DAVID GRANOVSKY

Archive for the ‘ALL ARTICLES’ Category

THE DOOR OPENS

In ALL ARTICLES, BEST OF THE BEST, BUSINESS OF STEM CELLS, CATCH UP!, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on May 30, 2017 at 11:20 am

UPDATE: JUNE 13TH 

In the next step of what may become the most monumental piece of medical legislature,

THE GOVERNOR OF TEXAS SIGNED HB 810!

HB 810 will be effective on 9/1/17  

I express virtually no surprise what so ever that there has been no media coverage of this.*  The only piece of confirming data I can find is on the Texas Legislature site and in articles written by the tireless and noble Patient Warriors, around the world, who have been fighting for their lives and for this for years.

 

HB-810
[original article below]
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Around the world, stem cells have been used for therapeutic application for decades, treating incurable illnesses, recovering terminal patients and improving qualities of life of untold numbers.  In some form or another, Rafael Nadal got them…along with Peyton Manning, Jarvis Greene, Kobe Bryant and Dana White and hundreds or thousands of other athletes and weekend warriors but mostly outside the US because they weren’t available here.
Sadly, we in the US were…a little slow…to get the message. Foolishly allowing ourselves to get embroiled in the distracting political, financial and religious controversies; we have not been allowed to treat our sick and dying. Tragically, listening to the uninformed who said: “they are unproven!” despite thousands of studies and trials from around the world, the US stuck to our guns and enjoyed some of the worst medical care in the world.  I wrote this in 2010:
“We are in fact about 8 years behind most of the developed world in stem cell research. The WHO ranks our health system at 37th, our life expectancy is 30th in the world, infant mortality is 34th in the world and this is all with our Health Expenditures as a % of GDP being almost the highest in the world (we are ranked #2).”
Like many before and after him, Gov Perry made some in roads in 2012 but hit the wall of American “backward thinking.” https://repairstemcell.wordpress.com/2012/04/14/texas-oks-experimental-stem-cell-therapy-limits-questions/
Now, Texas, House Bill 810 amended the bill which was “relating to the provision of certain investigational stem cell treatments to patients with certain severe chronic diseases or terminal illnesses and regulating the possession, use, and transfer of adult stem cells; creating a criminal offense,” and passed the Senate, unanimously.
STEM CELLS FOR SCLERODERMA
This is the bill now:

The bill is on its way to the Governor’s office for signature. This has been a LONG time coming.

A hearty congratulations goes out especially to the tireless patient advocates/patient warriors who said: “no more!” and threw off the yoke of servitude to a medical system which no longer served their self-interests. Their efforts and those of many, many others have inexorably, infinitesimally, pushed the needle over time against multiple immovable objects.

What happens next?  There will be chaos, turmoil and scrambling.  There will be resistance and bad mouthing and nay saying…and in the end, Texas industry will likely generate billions in revenue, treat the un-treatable, recover the unrecoverable, extend the lives of those told to get their affairs in order and become THE center of regenerative medical innovation in the US, if not, the world.

 

……………………………………………..

I now see that there was media coverage; we just apparently beat them all to the punch.  I am more than pleased that this advance is getting mass media coverage!

Stem Cell Therapy Becomes Law in Texas – Hawaii News Now … 2 hours ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

Health Care – FOX5 Vegas – KVVU  17 mins ago – House Bill (HB 810) on stem cell therapy has passed in the Texas state legislature and become law. Patients in Texas will now have access to this “Right to Try” …

Health Care – WDRB 41 Louisville News  36 mins ago – House Bill (HB 810) on stem cell therapy has passed in the Texas state legislature and become law. Patients in Texas will now have access to this “Right to Try” …

Stem Cell Therapy Becomes Law in Texas – WorldNews  3 hours ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

– TiGenix Launches Global Phase III Trial for Cx601 (EN – NL – ES …45 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

TiGenix announces final equity payment for cardiac platform …  41 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

Hope for Gabe Foundation Races Across America to Bring Awareness …   50 mins ago – LA JOLLA, Calif., June 13, 2017 /PRNewswire/ — House Bill (HB 810) on stem celltherapy has passed in the Texas state legislature and become law. Patients in …

 

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RESURRECTING THE DEAD WITH STEM CELLS

In ALL ARTICLES, BUSINESS OF STEM CELLS, Doctors Practicing Excellence, HOPE AND INSPIRATION, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on March 6, 2017 at 2:08 pm

Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death. It is also called rebirth or transmigration, and is a part of the Saṃsāra doctrine of cyclic existence.”
reincarnation-symbol-25893_960_720
“In Greek mythology, a phoenix is a long-lived bird that is cyclically regenerated or reborn. Associated with the Sun, a phoenix obtains new life by arising from the ashes of its predecessor.”
phoenix_rising_by_something44
“The resurrection of Jesus is the Christian religious belief that, after being put to death, Jesus rose again from the dead. It is the central tenet of Christian theology and part of the Nicene Creed: “On the third day he rose again in accordance with the Scriptures”.
christ-rresurrection

“Frankenstein; or, The Modern Prometheus is a novel written by English author Mary Shelley that tells the story of Victor Frankenstein, a young scientist who creates a grotesque but sapient creature in an unorthodox scientific experiment.”Frankenstein's_monster_(Boris_Karloff).jpg

Humanity has always been fascinated by resurrection – bringing the dead back to life.  The references are plentiful and many will cry out that science should not mess with the great barrier of death for it is absolute and divine and we should not mess with nature.  But, are life and death truly black and white?

