in India says it has used stem cells to treat Down’s syndrome in up to 14 people, but the announcement has alarmed independent researchers

By Andy Coghlan

A CLINIC claims it has used stem cells to treat Down’s syndrome in up to 14 people. “As far as we know, it’s the first time that stem cells have been used to treat Down’s syndrome,” says Jyoti Titus, manager at Nutech Mediworld clinic in New Delhi, India.

The announcement has set alarm bells ringing. It’s not clear to independent stem cell or Down’s experts how stem cells – which can form many types of tissue – might treat Down’s, a genetic disorder caused by having an extra chromosome.

Down'sDown’s: an extra chromosome 21 – Department of Clinical Cytogenetics, Addenbrookes Hospital/Science Photo Library

“The use of these cells does not make biological sense and may place the babies at considerable risk of side effects,”says John Rasko of the International Society for Cellular Therapy.

Clinically proven stem cell therapies are only just starting to become available. The first off-the-shelf stem cell treatment to gain regulatory approval was launched in Japan last year, and prevents transplanted organs from attacking their recipients. A number of research teams are putting other experimental stem cell therapies through stringent clinical trials.

But hundreds of clinics worldwide already offer stem cell treatments unvetted by regulatory authorities. A patent held by the clinic’s medical director, Geeta Shroff, from 2007 suggests that the cells offered by Nutech Mediworld could be helpful for over 70 types of conditions, from Down’s syndrome to Alzheimer’s disease, and even vegetative states.

“The use of stem cells doesn’t make sense and may place the babies at considerable risk”

Most treatments for children with Down’s syndrome centre on support – including speech and behavioural therapies. But in a study published last year Shroff, reported that a baby with Down’s syndrome developed better understanding, improved limb muscle tone, and the ability to recognise his relatives after receiving stem cells (Journal of Medical Cases, doi.org/bx3v).

No controls

“There’s no comparison to similar individuals with Down’s syndrome, and no indication this therapy had any effect whatsoever, so the author has no basis at all for saying the injections were beneficial,” says Elizabeth Fisher at University College London.

But since no other treatment was given, it is evident that the child’s improvements were due to stem cell treatment, says Titus. “He started babbling and crawling, and his facial features underwent a change.” The boy, who lives in Singapore, is now 3 years old. “He continues to develop age-appropriate skills,” says Titus.

Shroff’s study says she injected the cells, developed from a donated embryo, into his blood, back muscles and under his skin, as well as giving them as a nasal spray. “Stem cells have an innate ability to repair and regenerate, and that is how the baby’s condition improved,” says Titus.

“There’s no obvious way in which this treatment would have worked,” says Victor Tybulewicz at the Francis Crick Institute in London. To have any effect, neural stem cells would need to be injected into the brain, he says.

“The author appears to have no idea of where [the cells] are going, or what they’re doing,” says Fisher. “It’s even worse now we know they’ve treated 14 patients, not just one.”

Titus says that the way the cells were developed means recipients don’t need immunosuppressants. But Tybulewicz disagrees. “I expect the most likely outcome of the injections would have been that they were recognised as foreign and eliminated by the immune system,” he says. More details of the biological impact of the stem cells will be revealed in a study that has been submitted for publication, says Titus.

Nutech Mediworld isn’t the only clinic offering stem cells. An analysis led by Rasko last year identified 417 unique websites advertising stem cell treatments directly to patients. Of these, 187 were linked to 215 clinics in the US. Thirty-five websites were linked to organisations in India.

Although India introduced national guidelines on clinical stem cell research and treatments a decade ago, these are not legally binding.

This article appeared in print under the headline “Clinic claims stem cells treat Down’s syndrome”




A little over a week ago, I posted an article that described:
Of the 100 million BULK CANCER CELLS in a 1-cm cancer tumor, there are about 1,000 to 10,000 CANCER STEM CELLS and those cells are up to 15 times more active and may be the only cells responsible for cancer cell reproduction and metastasis.

