DAVID GRANOVSKY

Archive for October, 2011|Monthly archive page

SILENCE OF THE LAMBS MEETS STEM CELLS! – THE HARDCORE SCIENCE

In ALL ARTICLES on October 27, 2011 at 8:57 pm

Tolerance to Composite Tissue Allografts is Dependent on the Administration of Hematopoietic Stem Cells but not Long-Term Engraftment

David Mathes1,2, Jeff Chang1,2, Scott Graves2, Billana Huang2, Tiffany Miwongtum2, Rainer Storb2

1Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Washington; 2Transplantation Biology Research Center, Fred Hutchinson Cancer Research Center; Seattle, Washington, USA

Introduction: Composite tissue allografts (CTA) are a clinical reality.  However, the survival of these transplants is dependent on immunosuppression. This experiment sought to develop a large animal model for the simultaneous transplantation of hematopoietic stem cells (HSC) and CTA using our mixed chimerism protocol and to examine the role of the HSC infusion.

Methods: 4 transplants were performed across a DLA matched, minor mismatch barrier. All dogs received 200 cGy of radiation and a CTA transplant with injection of HSC. 3 dogs underwent the protocol except without an HSC infusion. All dogs received 35 days of post-grafting immunosuppression and were followed for donor cell chimerism and underwent biopsies. Tolerant animals underwent a donor and third-party skin graft. Finally, they were followed for levels of FoxP3 and GranzymeB in the transplanted muscle and skin.

Results: All of the experimental animals demonstrated long-term tolerance to the CTA (497, 467, 465, and 400 days). 3 of 4 dogs had long-term detectable donor chimerism. One dog lost its chimerism at 10 weeks post-transplant but remained tolerant to the CTA. The expression of CD3+ FoxP3 was stable in the tolerant transplanted muscle and skin.  It was also noted to be elevated in the draining lymph node. The three dogs transplanted without an HSC infusion rejected their transplants at 45 days after the cessation of post-grafting immunosuppression. All of the tolerant dogs accepted the donor skin graft and promptly rejected the third-party graft.

Conclusion: The simultaneous transplant of HSC and CTA leads to tolerance. This tolerance induction appears to be dependent on the administration of HSC but not its long-term engraftment. This finding suggests that modifications to the protocol that promote initial engraftment but not long-term presence of donor cells will be key to the development of a protocol that can used on complete mismatched transplants.

http://www.bss2011.org/index.php?option=com_content&view=article&id=169:557&catid=5:poster-abstracts&Itemid=39

DAMN! SILENCE OF THE LAMBS MEETS STEM CELLS!

In VICTORIES & SUCCESS STORIES on October 27, 2011 at 8:01 pm

SILENCE OF THE LAMBS MEETS STEM CELLS and future transplant recipients win big!!

https://repairstemcell.files.wordpress.com/2011/10/anthony_hopkins_hannibal_lecter.jpg?w=147Remember in Silence of the Lambs, at the end of the movie, when Hannibal Lecter cuts off the guards face and then wears it out to escape?  It turns out, if he had some stem cells to go with that face transplant, he could have just kept on wearing it. 

Surgical researchers did exactly that on four dogs and all 4 of the dogs tolerated the face transplants for over one year without immunosuppressive drugs after the first month.  – David

http://pagesfromserendipity.files.wordpress.com/2010/11/smiling-dog.jpg

Surgeons Develop Simultaneous Tissue and Stem Cell Transplant Technique

Released: 10/18/2011 11:00 AM EDT
Embargo expired: 10/27/2011 2:15 PM EDT
Source: American College of Surgeons (ACS)

New method shows promise in eliminating the need for long-term antirejection drugs, particularly for hand and face transplants

Newswise — SAN FRANCISCO: Surgical researchers at the University of Washington, Seattle, have pioneered a method using stem cells that may one day eliminate the need for antirejection drugs in transplants. Primary investigator David Mathes, MD, FACS, and his research fellow Jeff Chang, MD, MS, presented their findings today at the 2011 Clinical Congress of the American College Surgeons. Two groups of patients who might one day benefit from this early research breakthrough are hand and face transplant recipients. To date, survival of these transplants has depended on administering high-dose drugs to patients that suppress the immune system like those used in major organ transplants. However, these drugs are expensive and have a multitude of side effects, the researchers explained.

The surgeons performed simultaneous transplants of vascularized composite allografts—transplanted tissue with the blood vessels intact—and stem cells in four dogs followed by a short course of immune-suppressing drugs. All four dogs accepted the grafts without complications. After about a month, the researchers discontinued all immune system suppressing drugs. One dog rejected its stem cell transplant 10 weeks after the operation, but continued to tolerate the composite allograft for over one year without immunosuppression.

The other three dogs tolerated both stem cells and composite allografts for over one year. The investigators also performed vascularized composite allograft transplants without the stem cells on three other dogs. All three rejected the transplants after immune-suppressing drugs were stopped.