Perhaps not.  The “Lazarus syndrome, also known as autoresuscitation after failed cardiopulmonary resuscitation, is the spontaneous return of circulation after failed attempts at resuscitation. Its occurrence has been noted in medical literature at least 38 times since 1982.”

Are there shades of gray between the absolute states of life and death?
Miracle Max: It just so happens that your friend here is only MOSTLY dead. There’s a big difference between mostly dead and all dead. Mostly dead is slightly alive. With all dead, well, with all dead there’s usually only one thing you can do.
Inigo Montoya: What’s that?
Miracle Max: Go through his clothes and look for loose change.
billy-crystal
Perhaps Benjamin Franklin was only half right: “…in this world nothing can be said to be certain, except death and taxes

Death, it seems is not as final as we once thought.  But, can it be done?  Scientists have been given the green light to try:
“By implanting stem cells in the patient’s brain…they hope to reboot the brain and jump-start neural activity. The result could be people coming back to life.”

On a serious note 

The above pics and quips aside…
this work is monumental and can have huge ramifications to the treatments of chronic and terminal disease, brain disorders and more.  Many people would like to classify AGING as a disease which we need to study, treat and conquer and scientists around the world are making great strides in their efforts.  Maybe one day soon we will also classify DEATH as a disease which we need to study, treat and conquer.  Let’s keep an open mind and support the discovery of new methods for treating disease. 

Article

HOW YOUR GENES ARE FOLDED REALLY MATTERS!

In ALL ARTICLES, genetic, HEALTH AND WELLNESS, SCIENCE & STEM CELLS on March 5, 2017 at 1:40 pm
“The folding mechanism of DNA is believed to play a large role in how genes are read by the rest of the cell…The results confirm that this second layer of information exists. This led them to conclude that genetic mutations are not just caused by a change in the sequence of codes but also by a change in the way the strands are folded

jeans-genes-cuffs-folding

EVERY time I have a conversation with someone who is 100% sure, I laugh inside and remember that everything we know for sure will be disproved within our lifetimes.

 
Medical science was 100% sure:
the heart doesn’t regenerate…wrong
the brain and central nervous system doesn’t regenerate…wrong
all of the ligaments have been found…wrong
butter is healthier, margarine is healthier, butter, margarine…wrong
stem cells don’t work…wrong
cholesterol is bad…wrong
our DNA doesn’t change and is absolute…wrong
and now…
Physicists Confirm There’s a Second Layer of Information Hidden in Our DNA
IN BRIEF: Theoretical physicists have confirmed that it’s not just the information coded in our DNA that shapes who we are—it’s also the way DNA folds itself that controls which genes are expressed inside our bodies.
 This changes everything.

We all learned in high school how Watson and Crick pieced together the findings of many scientists to come up with a model of deoxyribonucleic acid (DNA). Information in DNA is stored as code sequences made up of nitrogenous bases. Each cell has the same sequence of codes but executes a different function. Code sequences determine the type of protein to be produced in a certain cell, but it is hypothesized that the mechanical properties of the DNA acts as a second layer of information.

Each cell in our body contains around 2 meters of DNA. But since our cells are so tiny, DNA strands have to be tightly wrapped into bundles called nucleosomes in order to fit.

Learn more about DNA and nucleosomes in the video below:

The folding mechanism of DNA is believed to play a large role in how genes are read by the rest of the cell. Biologists have started to isolate mechanical cues that determine how DNA is folded. Now, theoretical physicists from Leiden University in the Netherlands confirmed through computer simulations that these cues are actually coded into our DNA.

Physicist Helmut Schiessel and his group simulated the folding of DNA strands with randomly assigned cues. The team used genomes of baker’s yeast and fission yeast to find correlations between the mechanics and the actual folding structure of DNA in the two organisms.

The results confirm that this second layer of information exists. This led them to conclude that genetic mutations are not just caused by a change in the sequence of codes but also by a change in the way the strands are folded. This simulation may be helpful in hiding unwanted sequences like those that cause diseases.

ULTRASOUND GOES INSIDE LIVE CELLS

In ALL ARTICLES, SCIENCE & STEM CELLS on February 17, 2017 at 9:06 am

Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells…like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants

fat-cells1

Researchers at The University of Nottingham have developed a break-through technique that uses sound rather than light to see inside live cells, with potential application in stem-cell transplants and cancer diagnosis.

The new nanoscale ultrasound technique uses shorter-than-optical wavelengths of sound and could even rival the optical super-resolution techniques which won the 2014 Nobel Prize for Chemistry.

This new kind of sub-optical phonon (sound) imaging provides invaluable information about the structure, mechanical properties and behaviour of individual living cells at a scale not achieved before.

Researchers from the Optics and Photonics group in the Faculty of Engineering, University of Nottingham, are behind the discovery, which is published in the paper ‘High resolution 3D imaging of living cells with sub-optical wavelength phonons’ in the journal, Scientific Reports.

“People are most familiar with ultrasound as a way of looking inside the body — in the simplest terms we’ve engineered it to the point where it can look inside an individual cell. Nottingham is currently the only place in the world with this capability,” said Professor Matt Clark, who contributed to the study.