Scientists have zeroed in even deeper and targeted a new ‘CD99’ molecule expressed on certain stem cells that drive human leukemia malignancies.  They’ve designed antibodies that can directly kill human acute myeloid leukemia (AML) stem cells.


protein-sugar molecule, CD99

Researchers design antibody that recognizes and destroys blood cancer stem cells

Published on January 25, 2017 at 9:44 PM ·

Building on this discovery, the study authors designed an antibody that recognizes and destroys CD99-covered leukemia cells while sparing normal blood stem cells, a finding confirmed by experiments in human cells and in mice with AML cells. Antibodies are immune system proteins that stick to a specific target, like a protein on the surface of invading bacterium. In recent years, researchers have become capable of engineering antibodies so that they target disease-related molecules.

“Our findings not only identify a new molecule expressed on stem cells that drive these human malignancies, but we show that antibodies against this target can directly kill human AML stem cells,” says corresponding study author, Christopher Y. Park, MD, PhD, associate professor in the Department of Pathology at NYU Langone and its Perlmutter Cancer Center.

“While we still have important details to work out, CD99 is likely to be an exploitable therapeutic target for most AML and MDS patients, and we are working urgently to finalize a therapy for human testing,” says Park.

Direct Cell Killing

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) arise from abnormal stem cells that build up in bone marrow until they interfere with normal blood cell production. Patients struggle with anemia, increased risk for infection, and bleeding.

The study results are based on the understanding that cancers, like normal tissues, contain stem cells that give rise to all the other cells. Such “cancer stem cells” are known to be major drivers of many cancer types. In AML, a small group of leukemic stem cells become incapable of maturing into red or white blood cells as intended. Most leukemias respond initially to standard treatment, but relapse is common as standard treatments fail to kill leukemia stem cells, which continue to multiply.


The research team became interested in CD99 when they observed that it occurs frequently on AML and MDS cells, and then noted in the literature that CD99 is elevated in a rare bone cancer called Ewing’s Sarcoma. This prompted them to see if CD99 was important in the development of these blood diseases.

When researchers examined stem cell populations from 79 AML and 24 MDS patients, they found that approximately 85 percent of stem cells in both groups expressed high levels of CD99. The levels were so high that diseased stem cells could be cleanly separated from related, normal stem cells in AML patients.

Upon confirming that CD99 was abundant on leukemia stem cells, the research team then made several CD99 antibodies, and chose to focus on the one that most effectively killed those cells. Researchers found that when the study antibody attaches itself to CD99 on the surface of a cancer stem cell, it sends a signal inside the cell that increases the activity of enzymes called SRC-family kinases.

While the team does not yet know why, the binding of their antibody to CD99, and the subsequent activation of these enzymes, causes leukemia stem cells to die. Most cells with genetic mistakes leading to cancer “sense” they are flawed and self-destruct, but CD99, so the theory goes, may be part of a mechanism that prevents this. As the antibody binds to CD99, it appears to undo this block on self-destruction.

“With the appropriate support, we believe we can rapidly determine the best antibodies for use in patients, produce them at the quality needed to verify our results, and apply for permission to begin clinical trials,” says Park.

While the most common acute leukemia affecting adults (22,000 new cases each year) and expected to become more prevalent as the population ages, AML it is still relatively rare, accounting for 1.2 percent of U.S. cancer deaths. About 15,000 mostly elderly patients are diagnosed with MDS each year as well.




“[Bob]  received an infusion of cells called allogeneic human mesenchymal stem cells (hMSC), adult stem cells collected from the bone marrow of healthy volunteers”

“CF’s main effect is on the lungs. They fill with a sticky mucus as a reaction – really an over-reaction – by the body’s immune system to bacteria. The lungs are the source for much of the illness and shortened lifespan seen in CF.”


CYSTIC FIBROSIS The_fluorescent_microscopy_image_of_CFTR_tagged_with_EYFP

First stem cell study could lead to development of therapy to reduce inflammation caused by CF

Published on January 31, 2017 at 3:24 AM · 

A 39-year-old man with cystic fibrosis (CF) made history by becoming the first person to receive human adult stem cells in a new research study that researchers hope will someday lead to the development of a therapy to reduce the inflammation and infection caused by CF.

The pioneering subject in the study is Bob Held from Alliance, Ohio, who on Jan. 26 received an infusion of cells called allogeneic human mesenchymal stem cells (hMSC), adult stem cells collected from the bone marrow of healthy volunteers. Mr. Held was diagnosed with CF when he was 16 months old.

