Dental pulp stem cells: a promising tool for bone regeneration.
Human tissues are different in term of regenerative properties. Stem cells are a promising tool for tissue regeneration, thanks to their particular characteristics of proliferation, differentiation and plasticity. Several “loci” or “niches” within the adult human body are colonized by a significant number of stem cells. However, access to these potential collection sites often is a limiting point. The interaction with biomaterials is a further point that needs to be considered for the therapeutic use of stem cells. Dental pulp stem cells (DPSCs) have been demonstrated to answer all of these issues: access to the collection site of these cells is easy and produces very low morbidity; extraction of stem cells from pulp tissue is highly efficiency; they have an extensive differentiation ability; and the demonstrated interactivity with biomaterials makes them ideal for tissue reconstruction. SBP-DPSCs are a multipotent stem cell subpopulation of DPSCs which are able to differentiate into osteoblasts, synthesizing 3D woven bone tissue chips in vitro and that are capable to synergically differentiate into osteoblasts and endotheliocytes. Several studies have been performed on DPSCs and they mainly found that these cells are multipotent stromal cells that can be safety cryopreserved, used with several scaffolds, that can extensively proliferate, have a long lifespan and build in vivo an adult bone with Havers channels and an appropriate vascularization.
Dental stem cell banking facility launched by Stemade Biotech this week in Punjab, India with the intent to expand across the county. “This will help the people to secure their healthy future. Like timely monetary investments help plan future financial security, dental stem cell banking can help plan for a disease- free body.” said Dr Vikas Jindal.
“Stem cells have a defining property to self- regenerate, which can be used to treat serious ailments. Unlike bone marrow stem cells, extracting dental cells is a noninvasive procedure. Dental pulp contains stem cells, known as dental pulp stem cells. The finest dental pulp stem cells are found in baby teeth or milk teeth. Dental stem cells can generate solid structures such as bone, new dental tissue, cartilage and muscle. Dental pulp stem cell banking can be done on milk teeth of children in the age group of five to 12. Teens that are undergoing orthodontic procedures, such as getting braces, have the opportunity to bank their premolars that are often extracted during the procedure. Adults on the other hand have the opportunity to bank on their dental pulp stem cells through wisdom teeth.”
“Dental Stem cells are Mesenchymal (tissue-related) stem cells whilst umbilical cord blood provides hematopoietic (blood-related) stem cells. Hematopoietic stem cells have the potential to treat only blood-related disorders such as leukemia etc whereas, mesenchymal stem cells have potential applications in all other tissues of our body such as brain for treatment of Alzheimer’s, Parkinson’s, eye for corneal reconstruction and liver for cirrhosis, said Shailesh Gadre Managing Director, Stemade Biotech.”
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