In conventional optical microscopy, which uses light (photons), the size of the smallest object you can see (or the resolution) is limited by the wavelength.

For biological specimens, the wavelength cannot go smaller than that of blue light because the energy carried on photons of light in the ultraviolet (and shorter wavelengths) is so high it can destroy the bonds that hold biological molecules together damaging the cells.

Optical super-resolution imaging also has distinct limitations in biological studies. This is because the fluorescent dyes it uses are often toxic and it requires huge amounts of light and time to observe and reconstruct an image which is damaging to cells.

Unlike light, sound does not have a high-energy payload. This has enabled the Nottingham researchers to use smaller wavelengths and see smaller things and get to higher resolutions without damaging the cell biology.

“A great thing is that, like ultrasound on the body, ultrasound in the cells causes no damage and requires no toxic chemicals to work. Because of this we can see inside cells that one day might be put back into the body, for instance as stem-cell transplants,” adds Professor Clark.

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More information is available from Professor Matt Clark in the Faculty of Engineering, University of Nottingham on +44 (0)115 951 5536, matt.clark@nottingham.ac.uk; or Emma Lowry, Media Relations Manager, on +44 (0)115 846 7156, emma.lowry@nottingham.ac.uk

Our academics can now be interviewed for broadcast via our Media Hub, which offers a Globelynx fixed camera and ISDN line facilities at University Park campus. For further information please contact a member of the Communications team on +44 (0)115 951 5798, email mediahub@nottingham.ac.uk or see the Globelynx website for how to register for this service.

About The University of Nottingham: The University of Nottingham has 43,000 students and is ‘the nearest Britain has to a truly global university, with a “distinct” approach to internationalisation, which rests on those full-scale campuses in China and Malaysia, as well as a large presence in its home city.’ (Times Good University Guide 2016). It is also one of the most popular universities in the UK among graduate employers and winner of both ‘University of the Year for Graduate Employment’, according to the 2017 The Times and The Sunday Times Good University Guide and ‘Outstanding Support for Early Career Researchers’ at the Times Higher Education Awards 2015. It is ranked in the world’s top 75 by the QS World University Rankings 2015/16. More than 97 per cent of research at The University of Nottingham is recognised internationally and it is 8th in the UK by research power according to the Research Excellence Framework 2014. It has been voted the world’s greenest campus for four years running, according to Greenmetrics Ranking of World Universities.

(NOT) FIRST PARALYZED HUMAN TREATED WITH STEM CELLS FOR SCI

In ALL ARTICLES, DISEASE INFO, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, THIS IS SPINAL... on January 27, 2017 at 12:05 pm

First paralyzed human treated with stem cells has now regained his upper body movement http://theheartysoul.com/stem-cells-cure-paralysis/

stem-cell-patient

CONGRATS! But…
NOT the FIRST!

This is the sort of article which makes me crazy because on the one hand, it is a triumph!  A mainstream coverage of a stem cell success, increasing awareness and helping to erode our entrenched concepts of what can be done with medicine and what is and isn’t really “incurable.”

On the other….it grossly misrepresents the long history of stem cell successes versus spinal cord injury. It devalues the patients who have recovered, the loved ones who supported them during their treatments and the doctors who worked their butts off developing the protocols and pushing the envelops, often in the face of massive popular skepticism.

 
These people, these patients and loved ones and doctors who risked everything; life, limb, money, time and more…they are the mavericks, the trail blazers, the ones who sacrificed everything for the one pure goal of advancing medicine, of advancing healing. They deserve to be honored and credited with their barrier breaking work, not dismissed in some ill conceived misinformation campaign, weakly relying upon the un-sturdy columns of anti-Piaget-ian Object Permanence.

hear_speak_see_no_evil_toshogu_cropped_enhanced

And no mention of Spinal Cord Injury and Stem Cell Treatment should be made without a HUGE nod to the God-Fathers, Prof Mackay-Sim and Dr Carlos Lima.

Dr Mackay-Sim was researching olfactoric mucosal stem cell applications for spinal cord injury in murine models as far back as 2001:

  1. Lu, J.; Feron, F.; Ho, S. H.; Mackay-Sim, A.; Waite, P. M. E. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 2001, 889, 344-357.
  2. Lu, J.; Feron, F.; Mackay-Sim, A.; Waite, P. M. E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002, 125, 14-21.

Dr Lima was “improving” and “recovering” Spinal Cord Injury patients with stem cells derived from their own noses as far back as…wait for it…2003.

“Olfactory stem cells have been shown to be most versatile. Indeed, Adult stem cells from the nose have now helped paraplegic patients walk. From the primary source, Carlos Lima et al., Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury, Neurorehabil Neural Repair 24(1):10–22 | doi: 10.1177/1545968309347685.”

“Of the 13 patients assessed by functional studies, 1 paraplegic patient (patient 9) can ambulate with 2 crutches and knee braces with no physical assistance and 10 other patients can ambulate with walkers with or without braces with physical assistance.

One tetraplegic [paralyzed in both arms and legs] patient (patient 13) ambulates with a walker, without knee braces or physical assistance.”