“If this technique works and proceeds into a clinical model, we would be able to transplant patients with either face or hands or even solid organs without the need for long-term immunosuppression drugs,” according to Dr. Chang. Physicians prescribe these drugs to people who have undergone hand and face transplants because organ transplant recipients, such as those receiving a liver or kidney, must take high-dose drugs to suppress the immune system and stave off organ rejection. Innovators of the hand and face transplants have followed this protocol to similarly prevent tissue rejection.

However, the side effects of these drugs have been widely reported. Kidney transplant recipients, for example, have a heightened risk of developing diabetes and hypertension. These drugs also raise the likelihood of infections and malignancy in all transplant recipients, Dr. Chang explained. Moveover, the American Society of Transplant Surgeons has estimated that immune-suppressing drugs can cost up to $25,000 a year per person.

While solid organ transplants are considered life-prolonging procedures in which the benefits outweigh the drug side effects, Dr. Chang noted that hand and face transplants do not fit this category. “Face and hand transplants are not life-saving procedures, so not subjecting these patients to the risks of immunosuppression would certainly be beneficial to them,” Dr. Chang said.

Although this research is still in an early phase, an important new finding the University of Washington study unveiled is the role that stem cells play in making the body tolerant of transplanted tissue, Dr. Chang said. “It’s interesting that you can modulate the immune system in such a way that you can transplant other cells into the recipient and the recipient becomes tolerant of them,” he said.

The study involved vascularized composite allograft transplants matched to the recipient’s tissue type. The next step is to attempt transplants in what Dr. Chang called a “mismatched” setting—where the donor and recipient tissue types do not necessarily match. “If we can get this to work in a mismatched setting it would be more clinically relevant,” Dr. Chang said.

Dr. Mathes and his collaborators at the Fred Hutchinson Cancer Research Center are attempting to develop this experimental model into a more clinical model for humans. The use of a canine model for this research is significant because large animals more closely resemble human anatomy and physiology with regard to composite allograft transplants, whereas “trying this method in small animals, such as laboratory mice, would be more difficult to translate into humans,” Dr. Chang explained.

Although the researchers embarked on developing this technique with hand and face transplants in mind, simultaneous mismatched tissue and stem cell transplantation may also hold promise for solid organ transplants. “If we extend this technique into solid organ transplantation, it would assist with a major problem; whether or not you need a complete match,” Dr. Chang said. “The other problem is supply and demand. If we can break the immunological barriers in such a way that would let us transplant a mismatched kidney, it would help greatly with the shortage of organs.”

David Mathes, MD, FACS, is the primary investigator for this project. Jeff Chang, MD, MS, is his research fellow. Both collaborated with Rainer Storb, MD, at the Fred Hutchinson Cancer Research Center in Seattle.

Surgeons Develop Simultaneous Tissue and Stem Cell Transplant Technique.

For those of you interested in the https://i2.wp.com/www.imodownload.com/imageupload/hcb_01.jpgbehind this, go here:

https://repairstemcell.wordpress.com/2011/10/27/silence-of-the-lambs-meets-stem-cells-the-hardcore-science/

INTESTINAL STEM CELLS RESPOND TO FOOD BY SUPERSIZING THE GUT

In STEM CELLS IN THE NEWS on October 27, 2011 at 6:24 pm

Request more treatment info.

INTESTINAL STEM CELLS RESPOND TO FOOD BY SUPERSIZING THE GUT

SO now we know that stem cells change your body all the time to deal with changes in your environment and what you eat.  Is it getting clearer? – David

Intestinal stem cells respond to food by supersizing the gut

BERKELEY —

A new study from University of California, Berkeley, researchers demonstrates that adult stem cells can reshape our organs in response to changes in the body and the environment, a finding that could have implications for diabetes and obesity…

Intestinal stem cells respond to food by supersizing the gut.

DIABETES CLINICAL TRIALS

  • FIRST USE OF CORD BLOOD TO ALTER COURSE OF TYPE 1 DIABETES, June 25, 2007 – (I’ll bet nobody heard of this one!)transfusion of stored, autologous (i.e. the person’s own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association’s 67th Annual Scientific Sessions. –http://parentsguidecordblood.org/content/media/m_pdf/ADA_T1D_PR-06-25-07.pdf(The ADA in 2007 knew stem cells can treat Diabetes type 1 in children!)
  • Diabetes type 1 stem cell clinical trial – Enrollment 11/2003-4/2008, follow-up until December 2008 – https://repairstemcell.wordpress.com/2009/09/14/type-1-diabetes-stem-cells-clinical-trial/
  • Why no diabetes clinical trial s in the US when mice were cured of diabetes type 1 in the 1990’s? –  Weissman, a professor of pathology and developmental biology at Stanford University, states: “Stem cells are rare, self-renewing, and can regenerate body tissues.” He repeatedly expressed frustration that while many of his discoveries seemed to hold remarkable potential for life-saving treatments, commercial or regulatory hurdles have prevented his scientific research from benefiting human beings. One example is, his mid-’90s research on type I diabetes, in which he demonstrated the ability to fully cure type I diabetes in mice using stem cells. Even though the experiments avoided political controversy by using adult/repair stem cells, which do not come from embryos, Weissman ran into a road block when pharmaceutical companies refused to sponsor clinical trials. The therapy went nowhere. “The pharmaceutical companies had put profit over principle, preferring to keep diabetes sufferers dependent on costly insulin than to cure them once and for all.” – https://repairstemcell.wordpress.com/2009/09/13/research-from-90s-cures-type-1-diabetes/

