Archive for April 19th, 2013|Daily archive page


In STEM CELLS IN THE NEWS on April 19, 2013 at 4:43 pm

This is how it happens.  A-Rod says: yo, dude, them stem cells worked for me, try it out…then Dana White gets them and has “100% success!” and then Dana reaches out to Freddy Roach, boxing trainer extraordinaire all following Muhammad Ali who got them in 20010 and they’ll tell 2 friends and so on…and then it’s everywhere!  Damn right!  My 8 years of shouting from the rooftops have led to this moment in time.  Can I get an “Amen” and a “Tipping Point!”

Dana White Meniere’s Disease: A-Rod, German stem cell treatment cure UFC President ‘100 percent’

By Adam Guillen Jr. on Apr 18 2013, 7:00p  @AdamGuillenJr 54



Scott Cunningham

On a tip from New York Yankees third basemen Alex Rodriguez, UFC President Dana White recently made a pitstop in Germany to undergo a stem cell procedure to alleviate his battle with Menier’s Disease. It apparently did more than just that …

Ultimate Fighting Championship (UFC) President Dana White revealed last year he was suffering from Menier’s disease, an inner ear disorder that causes spontaneous episodes of vertigo, which is a spinning sensation that also includes fluctuating hearing loss, as well as ringing in the ear (tinnitus), among other debilitating symptoms.

After a failed surgery (see graphic footage ere) to correct the ailment, which resulted in the Las Vegas, Nevada, mixed martial arts (MMA) boss suffering a “bad attack” during a recent trip to Ireland, White rolled the dice, opting to go the experimental route to alleviate the problem.

And he can thank New York Yankees third basemen, Alex Rodriguez, for the advice.

After a recent exchange with $275 million man, White flew out to Germany to undergo a stem cell procedure that miraculously has him now feeling like “a million bucks.” He recently shared the bizarre road to recovery on a recent appearance on “Jay Mohr Sports” on Fox Sports Radio.

His explanation:

“Well, A-Rod from the Yankees, hit me up and told me that when he was hurt Kobe called him and they both went to Germany and did this stem cell stuff. Right. So he says listen bro, I don’t know if this is going to help you, but I’ll tell you what it’s worth a shot. Well long story short, we had the fight out in Sweden. I went to Germany. I got the stem cells. Dude, I am 100 percent cured. I am 100 percent a new guy, man. I’m working out again. I’m doing all the things that I used to do. I’m traveling. My life is back. All they do is they go in there, they take your blood, they incubate it, they spin it and add stuff to it. I don’t know what the hell they do, I’m no scientist. I’m a million bucks now, man. I couldn’t feel better.”

According to White, the original procedure only made the problem worse, causing him to live a pretty “miserable life.”

But, thanks to German doctors, he’s a “new guy” and is now looking to pass on the knowledge to world-famous boxing trainer Freddie Roach, who suffers from Parkinson’s Disease, because the same stem cell procedure can help improve the nervous system.

Spread the word.


A brand new rat kidney being built on the scaffold of an old one <i>(Image: Ott Lab, Center for Regenerative Medicine, Massachusetts General Hospital)</i>

A brand new rat kidney being built on the scaffold of an old one

(Image: Ott Lab, Center for Regenerative Medicine, Massachusetts General Hospital)

Kidney breakthrough: complete lab-grown organ works in rats


  • 18:00 14 April 2013 by Andy Coghlan


For the first time, complete lab-grown kidneys have been successfully transplanted into rats, filtering and discharging urine as a normal kidney would.


The breakthrough paves the way for human-scale versions, which could potentially provide an inexhaustible supply of organs, eliminating the need for recipients to wait for a matching donor kidney Movie Camera.


Similar techniques have already been applied successfully in people with simpler tissue, such as windpipes. But the kidney is by far the most complex organ successfully recreated.


“If this technology can be scaled to human-size grafts, patients suffering from renal failure, who are currently waiting for donor kidneys, could theoretically receive an organ grown on demand,” says Harald Ott, head of the team that developed the rat kidneys at the Massachusetts General Hospital in Boston.


“In an ideal world, such grafts could be produced from patient-derived cells, enabling us to overcome both donor organ shortages and the need for long-term immunosuppression drugs,” says Ott. Currently in the US alone, 18,000 transplants are carried out each year, but 100,000 Americans remain on waiting lists.


Strip and coat


To make the rat kidneys, Ott and his colleagues took kidneys from healthy “donor” rats and used a chemical solution to wash away the native cells, leaving behind the organ’s scaffold. Because this is made of collagen, a biologically inert material, there is no issue of the recipient’s body rejecting it.


Next, the team set about regrowing the “flesh” of the organ by coating the inner surfaces of the scaffold with new cells. In the case of humans, these would likely come from the recipient, so all the flesh would be their own.


The kidney was too complex to use the approach applied to the windpipe – in which its scaffold was coated by simply immersing it in a bath of the recipient’s cells.


Instead, the team placed the kidney scaffolds in glass chambers containing oxygen and nutrients, and attached tubes to the protruding ends of the renal artery, vein and ureter – through which urine normally exits the kidney. They recoated the insides of the blood vessels by flowing human stem cells through the tubes attached to the artery and vein. Through the ureter, they fed kidney cells from newborn rats, re-coating the labyrinthine tubules and ducts that make up the kidney’s urine filtration system.