Why haven’t you heard of this?  I don’t know.  Perhaps you missed the “Testimony of Ms. Laura Dominguez, delivered at a hearing held by the United States Senate Subcommittee on Science, Technology, and Space on July 14, 2004. Accessed at: http://commerce.senate.gov/hearings/testimony.cfm?id=1268andwit_id=3673

If that doesn’t work, go here and skip ahead to 1 hour, 16 minutes to 2hrs 21min: https://www.c-span.org/video/?182693-1/stem-cell-research-treatment

Laura Dominguez, also featured in the article  here, was treated in 2004.  By then,

Dr “Lima’s procedure had proven successful in 26 patients, states Dr. Jean D. Peduzzi-Nelson, a co-researcher at the University of Alabama in Birmingham. [9] Dominguez was the tenth person in the world and the second American to undergo the surgery.

Completion of the surgery permitted a return to the United States, which ushered in the continuation of the therapeutic process and the resumption of home life in San Antonio. After an MRI was conducted, physicians informed her that her spinal cord had begun healing and that 70 percent of the lesion had recovered into normal spinal tissue. Within six months she had acquired sensation down to the abdominal region. By 2004, she had gained upper body agility and the ability to stand for extended periods of time with the aid of a walker. In addition, she reported improved motor skills, including the ability to stand on her toes and contract her quadriceps and hamstring muscles. She also announced that she had walked more than 1400 feet with the use of braces and outside help. Laura is inspired by the results and hopes to walk unassisted by the time she turns 21. [10]

Not first.  Missed it by just a baker’s dozen of years.

Here are just a small selection of more stem cell heroes from the past:

SPINAL CORD SUCCESSES

 https://repairstemcell.wordpress.com/2009/03/25/spinal-cord-injury-success/

 

MORE SPINAL CORD SUCCESSES

https://repairstemcell.wordpress.com/2009/03/25/more-spinal-cord-injury-success-from-adult-stem-cells/

 

STEM CELLS FOR SPINAL CORD

https://repairstemcell.wordpress.com/2009/03/20/stem-cell-surgery-spinal-cord-injury/

 

16 YEAR OLD PARALYZED KARTING CHAMP

https://repairstemcell.wordpress.com/2009/09/07/16-year-old-paralyzed-karting-champ-undergoing-stem-cell-treatment/

 

PARALYZED WOMAN WALKS ON 21ST BIRTHDAY
https://repairstemcell.wordpress.com/2009/04/23/strength-and-determination-help-paralyzed-woman-walk-on-21st-birthday/

 

QUEST TO CURE HIS DAUGHTER

https://repairstemcell.wordpress.com/2009/04/14/a-father%e2%80%99s-quest-to-cure-his-daughter-well-blog-nytimescom/

 

PARALYSIS IN RATS REVERSED

https://repairstemcell.wordpress.com/2009/04/02/adult-spinal-stem-cells-reverse-paralysis-in-rats/

 

ADULT STEM CELL PROGRAMS

https://repairstemcell.wordpress.com/2009/03/30/il-sussidiarionet-raisman-the-best-results-are-coming-from-the-adult-stem-cell-research-programmes/

 

IMPROVED QUALITY OF LIFE FOR THE PARALYZED

https://repairstemcell.wordpress.com/2009/03/26/adult-stem-cell-study-demonstrates-improved-quality-of-life-for-patients-suffering-from-spinal-cord-injury/

 

A PERSONAL NOTE

http://reflectionsofaparalytic.com/?p=2052

 

FUNDRAISING FOR SPINAL CORD/STEM CELL THERAPY

https://repairstemcell.wordpress.com/2009/03/20/fundraiser-for-spinal-cord-injury-patient-for-stem-cell-treatment/

 

STEM CELLS HELP 52 SPINAL CORD INJURY PATIENTS

https://repairstemcell.wordpress.com/2009/03/19/stem-cell-research-helps-52-spinal-cord-injury-patients-stem-cell-research-adult-stem-cell-research-spinal-cord-injury/

 

PARALYZED LAWMAKER MAKES STEM CELL DECISION

https://repairstemcell.wordpress.com/2009/03/11/paralyzed-ri-lawmaker-hails-stem-cell-decision-international-herald-tribune/

 

JAPAN AHEAD OF USA IN STEM CELLS FOR SCI

https://repairstemcell.wordpress.com/2009/02/10/spinal-cord-injury-sci-stem-cell-trials-japan-plays-catch-up/

 

CHINA AHEAD OF USA FOR STEM CELL TREATMENTS/SCI

https://repairstemcell.wordpress.com/2009/02/27/stem-cell-research-yields-benefits-for-american-man-traveling-to-china/

 

WHY DO WE PRETEND STEM CELLS DON’T WORK?

https://repairstemcell.wordpress.com/2009/02/18/adult-stem-cells-get-the-shaft-none-are-so-blind-as-those-who-will-not-see/

 

IRAN AHEAD OF USA IN STEM CELLS

https://repairstemcell.wordpress.com/2009/02/12/stem-cells-in-iran-catch-up/

 

 

TODDLER, CANCER, STEM CELLS, SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/02/08/toddler-helps-bring-about-a-medical-miracle-cancer-spimal-cord-injury/

 

REGENERATING THE CENTRAL NERVOUS SYSTEM https://repairstemcell.wordpress.com/2011/10/17/regenerating-the-central-nervous-system/

 

