DAVID GRANOVSKY

STEM CELLS USED TO ELIMINATE ANTI-REJECTION MEDICATION

In SCIENCE & STEM CELLS, STEM CELLS IN THE NEWS, VICTORIES & SUCCESS STORIES on December 8, 2012 at 9:35 am

White blood cells in the bloodstream

A new ground-breaking study was performed at Northwestern University focused on ridding Kidney transplants patients of the arduous task of the “never-ending” anti-rejection medications.  Dr. Joseph R. Leventhal and his team successfully created chimerism (two immune systems in the same recipient) which eliminates the need for anti-rejection medications within six months to a year of the surgery.

“The results have been remarkable…It may reshape the landscape of how we perform transplants over the next decade”, said Dr. Leventhal.

 

People whose kidneys are failing can wait years to get a transplant. About one in 20 will die during that wait. New kidneys offer transplant patients a second chance at life. But what they have to do for the rest of their lives is a big concern to many. “The thing that scared me the most about the transplant wasn’t the operation,” said Lindsay Porter, who had polycystic kidney disease. Porter’s kidneys had swelled to eight pounds apiece “At the end, I was wearing maternity clothes,” she said. She had PKD, or polycystic kidney disease, and needed a transplant. She wasn’t scared of the surgery, but something did frighten her. “It was really the medications,” said Porter. She feared the anti-rejection drugs she would have to take for the rest of her life and the other medications to help with the possible side effects of those drugs.

Lori Felber Knows All About That. Nine pills a day–3285 pills a year. That’s what she’s had to take since her kidney transplant in 2008. Felber is grateful her husband was able to save her life by donating his kidney, but not for having to take these expensive drugs all the time. But today, Porter’s doesn’t have to. “I take nothing, nothing,” she said. She took part in a pioneering study at Northwestern University. It involved 18 kidney transplants, where the unmatched, unrelated donors gave more than kidneys to the recipients. They also gave their stem cells. “The results have been remarkable,” said Joseph R. Leventhal, MD, PhD, Associate Professor of Surgery and Director of Kidney and Pancreas Transplantation at Northwestern University. Dr. Leventhal heads up the study. He says the idea is to create chimerism, or two immune systems in the recipient. Joseph R. Leventhal, MD, PhD, “So, you have peaceful co-existence, if you will, of the donor’s stem cells with the other aspects of the recipient’s immune system,” said Dr Leventhal. To make that happen, Porter had chemotherapy and radiation before the transplant, to weaken her own immune system. The day after her transplant, engineered stem cells from her donor were infused into Porter’s body. Days later, one more chemo session was given. While she started off on the full regimen of anti-rejection drugs, “I was on the medications for about six months before they started weaning me off of it,” said Porter. Unlike Felber, who faces a lifetime of medications and potential side effects, Porter was off all the drugs after just one year. Dr. Leventhal says most recipients who went through the procedure had similar results. While there was a risk of the injected stem cells reacting against their bodies, none experienced that. “It may reshape the landscape of how we do transplant over the next decade,” said Dr. Leventhal. With a healthy kidney and no more anti-rejection drugs to take, Porter’s free to spend her time with her son “I’m so glad that I’ve had the last two years to really be with him 100%,” she said. Porter said the procedure cured her of her high blood pressure, and her blood type changed to the blood type of her donor. The transplant study she was involved in is ongoing. A second trial is also being planned. It will offer a similar treatment to people, like Felber, who’ve already undergone a living donor kidney transplant.

BACKGROUND:
TRANSPLANTATION: Organ transplantation is the surgical removal of an organ or tissue from one person and putting it another. Organs that can be donated include the kidney, heart, liver, lung, pancreas, and intestine, but tissues such as bone, cartilage, and the cornea can also be transplanted. With about 4,100 transplant candidates added to the national waiting list each month, the number of people in need of a transplant is rising faster than the number of donors. Although around 77 people a day receives transplants, there are also about 18 that die waiting due to the shortage of donated organs. (Source: http://www.womenshealth.gov)
CARE AFTERWARDS: After a transplant, most people need to take a lot of medications. These medications include immunosuppressants, which stops the body from rejecting the organ. Other than the annoyance of having to take multiple pills for the rest of their lives, the immunosuppressants may also make the person more likely to get infections and make it harder to recover from some infections and illnesses. Patients will continue to have their health monitored by their doctor for many years after the surgery as well. (Source: http://www.womenshealth.gov)

DONATION: Most of the donated organs and tissues come from people that have already died but living people can donate a kidney or a part of their liver, intestine, pancreas, and lung as well. Becoming an organ donor is a personal decision and there are many reasons why some people decide not to donate. For living donors, the operation can be risky and for those who have died, religious views may stand in the way. Disease or a medical condition will not exclude a person from donating, but here are some medical conditions that mean a person cannot donate:
1. HIV
2. Actively spreading brain cancer
3. Certain severe, current infections (Source: http://www.womenshealth.gov)

NEW TRANSPLANT THEORY: The new clinical trial by researchers from Northwestern Medicine and the University of Louisville is hoping to ‘trick’ the recipient’s immune system into thinking that the transplanted organ is a part of the patients natural self so the need for anti-rejection medication will be reduced or eliminated gradually. A month before the transplant, bone marrow stem cells are collected from the kidney donor’s blood, then sent to the University of Louisville where researchers enrich for “facilitating cells” believed to help transplants succeed. At the same time, the recipient undergoes chemotherapy and radiation to suppress bone marrow in order to make room for the donor’s stem cells to grow. The day after the transplant, the donor’s stem cells are put into the recipient and hopefully the two systems exist and function in one person. So far, results have been good. (Source: http://www.northwestern.edu)

http://www.wndu.com/home/headlines/Stem-cells-may-help-transplant-patients-avoid-medication-180215951.html

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  1. Informative article and paints the picture of a promising future for patients. Kidney donation is truly a gift of life. With modern medication kidney donors and recipients usually go on to live normal and healthy lives.

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