If you or a loved one is interested in receiving FREE information on currently available stem cell treatments for DIABETES or PERIPHERAL ARTERY DISEASE, please contact me at dsgrano@gmail.com or for other options, go to: CONTACT ME

HOPE FOR DIABETES SUFFERERS

In ALL ARTICLES on October 27, 2011 at 2:05 pm

THERE IS HOPE

I am continuously amazed at the wet blanket attitude that is projected by so many in light of significant stem cell breakthroughs.

First they say: “stem cell treatment has enabled patients with type 1 diabetes to go for as long as four years without insulin injections”

…pretty awesome huh?

Then they say: “the team warned the treatment may only work in those very recently diagnosed”

…oh, really…bummer.

Let’s just overlook that “recently diagnosed” actually means “recently developed symptoms” (I am fairly sure they don’t mean a 75 yr old grandmother who was “recently diagnosed” as having lived with diabetes for 55 years.) and as my friend the actuary likes to say: “Let’s just concentrate on the numbers.”

  • · Diabetes Prevalence – Total: 23.6 million children and adults — 8.0% of the population — have diabetes.  The total prevalence of diabetes increased 13.5% from 2005-2007.
  • · Diagnosed: 17.9 million people
  • · Undiagnosed: 5.7 million people (24%!)
  • · Pre-diabetes: 57 million people
  • · 1.6 million new cases of diabetes were diagnosed in people aged 20 years or older in 2007.

http://www.diabetes.org/diabetes-statistics.jsp

———————–

Ok, those are the numbers….So how SHOULD this article have been written?

How about…

World celebrates as new results prove diabetes pandemic can be stopped in it’s tracks with early detection!  Government to spend 10 million on improved early diabetes detection. (wait, where would they get the money…oh!) Money to be saved from not having to spend 100 million on late stage diabetes treatments.

Or….

5.7 million undiagnosed diabetes victims can now be saved from the trials of diabetes, amputation, blindness, kidney disease…etc with a single blood test.

Maybe you can come up with a different slant?

Point is; this is HUGE news!  Can we now cure every diabetic in the world?  No.  But we can potentially cure MILLIONS and this is a time for celebration for those people…and a time for optimism for the potential cures for others who are more advanced (as the science improves)…not a time for warnings of limitations.

But no, they stick to the glass is half empty position and say:
“It would be wrong to unnecessarily raise the hopes of people living with diabetes about a new treatment for the condition on the back of the evidence provided in this study.”

But you know what I think?

I think caution is good…but we are talking about people who are living with diabetes!  In my book, that makes them pretty damn tough already.  They are not little kittens and they don’t have to have their hopes “managed” or “spoon fed” to them.  In fact, raising their hopes may be EXACTLY what they need to survive through one more day of diabetes related pills and insulin, threats of blindness and amputation, reduction of lifespan, kidney and liver disease…etc. etc.

So celebrate the victories, embrace the hope and ALWAYS remember:

“If you lose hope, somehow you lose the vitality that keeps life moving, you lose that courage to be, that quality that helps you go on in spite of it all. And so today I still have a dream.” Martin Luther King, Jr.

And as far as false hope, there is no such thing. There is only hope or the absence of hope-nothing else. – Patti Davis

 

hope-1

“There is only hope or the absence of hope-nothing else.

DAMN STRAIGHT!

FAKE AND FRAUDULENT SCIENCE

In DISEASE INFO on October 27, 2011 at 2:32 am

FAKE AND FRAUDULENT SCIENCE

  • Scientific empirical data is subject to misinformation and corruption as much as what some refer to as the “soccer mom hysteria.”
    For example:  Dr Thorsen’s data on the correlation between MMR vaccines and Autism is corrupt and dependent on elements outside the study both ignored and cherry picked around:

    “Thorsen was a leading member of a Danish research group that wrote several key studies supporting CDC’s claims that the MMR vaccine and mercury-laden vaccines were safe for children. Thorsen’s 2003 Danish study reported a 20-fold increase in autism in Denmark after that country banned mercury based preservatives in its vaccines. His study concluded that mercury could therefore not be the culprit behind the autism epidemic.