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6…-C7 injury

https://repairstemcell.wordpress.com/2009/03/28/stepping-towards-a-paralysis-cure-a-tale-of-two-supermen-stem-cells-cure-23-year-old-male-of-paralysis-c6-c7-injury/

 

Paraplegic – Adult Stem Cell Success Stories – Laura Dominguez

https://repairstemcell.wordpress.com/2010/05/05/paraplegic-adult-stem-cell-success-stories-laura-dominguez/

 

PARALYZED COUSINS PLEASED WITH STEM CELL TREATMENT

https://repairstemcell.wordpress.com/2010/02/15/paralyzed-cousins-pleased-with-stem-cell-treatment/

 

Successful Stem Cell Treatment of Spinal Cord Injury in Dogs

https://repairstemcell.wordpress.com/2010/02/08/successful-stem-cell-treatment-of-spinal-cord-injury-in-dogs/

 

Spinal Cord Injury Patient Wins…and Loses

https://repairstemcell.wordpress.com/2010/02/08/spinal-cord-injury-patient-wins-and-loses/

 

STEM CELLS FOR SPINAL CORD INJURY

https://repairstemcell.wordpress.com/2009/12/31/stem-cells-for-spinal-cord-injury/

 

Adult Stem Cell Grafts Help Paralyzed Heal

https://repairstemcell.wordpress.com/2009/10/21/adult-stem-cell-grafts-help-paralyzed-heal/

 

Medical hope as paralysed dog cured by stem cell therapy

https://repairstemcell.wordpress.com/2009/10/08/medical-hope-as-paralysed-dog-cured-by-stem-cell-therapy-mirror-co-uk/

 

and even, Major the Roseville police dog gets stem cell treatment

http://blogs.citypages.com/blotter/2011/01/major_police_dog_stem_cell.php

 

Time to set the record straight.  Too many have waited too long to get news which blacks out a dozen years of research and progress.

MOSES, STEM CELL PATHWAYS AND MAYBE METASTATIC CANCERS

In ALL ARTICLES, DISEASE INFO, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 20, 2017 at 9:32 am

When white blood cells leave a vessel through the vessel wall, they contort their shape to pass through.  But when stem cells exit a blood vessel, they don’t change their shape.  They just pass on through the wall and the endothelial cells lining the vessel do the work by stretching around them and then actively expelling them.   In other words, the stem cells are the Moses to the parting of the cells of the blood vessels:
“…when we looked at therapeutic stem cells… the endothelial cells not only changed their shape in order to surround the stem cell, they actually pushed the stem cells out of the blood vessel. We’ve named this process angiopellosis, and it represents an alternative way for cells to leave blood vessels.”  Which begs the question…is this how cancer cells move around too?

Stem Cell Finding May Improve Understanding of Metastatic Cancers

  • A stem cell exits the bloodstream through angiopellosis. [Alice MacGregor Harvey, North Carolina State University]

  • Researchers at North Carolina State University have discovered that therapeutic stem cells exit the bloodstream in a different manner than was previously thought. This process, called angiopellosis by the researchers, has implications for improving our understanding of not only intravenous stem cell therapies, but also metastatic cancers.

    When white blood cells need to get to the site of an infection, they can exit the bloodstream via a process known as diapedesis. In diapedesis, the white blood cell changes its shape to squeeze between or through the epithelial cells that form the walls of the blood vessel. Diapedesis is a well-understood process, and researchers believed that other types of cells, like therapeutic stem cells or even metastatic cancer cells, exited blood vessels in a similar way, with the cells pushing or squeezing themselves out.

    But a group of researchers led by Ke Cheng, Ph.D., associate professor of molecular biomedical sciences at NC State with a joint appointment in the NC State/University of North Carolina (UNC)-Chapel Hill Department of Biomedical Engineering, found that these stem cells behaved differently. Their study (“Angiopellosis as an Alternative Mechanism of Cell Extravasation”) appears online in Stem Cells.

    Therapeutic stem cells share the same ability to exit the bloodstream and target particular tissues that white blood cells do. But the precise way that they did so was not well understood, so Dr. Cheng and his team used a zebrafish model to study the process. The genetically modified zebrafish embryos were transparent and had fluorescently marked green blood vessels. Researchers injected the embryos with white blood cells and cardiac stem cells from humans, rats, and dogs. These cells had all been marked with a red fluorescent protein.

    Through time-lapse, three-dimensional, light sheet microscopic imaging, Dr. Cheng and his team could trace the progress of these cells as they left the blood vessel. The white blood cells exited via diapedesis, as expected. When stem cells exited the blood vessel, however, the endothelial cells lining the vessel actively expelled them. Membranes surrounding the endothelial cells on either side of the stem cell stretched themselves around the stem cell, then met in the middle to push the stem cell out of the vessel.

    “When you’re talking about diapedesis, the white blood cell is active because it changes its shape in order to exit. The endothelial cells in the blood vessel are passive,” Dr. Cheng says. “But when we looked at therapeutic stem cells, we found the opposite was true—the stem cells were passive—and the endothelial cells not only changed their shape in order to surround the stem cell, they actually pushed the stem cells out of the blood vessel. We’ve named this process angiopellosis, and it represents an alternative way for cells to leave blood vessels.”

    The researchers found two other key differences between angiopellosis and diapedesis: one, that angiopellosis takes hours, rather than minutes, to occur and two, that angiopellosis allows more than one cell to exit at a time.