Currently, there is no cure for CF, and life expectancy for patients who survive into adulthood is approximately 41 years of age.

“It was a very exciting day for us with the very first participant in the first stem cell trial for cystic fibrosis,” said James Chmiel, MD, the principal investigator of the study at University Hospitals Rainbow Babies & Children’s Hospital.

The Phase 1 trial will assess the safety and tolerability of hMSCs in adult patients with CF.

“This is an early phase trial, and the most important thing is to ensure safety,” said Dr. Chmiel. “This study consists of a single infusion of stem cells. We will follow the study participants for a year to make sure it’s safe. Before applying any therapy on a broad basis, we want to make sure that it’s safe.”

While the goal of the study is safety, Dr. Chmiel hopes this is a first step towards the ultimate goal of developing a therapy to reduce lung inflammation and infection, resulting in longer and healthier lives for people with CF.

“While there’s been a tremendous increase in survival for people with CF from when I entered the field in the 1990s, that’s still not good enough,” said Dr. Chmiel, Director of the Cystic Fibrosis Therapeutics Development Center at UH Rainbow Babies & Children’s Hospital and Professor of Pediatrics at Case Western Reserve University School of Medicine. “While we’ve made great progress, we still have a long way to go.”
The stem cells that Mr. Held received were collected from the bone marrow of a healthy adult volunteer. UH is a national leader in the use of stem cell therapy with hMSCs. Researchers from UH, along with the CWRU School of Medicine, discovered hMSCs. The hMSCs possess many properties that are ideal for the treatment of inflammatory and degenerative diseases, and they possess natural abilities to detect changes in their environment, such as inflammation. The hope is that hMSCs can reduce the inflammation in the lungs caused by CF.

CF’s main effect is on the lungs. They fill with a sticky mucus as a reaction – really an over-reaction – by the body’s immune system to bacteria. The lungs are the source for much of the illness and shortened lifespan seen in CF.

“One of the issues in CF is that people with the disease get bacterial infections in their lungs, and these bacteria incite a vigorous and excessive inflammatory response,” explained Dr. Chmiel. “It’s actually the body’s inflammatory response that damages the lungs. The inflammatory response tries to eliminate the bacteria, but it’s not successful. Instead, the inflammatory system releases molecules that damage the individual’s own airways. The lung disease causes much of the illness and is responsible for the majority of the mortality of the disease.”

The stem cells are donated by healthy adult volunteers who go through a rigorous screening process. The stem cells are cultured in the UH stem cell facility. Volunteers with CF who are in the study receive an infusion through an IV.
“Once in the patient’s body, the stem cell tracks to the area where there’s a significant amount of inflammation, and they take up residence there. The stem cells then respond to the environment, and hopefully reverse some of the abnormalities,” said Dr. Chmiel. “We hope in future studies to demonstrate that the stem cells reduce the infection and inflammation and return the lungs to a more normal state.”

“This therapy aims to turn down the inflammatory response, not eliminate it because we still have to keep the bacteria in check. We want to reduce inflammation and the subsequent lung damage caused by inflammation without allowing the bacteria to proliferate,” said Dr. Chmiel.

A total of 15 clinically stable adults with CF will be enrolled in the study. Support for the study is from the Cystic Fibrosis Foundation.

The patient, Mr. Held, considers himself fortunate to be close to 40 with CF. When he was growing up, he said he’d miss 50 days of school each year because of the disease. Every day, he needs to breathe in aerosols for about two hours in the morning and 1-1/2 hours before bed to keep his lungs functioning. While he hasn’t been sick from the illness since his late teens, he does check himself into the hospital a couple of times a year for precautionary measures and to prevent himself from “getting into a valley” with CF.

His late wife, Michelle, died of CF seven years ago. They had met when they were kids, but didn’t get married until 2012. She died from the disease suddenly 28 days after they married.

“My only regret is that I didn’t ask her out sooner,” said Mr. Held.
He is participating in the study to carry on Michelle’s legacy, and “I am hoping the future generations of CF patients can get better treatments and that eventually a cure will be found for them,” he said.

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