Egg-making stem cells found in adult ovaries
Discovery could pave the way for new fertility treatments and a longer reproductive life.
It’s time to rewrite the textbooks. For 60 years, everyone from high-school biology teachers to top fertility specialists has been operating under the assumption that women are born with all the eggs they will ever produce, with no way to replenish that supply. But the discovery of human egg-producing stem cells, harvested from the ovaries of six women aged 22 to 33, puts that dogma in doubt.
The work, published online in Nature Medicine1 by Jonathan Tilly and colleagues at Massachusetts General Hospital in Boston, parallels the findings of a Shanghai-based group2 that isolated similar stem cells from mice in 2009. However, both this and Tilly’s earlier work in mice3 remained controversial, with many experts sceptical that such stem cells existed.
“This is unequivocal proof that not only was the mouse biology correct, but what we proposed eight years ago was also correct — that there was a human population of stem cells in young adult tissue,” says Tilly…
SOURCES & REFERENCES
|Nature Medicine | 26 February 2012|
|Nature | 11 April 2004|
|Cell | 23 September 2005|
|Cell | 29 July 2005|
|Nature | 14 June 2006|
|Nature Cell Biology | 12 April 2009|
|Science | 02 March 2012|
|27 February 2012 – by Antony Blackburn-Starza|
|Scientists in the USA have shown it may be possible to isolate egg-producing stem cells from women’s ovaries….[Read More]|
|20 April 2009 – by Dr Charlotte Maden|
|New work in stem cell research has challenged the long-standing belief that women are born with all the eggs they will ever need. The results were published in the journal Nature Stem Cell, although the study was received with caution. The scientists at Shanghai Jiao Tong University…[Read More]|
|21 May 2007 – by Stuart Scott|
|Hopes aroused by a controversial study suggesting that women may be able to produce new egg cells have been seemingly dashed. The 2005 paper, published in the journal Cell by researchers at Massachusetts General Hospital, fleetingly gave hope to infertile women when it suggested that egg production…[Read More]|
|16 June 2006 – by Dr Jess Buxton|
|A new US study has cast serious doubt on controversial research that suggested bone marrow stem cells can produce new eggs in adult mice. Last year, a team based at Massachusetts General Hospital reported in the journal Cell that the eggs of mice rendered sterile could…[Read More]|
|03 October 2005 – by BioNews|
|A US woman who became infertile after cancer treatment has stunned doctors by becoming pregnant naturally, following a transplant of ovarian tissue into her abdomen. Ann Dauer, from Canton, Ohio has now given birth to a healthy baby girl, named Sienna. Mrs Dauer had one of her ovaries removed and…[Read More]|