    His study has long been criticized as fraudulent since it failed to disclose that the increase was an artifact of new mandates requiring, for the first time, that autism cases be reported on the national registry. This new law and the opening of a clinic dedicated to autism treatment in Copenhagen accounted for the sudden rise in reported cases rather than, as Thorsen seemed to suggest, the removal of mercury from vaccines. Despite this obvious chicanery, CDC has long touted the study as the principal proof that mercury-laced vaccines are safe for infants and young children. Mainstream media, particularly the New York Times, has relied on this study as the basis for its public assurances that it is safe to inject young children with mercury — a potent neurotoxin — at concentrations hundreds of times over the U.S. safety limits.

    Thorsen, who was a psychiatrist and not a research scientist or toxicologist, parlayed that study into a long-term relationship with CDC. He built a research empire called the North Atlantic Epidemiology Alliances (NANEA) that advertised its close association with the CDC autism team, a relationship that had the agency paying Thorsen and his research staff millions of dollars to churn out research papers, many of them assuring the public on the issue of vaccine safety.

    The discovery of Thorsen’s fraud came as the result of an investigation by Aarhus University and CDC which discovered that Thorsen had falsified documents and, in violation of university rules, was accepting salaries from both the Danish university and Emory University in Atlanta — near CDC headquarters — where he led research efforts to defend the role of vaccines in causing autism and other brain disorders. Thorsen’s center has received $14.6 million from CDC since 2002.

    Thorsen’s partner Kreesten Madsen recently came under fierce criticism after damning e-mails surfaced showing Madsen in cahoots with CDC officials intent on fraudulently cherry picking facts to prove vaccine safety.

    Leading independent scientists have accused CDC of concealing the clear link between the dramatic increases in mercury-laced child vaccinations beginning in 1989 and the epidemic of autism, neurological disorders and other illnesses affecting every generation of American children since. Questions about Thorsens’s scientific integrity may finally force CDC to rethink the vaccine protocols since most of the other key pro vaccine studies cited by CDC rely on the findings of Thorsen’s research group. These include oft referenced research articles published by the Journal of the American Medical Association, the American Journal of Preventive Medicine, the American Academy of Pediatrics, the New England Journal of Medicine and others. The validity of all these studies is now in question.”

    via https://repairstemcell.wordpress.com/2010/03/15/cdc-vaccine-cover-up-mercury-actually-does-cause-autism/

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  • PFIZER, CELEBREX, BEXTRA + VIOXX CLINICAL TRIAL RESULTS WERE FAKE- FRAUD
    February 18, 2010 at 1:55 pm “It’s being called the largest research fraud in medical history. Dr. Scott Reuben, a former member of Pfizer’s speakers’ bureau, has agreed to plead guilty to faking dozens of research studies that were published in medical journals. Now being reported across the mainstream media is the fact that Dr. Reuben accepted a $75,000 grant from Pfizer to study Celebrex in 2005. His research, which was published in a medical journal, has since been quoted by hundreds of other doctors and researchers as “proof” that Celebrex helped reduce pain during post-surgical recovery. There’s only one problem with all this: No patients were ever enrolled in the study!” https://repairstemcell.wordpress.com/2010/02/18/pfizer-celebrex-bextra-vioxx-clinical-trial-results-were-fake-fraud/


    repairstemcell.wordpress.com

    ‎”It’s being called the largest research fraud in medical history. Dr. Scott Reu…

 

  • and need I mention the Embyonic hoax perpetrated on the US populace for a decade?

    The pure and impartial and just eye of the scientist is just as susceptible to partiality as any other if not more so because they think thy can get away with it.

    The Placebo Defecthttp://naturalnews.com/030209_placebo_medical_fraud.html

    “This is the conclusion from researchers at the University of California who published their findings in the October issue of the Annals of Internal Medicine. They reviewed 167 placebo-controlled trials published in peer-reviewed medical journals in 2008 and 2009 and found that 92 percent of those trials never even described the ingredients of their placebo pills.”

    Empirical science is not a hat you take off when it is convenient. Everything has an effect and if test tubes are not sterile and compounds are contaminated and trials are screwed up then they can not be considered valid. 92%. Nuff said.

https://i2.wp.com/no92.com/assets/images/autogen/a_nO92_logo.gif

47 DEATHS FROM HPV VACCINES YOU WILL NEVER READ ABOUT

In ALL ARTICLES, DISEASE INFO on October 26, 2011 at 1:55 am

THE UNLUCKY 47…

AND WHAT REALLY SCARES ME IS THAT OVER 1/2 OF THEM ARE

“CAUSE OF DEATH = UNKNOWN!”

via http://www.judicialwatch.org/files/documents/2009/vaersdeathsALL_20090616.pdf

HPV VACCINES FOR ALL CHILDREN NOW!

In DISEASE INFO on October 26, 2011 at 1:54 am

WARNING, THE FOLLOWING ARTICLE IS NOT FOR THE FAINT OF HEART!  READ AT YOUR OWN RISK!