    “Angiopellosis is really a group ticket for cells to get out of blood vessels,” notes Dr. Cheng. “We observed clusters of cells passing through in this way. Obviously, this leads us to questions about whether other types of cells, like metastatic cancer cells, may be using this more effective way to exit the bloodstream, and what we may need to do to stop them.”

 

via

STEM CELL ‘LIVING BANDAGE’ FOR KNEE INJURIES

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 19, 2017 at 4:31 pm

Can we regrow a meniscus with stem cells?  Yes, of course.

  1. stem cells are harvested from the patient’s bone marrow
  2. cells are grown for 2 weeks
  3. cells are seeded onto a membrane scaffold
  4. the manufactured cell bandage is surgically implanted into the tear
  5. the cartilage is sewn up around the bandage to keep it in place

    All five patients had an intact meniscus 12 months post implantation

Stem cell ‘living bandage’ for knee injuries trialled in humans

December 16, 2016
Stem cell ‘living bandage’ for knee injuries trialled in humans
Credit: University of Bristol

A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.

Meniscal tears are suffered by over one million people a year in the US and Europe alone and are particularly common in contact sports like football and rugby. 90 per cent or more of tears occur in the white zone of meniscus which lacks a blood supply, making them difficult to repair. Many professional sports players opt to have the torn tissue removed altogether, risking osteoarthritis in later life.

The cell bandage has been developed by Bristol University spin-out company Azellon, and is designed to enable the meniscal tear to repair itself by encouraging cell growth in the affected tissue.

A prototype version of the cell bandage was trialled in five patients, aged between 18 and 45, with white-zone meniscal tears. The trial received funding support from Innovate UK and the promising results have been published today in the journal Stem Cells Translational Medicine.

The procedure involved taking , harvested from the patient’s own bone marrow, which were then grown for two weeks before being seeded onto a membrane scaffold that helps to deliver the cells into the injured site. The manufactured cell bandage was then surgically implanted into the middle of the tear and the cartilage was sewn up around the bandage to keep it in place.

All five patients had an intact meniscus 12 months post implantation. By 24 months, three of the five patients retained an intact meniscus and had returned to normal knee functionality whilst the other two patients required surgical removal of the damaged meniscus due to a new tear or return of symptoms.

Professor Anthony Hollander, formerly of Bristol and now Chair of Stem Cell Biology at the University of Liverpool and Founder and Chief Scientific Officer of Azellon, said: “The cell bandage trial results are very encouraging and offer a potential alternative to surgical removal that will repair the damaged tissue and restore full knee function.

“We are currently developing an enhanced version of the cell bandage using donor stem cells, which will reduce the cost of the procedure and remove the need for two operations.”

The cell bandage was produced by the Advanced Therapies Unit at the NHS Blood & Transplant facility in Speke, Liverpool and implanted into patients at Southmead Hospital in Bristol, under the supervision of Professor Ashley Blom, Head of Orthopaedic Surgery at the University of Bristol.

Professor Blom, from Bristol’s School of Clinical Sciences, commented: “The cell bandage offers an exciting potential new treatment option for surgeons that could particularly benefit younger patients and athletes by reducing the likelihood of early onset osteoarthritis after meniscectomy.”

A spokesperson for Innovate UK said: “Turning into clinical and commercial reality requires close collaboration between businesses, universities, and Hospitals. It’s great to see this inter-disciplinary approach has led to such an exciting outcome from this first-in-human trial.”

Explore further: Pioneering stem cell bandage receives approval for clinical trial

More information: Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study, , DOI: 10.1002/sctm.16-0199, http://onlinelibrary.wiley.com/doi/10.1002/sctm.16-0199/abstract

Read more at: https://medicalxpress.com/news/2016-12-stem-cell-bandage-knee-injuries.html#jCp

Is Donald Trump FOR or AGAINST Stem Cells?

In ALL ARTICLES, BUSINESS OF STEM CELLS, STEM CELLS IN THE NEWS on January 17, 2017 at 11:08 am

Same old tug of war

While much has been written about this, few have answered it well.  Let’s try.  A brief recap.

  1. President-Elect is considering representative Andrew Harris (R-MD) as Director of the National Institutes of Health.
  2. “Some researchers are concerned about how Harris might approach human embryonic stem cell research. In 2005, when Harris was a member of the Maryland legislature, he led an ultimately unsuccessful effort to derail legislation creating a state [Embryonic] stem cell research fund.” via
  3. If Harris is NIH Director, he will support adult stem cells but not embryonic stem cells.

So, if Trump places Harris, there will be more support for Adult stem cells and less for Embryonic.

Is that good or bad?

  1.  While there are different stem cells sources; embryonic, adult (about 70), iPSC, etc., in the US, the POLITICAL debate is only about Embryonic vs Adult stem cells.
  2.  Embryonic stem cells are powerful BUT have a history of generating cysts, tumors, teratomas and cancer and virtually zero successes to date.
  3. Many of the 70+ adult stem cells are less powerful but…SOME may be AS powerful as embryonic stem cells.
  4. Many conditions can be treated with the adult stem cells from your own body (autologous).
  5. Adult stem cells have almost 1,000 clinical trials proving safety and efficacy.  https://repairstemcell.wordpress.com/stem-cells-for-newbies/

So…

if Trump picks Harris = Pro Adult = Anti Embryonic = Pro Treatments Now

Donald Trump And The Great Stem Cell Decision

01/16/2017 02:13 pm ET

I do not think President-elect Donald Trump has his mind completely made up on the subject of stem cell research. Certainly I cannot find any quotes from him opposing the research.