It took many attempts to establish the precise pressures at which to feed the cells into the organ, as if it was growing in an embryonic rat. Remarkably, given the complexity of the kidney, the cells differentiated into exactly those required in the different compartments of the organ. “We found the correct cell types homed in to specific regions in the organ matrix,” says Ott.


The kidneys, which took about a fortnight to fully recoat, worked both in the lab and when transplanted into rats. They filtered out and discharged urine, although they did not sieve it as well as a natural kidney would. Ott is confident that the function can be improved by refining the technique.


Humans and pigs


The team is now attempting the same procedure using human kidneys, and also pig kidneys, which could be used to make scaffolds if there were a scarcity of human donors. The team has already successfully repopulated pig kidneys with human cells, but Ott says further studies are vital to guarantee that the pig components of the organ do not cause rejection when transplanted into humans.


The fact that heart valves and other “inert” tissues from pigs are already successfully used in humans without rejection suggests that this will not be a big problem.


Other researchers working in the field hailed the team’s success at recreating such a complex organ. “The researchers have taken a technique that most in the field thought would be impossible for complex organs such as the kidney, and have painstakingly developed a method to make it work,” says Jamie Davies at the University of Edinburgh, UK, who was part of a team that last year made some headway in their attempts to grow kidneys from scratch in the lab. “By showing that recellularisation is feasible even for complicated organs, their work will stimulate similar approaches to the engineering of other body systems.”


Journal reference: Nature Medicine, DOI: 10.1038/nm.3154


In ALL ARTICLES, OFF THE BEATEN PATH on April 19, 2013 at 3:42 pm
Why New Atoms Aren’t a Fountain of Youth

by Shannon Fowler

July 14, 2007 2:58 PM
Photo of Atomic Model

Even though our atoms are replaced each year, the cells that carry the atoms eventually become damaged and stop working as efficiently.

Three Lions/Getty Images

If our atoms are being replaced every day, why do we age?

In a study published in the Annual Report for Smithsonian Institution in 1953, scientists found that 98 percent of our atoms are replaced each year. Atoms make up molecules, which make up cells, which make up tissues, which make up organs.

So with all these new atoms in our bodies every year, why do we get old?

Lawrence Brody, Ph.D., a physicist at the National Human Genome Research Institute, says the problem isn’t that the atoms are getting old, but that the structure is.

“Imagine building a sand castle. Four walls, some nice turrets, central spire, a moat—you gotta have a moat,” Dr. Brody says. “Now start replacing 100 percent of the sand with nice new sand.”

Think about what would happen to the structures of the walls and the turrets. How well would the moat continue to function after all that sand was replaced?

Carbon Copy

Every day, our bodies take in new atoms from the air we breathe, the food we eat, and the liquids we drink. These atoms are incorporated into our cells and fuel the chemical processes that keep us alive.

But our cells are constantly being regenerated. The DNA in each cell copies itself over and over again. Eventually, mistakes creep in and cells develop faults which get copied and passed on.

Suppose a chain mail goes out by fax — it goes to a friend, who faxes it to a friend, and so on. Over time, spots and wrinkles on the paper appear, and these turn up in subsequent copies.

Environmental Damage

Some cells, like red blood cells, white cells or skin cells, have short life spans of weeks to months. Because they replace themselves so often, there is a higher chance a copying mistake will arise.

Cells in our brains, heart, and bones last longer. Although these cells are less vulnerable to copying mistakes, they are more susceptible to damage caused by environmental factors such as radiation or toxins. Either way, cells stop working as well and we grow old.

Oxygen Damage

We need oxygen to survive. But during the normal chemical processes that take place in our bodies, oxygen can produce free radicals. These are highly unstable molecules that can set off chemical reactions that interfere with DNA and damage cells.

Free radicals are thought to play a key role in aging. So what can we do about oxygen?

“Avoid it, and you’d stay young forever,” Dr. Brody advises.



In ALL ARTICLES, OFF THE BEATEN PATH on April 19, 2013 at 3:40 pm
Atomic Tune-Up: How the Body Rejuvenates Itself


July 14, 2007 6:49 PM
Image of Star Trek actor DeForest Kelley

On Star Trek, Dr. Leonard McCoy, played by actor DeForest Kelley, never wanted to be beamed anywhere because he worried it would scatter his atoms across the universe.

Hulton Archive/Getty Images

For most people, a makeover means losing weight and getting new clothes, hair and makeup.

But what they may not know is that the body does its own extreme makeover regularly. In fact, 98 percent of the atoms in the body are replaced yearly.

Researchers in the 1950s made the discovery by feeding their subjects radioactive atoms. Using radiation detectors, the researchers watched the atoms move all over the body. They found that the new atoms replaced old ones and ended up in all tissues of the human body.

But these atomic makeovers prompt a more philosophical question: Are people really themselves if their atoms are always new, or are they new people each year? David Kestenbaum tackled that philosophical question — and discussed atomic makeovers — with the experts.


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