[For what it’s worth; writing this article made me nauseous. So much for professional objectivity.]

—————————————-

So you’re considering vaccinating little Susy and little Jimmy?  Of course you are!  You are a responsible parent and we are talking about preventing cancer gosh darn it!

https://i1.wp.com/www.gamstonschool.com/Resources/user/docs/Gamston%20logos/Cartoon%20parents.jpg

Well, here are 47 children that will never ever get cervical cancer or even spread it!  Do you know why?

BECAUSE HERE ARE 47 HPV VACCINE VICTIMS, 11 to 22 YEARS OLD, WHO ARE DEAD:
THE UNLUCKY 47 YOU WILL NEVER READ ABOUT

(this information via)

Do you know why the HPV vaccine is recommended for all children? Because there is no cure for it…or MS or CP or autism or AIDs or any other significant disease out there.

How long will it be before you MUST get a vaccine for ALL diseases whether there is a real chance of contracting it or not?
Only as long as it takes to make the drugs my friends.

And why do we have to vaccinate in the first place?
Because there is not a single disease treatable” with drugs which has been cured since Polio in the 1950s.  

What are vaccines? 

Vaccines are Pharmas way of saying:
WE CAN’T CURE IT, SORRY, NOW PONY UP THE CASH SO WE CAN USE YOU AS A LAB RAT, INJECTING ALL SORTS OF WHO KNOWS WHAT THAT WILL COMBINE IN YOUR AND YOUR CHILDREN’s BODIES WITH THE POLLUTION IN THE AIR WE HELPED CREATE, SODIUM FLOURIDE IN RAT POISON AND YOUR TOOTHPASTE, PESTICIDES, STEROIDS, ANTIBIOTICS, FLOURIDE, RITALIN AND PROZAX AND BIRTH CONTROL CHEMICALS IN YOUR DRINKING WATER, TEFLON FROM YOUR PANS AND FOLATES FROM YOUR PLASTIC AND MIX UP IN A DELIGHTFUL CHEMICAL STEW AND CAUSE WHO KNOWS WHAT KINDS OF ISSUES DOWN THE ROAD.  THEN, WE CAN GET RICHER AND SELL YOU MORE DRUGS FOR UNKNOWN DISEASES TOMORROW WHICH WE WON’T BE ABLE TO CURE BUT WE WILL DEVELOP VACCINES FOR THEM TOO!

Now don’t get me wrong.  I’m all for preventative care.  But there is good prevention and bad prevention. 

Have you noticed this prevention trend?
Eastern medicine believes in eating, exercising and taking care of oneself now to prevent disease.

Western medicine believes in taking a pill now to prevent a symptom.  Prilosec for example is taken daily to avoid acid reflux.

So what’s the difference?

There’s only one problem (there are many but let’s focus on one.)  Long term use of exercise, teas, acupuncture, wheat grass juice or dandelion leaves have virtually no side effects.  Long term use of Prilosec (for example) has these:

Bone Fractures – A fracture is a break in the continuity of the bone. According to the U.S. Food and Drug Administration, long-term use of high doses of Prilosec may cause increased of fractures of the hip, wrist and spine. The risk of fractures is even greater in patients older than 50 years who have used Prilosec for a long-time. The FDA recommends that doctors prescribe low doses of Prilosec and for the shortest duration.

Liver Damage – According to Drugs.com, Prilosec is metabolized in the liver. The liver converts Prilosec into by products which can be easily excreted from the body. Constant exposure of the liver to high doses of Prilosec damages the liver leading to liver failure. Signs and symptoms of liver failure include nausea, right upper abdominal pain, clay colored stool and yellowing of the eyes and the skin.

Esophageal Candidiasis – Esophageal candidiasis as the overgrowth of fungus in the esophagus. Stomach acid is important in preventing growth of fungus in the esophagus. According to Drugs.com, use of Prilosec for a long-time creates a favorable environment for the growth of fungus in esophagus as Prilosec blocks the production of acid in the stomach. Esophageal candidiasis causes painful swallowing which may lead to excess weight loss.

Oh come on David, this isn’t Prilosec, it’s an HPV vaccine for boys to avoid potential cancer, just like the “very safe” HVP vaccine for girls.  Very safe?

For our sweet young ladies! 🙂
“The FDA adverse event reports on the HPV vaccine read like a catalog of horrors. Any state or local government now beset by Merck’s lobbying campaigns to mandate this HPV vaccine for young girls ought to take a look at these adverse health reports.” –  Via

“…ignored the shocking statistics about the HPV vaccine available at the CDC’s Vaccine Adverse Event Reporting System website. The Center received a total of 18,727 reports of adverse events following Gardasil HPV vaccination, with 1,498 of them (8%) considered “serious”—such as blood clots, the neurological disorder Guillain-Barre Syndrome, and 68 reports of death.” – via

“…Gardasil was approved to protect against four [of the 100+] strains of HPV, which can lead to cervical and other cancers, in girls and women between the ages of 9 and 26 years old. Later, the vaccine was approved in boys and young men in the same age range to combat two [of the 100+] HPV strains that can cause genital warts. GlaxoSmithKline’s Cervarix is approved for preventing HPV in females ages 9 through 25.” via

“Cervarix will not prevent diseases caused by HPV types other than types 16 and 18. There are over 100 different types of HPV.” via

It really freaks me out when virtually every site I go to says:  “This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at           1-800-822-7967.”