But if the President-Elect chooses representative Andrew Harris (R-MD) as Director of the National Institutes of Health, that will signify an irrevocable decision. The President-elect will have boxed himself in as an opponent not only of stem cell research supporters, but also the one in five Americans with a disability—and we, their families, who dream of cure.

Families like mine.

My paralyzed son Roman Reed’s name is on state legislation which funded the first embryonic stem cell research therapy in the nation: The Roman Reed Spinal Cord Injury Research Act of 1999. “Roman’s Law” funded Dr. Hans Keirstead’s famous method of using embryonic stem cells to “re-insulate” damaged spinal cord nerves, currently in human trials.

In California, voters backed a $6 billion stem cell program, which has led to therapies in clinical trials for blindness, diabetes, spinal cord injuries, cancer and much more.

We felt so strongly about protecting our research that we established protections for it in the California State Constitution.

This was done precisely because of political ideologues like Representative Harris, a determined enemy of the research California supports. In public and behind the scenes, Harris has worked against embryonic stem cell research since 2005, when he tried (unsuccessfully) to kill a stem cell program for his own home state of Maryland. But that was not the end of his attacks.

Harris co-sponsored a “personhood” bill, House Resolution 816, which defined every fertilized egg as a person with rights under law. Bear in mind a fertilized egg is essentially liquid, often shed unnoticed in a woman’s monthly cycle. Yet personhood bills would criminalize embryonic stem cell research.

It was almost certainly Harris who manipulated the 21st Century Cures Act so that its funds were limited to the less effective adult stem cells, with zero funding allowed for the far more powerful embryonic.

President-Elect Trump might wish to consider retaining the services of Francis Collins, the current Director of the National Institutes of Health. A born-again Christian, Dr. Collins is a moderate, not a boat-rocker. But he is also pro-stem cell.

Dr. Collins is strongly supported by such key Republicans as Lamar Alexander, Chairman, Senate Health, Education, Labor and Pensions Committee; Roy Blunt, Chairman, Senate Appropriations Subcommittee on Labor, Health and Human Services; Fred Upton, Chairman, House Committee on Energy and Commerce; and Tom Cole, Chairman, House Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies.

On December 2, 2016, these Republican leaders sent an open letter to President-elect Trump, recommending the retention of Dr. Collins, saying:

“Dr. Collins is the right person, at the right time, to continue to lead the world’s premier biomedical research agency. He possesses all the attributes one should have as the Director of the National Institutes of Health—intellectual prowess, renowned scientific experience, and outstanding leadership skills. We are confident that under his leadership and with Congress’ commitment to biomedical research as a national priority, the National Institutes of Health will thrive and continue to enhance the Nation’s health through scientific discovery and biomedical research.”

Selecting Francis Collins as NIH Director puts the President on the side of science.

But for all who hope for a positive stem cell policy, hiring Andrew Harris would be an absolute deal-breaker.

Don C. Reed is the author of “STEM CELL BATTLES: Proposition 71 and Beyond: How Ordinary People Can Fight Back Against the Crushing Burden of Chronic Disease”, World Scientific Publishing, Inc.

http://www.huffingtonpost.com/don-c-reed/post_13911_b_14152616.html

SCIENTISTS “STUNNED” AS STROKE PATIENT WALKS AGAIN

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS FROM THE PAST, STEM CELLS IN THE NEWS on January 14, 2017 at 12:34 pm

“Stunned?”
C’mon guys…

stroke

STROKE CLINICAL TRIALS

  • The University of Texas, Health Science Center at Houston July 1, 2009       Several months after becoming the first patient in the United States to undergo a revolutionary new stroke treatment, Roland “Bud” Henrich continues to improve. Doctors intravenously injected Henrich, 61, with stem cells taken from his own bone marrow…”The stem cells, we believe, may help repair the damage to his brain caused by the stroke,” said Sean Savitz, M.D., assistant professor of neurology at The University of Texas Medical School at Houston and the study’s lead investigator. “Animal studies have shown that when you administer stem cells after stroke, the cells enhance the healing. We know that stem cells have some kind of guidance system and migrate to the area of injury. They’re not making new brain cells but they may be enhancing the repair processes and reducing inflammatory damage.” http://www.texmedctr.tmc.edu/root/en/TMCServices/News/2009/07-01/Stem+Cells+Tested+for+Treatment+of+Stroke.htm

Other STROKE articles:

  1. https://repairstemcell.wordpress.com/2010/09/21/autologous-neural-stem-cells-benefit-parkinson%e2%80%99s-patients-adultstemcell-com/
  2. https://repairstemcell.wordpress.com/2010/09/20/stem-cell-treatment-for-stroke-and-traumatic-brain-injury-wholewellness-net/
  3. http://www.scientificamerican.com/article.cfm?id=can-stem-cells-block-stroke-damage
  4. http://www.sciencedaily.com/releases/2011/08/110831160216.htm
  5. https://repairstemcell.wordpress.com/2010/04/28/stem-cells-from-menstrual-blood-may-benefit-stroke-patients/
  6. http://www.philly.com/philly/health/HealthDay686541_20140407_Stem_Cells_Show_Pro

—————-

New Stem Cell Treatment Leaves Scientists “Stunned” As Wheelchair-Bound Stroke Patient Walks Again

MORE THAN 70 PERCENT OF STROKE PATIENTS END UP WITH LONG-TERM DISABILITIES.