But I did find this very complete clinical assessment of the side effects:

http://www.drugs.com/sfx/cervarix-side-effects.html

And I’ll just leave you with these:

Get the picture?

Panel Endorses HPV Vaccine for Boys of 11

By GARDINER HARRIS – Published: October 25, 2011

Boys and young men should be vaccinated against human papillomavirus, or HPV, to protect against anal and throat cancers that can result from sexual activity, a federal advisory committee said Tuesday.

The recommendation by the panel, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention, is likely to transform the use of the HPV vaccine, since most private insurers pay for vaccines once the committee recommends them for routine use. The HPV vaccine is unusually expensive. Its three doses cost pediatricians more than $300, and pediatricians often charge patients hundreds more.

The committee recommended that boys ages 11 and 12 should be vaccinated. It also recommended vaccination of males ages 13 through 21 who had not already had all three shots. Vaccinations may be given to boys as young as 9 and to men between the ages of 22 and 26.

The committee recommended in 2006 that girls and young women ages 11 to 26 should be vaccinated, but vaccination rates in the United States have so far been disappointing.

The vaccine has been controversial because the disease it prevents results from sexual activity, and that controversy is likely to intensify with the committee’s latest recommendation since many of the cancers in men result from homosexual sex. The HPV vaccine became a source of contention among Republican presidential candidates after some candidates criticized Gov. Rick Perry of Texas for trying to require that girls in his state be vaccinated. Representative Michele Bachmann falsely suggested that the vaccine causes mental retardation.

But for the public health experts gathered in Atlanta, the vaccine’s remarkable effects were irresistible.

“This is cancer, for Pete’s sake,” said Dr. William Schaffner, chairman of the department of preventive medicine at Vanderbilt University School of Medicine and a nonvoting member of the committee. “A vaccine against cancer was the dream of our youth.”

HPV infection is the most common sexually transmitted disease — between 75 percent and 80 percent of females and males in the United States will be infected at some point in their lives. Most will overcome the infection with no ill effects. But in some people, infections lead to cellular changes that cause warts or cancer, including cervical, vaginal and vulvar cancers in women and anal cancers in men and women. A growing body of evidence suggests that HPV also causes throat cancers in men and women as a result of oral sex.

HPV infections cause about 15,000 cancers in women and 7,000 cancers in men each year. And while cervical cancer rates have plunged over the past four decades because of widespread screening, anal cancer rates in men and women have been increasing. Head and neck cancers have also been increasing, with the share associated with HPV infection increasing rapidly — perhaps because oral sex has increased in popularity.

Parents of boys face some uncomfortable realities when choosing whether to have their child vaccinated. The burden of disease in males results mostly from oral or anal sex, but vaccinating boys will also benefit female partners since cervical cancer in women results mostly from vaginal sex with infected males.

Vaccinating the nation’s 11- and 12-year-old boys will cost almost $140 million annually, but the one-time catch-up among males 13 to 21 will cost hundreds of millions more. The government generally pays for about half of all vaccinations.

The committee has become increasingly concerned about the cost effectiveness of vaccines, since the newest vaccines tend to be very expensive while protecting against diseases that affect fewer people. Vaccinating boys is cost effective when vaccination rates in girls are relatively low, which they are now. Fewer than half of girls between the ages of 13 and 17 have received at least one dose of the HPV vaccine, and fewer than a third have received all three doses.

Only about 1 percent of boys have received the HPV vaccine, even though the vaccine advisory committee has said that boys could be vaccinated against the disease if they or their parents wished.

Vaccinating homosexual boys would be far more cost effective than vaccinating all boys, since the burden of disease is far higher in homosexuals. “But it’s not necessarily effective or perhaps even appropriate to be making those determinations at the 11- to 12-year-old age,” said Kristen R. Ehresmann of the Minnesota Department of Health and a committee member.

Dr. S. Michael Marcy, a clinical professor of pediatrics at the University of Southern California and a committee member, said that the money needed to vaccinate 11- and 12-year-old boys would pay for only a few hours of the war in Afghanistan while potentially saving thousands of lives in the United States.

“I’m constantly being told we don’t have the money. Well, we do have the money,” Dr. Marcy said. “We need a new set of priorities, and we if we don’t set those priorities, who will?”

The vaccine loses effectiveness if it is given after the onset of sexual activity. More than one in five boys and girls have had vaginal sex by the age of 15, surveys show. But there are many strains of HPV, and Gardasil — the HPV vaccine manufactured by Merck — protects against four of those strains. Older boys and young men may receive the vaccine even after becoming sexually active in hopes that it might protect them against an HPV strain they have yet to encounter.

Separately, the advisory committee voted to recommend routine vaccination of diabetics under age 60 against hepatitis B infections, which commonly occur in older diabetics in long-term care facilities where blood sugar levels are checked using unsanitary methods. Diabetics 60 and older may get vaccinated as well, but the panel recommended vaccines only for those under 60 because that is when immune systems respond best to vaccination.

For HPV, the committee voted 8 to 5, with one abstention, to approve a recommendation that males 13 to 21 be vaccinated, with those voting against the recommendation hoping to make the upper age limit 26. Vaccinating men ages 22 to 26 is expensive and is likely to provide relatively few health benefits.

“The bottom line is that not all kids start having sex when they’re 13. Mine didn’t, I promise you,” Dr. Sandra Adamson Fryhofer, a clinical associate professor of medicine at Emory University School of Medicine and a committee member, said to laughter from the audience.

Not only are the committee’s recommendations routinely used by private insurers to determine which vaccines to pay for, but the health reform legislation of 2010 requires insurers that participate in health exchanges to offer vaccines that are routinely recommended by the committee.

Can MS be treated with stem cells?

In ALL ARTICLES on October 25, 2011 at 2:13 pm

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

I did some digging and would like to present the preliminary results to answer the question:

Can MS be treated with stem cells?

https://i2.wp.com/www.msconnections.org/ms-myelin.gifSOME MULTIPLE SCLEROSIS CLINICAL TRIALS

  • Hematopoietic stem cell transplantation for multiple sclerosis – 2002 clinical trial based on data collected from TWENTY medical institutes around the world.  Conclusion: Autologous HSCT suggest positive early results in the management of progressive MS and is feasible – http://www.springerlink.com/content/1b19ldgyecqvny3w/
  • Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis, Sep 16, 1999  These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon… – http://www.springerlink.com/index/H6X0866N90633266.pdf
  • “Dose of stem cells reverses some MS” – January 31, 2009 – STUDY – “A dose of their own stem cells “reset” the malfunctioning immune system of patients with early-stage multiple sclerosis and, for the first time, reversed their disability, according to researchers at Northwestern University in Chicago. Three years after being treated, on average, 17 of the 21 patients had improved on tests, suffering fewer problems with their balance or vision, 16 had experienced no relapse, and none had deteriorated.  This marks the first “reversal” of neurologic loss caused by this disease, says Richard Burt of Northwestern University in Chicago.
  • More – https://repairstemcell.wordpress.com/2009/09/02/multiple-sclerosis-and-stem-cells-need-more-info/

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Can MS be treated with stem cells?

You decide. Here are 11 articles from my blog,  28,000 from google news and there are a total of 20 clinical trials from clinicaltrials.gov

From my blog…

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

***https://repairstemcell.wordpress.com/2010/05/18/ms-and-stem-cells-time-is-brain-in-ms/

*** https://repairstemcell.wordpress.com/2009/09/02/my-ms-pain-is-gone/

* * * https://repairstemcell.wordpress.com/2009/04/26/fat-derived-stem-cells-might-treat-ms-us-news-and-world-report/

* * * https://repairstemcell.wordpress.com/2009/04/15/britt%e2%80%99s-fight-against-multiple-sclerosis-hits-home-for-uncw-starnewsonlinecom-star-news-wilmington-nc/

* * * https://repairstemcell.wordpress.com/2009/04/09/stem-cell-breakthrough-may-lead-to-ms-treatments-forbescom/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-2/

* * * https://repairstemcell.wordpress.com/2009/04/07/my-battle-with-and-victory-over-ms-by-preston-walker-part-1/

* * * https://repairstemcell.wordpress.com/2009/03/07/study-stem-cell-transplants-could-reverse-ms-cloning-and-stem-cells-msnbccom/

* * * https://repairstemcell.wordpress.com/2009/02/23/foxnewscom-college-student-with-multiple-sclerosis-symptom-free-after-stem-cell-treatment-health-news-current-health-news-medical-news/

* * * https://repairstemcell.wordpress.com/2009/02/12/stem-cells-ms-multiple-sclerosis-cured-by-adult-stem-cells-video-stem-cell-research-and-stem-cell-therapy/

* * * https://repairstemcell.wordpress.com/2009/02/11/multiple-sclerosis-ms-stem-cell-trials-us-is-starting-to-%e2%80%9ccatch-up%e2%80%9d/

* * * https://repairstemcell.wordpress.com/2009/02/10/the-us-is-playing-catch-up-with-stem-cells-ms/

* * * https://repairstemcell.wordpress.com/2009/02/08/stem-cell-transplants-help-ms-victims/