Researchers are said to be “stunned” by the success of a recent clinical trial of a new stem cell treatment for stroke patients. By injecting the cells into participants’ brains, scientists were able to produce some remarkable improvements, with several patients regaining motor function in their limbs.

A full report of the study has been published in the journal Stroke, with lead author Gary Steinberg telling the Washington Post that patients’ improvements were “not just minimal recovery like someone who couldn’t move a thumb now being able to wiggle it. It was much more meaningful. One 71-year-old wheelchair-bound patient was walking again.”

The trial involved the use of modified bone marrow–derived mesenchymal stem cells, which were injected into the specific region of each patient’s brain that had become damaged following their stroke. Amazingly, the researchers were not actually expecting to see any clinically relevant results at this stage, as they were just testing out a low dose of the treatment in order to assess its safety.

However, of the 18 patients involved in the study, seven experienced dramatic improvements in their cognitive and motor capabilities. In terms of safety, the study authors report that all participants experienced at least one temporary adverse effect, ranging from headaches and nausea to muscle spasticity. Importantly, though, all of these are thought to have been caused by the surgical procedure itself rather than the stem cells.

 

To evaluate the success of the treatment, the researchers used a number of standardized scales that are commonly used to assess the severity of symptoms in stroke patients. For instance, the Fugl-Meyer motor function total score is often used to measure recovery, with an improvement of 10 points representing a “clinically meaningful” change.

The patients involved in the study experienced an average improvement of 11.4 points on this scale, which translated into a “clinical improvement in the power of upper and lower limbs, ranging from an improvement in the ability to stand to the disappearance of tremor.”

Furthermore, the study authors make a point of noting that their patients had been suffering from their various symptoms for an average of 22 months prior to treatment. This is well beyond the six-month cut-off period that is typically considered to represent the point at which stroke-related brain damage becomes permanent and untreatable.

Exactly how the treatment works is not entirely understood, although Steinberg suspects that the stem cells somehow kick-start the brain’s own ability to repair itself, rather than developing into new neurons themselves.

Given that at present, more than 70 percent of people who suffer strokes end up with some sort of enduring disability, this new treatment could potentially be a game-changer – although more trials will be needed before it becomes readily available.

 

http://www.iflscience.com/brain/new-stem-cell-treatment-leaves-scientists-stunned-as-wheelchairbound-stroke-patient-walks-again/

SCARS: Hair Today, Gone Tomorrow

In ALL ARTICLES, SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS on January 12, 2017 at 9:27 am

The End of Scars: Scientists Discovered How to Regenerate Human Skin

IN BRIEF
  • A team of scientists from the Perelman School of Medicine at the University of Pennsylvania found a way to get skin to regenerate using fat cells.
  • According to the researchers, the secret is to regenerate hair follicles first – the fat will regenerate in response to the signals from those follicles

AS IF IT NEVER HAPPENED

The human body can do many impressive things. Despite years of evolution honing its capability to carry out the complicated mechanisms needed to ensure our survival, the body has not refined the process of healing skin. Sure, wounds inflicted on the body’s largest organ can heal, but we are left with scar tissue.

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania however, believe they have found a way to do the previously impossible – allow skin to regenerate using fat cells.

Image Credit: Penn Medicine

Adipocytes, the type of skin that regenerates after we get superficial cuts, is filled with fat cells that allow it to blend easily to the rest of your skin as it heals. Scar tissue (made up cells called myofibroblasts), which occurs as our skin heals from deep cuts, looks very different because it contains no fat cells or hair follicles.

“The findings show we have a window of opportunity after wounding to influence the tissue to regenerate rather than scar,” said the study’s lead author Maksim Plikus, PhD, an assistant professor of Developmental and Cell Biology at the University of California, Irvine.

George Cotsarelis, chair of the Department of Dermatology at the University of Pennsylvania, explains,”the secret is to regenerate hair follicles first. After that, the fat will regenerate in response to the signals from those follicles.”

WINDOW OF OPPORTUNITY

The scientists just had to figure out where the signals were coming from. They eventually identified a factor called Bone Morphogenetic Protein which instructs the myofibroblasts to become fat. “Typically, myofibroblasts were thought to be incapable of becoming a different type of cell,” Cotsarelis said. “But our work shows we have the ability to influence these cells, and that they can be efficiently and stably converted into adipocytes.”

While the discovery is indeed impressive, it should be noted that the experiment is still in its early stages and serves only to demonstrate proof of concept.

Currently the process has only been proven to work in mice and human skin samples. Achieving hair follicle growth in a wound attached to a living human might prove to be more difficult. But should science find a way to do this, we may not have to worry about wounds leaving scars ever again.

Outside of obvious applications to prevent scarring, adipocyte loss is also a known side-effect of other medical conditions, including HIV treatments. The aging process leads to natural loss of these cells as well, which causes permanent wrinkling of the skin. These findings could pave the way for a safer, and possibly permanent, way to address these cosmetic concerns.

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