…and about 28,000 scholarly papers/studys on “MS stem cell” here:
http://scholar.google.com/scholar?q=multiple%20sclerosis%20trial%20stem%20cell&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=ws\

…and 20 responses from clinicaltrials.gov on “multiple sclerosis stem cell”
http://clinicaltrial.gov/ct2/results?term=multiple+sclerosis+stem+cell

For more information and to see if you are a candidate for adult stem cell treatment: http://bit.ly/PATIENTQUESTIONNAIRE

Autologous Stem Cell Transplants, Visible Progress in 8 of 10 Patients

In STEM CELLS IN THE NEWS on October 25, 2011 at 1:49 pm

Transplanting stem cells from one’s own bone marrow (autologous stem cell transplants) improves the symptoms of muscular sclerosis (MS), and in some cases the neurological disease actually regressed. These are the encouraging results obtained from a small study performed on 21 remittent MS patients by a group from the Northwestern University School of Medicine in Chicago and published in Lancet Neurology. “All of the patients,” said the neurologists, “witnessed an improvement in their conditions three years after the stem cell transplants were performed. Of these, 81pct benefited from visible progress, measured in terms of the scale of their disability.”

With these “encouraging” results, the researchers decided to perform another study involving more patients, and compared their results with traditional treatments. The experiment involved the removal and freezing of bone marrow after treating the marrow with drugs to remove the lymphocytes of the immune system which are responsible for attacking nerve system fibers in MS patients.

At the end of the process, doctors implanted stem cells, which proved to be able to give the MS patients a normally functioning immune system. The time factor, underlined neurologists, seems crucial in the efficiency for stem cells because “if we intervene quickly, we are able to exploit the body’s ability to repair itself, which in the long term is lost”. In any case, scientists say that “ it is not a definitive cure for muscular sclerosis”.

No Wedding Day for Jay Cutler – Diabetes

In ALL ARTICLES on October 24, 2011 at 6:59 pm

No Wedding Day for Jay

by on July 26, 2011 in Entertainment, Sports

It appears Jay Cutler will not be walking down the aisle next spring. The Chicago Bears quarterback broke off his engagement to The Hills star, Kristin Cavallari just weeks before the start of football season. Cutler, now 28, was diagnosed with diabetes three years ago. He has Type 1, sometimes referred to as “juvenile diabetes,” which is a misnomer. While the onset typically occurs in children and adolescents, people of any age can be affected. Cutler himself was 25. He exhibited all the classic signs of diabetes: weight loss (he went from 238 pounds to 203 in a few short months), frequent urination, insatiable thirst, and lack of energy. As a result of untreated diabetes, his game suffered. It was not until a routine blood test (required to participate in offseason training), that Cutler learned he had diabetes.

Diabetes, generally speaking, is a condition in which the body’s cells do not receive adequate supply of sugar, in particular, a sugar called glucose. When our food is digested,  glucose makes its way into our bloodstream. Our cells use the glucose for energy and growth. But glucose cannot enter our cells without insulin. It is insulin which enables our cells to take in glucose. Without insulin, the sugar levels in the bloodstream rise.

Cutler’s adult-onset type 1 diabetes highlights the importance of distinguishing the three different types of diabetes:

Type 1 may more accurately be termed “insulin-dependent” diabetes. This is because people with the condition require daily, subcutaneous injections of insulin for the rest of their lives. In type 1, the body’s immune system attacks cells in the pancreas that make insulin.

Type 2 diabetes is sometimes referred to as “adult diabetes.” This is another misconception. In fact, recent studies conducted by the CDC have found that children and teenagers are being diagnosed with the disease at an alarming rate. About 95% of those children were obese at the time of diagnosis. Type 2 diabetes occurs when the pancreas does not make enough insulin, suffers from “insulin resistance”, or both.  Insulin resistance means that the cells no longer respond properly to the insulin present.  An unhealthy weight is a major risk factor.

A third type, gestational diabetes, occurs in pregnant women, and is usually temporary. Complications can still endanger the health of the woman and her fetus.

There is also an uncommon medical condition called diabetes insipidus which actually has nothing to do with insulin. In diabetes insipidus, the kidneys are unable to conserve water as they filter blood. This problem arises either directly from the kidney, or from a part of the brain called the hypothalamus, which produces a hormone, called ADH, that controls water conservation.

Despite the differences between type 1 and 2, the complications are often the same. The higher the blood sugars over an extended period of time, the greater the risk for complications such as blindness, stroke, nerve damage,  limb amputation, kidney failure, and premature death.

Celebrities with Diabetes (type 1 or 2)

Type 1

Type 2

  • Halle Berry – actress
  • BB King – musician
  • Sugar Ray Leonard – boxer
  • Drew Carey – actor; comedian; game show host
  • Tommy Lee – drummer for Motley Crue
  • Billie Jean King – tennis player

Salma Hayek (gestational diabetes)

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